LOCUS HSU92436 3160 bp mRNA linear HUM 01-APR-1997 DEFINITION Human mutated in multiple advanced cancers protein (MMAC1) mRNA, complete cds. ACCESSION U92436 VERSION U92436.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3160) AUTHORS Steck,P.A., Pershouse,M.A., Jasser,S.A., Lin,H., Yung,W.K.A., Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T., Frye,C., Hu,R., Swedlund,B., Teng,D.H.F. and Tavtigian,S.V. TITLE Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers JOURNAL Nat. Genet. 15 (4), 356-362 (1997) PUBMED 9090379 REFERENCE 2 (bases 1 to 3160) AUTHORS Steck,P.A., Pershouse,M.A., Jasser,S.A., Lin,H., Yung,W.K.A., Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T., Frye,C., Hu,R., Swedlund,B., Teng,D.H.F. and Tavtigian,S.V. TITLE Direct Submission JOURNAL Submitted (07-MAR-1997) Research, Myriad Genetics Inc., 190 Wakara Way, Salt Lake City, UT 84108, USA REMARK Collaboration between the Departments of Neuro-Oncology and Pathology at the Brain Tumor Center University of Texas M.D. Anderson Cancer Center and Myriad Genetics Inc. FEATURES Location/Qualifiers source 1..3160 /db_xref="H-InvDB:HIT000222622" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q23.3" gene 1..3160 /gene="MMAC1" /note="mutated in multiple advanced cancers" CDS 1035..2246 /gene="MMAC1" /codon_start=1 /product="MMAC1" /protein_id="AAC51182.1" /translation="MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEG VYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIK PFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT RDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVN TFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKAN RYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF DEDQHTQITKV" BASE COUNT 853 a 742 c 788 g 777 t ORIGIN 1 cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 61 ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt 121 gatgtggcag gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact 181 gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc 241 tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga 301 gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct 361 gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct 421 cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg 481 aggcgcggcg gcggcggcgg cggcacctcc cgctcctgga gcggggggga gaagcggcgg 541 cggcggcggc cgcggcggct gcagctccag ggagggggtc tgagtcgcct gtcaccattt 601 ccagggctgg gaacgccgga gagttggtct ctccccttct actgcctcca acacggcggc 661 ggcggcggcg gcacatccag ggacccgggc cggttttaaa cctcccgtcc gccgccgccg 721 caccccccgt ggcccgggct ccggaggccg ccggcggagg cagccgttcg gaggattatt 781 cgtcttctcc ccattccgct gccgccgctg ccaggcctct ggctgctgag gagaagcagg 841 cccagtcgct gcaaccatcc agcagccgcc gcagcagcca ttacccggct gcggtccaga 901 gccaagcggc ggcagagcga ggggcatcag ctaccgccaa gtccagagcc atttccatcc 961 tgcagaagaa gccccgccac cagcagcttc tgccatctct ctcctccttt ttcttcagcc 1021 acaggctccc agacatgaca gccatcatca aagagatcgt tagcagaaac aaaaggagat 1081 atcaagagga tggattcgac ttagacttga cctatattta tccaaacatt attgctatgg 1141 gatttcctgc agaaagactt gaaggcgtat acaggaacaa tattgatgat gtagtaaggt 1201 ttttggattc aaagcataaa aaccattaca agatatacaa tctttgtgct gaaagacatt 1261 atgacaccgc caaatttaat tgcagagttg cacaatatcc ttttgaagac cataacccac 1321 cacagctaga acttatcaaa cccttttgtg aagatcttga ccaatggcta agtgaagatg 1381 acaatcatgt tgcagcaatt cactgtaaag ctggaaaggg acgaactggt gtaatgatat 1441 gtgcatattt attacatcgg ggcaaatttt taaaggcaca agaggcccta gatttctatg 1501 gggaagtaag gaccagagac aaaaagggag taactattcc cagtcagagg cgctatgtgt 1561 attattatag ctacctgtta aagaatcatc tggattatag accagtggca ctgttgtttc 1621 acaagatgat gtttgaaact attccaatgt tcagtggcgg aacttgcaat cctcagtttg 1681 tggtctgcca gctaaaggtg aagatatatt cctccaattc aggacccaca cgacgggaag 1741 acaagttcat gtactttgag ttccctcagc cgttacctgt gtgtggtgat atcaaagtag 1801 agttcttcca caaacagaac aagatgctaa aaaaggacaa aatgtttcac ttttgggtaa 1861 atacattctt cataccagga ccagaggaaa cctcagaaaa agtagaaaat ggaagtctat 1921 gtgatcaaga aatcgatagc atttgcagta tagagcgtgc agataatgac aaggaatatc 1981 tagtacttac tttaacaaaa aatgatcttg acaaagcaaa taaagacaaa gccaaccgat 2041 acttttctcc aaattttaag gtgaagctgt acttcacaaa aacagtagag gagccgtcaa 2101 atccagaggc tagcagttca acttctgtaa caccagatgt tagtgacaat gaacctgatc 2161 attatagata ttctgacacc actgactctg atccagagaa tgaacctttt gatgaagatc 2221 agcatacaca aattacaaaa gtctgaattt ttttttatca agagggataa aacaccatga 2281 aaataaactt gaataaactg aaaatggacc tttttttttt taatggcaat aggacattgt 2341 gtcagattac cagttatagg aacaattctc ttttcctgac caatcttgtt ttaccctata 2401 catccacagg gttttgacac ttgttgtcca gttgaaaaaa ggttgtgtag ctgtgtcatg 2461 tatatacctt tttgtgtcaa aaggacattt aaaattcaat taggattaat aaagatggca 2521 ctttcccgtt ttattccagt tttataaaaa gtggagacag actgatgtgt atacgtagga 2581 attttttcct tttgtgttct gtcaccaact gaagtggcta aagagctttg tgatatactg 2641 gttcacatcc tacccctttg cacttgtggc aacagataag tttgcagttg gctaagagag 2701 gtttccgaaa ggttttgcta ccattctaat gcatgtattc gggttagggc aatggagggg 2761 aatgctcaga aaggaaataa ttttatgctg gactctggac catataccat ctccagctat 2821 ttacacacac ctttctttag catgctacag ttattaatct ggacattcga ggaattggcc 2881 gctgtcactg cttgttgttt gcgcattttt ttttaaagca tattggtgct agaaaaggca 2941 gctaaaggaa gtgaatctgt attggggtac aggaatgaac cttctgcaac atcttaagat 3001 ccacaaatga agggatataa aaataatgtc ataggtaaga aacacagcaa caatgactta 3061 accatataaa tgtggaggct atcaacaaag aatgggcttg aaacattata aaaattgaca 3121 atgatttatt aaatatgttt tctcaattgt aaaaaaaaaa //