LOCUS HSU89344 7452 bp mRNA linear HUM 31-MAY-1997
DEFINITION Human acetyl-CoA carboxylase (ACC2) mRNA, complete cds.
ACCESSION U89344
VERSION U89344.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7452)
AUTHORS Abu-Elheiga,L., Almarza-Ortega,D.B., Baldini,A. and Wakil,S.J.
TITLE Human acetyl-CoA carboxylase 2. Molecular cloning,
characterization, chromosomal mapping, and evidence for two
isoforms
JOURNAL J. Biol. Chem. 272 (16), 10669-10677 (1997)
PUBMED 9099716
REFERENCE 2 (bases 1 to 7452)
AUTHORS Abu-Elheiga,L.
TITLE Direct Submission
JOURNAL Submitted (11-FEB-1997) Biochemistry, Baylor College of Medicine,
One Baylor Plaza, Houston, TX 77030, USA
FEATURES Location/Qualifiers
source 1..7452
/db_xref="H-InvDB:HIT000222127"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q23"
/sex="male"
/tissue_type="liver"
/clone_lib="Clontech catalog number 7300-1"
/dev_stage="adult"
gene 1..7452
/gene="ACC2"
CDS 1..7452
/gene="ACC2"
/EC_number="6.4.1.2"
/function="synthesis of malonyl-CoA"
/note="acc280"
/codon_start=1
/product="acetyl-CoA carboxylase"
/protein_id="AAB58382.1"
/translation="MVLLLCLSCLIFSCLTFSWLKIWEKMTDSKPITKSKSEANLIPS
QEPFPASDNSGETPQRNGEGHTLHKDTQPGRAQPPTKAQRSGRRRNSLPPSRQKPPRN
PLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGSKLVPSKEDKKQANIKRQL
MTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRP
SMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMR
SIRRWAYEMFRNERAIRFVRMVTPEDLKANAEYIKMADHYGPAPGGPNNNNYANVELI
VDIAKRIPLQAVWAGWGHALENPKLPELLCKNGVAFLGPPRLRPMVGLGDKIASTVVA
QTLQVPTLPRSGSALTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFP
LMIKASEGGGGKGIRETESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILAD
QYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTV
EYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGAPLHRLKDIRLLYG
ESPWGDSPISFENSAHLPCPRGHVIATRITSENPDEGFKPSSGTVQELNFRSSKNVWG
YFTVAATGGLHEFAISQFGHCFSWGENRKEAISNMVVALKELSLRGDFRTTVEYLINL
LETESFQNNYIDTGWLDYLIAEKVQKKPNIMLGVVCGALERGDAMFRTCMTDFLHSLE
RGQVLPADSLLNLVDVELIYEGVKYILKVTRQSLTMFVLIMNGCHIEIDAHRLNDGGL
LLSYNGNSYTTYMKEEVDSYRTIGNKTCVFEKENDPTVLRSPSAGKLTQITVEDGGHV
EAGRRYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEP
FTGELPAQQNTADLGKKLHRVFHSVLGSLTNVMSGFCLPEPFFSIKLKEWVQKLMMTL
RHPSLLLDVQEIMTSRAGRIPPPVEKSVRKVMAQYASNITSVLCQFPSQQIATILDCH
AATLQRKADREVFFINTQSMVQLVQRYRSGIRGHMKTVVIDLLRRYLRVETIFGKARD
ADANSSGMVGGVRSLSFTSVWVVLSPPAHYDKCVINLREQFKPDMSQVLDCIFSHAQV
TKKNQLVIMLIDELCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASPSYE
LRHNQVESIFLSAIDMYGHQFCPENLQKLILSETTIFDVLNTFFYHANKVVCMASLEV
YVGGAYIAYVLNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRHTTEL
FMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDPPLFSEARTSLYSEDD
CKSLREEPIHILNVSIQCADHLEDEALVPILRTFVQSKKNILVDYGLRRIPFLIAQEK
EFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVPCANHKMHLYLGAA
KVEGRYEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTNV
RTDCNHIFLNFVPTVIMDPNKIEESVRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGS
AVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGPQHGMLINTPYVTKDL
LQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPKDILTYTELVLDSQGQLVEM
NRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMA
RAEAIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFKYLYLTPQDYTRISSL
NSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTC
RAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGV
SHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSRAPYDPRWML
AGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVA
VPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNREKLPLMIFANWRGFSGGMK
DMYDQVLKFGAYIVDGLRQYKQPILIYIRPMRELRGGSWVVIDATINPLCIEMYADKE
SRGGVLEPEGTVEIKFRKEDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKA
REDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQV
KQEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRS
TIRENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSP
AST"
BASE COUNT 1787 a 2076 c 2066 g 1523 t
ORIGIN
1 atggtcttgc ttctttgtct atcttgtctg attttctcct gtctgacctt ttcctggtta
61 aaaatctggg agaaaatgac ggactccaag ccgatcacca agagtaaatc agaagcaaac
121 ctcatcccga gccaggagcc ctttccagcc tctgataact caggggagac accgcagaga
181 aatggggagg gccacactct gcacaaagac acccagccag gccgagccca gcctcccaca
241 aaggcccaaa gatccggtcg gcggagaaac tccctaccac cctcccgcca gaagccccca
301 agaaaccccc tttcttccag tgacgcagca ccctccccag agcttcaagc caacgggact
361 gggacacaag gtctggaggc cacagatacc aatggcctgt cctcctcagc caggccccag
421 ggcagcaagc tggtcccctc caaagaagac aagaagcagg caaacatcaa gaggcagctg
481 atgaccaact tcatcctggg ctcttttgat gactactcct ccgacgagga ctctgttgct
541 ggctcatctc gtgagtctac ccggaagggc agccgggcca gcttgggggc cctgtccctg
601 gaggcttatc tgaccacagg tgaagctgag acccgcgtcc ccactatgag gccgagcatg
661 tcgggactcc acctggtgaa gaggggacgg gaacacaaga agctggacct gcacagagac
721 tttaccgtgg cttctcccgc tgagtttgtc acacgctttg ggggggatcg ggtcatcgag
781 aaggtgctta ttgccaacaa cgggattgcc gctgtgaagt gcatgcgctc catccgcagg
841 tgggcctatg agatgttccg caacgagcgg gccatccggt ttgttcgcat ggtgaccccc
901 gaggacctta aggccaacgc agagtacatc aagatggcgg atcattacgg gcccgcccca
961 ggagggccca ataacaacaa ctatgccaac gtggagctga ttgtggacat tgccaagaga
1021 atcccgttgc aggcggtgtg ggctggctgg ggccatgctt tagaaaaccc taaacttccg
1081 gagctgctgt gcaagaatgg agttgctttc ttaggccctc ccaggttgag gccaatggtg
1141 ggtctaggag ataagatcgc ctccaccgtt gtcgcccaga cgctacaggt cccaaccctg
1201 cccaggagtg gaagcgccct gacagtggag tggacagaag atgatctgca gcagggaaaa
1261 agaatcagtg tcccagaaga tgtttatgac aagggttgcg tgaaagacgt agatgagggc
1321 ttggaggcag cagaaagaat tggttttcca ttgatgatca aagcttctga aggtggcgga
1381 gggaagggaa tccgggaaac tgagagtgcg gaggacttcc cgatcctttt cagacaagta
1441 cagagtgaga tcccaggctc gcccatcttt ctcatgaagc tggcccagca cgcccgtcac
1501 ctggaagttc agatcctcgc tgaccagtat gggaatgctg tgtctctgtt tggtcgcgac
1561 tgctccatcc agcggcggca tcagaagatc gttgaggaag caccggccac catcgcgccg
1621 ctggccatat tcgagttcat ggagcagtgt gccattcgcc tggccaagac cgtgggctat
1681 gtgagtgcag ggacagtgga atacctctat agtcaggatg gtagcttcca cttcttggag
1741 ctgaatcctc gcttgcaggt ggaacatccc tgcacagaaa tgattgctga cgttaatctg
1801 ccggccgccc agctacagat cgccatgggt gccccactgc accggctgaa agatatccgg
1861 cttctgtatg gagagtcacc ctggggagac tccccaattt cttttgaaaa ctcagctcat
1921 ctcccctgcc cccgaggcca cgtcattgcc accagaatca ccagcgaaaa cccagacgag
1981 ggttttaagc cgagctccgg gactgtccag gaactgaatt tccggagcag caagaacgtc
2041 tggggttact tcacggtggc cgctactgga ggcctgcacg agtttgcgat ttcccagttt
