LOCUS HSU89344 7452 bp mRNA linear HUM 31-MAY-1997 DEFINITION Human acetyl-CoA carboxylase (ACC2) mRNA, complete cds. ACCESSION U89344 VERSION U89344.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7452) AUTHORS Abu-Elheiga,L., Almarza-Ortega,D.B., Baldini,A. and Wakil,S.J. TITLE Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms JOURNAL J. Biol. Chem. 272 (16), 10669-10677 (1997) PUBMED 9099716 REFERENCE 2 (bases 1 to 7452) AUTHORS Abu-Elheiga,L. TITLE Direct Submission JOURNAL Submitted (11-FEB-1997) Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA FEATURES Location/Qualifiers source 1..7452 /db_xref="H-InvDB:HIT000222127" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q23" /sex="male" /tissue_type="liver" /clone_lib="Clontech catalog number 7300-1" /dev_stage="adult" gene 1..7452 /gene="ACC2" CDS 1..7452 /gene="ACC2" /EC_number="6.4.1.2" /function="synthesis of malonyl-CoA" /note="acc280" /codon_start=1 /product="acetyl-CoA carboxylase" /protein_id="AAB58382.1" /translation="MVLLLCLSCLIFSCLTFSWLKIWEKMTDSKPITKSKSEANLIPS QEPFPASDNSGETPQRNGEGHTLHKDTQPGRAQPPTKAQRSGRRRNSLPPSRQKPPRN PLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGSKLVPSKEDKKQANIKRQL MTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRP SMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMR SIRRWAYEMFRNERAIRFVRMVTPEDLKANAEYIKMADHYGPAPGGPNNNNYANVELI VDIAKRIPLQAVWAGWGHALENPKLPELLCKNGVAFLGPPRLRPMVGLGDKIASTVVA QTLQVPTLPRSGSALTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFP LMIKASEGGGGKGIRETESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILAD QYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTV EYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGAPLHRLKDIRLLYG ESPWGDSPISFENSAHLPCPRGHVIATRITSENPDEGFKPSSGTVQELNFRSSKNVWG YFTVAATGGLHEFAISQFGHCFSWGENRKEAISNMVVALKELSLRGDFRTTVEYLINL LETESFQNNYIDTGWLDYLIAEKVQKKPNIMLGVVCGALERGDAMFRTCMTDFLHSLE RGQVLPADSLLNLVDVELIYEGVKYILKVTRQSLTMFVLIMNGCHIEIDAHRLNDGGL LLSYNGNSYTTYMKEEVDSYRTIGNKTCVFEKENDPTVLRSPSAGKLTQITVEDGGHV EAGRRYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEP FTGELPAQQNTADLGKKLHRVFHSVLGSLTNVMSGFCLPEPFFSIKLKEWVQKLMMTL RHPSLLLDVQEIMTSRAGRIPPPVEKSVRKVMAQYASNITSVLCQFPSQQIATILDCH AATLQRKADREVFFINTQSMVQLVQRYRSGIRGHMKTVVIDLLRRYLRVETIFGKARD ADANSSGMVGGVRSLSFTSVWVVLSPPAHYDKCVINLREQFKPDMSQVLDCIFSHAQV TKKNQLVIMLIDELCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASPSYE LRHNQVESIFLSAIDMYGHQFCPENLQKLILSETTIFDVLNTFFYHANKVVCMASLEV YVGGAYIAYVLNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRHTTEL FMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDPPLFSEARTSLYSEDD CKSLREEPIHILNVSIQCADHLEDEALVPILRTFVQSKKNILVDYGLRRIPFLIAQEK EFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVPCANHKMHLYLGAA KVEGRYEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTNV RTDCNHIFLNFVPTVIMDPNKIEESVRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGS AVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGPQHGMLINTPYVTKDL LQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPKDILTYTELVLDSQGQLVEM NRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMA RAEAIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFKYLYLTPQDYTRISSL NSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTC RAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGV SHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSRAPYDPRWML AGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVA VPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNREKLPLMIFANWRGFSGGMK DMYDQVLKFGAYIVDGLRQYKQPILIYIRPMRELRGGSWVVIDATINPLCIEMYADKE SRGGVLEPEGTVEIKFRKEDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKA REDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQV KQEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRS TIRENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSP AST" BASE COUNT 1787 a 2076 c 2066 g 1523 t ORIGIN 1 atggtcttgc ttctttgtct atcttgtctg attttctcct gtctgacctt ttcctggtta 61 aaaatctggg agaaaatgac ggactccaag ccgatcacca agagtaaatc agaagcaaac 121 ctcatcccga gccaggagcc ctttccagcc tctgataact caggggagac accgcagaga 181 aatggggagg gccacactct gcacaaagac acccagccag gccgagccca gcctcccaca 241 aaggcccaaa gatccggtcg gcggagaaac tccctaccac cctcccgcca gaagccccca 301 agaaaccccc tttcttccag tgacgcagca ccctccccag agcttcaagc caacgggact 361 gggacacaag gtctggaggc cacagatacc aatggcctgt cctcctcagc caggccccag 421 ggcagcaagc tggtcccctc caaagaagac aagaagcagg caaacatcaa gaggcagctg 481 atgaccaact tcatcctggg ctcttttgat gactactcct ccgacgagga ctctgttgct 541 ggctcatctc gtgagtctac ccggaagggc agccgggcca gcttgggggc cctgtccctg 601 gaggcttatc tgaccacagg tgaagctgag acccgcgtcc ccactatgag gccgagcatg 661 tcgggactcc acctggtgaa gaggggacgg gaacacaaga agctggacct gcacagagac 721 tttaccgtgg cttctcccgc tgagtttgtc acacgctttg ggggggatcg ggtcatcgag 781 aaggtgctta ttgccaacaa cgggattgcc gctgtgaagt gcatgcgctc catccgcagg 841 tgggcctatg agatgttccg caacgagcgg gccatccggt ttgttcgcat ggtgaccccc 901 gaggacctta aggccaacgc agagtacatc aagatggcgg atcattacgg gcccgcccca 961 ggagggccca ataacaacaa ctatgccaac gtggagctga ttgtggacat tgccaagaga 1021 atcccgttgc aggcggtgtg ggctggctgg ggccatgctt tagaaaaccc taaacttccg 1081 gagctgctgt gcaagaatgg agttgctttc ttaggccctc ccaggttgag gccaatggtg 1141 ggtctaggag ataagatcgc ctccaccgtt gtcgcccaga cgctacaggt cccaaccctg 1201 cccaggagtg gaagcgccct gacagtggag tggacagaag atgatctgca gcagggaaaa 1261 agaatcagtg tcccagaaga tgtttatgac aagggttgcg tgaaagacgt agatgagggc 1321 ttggaggcag cagaaagaat tggttttcca ttgatgatca aagcttctga aggtggcgga 1381 gggaagggaa tccgggaaac tgagagtgcg gaggacttcc cgatcctttt cagacaagta 1441 cagagtgaga tcccaggctc gcccatcttt ctcatgaagc tggcccagca cgcccgtcac 1501 ctggaagttc agatcctcgc tgaccagtat gggaatgctg tgtctctgtt tggtcgcgac 1561 tgctccatcc agcggcggca tcagaagatc gttgaggaag caccggccac catcgcgccg 1621 ctggccatat tcgagttcat ggagcagtgt gccattcgcc tggccaagac cgtgggctat 1681 gtgagtgcag ggacagtgga atacctctat agtcaggatg gtagcttcca cttcttggag 1741 ctgaatcctc gcttgcaggt ggaacatccc tgcacagaaa tgattgctga cgttaatctg 1801 ccggccgccc agctacagat cgccatgggt gccccactgc accggctgaa agatatccgg 1861 cttctgtatg gagagtcacc ctggggagac tccccaattt cttttgaaaa ctcagctcat 1921 ctcccctgcc cccgaggcca cgtcattgcc accagaatca ccagcgaaaa cccagacgag 1981 ggttttaagc cgagctccgg gactgtccag gaactgaatt tccggagcag caagaacgtc 2041 tggggttact tcacggtggc cgctactgga ggcctgcacg agtttgcgat ttcccagttt 2101 gggcactgct tctcctgggg