LOCUS HSU89330 5595 bp mRNA linear HUM 27-FEB-1997
DEFINITION Human alternatively spliced microtubule-associated protein 2 (MAP2)
mRNA, complete cds.
ACCESSION U89330 L12563 Z21958
VERSION U89330.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5595)
AUTHORS Albala,J.S., Kalcheva,N. and Shafit-Zagardo,B.
TITLE Characterization of the transcripts encoding two isoforms of human
microtubule-associated protein-2 (MAP-2)
JOURNAL Gene 136 (1-2), 377-378 (1993)
PUBMED 8294038
REFERENCE 2 (bases 1 to 5595)
AUTHORS Albala,J.S.
TITLE Direct Submission
JOURNAL Submitted (15-MAR-1993) Department of Pathology, Albert Einstein
College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
FEATURES Location/Qualifiers
source 1..5595
/db_xref="H-InvDB:HIT000222125"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q34-q35"
/tissue_type="brain"
/dev_stage="adult"
gene 1..5595
/gene="MAP2"
CDS 1..5475
/gene="MAP2"
/codon_start=1
/product="microtubule-associated protein 2"
/protein_id="AAB48098.1"
/translation="MADERKDEGKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRS
ANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEA
VAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEASKMEFHDQ
QELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAP
LALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGL
VAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETS
PFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHI
PVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKE
AVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAM
TSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMS
KYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQP
SPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRS
LGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDD
YLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVM
APDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKT
DSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVK
LAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEH
AKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKV
EQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFM
GVESGHMKEGTKVSETEVKQKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEG
KKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETP
DISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAR
EEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPS
PHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSI
MDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRIST
PERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTH
LSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSG
DRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP
GTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPGLTPKQLRLINQPLPDLK
NVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVK
LDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSS
VASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL"
misc_feature 247..339
/gene="MAP2"
/note="encodes type II cAMP-dependent protein kinase
regulatory subunit II binding site"
misc_feature 5005..5061
/gene="MAP2"
/note="encodes microtubule binding domain"
misc_feature 5101..5154
/gene="MAP2"
/note="encodes microtubule binding domain"
misc_feature 5197..5250
/gene="MAP2"
/note="encodes microtubule binding domain"
3'UTR 5476..5595
/gene="MAP2"
/note="putative"
regulatory 5574..5579
/regulatory_class="polyA_signal_sequence"
/gene="MAP2"
/note="putative"
BASE COUNT 1819 a 1260 c 1332 g 1184 t
ORIGIN
1 atggctgacg agcggaaaga cgaaggaaag gcacctcact ggacctcagc accgctaaca
61 gaggcatctg cacactcaca tccacctgag attaaggatc aaggcggagc aggggaagga
121 cttgtccgaa gcgccaatgg attcccatac agggaggatg aagagggtgc ctttggagag
181 catgggtcac agggcaccta ttcaaatacc aaagagaatg ggatcaacgg agagctgacc