2101 gggcactgct tctcctgggg agagaaccgg aaagaggcca tttcgaacat ggtggtggct
2161 ttgaaggaac tgtccctccg aggcgacttt aggactaccg tggaatacct cattaacctc
2221 ctggagaccg agagcttcca gaacaactac atcgacaccg ggtggttgga ctacctcatt
2281 gctgagaaag tgcaaaagaa accgaatatc atgcttgggg tggtatgcgg ggcccttgaa
2341 cgtggagatg cgatgttcag aacgtgcatg acagatttct tacactccct ggaaaggggc
2401 caggtcctcc cagcggattc actactgaac ctcgtagatg tggaattaat ttacgagggt
2461 gtaaagtaca ttctaaaggt gacccggcag tctctgacca tgttcgttct catcatgaat
2521 ggctgccaca tcgagattga tgcccaccgg ctgaatgatg gggggctcct gctctcctac
2581 aatgggaaca gctacaccac ctacatgaag gaagaggttg acagttaccg taccatcggc
2641 aataagacgt gtgtttttga gaaggagaac gatcctacag tcctgagatc cccctcggct
2701 gggaagctga cacagatcac agtggaggat gggggccacg ttgaggctgg gagacgctac
2761 gctgagatgg aggtgatgaa gatgatcatg accctgaacg ttcaggaaag aggccgggtg
2821 aagtacatca agcgtccagg tgcggtgctg gaagcaggct gcgtggtggc caggctggag
2881 ctcgatgacc cttctaaagt ccacccggct gaaccgttca caggagaact ccctgcccag
2941 cagaacactg ccgacctcgg aaagaaactg cacagggtct tccacagcgt cctgggaagc
3001 ctcaccaacg tcatgagtgg cttttgtctg ccagagccgt tttttagcat aaagctgaag
3061 gagtgggtgc agaagctcat gatgaccctc cggcacccgt cactgctgct ggacgtgcag
3121 gagatcatga ccagtcgtgc aggccgcatc cccccccctg ttgagaagtc tgtccgcaag
3181 gtgatggccc agtatgccag caacatcacc tcggtgctgt gccagttccc cagccagcag
3241 atagccacca tcctggactg ccatgcagcc accctgcagc ggaaggctga tcgagaggtc
3301 ttcttcatca acacccagag catggtgcag ttggtccaga ggtaccgaag tggaatccgc
3361 ggtcatatga aaacagtggt gatcgatctc ttgagaagat acttgcgtgt tgagaccatt
3421 ttcggcaagg caagagatgc tgatgccaac tccagtggga tggtgggggg cgtgaggagc
3481 ctgagcttta cctctgtgtg ggtggttttg tctcccccag cccactacga caagtgtgtg
3541 ataaacctca gggaacagtt caagccagac atgtcccagg tgctggactg catcttctcc
3601 cacgcacagg tgaccaagaa gaaccagctg gtgatcatgt tgatcgatga gctgtgtggc
3661 ccagaccctt ccctgtcgga cgagctgatc tccatcctca acgagctcac tcagctgagc
3721 aaaagcgagc actgcaaagt ggccctcaga gcccggcaga tcctgatcgc ctccccctcc
3781 tacgagctgc ggcataacca ggtggagtcc attttcctgt ctgccattga catgtacggc
3841 caccagttct gccccgagaa cctccagaaa ttaatacttt cggaaacaac catcttcgac
3901 gtcctgaata ctttcttcta tcacgcaaac aaagtcgtgt gcatggcgtc cttggaggtt
3961 tacgtggggg gggcttacat cgcctatgtg ttaaacagcc tgcagcaccg gcagctcccg
4021 gacggcacct gcgtggtaga attccagttc atgctgccgt cctcccaccc aaaccggatg
4081 accgtgccca tcagcatcac caaccctgac ctgctgaggc acacgacaga gctcttcatg
4141 gacagcggct tctccccact gtgccagcgc atgggagcca tggtagcctt caggagattc
4201 gaggacttca ccagaaattt tgatgaagtc atctcttgct tcgccaacgt gccgaaagac
4261 ccccccctct tcagcgaggc ccgcacctcc ctatactccg aggatgactg caagagcctc
4321 agagaagagc ccatccacat tctgaatgtg tccatccagt gtgcggacca cctggaggat
4381 gaggcactgg tgccgatttt acgtacattc gtacagtcca agaaaaatat ccttgtggat
4441 tatggactcc gacgaatccc attcttgatt gcccaagaga aagaatttcc caagtttttc
4501 acattcagag caagagatga gtttgcagaa gatcgcattt accgtcactt ggaacctgcc
4561 ctggctttcc agctggaact caaccggatg cgtaacttcg atctgaccgc cgtgccctgt
4621 gccaaccaca agatgcacct ttacctgggt gctgccaagg tggaaggaag gtatgaagtg
4681 acggaccata ggttcttcat ccgtgccatc atcaggcact ctgacctgat cacaaaggaa
4741 gcctccttcg aatacctgca gaacgagggt gagcggctgc tcctggaggc catggacgag
