LOCUS       HSU89364                2821 bp    mRNA    linear   HUM 09-OCT-1997
DEFINITION  Homo sapiens voltage gated potassium channel (KVLQT1) mRNA,
            complete cds.
ACCESSION   U89364 U40990 U71077
VERSION     U89364.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 189 to 2821)
  AUTHORS   Wang,Q., Curran,M.E., Splawski,I., Burn,T.C., Millholland,J.M.,
            VanRaay,R.J., Shen,J., Timothy,K.W., Vincent,G.M., de Jager,T.,
            Schwartz,P.J., Towbin,J.A., Moss,A.J., Atkinson,D.L., Landes,G.M.,
            Connors,T.D. and Keating,M.T.
  TITLE     Positional cloning of a novel potassium channel gene: KVLQT1
            mutations cause cardiac arrhythmias
  JOURNAL   Nat. Genet. 12 (1), 17-23 (1996)
   PUBMED   8528244
REFERENCE   2  (bases 1 to 270)
  AUTHORS   Sanguinetti,M.C., Curran,M.E., Zou,A., Shen,J., Spector,P.S.,
            Atkinson,D.L. and Keating,M.T.
  TITLE     Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac
            I(Ks) potassium channel
  JOURNAL   Nature 384 (6604), 80-83 (1996)
   PUBMED   8900283
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Splawski,I., Timothy,K.W., Vincent,G.M., Atkinson,D.L. and
            Keating,M.T.
  TITLE     Molecular basis of the long-QT syndrome associated with deafness
  JOURNAL   N. Engl. J. Med. 336 (22), 1562-1567 (1997)
   PUBMED   9164812
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Splawski,I., Timothy,K.W., Vincent,G.M., Atkinson,D.L. and
            Keating,M.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JAN-1997) Howard Hughes Medical Institute, University
            of Utah, 10 North 2030 East Street, Salt Lake City, UT 84112, USA
COMMENT     On or before Oct 7, 1997 this sequence version replaced gi:1147606,
            gi:1669858.
FEATURES             Location/Qualifiers
     source          1..2821
                     /db_xref="H-InvDB:HIT000222132"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..2821
                     /gene="KVLQT1"
     CDS             88..1833
                     /gene="KVLQT1"
                     /codon_start=1
                     /product="voltage gated potassium channel"
                     /protein_id="AAC51781.1"
                     /translation="METRGSRLTGGQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIF
                     SVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKP
                     ISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVV
                     FIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTI
                     GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAA
                     ASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDN
                     GVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAE
                     DLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQY
                     SQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLD
                     QRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPT
                     YEQLTVPRRGPDEGS"
BASE COUNT          562 a          892 c          843 g          524 t
ORIGIN      
        1 ggcttcctcg agcgtcccac cggctggaag ttgtagacgc ggccctggac gtgggtgcgc
       61 gccaacaccg ggcggcgcgt gctgtagatg gagacgcgcg ggtctaggct caccggcggc
      121 cagggccgcg tctacaactt cctcgagcgt cccaccggct ggaaatgctt cgtttaccac
