LOCUS       HSU89353                1557 bp    mRNA    linear   HUM 25-MAR-1999
DEFINITION  Homo sapiens transcription factor T-box 5 (TBX5) mRNA,
            alternatively spliced, complete cds.
ACCESSION   U89353
VERSION     U89353.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Basson,C.T., Bachinsky,D.R., Lin,R.C., Levi,T., Elkins,J.A.,
            Soults,J., Grayzel,D., Kroumpouzou,E., Traill,T.A.,
            Leblanc-Straceski,J., Renault,B., Kucherlapati,R., Seidman,J.G. and
            Seidman,C.E.
  TITLE     Mutations in human TBX5 [corrected] cause limb and cardiac
            malformation in Holt-Oram syndrome
  JOURNAL   Nat. Genet. 15 (1), 30-35 (1997)
   PUBMED   8988165
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Basson,C.T., Huang,T., Lin,R.C., Bachinsky,D.R., Weremowicz,S.,
            Vaglio,A., Bruzzone,R., Quadrelli,R., Lerone,M., Romeo,G.,
            Silengo,M., Pereira,A., Krieger,J., Mesquita,S.F., Kamisago,M.,
            Morton,C.C., Pierpont,M.E., Muller,C.W., Seidman,J.G. and
            Seidman,C.E.
  TITLE     Different TBX5 interactions in heart and limb defined by Holt-Oram
            syndrome mutations
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (6), 2919-2924 (1999)
   PUBMED   10077612
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Basson,C.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-1997) Molecular Cardiology Laboratory, Cardiology
            Division, Cornell University Medical College, Starr 4, 525 E. 68th
            Street, New York, NY 10021, USA
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Basson,C.T., Lin,R.C., Bachinksy,D.R., Seidman,J.G. and
            Seidman,C.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-1997) Medicine, Brigham and Women's Hospital, 75
            Francis Street, Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..1557
                     /db_xref="H-InvDB:HIT000222128"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.1"
     gene            1..1557
                     /gene="TBX5"
     CDS             1..1557
                     /gene="TBX5"
                     /note="TBX5; alternatively spliced; see alternative TBX5
                     mRNA in GenBank Accession Number U80987; T-box
                     transcription factor family member"
                     /codon_start=1
                     /product="transcription factor T-box 5"
                     /protein_id="AAC04619.1"
                     /translation="MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQA
                     AFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYIL
                     LMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKL
                     TNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQ
                     NHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSS
                     ESRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTT
                     DHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPS
                     LEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQL
                     GEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPHQYHSVHGV
                     GMVPEWSDNS"
BASE COUNT          393 a          489 c          376 g          299 t
ORIGIN      
        1 atggccgacg cagacgaggg ctttggcctg gcgcacacgc ctctggagcc tgacgcaaaa
       61 gacctgccct gcgattcgaa acccgagagc gcgctcgggg cccccagcaa gtccccgtcg
      121 tccccgcagg ccgccttcac ccagcagggc atggagggaa tcaaagtgtt tctccatgaa
      181 agagaactgt ggctaaaatt ccacgaagtg ggcacggaaa tgatcataac caaggctgga
      241 aggcggatgt ttcccagtta caaagtgaag gtgacgggcc ttaatcccaa aacgaagtac
      301 attcttctca tggacattgt acctgccgac gatcacagat acaaattcgc agataataaa
      361 tggtctgtga cgggcaaagc tgagcccgcc atgcctggcc gcctgtacgt gcacccagac
      421 tcccccgcca ccggggcgca ttggatgagg cagctcgtct ccttccagaa actcaagctc
      481 accaacaacc acctggaccc atttgggcat attattctaa attccatgca caaataccag
      541 cctagattac acatcgtgaa agcggatgaa aataatggat ttggctcaaa aaatacagcg
      601 ttctgcactc acgtctttcc tgagactgcg tttatagcag tgacttccta ccagaaccac
      661 aagatcacgc aattaaagat tgagaataat ccctttgcca aaggatttcg gggcagtgat
      721 gacatggagc tgcacagaat gtcaagaatg caaagtaaag aatatcccgt ggtccccagg
      781 agcaccgtga ggcaaaaagt ggcctccaac cacagtcctt tcagcagcga gtctcgagct
      841 ctctccacct catccaattt ggggtcccaa taccagtgtg agaatggtgt ttccggcccc
      901 tcccaggacc tcctgcctcc acccaaccca tacccactgc cccaggagca tagccaaatt
      961 taccattgta ccaagaggaa agaggaagaa tgttccacca cagaccatcc ctataagaag
     1021 ccctacatgg agacatcacc cagtgaagaa gattccttct accgctctag ctatccacag
     1081 cagcagggcc tgggtgcctc ctacaggaca gagtcggcac agcggcaagc ttgcatgtat
     1141 gccagctctg cgccccccag cgagcctgtg cccagcctag aggacatcag ctgcaacacg
     1201 tggccaagca tgccttccta cagcagctgc accgtcacca ccgtgcagcc catggacagg
     1261 ctaccctacc agcacttctc cgctcacttc acctcggggc ccctggtccc tcggctggct
     1321 ggcatggcca accatggctc cccacagctg ggagagggaa tgttccagca ccagacctcc
     1381 gtggcccacc agcctgtggt caggcagtgt gggcctcaga ctggcctgca gtcccctggc
     1441 acccttcagc cccctgagtt cctctactct catggcgtgc caaggactct atcccctcat
     1501 cagtaccact ctgtgcacgg agttggcatg gtgccagagt ggagcgacaa tagctaa
//