4801 ctggaggtgg cgttcaataa caccaacgtg cgcaccgact gcaaccacat cttcctcaac
4861 ttcgtgccca ctgtcatcat ggaccccaac aagatcgagg agtccgtgcg ctacatggtt
4921 atgcgctacg gcagccggct gtggaaactc cgtgtgctac aggctgaggt caagatcaac
4981 atccgccaga ccaccaccgg cagtgccgtt cccatccgcc tgttcatcac caatgagtcg
5041 ggctactacc tggacatcag cctctacaaa gaagtgactg actccagatc tggaaatatc
5101 atgtttcact ccttcggcaa caagcaaggg ccccagcacg ggatgctgat caatactccc
5161 tacgtcacca aggatctgct ccaggccaag cgattccagg cccagaccct gggaaccacc
5221 tacatctatg acttcccgga aatgttcagg caggctctct ttaaactgtg gggctcccca
5281 gacaagtatc ccaaagacat cctgacatac actgaattag tgttggactc tcagggccag
5341 ctggtggaga tgaaccgact tcctggtgga aatgaggtgg gcatggtggc cttcaaaatg
5401 aggtttaaga cccaggagta cccggaagga cgggatgtga tcgtcatcgg caatgacatc
5461 acctttcgca ttggatcctt tggccctgga gaggaccttc tgtacctgcg ggcatccgag
5521 atggcccggg cagaggcgat tcccaaaatt tacgtggcag ccaacagtgg cgcccgtatt
5581 ggcatggcag aggagatcaa acacatgttc cacgtggctt gggtggaccc agaagacccc
5641 cacaaaggat ttaaatacct gtacctgact ccccaagact acaccagaat cagctccctg
5701 aactccgtcc actgtaaaca catcgaggaa ggaggagagt ccagatacat gatcacggat
5761 atcatcggga aggatgatgg cttgggcgtg gagaatctga ggggctcagg catgattgct
5821 ggggagtcct ctctggctta cgaagagatc gtcaccatta gcttggtgac ctgccgagcc
5881 attgggattg gggcctactt ggtgaggctg ggccagcgag tgatccaggt ggagaattcc
5941 cacatcatcc tcacaggagc aagtgctctc aacaaggtcc tgggaagaga ggtctacaca
6001 tccaacaacc agctgggtgg cgttcagatc atgcattaca atggtgtctc ccacatcacc
6061 gtgccagatg actttgaggg ggtttatacc atcctggagt ggctgtccta tatgccaaag
6121 gataatcaca gccctgtccc tatcatcaca cccactgacc ccattgacag agaaattgaa
6181 ttcctcccat ccagagctcc ctacgacccc cggtggatgc ttgcaggaag gcctcaccca
6241 actctgaagg gaacgtggca gagcggattc tttgaccacg gcagtttcaa ggaaatcatg
6301 gcaccctggg cgcagaccgt ggtgacagga cgagcaaggc ttggggggat tcccgtggga
6361 gtgattgctg tggagacacg gactgtggag gtggcagtcc ctgcagaccc tgccaacctg
6421 gattctgagg ccaagataat tcagcaggca ggacaggtgt ggttcccaga ctcagcctac
6481 aaaaccgccc aggccatcaa ggacttcaac cgggagaagt tgcccctgat gatctttgcc
6541 aactggaggg ggttctccgg tggcatgaaa gacatgtatg accaggtgct gaagtttgga
6601 gcctacatcg tggacggcct tagacaatac aaacagccca tcctgatcta tatccgccct
6661 atgcgggagc tccggggagg ctcctgggtg gtcatagatg ccaccatcaa cccgctgtgc
6721 atagaaatgt atgcagacaa agagagcagg ggtggtgttc tggaaccaga ggggacagtg
6781 gagattaagt tccgaaagga agatctgata aagtccatga gaaggatcga tccagcttac
6841 aagaagctca tggaacagct aggggaacct gatctctccg acaaggaccg aaaggacctg
6901 gagggccggc taaaggctcg cgaggacctg ctgctcccca tctaccacca ggtggcggtg
6961 cagttcgccg acttccatga cacacccggc cggatgctgg agaagggcgt catatctgac
7021 atcctggagt ggaagaccgc acgcaccttc ctgtattggc gtctgcgccg cctcctcctg
7081 gaggaccagg tcaagcagga gatcctgcag gccagcgggg agctgagtca cgtgcatatc
7141 cagtccatgc tgcgtcgctg gttcgtggag acggaggggg ctgtcaaggc ctacttgtgg
7201 gacaacaacc aggtggttgt gcagtggctg gaacagcact ggcaggcagg ggatggcccg
7261 cgctccacca tccgtgagaa catcacgtac ctgaagcacg actctgtcct caagaccatc
7321 cgaggcctgg ttgaagaaaa ccccgaggtg gccgtggact gtgtgatata cctgagccag
7381 cacatcagcc cagctgagcg ggcgcaggtc gttcacctgc tgtctaccat ggacagcccg
7441 gcctccacct ga
//