      181 ttcgccgtct tcctcatcgt cctggtctgc ctcatcttca gcgtgctgtc caccatcgag
      241 cagtatgccg ccctggccac ggggactctc ttctggatgg agatcgtgct ggtggtgttc
      301 ttcgggacgg agtacgtggt ccgcctctgg tccgccggct gccgcagcaa gtacgtgggc
      361 ctctgggggc ggctgcgctt tgcccggaag cccatttcca tcatcgacct catcgtggtc
      421 gtggcctcca tggtggtcct ctgcgtgggc tccaaggggc aggtgtttgc cacgtcggcc
      481 atcaggggca tccgcttcct gcagatcctg aggatgctac acgtcgaccg ccagggaggc
      541 acctggaggc tcctgggctc cgtggtcttc atccaccgcc aggagctgat aaccaccctg
      601 tacatcggct tcctgggcct catcttctcc tcgtactttg tgtacctggc tgagaaggac
      661 gcggtgaacg agtcaggccg cgtggagttc ggcagctacg cagatgcgct gtggtggggg
      721 gtggtcacag tcaccaccat cggctatggg gacaaggtgc cccagacgtg ggtcgggaag
      781 accatcgcct cctgcttctc tgtctttgcc atctccttct ttgcgctccc agcggggatt
      841 cttggctcgg ggtttgccct gaaggtgcag cagaagcaga ggcagaagca cttcaaccgg
      901 cagatcccgg cggcagcctc actcattcag accgcatgga ggtgctatgc tgccgagaac
      961 cccgactcct ccacctggaa gatctacatc cggaaggccc cccggagcca cactctgctg
     1021 tcacccagcc ccaaacccaa gaagtctgtg gtggtaaaga aaaaaaagtt caagctggac
     1081 aaagacaatg gggtgactcc tggagagaag atgctcacag tcccccatat cacgtgcgac
     1141 cccccagaag agcggcggct ggaccacttc tctgtcgacg gctatgacag ttctgtaagg
     1201 aagagcccaa cactgctgga agtgagcatg ccccatttca tgagaaccaa cagcttcgcc
     1261 gaggacctgg acctggaagg ggagactctg ctgacaccca tcacccacat ctcacagctg
     1321 cgggaacacc atcgggccac cattaaggtc attcgacgca tgcagtactt tgtggccaag
     1381 aagaaattcc agcaagcgcg gaagccttac gatgtgcggg acgtcattga gcagtactcg
     1441 cagggccacc tcaacctcat ggtgcgcatc aaggagctgc agaggaggct ggaccagtcc
     1501 attgggaagc cctcactgtt catctccgtc tcagaaaaga gcaaggatcg cggcagcaac
     1561 acgatcggcg cccgcctgaa ccgagtagaa gacaaggtga cgcagctgga ccagaggctg
     1621 gcactcatca ccgacatgct tcaccagctg ctctccttgc acggtggcag cacccccggc
     1681 agcggcggcc cccccagaga gggcggggcc cacatcaccc agccctgcgg cagtggcggc
     1741 tccgtcgacc ctgagctctt cctgcccagc aacaccctgc ccacctacga gcagctgacc
     1801 gtgcccagga ggggccccga tgaggggtcc tgaggagggg atggggctgg gggatgggcc
     1861 tgagtgagag gggaggccaa gagtggcccc acctggccct ctctgaagga ggccacctcc
     1921 taaaaggccc agagagaaga gccccactct cagaggcccc aataccccat ggaccatgct
     1981 gtctggcaca gcctgcactt gggggctcag caaggccacc tcttcctggc cggtgtgggg
     2041 gccccgtctc aggtctgagt tgttacccca agcgccctgg cccccacatg gtgatgttga
     2101 catcactggc atggtggttg ggacccagtg gcagggcaca gggcctggcc catgtatggc
     2161 caggaagtag cacaggctga gtgcaggccc accctgcttg gcccaggggg cttcctgagg
     2221 ggagacagag caacccctgg accccagcct caaatccagg accctgccag gcacaggcag
     2281 ggcaggacca gcccacgctg actacagggc caccggcaat aaaagcccag gagcccattt
     2341 ggagggcctg ggcctggctc cctcactctc aggaaatgct gacccatggg caggagactg
     2401 tggagactgc tcctgagccc ccagcttcca gcaggaggga cagtctcacc atttccccag
     2461 ggcacgtggt tgagtggggg gaacgcccac ttccctgggt tagactgcca gctcttccta
     2521 gctggagagg agccctgcct ctccgcccct gagcccactg tgcgtggggc tcccgcctcc
     2581 aacccctcgc ccagtcccag cagccagcca aacacacaga aggggactgc cacctcccct
     2641 tgccagctgc tgagccgcag agaagtgacg gttcctacac aggacagggg ttccttctgg
     2701 gcattacatc gcatagaaat caataatttg tggtgatttg gatctgtgtt ttaatgagtt
     2761 tcacagtgtg attttgatta ttaattgtgc aagcttttcc taataaacgt ggagaatcac
     2821 a
//