LOCUS HSU91616 2067 bp mRNA linear HUM 12-APR-1997
DEFINITION Human I kappa B epsilon (IkBe) mRNA, complete cds.
ACCESSION U91616
VERSION U91616.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2067)
AUTHORS Whiteside,S.T., Epinat,J.C., Rice,N.R. and Israel,A.
TITLE I kappa B epsilon, a novel member of the I kappa B family, controls
RelA and cRel NF-kappa B activity
JOURNAL EMBO J. 16 (6), 1413-1426 (1997)
PUBMED 9135156
REFERENCE 2 (bases 1 to 2067)
AUTHORS Whiteside,S.T., Epinat,J.C., Rice,N.R. and Israel,A.
TITLE Direct Submission
JOURNAL Submitted (28-FEB-1997) Biologie Moleculaire de l'Expression
Genique, Institut Pasteur, 25 rue du Dr Roux, Paris 75015, France
FEATURES Location/Qualifiers
source 1..2067
/db_xref="H-InvDB:HIT000222581"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="stG110; between D6S426 and D6S271"
/tissue_type="brain"
/dev_stage="fetus"
gene 1..2067
/gene="IkBe"
CDS 34..1536
/gene="IkBe"
/function="cytoplasmic NF-kappa B inhibitor"
/codon_start=1
/product="I kappa B epsilon"
/protein_id="AAC51216.1"
/translation="MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGG
AIRVRRPCWSGGAGRGGGRPWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRRP
RAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIE
SLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLT
YTLSLLGGPEAEDPPPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLL
CCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVA
CQRQSWPVPAACWKGGPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRN
GADIDVQEGSSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLM
GISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD"
misc_feature 103..117
/gene="IkBe"
/note="encodes serine active site"
misc_feature 451..453
/gene="IkBe"
/note="encodes internal initiation of translation"
misc_feature 490..501
/gene="IkBe"
/note="encodes CK2 phosphorylation site"
misc_feature 499..504
/gene="IkBe"
/note="encodes CK2 phosphorylation site"
misc_feature 502..504
/gene="IkBe"
/note="encodes signal induced phosphorylation site"
misc_feature 514..516
/gene="IkBe"
/note="encodes signal induced phosphorylation site"
misc_feature 532..543
/gene="IkBe"
/note="encodes CK2 phosphorylation site"
misc_feature 805..903
/gene="IkBe"
/note="encodes ankyrin repeat"
misc_feature 910..1008
/gene="IkBe"
/note="encodes ankyrin repeat"
misc_feature 1009..1107
/gene="IkBe"
/note="encodes ankyrin repeat"
misc_feature 1138..1236
/gene="IkBe"
/note="encodes ankyrin repeat"
misc_feature 1240..1338
/gene="IkBe"
/note="encodes ankyrin repeat"
misc_feature 1339..1437
/gene="IkBe"
/note="encodes ankyrin repeat"
misc_feature 1447..1458
/gene="IkBe"
/note="encodes CK2 phosphorylation site"
BASE COUNT 419 a 622 c 669 g 357 t
ORIGIN
1 ggaattccaa tgaatgaatg aatgaatgag tgaatgaatc aacgaaggag tgagtcaagg
61 cccgggaacc acagactcca agcctacgca gagcccggga agggggattc cggaggggcg
121 gggcctcttt ccggaagcgc ccgccggggg cggggagggg gcggggccat ccgcgtgagg
181 cgaccctgtt ggtccggagg ggcggggcga ggaggaggac ggccttgggc ggttcggctg
241 cccacagtaa ccgctgggtg gacctggcca gcgctccgaa ccttgtcctc gctgcgcgcc
301 ggcccctcgg agccccacag cccgggaagg aggcggccgc gggcggggcg cccgctctgc
361 caagcggacc cgcaacccgg aaaggcggcg cggcggagcc tggagccgga tcctgctcag
421 accgggcccc ggccggccag agccgcgggc atgtcggagg cgcggaaggg gccggacgag
481 gcggaggaga gccagtacga ctctggcatt gagtctctgc gctctctgcg ctccctaccc
541 gagtccacct cggctccagc ctccgggccc tcggacggca gcccccagcc ctgcacccat
601 cctccgggac ccgtcaagga accacaggag aaggaagacg cggatgggga gcgggctgat
661 tccacctatg gctcctcctc gctcacctac accctgtcct tgctgggggg ccccgaggct
721 gaggacccgc ccccacgcct gccactcccc cacgtggggg cgctgagccc tcagcagctg
781 gaagcactca cttacatctc cgaggacgga gacacgctgg tccacctggc agtgattcat
841 gaggccccag cggtgctgct ctgttgcctg gctttgctgc cccaggaggt cctggacatt
901 caaaataacc tttaccagac agcactccat ctggctgtac atctggacca accgggcgca
961 gttcgggcac tggtgctgaa gggggccagc cgggcactac aggaccggca tggagacaca
1021 gcccttcatg tggcctgcca gcgccagtct tggcctgtgc ccgctgcctg ctggaagggc
1081 gggccagagc caggcagagg aacatctcac tctctggacc tccagctgca aaactggcaa
1141 ggtctggctt gtctccacat tgccaccctt cagaagaacc aaccactcat ggaattgctg
1201 cttcggaatg gagctgacat tgatgtgcag gagggctcca gtggtaagac agcgctgcac
1261 ctggctgtgg aaacccaaga gcggggcctg gtacagttcc tgctccaggc tggtgcccag
1321 gtagatgccc gcatgctgaa cgggtgcaca cccctgcacc tggcagctgg ccggggtctc
1381 atgggcatct catccactct gtgcaaggcg ggtgctgact ccctgctgcg gaatgtggag
1441 gatgagacgc cccaggacct gactgaggaa tcccttgtcc ttttgccctt tgatgacctg
1501 aagatctcag ggaaactgct gctgtgtacc gactgaagcc aggcagggtc tgggatcctc
1561 agggctccac ctctccatct ggaagccgga gccataactg ctgcagtttg ggcccaggct
1621 atgtgctctt ctggtgccct agggactgct gtggccagag cctggggcca gccagtacag
1681 tcctgagccg aggaggaggg actgcaagtg gaagagagcc agtctggaag gaagagcttt
1741 ccaggtggac agggcttctt ggaagacccc caaagcccca ggtatcctgg gtgaagcctg
1801 tttgcctctc ttgaaaatgg caggtgctct tgttttaccc atgttgggtc agcctgaaac
1861 tgccaaccag taggaagcat ggactctcct gagtgagaag agactgaaat aggagcaagc
1921 agaaccctga gaggtgtcca tcttcttgct gttgaggacc ctgaaacacc gttgtttaaa
1981 gacttcacac agaaggctct gaactgagcc actggggaag ggaagtttca gtaacatgac
2041 actaaaatgg cagagacgtt aaaaaaa
//