agagaaccgg aaagaggcca tttcgaacat ggtggtggct 2161 ttgaaggaac tgtccctccg aggcgacttt aggactaccg tggaatacct cattaacctc 2221 ctggagaccg agagcttcca gaacaactac atcgacaccg ggtggttgga ctacctcatt 2281 gctgagaaag tgcaaaagaa accgaatatc atgcttgggg tggtatgcgg ggcccttgaa 2341 cgtggagatg cgatgttcag aacgtgcatg acagatttct tacactccct ggaaaggggc 2401 caggtcctcc cagcggattc actactgaac ctcgtagatg tggaattaat ttacgagggt 2461 gtaaagtaca ttctaaaggt gacccggcag tctctgacca tgttcgttct catcatgaat 2521 ggctgccaca tcgagattga tgcccaccgg ctgaatgatg gggggctcct gctctcctac 2581 aatgggaaca gctacaccac ctacatgaag gaagaggttg acagttaccg taccatcggc 2641 aataagacgt gtgtttttga gaaggagaac gatcctacag tcctgagatc cccctcggct 2701 gggaagctga cacagatcac agtggaggat gggggccacg ttgaggctgg gagacgctac 2761 gctgagatgg aggtgatgaa gatgatcatg accctgaacg ttcaggaaag aggccgggtg 2821 aagtacatca agcgtccagg tgcggtgctg gaagcaggct gcgtggtggc caggctggag 2881 ctcgatgacc cttctaaagt ccacccggct gaaccgttca caggagaact ccctgcccag 2941 cagaacactg ccgacctcgg aaagaaactg cacagggtct tccacagcgt cctgggaagc 3001 ctcaccaacg tcatgagtgg cttttgtctg ccagagccgt tttttagcat aaagctgaag 3061 gagtgggtgc agaagctcat gatgaccctc cggcacccgt cactgctgct ggacgtgcag 3121 gagatcatga ccagtcgtgc aggccgcatc cccccccctg ttgagaagtc tgtccgcaag 3181 gtgatggccc agtatgccag caacatcacc tcggtgctgt gccagttccc cagccagcag 3241 atagccacca tcctggactg ccatgcagcc accctgcagc ggaaggctga tcgagaggtc 3301 ttcttcatca acacccagag catggtgcag ttggtccaga ggtaccgaag tggaatccgc 3361 ggtcatatga aaacagtggt gatcgatctc ttgagaagat acttgcgtgt tgagaccatt 3421 ttcggcaagg caagagatgc tgatgccaac tccagtggga tggtgggggg cgtgaggagc 3481 ctgagcttta cctctgtgtg ggtggttttg tctcccccag cccactacga caagtgtgtg 3541 ataaacctca gggaacagtt caagccagac atgtcccagg tgctggactg catcttctcc 3601 cacgcacagg tgaccaagaa gaaccagctg gtgatcatgt tgatcgatga gctgtgtggc 3661 ccagaccctt ccctgtcgga cgagctgatc tccatcctca acgagctcac tcagctgagc 3721 aaaagcgagc actgcaaagt ggccctcaga gcccggcaga tcctgatcgc ctccccctcc 3781 tacgagctgc ggcataacca ggtggagtcc attttcctgt ctgccattga catgtacggc 3841 caccagttct gccccgagaa cctccagaaa ttaatacttt cggaaacaac catcttcgac 3901 gtcctgaata ctttcttcta tcacgcaaac aaagtcgtgt gcatggcgtc cttggaggtt 3961 tacgtggggg gggcttacat cgcctatgtg ttaaacagcc tgcagcaccg gcagctcccg 4021 gacggcacct gcgtggtaga attccagttc atgctgccgt cctcccaccc aaaccggatg 4081 accgtgccca tcagcatcac caaccctgac ctgctgaggc acacgacaga gctcttcatg 4141 gacagcggct tctccccact gtgccagcgc atgggagcca tggtagcctt caggagattc 4201 gaggacttca ccagaaattt tgatgaagtc atctcttgct tcgccaacgt gccgaaagac 4261 ccccccctct tcagcgaggc ccgcacctcc ctatactccg aggatgactg caagagcctc 4321 agagaagagc ccatccacat tctgaatgtg tccatccagt gtgcggacca cctggaggat 4381 gaggcactgg tgccgatttt acgtacattc gtacagtcca agaaaaatat ccttgtggat 4441 tatggactcc gacgaatccc attcttgatt gcccaagaga aagaatttcc caagtttttc 4501 acattcagag caagagatga gtttgcagaa gatcgcattt accgtcactt ggaacctgcc 4561 ctggctttcc agctggaact caaccggatg cgtaacttcg atctgaccgc cgtgccctgt 4621 gccaaccaca agatgcacct ttacctgggt gctgccaagg tggaaggaag gtatgaagtg 4681 acggaccata ggttcttcat ccgtgccatc atcaggcact ctgacctgat cacaaaggaa 4741 gcctccttcg aatacctgca gaacgagggt gagcggctgc tcctggaggc