LOCUS HSU89364 2821 bp mRNA linear HUM 09-OCT-1997 DEFINITION Homo sapiens voltage gated potassium channel (KVLQT1) mRNA, complete cds. ACCESSION U89364 U40990 U71077 VERSION U89364.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 189 to 2821) AUTHORS Wang,Q., Curran,M.E., Splawski,I., Burn,T.C., Millholland,J.M., VanRaay,R.J., Shen,J., Timothy,K.W., Vincent,G.M., de Jager,T., Schwartz,P.J., Towbin,J.A., Moss,A.J., Atkinson,D.L., Landes,G.M., Connors,T.D. and Keating,M.T. TITLE Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias JOURNAL Nat. Genet. 12 (1), 17-23 (1996) PUBMED 8528244 REFERENCE 2 (bases 1 to 270) AUTHORS Sanguinetti,M.C., Curran,M.E., Zou,A., Shen,J., Spector,P.S., Atkinson,D.L. and Keating,M.T. TITLE Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel JOURNAL Nature 384 (6604), 80-83 (1996) PUBMED 8900283 REFERENCE 3 (bases 1 to 2821) AUTHORS Splawski,I., Timothy,K.W., Vincent,G.M., Atkinson,D.L. and Keating,M.T. TITLE Molecular basis of the long-QT syndrome associated with deafness JOURNAL N. Engl. J. Med. 336 (22), 1562-1567 (1997) PUBMED 9164812 REFERENCE 4 (bases 1 to 2821) AUTHORS Splawski,I., Timothy,K.W., Vincent,G.M., Atkinson,D.L. and Keating,M.T. TITLE Direct Submission JOURNAL Submitted (09-JAN-1997) Howard Hughes Medical Institute, University of Utah, 10 North 2030 East Street, Salt Lake City, UT 84112, USA COMMENT On or before Oct 7, 1997 this sequence version replaced gi:1147606, gi:1669858. FEATURES Location/Qualifiers source 1..2821 /db_xref="H-InvDB:HIT000222132" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.5" gene 1..2821 /gene="KVLQT1" CDS 88..1833 /gene="KVLQT1" /codon_start=1 /product="voltage gated potassium channel" /protein_id="AAC51781.1" /translation="METRGSRLTGGQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIF SVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKP ISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVV FIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTI GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAA ASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDN GVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAE DLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQY SQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLD QRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPT YEQLTVPRRGPDEGS" BASE COUNT 562 a 892 c 843 g 524 t ORIGIN 1 ggcttcctcg agcgtcccac cggctggaag ttgtagacgc ggccctggac gtgggtgcgc 61 gccaacaccg ggcggcgcgt gctgtagatg gagacgcgcg ggtctaggct caccggcggc 121 cagggccgcg tctacaactt cctcgagcgt cccaccggct ggaaatgctt cgtttaccac 181 ttcgccgtct tcctcatcgt cctggtctgc ctcatcttca gcgtgctgtc caccatcgag 241 cagtatgccg ccctggccac ggggactctc ttctggatgg agatcgtgct ggtggtgttc 301 ttcgggacgg agtacgtggt ccgcctctgg tccgccggct gccgcagcaa gtacgtgggc 361 ctctgggggc ggctgcgctt tgcccggaag cccatttcca