catggacgag 4801 ctggaggtgg cgttcaataa caccaacgtg cgcaccgact gcaaccacat cttcctcaac 4861 ttcgtgccca ctgtcatcat ggaccccaac aagatcgagg agtccgtgcg ctacatggtt 4921 atgcgctacg gcagccggct gtggaaactc cgtgtgctac aggctgaggt caagatcaac 4981 atccgccaga ccaccaccgg cagtgccgtt cccatccgcc tgttcatcac caatgagtcg 5041 ggctactacc tggacatcag cctctacaaa gaagtgactg actccagatc tggaaatatc 5101 atgtttcact ccttcggcaa caagcaaggg ccccagcacg ggatgctgat caatactccc 5161 tacgtcacca aggatctgct ccaggccaag cgattccagg cccagaccct gggaaccacc 5221 tacatctatg acttcccgga aatgttcagg caggctctct ttaaactgtg gggctcccca 5281 gacaagtatc ccaaagacat cctgacatac actgaattag tgttggactc tcagggccag 5341 ctggtggaga tgaaccgact tcctggtgga aatgaggtgg gcatggtggc cttcaaaatg 5401 aggtttaaga cccaggagta cccggaagga cgggatgtga tcgtcatcgg caatgacatc 5461 acctttcgca ttggatcctt tggccctgga gaggaccttc tgtacctgcg ggcatccgag 5521 atggcccggg cagaggcgat tcccaaaatt tacgtggcag ccaacagtgg cgcccgtatt 5581 ggcatggcag aggagatcaa acacatgttc cacgtggctt gggtggaccc agaagacccc 5641 cacaaaggat ttaaatacct gtacctgact ccccaagact acaccagaat cagctccctg 5701 aactccgtcc actgtaaaca catcgaggaa ggaggagagt ccagatacat gatcacggat 5761 atcatcggga aggatgatgg cttgggcgtg gagaatctga ggggctcagg catgattgct 5821 ggggagtcct ctctggctta cgaagagatc gtcaccatta gcttggtgac ctgccgagcc 5881 attgggattg gggcctactt ggtgaggctg ggccagcgag tgatccaggt ggagaattcc 5941 cacatcatcc tcacaggagc aagtgctctc aacaaggtcc tgggaagaga ggtctacaca 6001 tccaacaacc agctgggtgg cgttcagatc atgcattaca atggtgtctc ccacatcacc 6061 gtgccagatg actttgaggg ggtttatacc atcctggagt ggctgtccta tatgccaaag 6121 gataatcaca gccctgtccc tatcatcaca cccactgacc ccattgacag agaaattgaa 6181 ttcctcccat ccagagctcc ctacgacccc cggtggatgc ttgcaggaag gcctcaccca 6241 actctgaagg gaacgtggca gagcggattc tttgaccacg gcagtttcaa ggaaatcatg 6301 gcaccctggg cgcagaccgt ggtgacagga cgagcaaggc ttggggggat tcccgtggga 6361 gtgattgctg tggagacacg gactgtggag gtggcagtcc ctgcagaccc tgccaacctg 6421 gattctgagg ccaagataat tcagcaggca ggacaggtgt ggttcccaga ctcagcctac 6481 aaaaccgccc aggccatcaa ggacttcaac cgggagaagt tgcccctgat gatctttgcc 6541 aactggaggg ggttctccgg tggcatgaaa gacatgtatg accaggtgct gaagtttgga 6601 gcctacatcg tggacggcct tagacaatac aaacagccca tcctgatcta tatccgccct 6661 atgcgggagc tccggggagg ctcctgggtg gtcatagatg ccaccatcaa cccgctgtgc 6721 atagaaatgt atgcagacaa agagagcagg ggtggtgttc tggaaccaga ggggacagtg 6781 gagattaagt tccgaaagga agatctgata aagtccatga gaaggatcga tccagcttac 6841 aagaagctca tggaacagct aggggaacct gatctctccg acaaggaccg aaaggacctg 6901 gagggccggc taaaggctcg cgaggacctg ctgctcccca tctaccacca ggtggcggtg 6961 cagttcgccg acttccatga cacacccggc cggatgctgg agaagggcgt catatctgac 7021 atcctggagt ggaagaccgc acgcaccttc ctgtattggc gtctgcgccg cctcctcctg 7081 gaggaccagg tcaagcagga gatcctgcag gccagcgggg agctgagtca cgtgcatatc 7141 cagtccatgc tgcgtcgctg gttcgtggag acggaggggg ctgtcaaggc ctacttgtgg 7201 gacaacaacc aggtggttgt gcagtggctg gaacagcact ggcaggcagg ggatggcccg 7261 cgctccacca tccgtgagaa catcacgtac ctgaagcacg actctgtcct caagaccatc 7321 cgaggcctgg ttgaagaaaa ccccgaggtg gccgtggact gtgtgatata cctgagccag 7381 cacatcagcc cagctgagcg ggcgcaggtc gttcacctgc tgtctaccat ggacagcccg 7441 gcctccacct ga //