tcatcgacct catcgtggtc 421 gtggcctcca tggtggtcct ctgcgtgggc tccaaggggc aggtgtttgc cacgtcggcc 481 atcaggggca tccgcttcct gcagatcctg aggatgctac acgtcgaccg ccagggaggc 541 acctggaggc tcctgggctc cgtggtcttc atccaccgcc aggagctgat aaccaccctg 601 tacatcggct tcctgggcct catcttctcc tcgtactttg tgtacctggc tgagaaggac 661 gcggtgaacg agtcaggccg cgtggagttc ggcagctacg cagatgcgct gtggtggggg 721 gtggtcacag tcaccaccat cggctatggg gacaaggtgc cccagacgtg ggtcgggaag 781 accatcgcct cctgcttctc tgtctttgcc atctccttct ttgcgctccc agcggggatt 841 cttggctcgg ggtttgccct gaaggtgcag cagaagcaga ggcagaagca cttcaaccgg 901 cagatcccgg cggcagcctc actcattcag accgcatgga ggtgctatgc tgccgagaac 961 cccgactcct ccacctggaa gatctacatc cggaaggccc cccggagcca cactctgctg 1021 tcacccagcc ccaaacccaa gaagtctgtg gtggtaaaga aaaaaaagtt caagctggac 1081 aaagacaatg gggtgactcc tggagagaag atgctcacag tcccccatat cacgtgcgac 1141 cccccagaag agcggcggct ggaccacttc tctgtcgacg gctatgacag ttctgtaagg 1201 aagagcccaa cactgctgga agtgagcatg ccccatttca tgagaaccaa cagcttcgcc 1261 gaggacctgg acctggaagg ggagactctg ctgacaccca tcacccacat ctcacagctg 1321 cgggaacacc atcgggccac cattaaggtc attcgacgca tgcagtactt tgtggccaag 1381 aagaaattcc agcaagcgcg gaagccttac gatgtgcggg acgtcattga gcagtactcg 1441 cagggccacc tcaacctcat ggtgcgcatc aaggagctgc agaggaggct ggaccagtcc 1501 attgggaagc cctcactgtt catctccgtc tcagaaaaga gcaaggatcg cggcagcaac 1561 acgatcggcg cccgcctgaa ccgagtagaa gacaaggtga cgcagctgga ccagaggctg 1621 gcactcatca ccgacatgct tcaccagctg ctctccttgc acggtggcag cacccccggc 1681 agcggcggcc cccccagaga gggcggggcc cacatcaccc agccctgcgg cagtggcggc 1741 tccgtcgacc ctgagctctt cctgcccagc aacaccctgc ccacctacga gcagctgacc 1801 gtgcccagga ggggccccga tgaggggtcc tgaggagggg atggggctgg gggatgggcc 1861 tgagtgagag gggaggccaa gagtggcccc acctggccct ctctgaagga ggccacctcc 1921 taaaaggccc agagagaaga gccccactct cagaggcccc aataccccat ggaccatgct 1981 gtctggcaca gcctgcactt gggggctcag caaggccacc tcttcctggc cggtgtgggg 2041 gccccgtctc aggtctgagt tgttacccca agcgccctgg cccccacatg gtgatgttga 2101 catcactggc atggtggttg ggacccagtg gcagggcaca gggcctggcc catgtatggc 2161 caggaagtag cacaggctga gtgcaggccc accctgcttg gcccaggggg cttcctgagg 2221 ggagacagag caacccctgg accccagcct caaatccagg accctgccag gcacaggcag 2281 ggcaggacca gcccacgctg actacagggc caccggcaat aaaagcccag gagcccattt 2341 ggagggcctg ggcctggctc cctcactctc aggaaatgct gacccatggg caggagactg 2401 tggagactgc tcctgagccc ccagcttcca gcaggaggga cagtctcacc atttccccag 2461 ggcacgtggt tgagtggggg gaacgcccac ttccctgggt tagactgcca gctcttccta 2521 gctggagagg agccctgcct ctccgcccct gagcccactg tgcgtggggc tcccgcctcc 2581 aacccctcgc ccagtcccag cagccagcca aacacacaga aggggactgc cacctcccct 2641 tgccagctgc tgagccgcag agaagtgacg gttcctacac aggacagggg ttccttctgg 2701 gcattacatc gcatagaaat caataatttg tggtgatttg gatctgtgtt ttaatgagtt 2761 tcacagtgtg attttgatta ttaattgtgc aagcttttcc taataaacgt ggagaatcac 2821 a //