241 tcagctgaca gagaaacagc agaggaggtg tctgcaagga tagttcaagt agtcactgct
301 gaggctgtag cagtcctgaa aggtgaacaa gagaaagaag ctcaacataa agaccagact
361 gcagctctgc ctttagcagc tgaagaaaca gctaatctgc ctccttctcc acccccatca
421 cctgcctcag aacagactgt cacagtggag gaagcctcga agatggagtt ccacgatcaa
481 caggaattga ctccctctac agctgagcct tcagaccaga aggaaaagga gtcagagaag
541 caaagtaagc ctggtgaaga ccttaaacat gctgccttag tttctcagcc agagacaact
601 aaaacttacc ctgataaaaa ggacatgcaa ggcacggaag aagaaaaagc acccctagct
661 ttgtttgggc acactcttgt tgccagcctg gaagacatga aacagaagac agaaccaagc
721 cttgtagtac ctggcattga cctccctaaa gagcctccaa ctccaaaaga acaaaaggac
781 tggttcatcg aaatgccaac ggaagcaaaa aaggatgagt ggggtttagt tgcccccata
841 tctcctggcc ctctgactcc catgagggaa aaagatgtat ttgatgatat cccaaaatgg
901 gaagggaaac agtttgattc tcccatgcca agtccctttc aagggggaag cttcactctt
961 cctttagatg tcatgaagaa tgaaatagtt acagaaacat cgccctttgc ccctgccttt
1021 ttacagccag atgacaaaaa atctctgcaa caaaccagtg gcccagctac tgccaaagat
1081 agttttaaaa ttgaagagcc ccatgaggct aaacctgaca aaatggcaga agcaccaccc
1141 tcagaggcaa tgaccttacc caaagatgct cacattccag ttgtagaaga acatgttatg
1201 gggaaagttt tagaggaaga aaaggaggcc ataaatcaag agactgtgca gcaaagggat
1261 actttcaccc ccagtggaca ggaacctata cttactgaaa aggaaactga gctgaagctt
1321 gaagaaaaaa ccaccatttc tgacaaagaa gctgtgccaa aagagagtaa acccccaaaa
1381 cctgcagatg aagaaatagg cataattcag acctccacag agcacacttt ctcagaacag
1441 aaagaccaag agcctaccac agatatgttg aaacaggact cgttccctgt aagtttggag
1501 caagcagtta cagattcagc catgacctct aaaacactgg agaaagccat gaccgaacca
1561 tctgcattaa ttgaaaagag ctcaattcag gaactttttg aaatgagagt tgatgacaaa
1621 gataagattg aaggagttgg agctgcaaca tcagctgagc ttgatatgcc attttatgaa
1681 gataaatcag gaatgtccaa gtactttgaa acatctgcct tgaaagaaga agcaacaaaa
1741 agcattgagc caggcagtga ttactatgaa ctgagtgaca ctagagaaag tgtccatgag
1801 tctattgata ccatgtctcc catgcataaa aatggtgaca aggagtttca aacaggaaaa
1861 gaatcccagc ccagtcctcc agcacaagaa gcagggtaca gcactctcgc acagagttat
1921 ccatcagatt tacctgaaga acccagttct cctcaagaaa gaatgttcac tattgatcca
1981 aaagtgtatg gagagaaaag ggacctccac agtaagaata aggatgattt gacccttagc
2041 aggagtttag gacttggtgg taggtctgca atagaacaaa gaagcatgtc aatcaatttg
2101 ccgatgtctt gcctagattc catagccctt ggatttaact ttggtcgggg acatgatctt
2161 tctcctctgg cttccgatat tctaaccaac actagtggaa gtatggatga aggggatgat
2221 taccttccag ccaccacacc tgcactggag aaagcccctt gcttccctgt agaaagcaaa
2281 gaggaagaac agatagagaa agtaaaagct actggagaag aaagtactca agcggagata
2341 tcatgtgagt ctcctttcct agccaaagat ttttacaaaa atggtactgt catggcacct
2401 gaccttcctg aaatgctaga tctggcaggc acaaggtcaa gattggcttc tgtgagtgca
2461 gatgctgagg ttgccaggag gaaatcagtc ccatcagaga ctgtggttga ggatagtcgt
2521 actggcttgc ccccggtaac tgatgaaaac catgtcattg taaaaacgga cagtcagctc
2581 gaagacctgg gctactgtgt gttcaataag tacacagtcc cattgccatc acctgttcaa
2641 gacagtgaga atttatcagg ggagagtggt accttttacg aaggcactga tgataaagtt
2701 cgaagagatt tggccacaga cctttcactg attgaagtga aactggcagc agccggaaga
2761 gtcaaagatg agttcagtgt tgacaaagaa gcatccgcgc atatctctgg tgacaaatca
2821 ggactgagta aggagtttga ccaagagaag aaagctaatg ataggttgga tactgtacta
2881 gaaaagagtg aagaacatgc tgattcaaaa gaacatgcca agaaaactga agaggctggt
2941 gatgaaatag aaacattcgg attaggagta acctatgagc aagctttggc caaagatttg
3001 tcaataccaa cagatgcatc ctctgagaaa gcagagaagg gtcttagttc agttccagag
3061 atagctgagg tagaaccatc caaaaaggtg gaacaaggtc tggattttgc tgtccagggt
3121 caactagatg ttaaaattag tgactttgga cagatggctt cagggctaaa catagatgat
3181 agaagggcaa cagagctaaa acttgaggct acacaggaca tgaccccctc atccaaagca
3241 ccgcaggagg cagatgcatt tatgggtgtt gagtctggcc acatgaaaga aggcactaaa
3301 gttagtgaga cagaagtcaa acagaaggtg gccaagcctg acttggtgca ccaggaggct
3361 gtagacaagg aggagtccta tgaatctagt ggtgagcatg aaagtctcac catggagtcc
3421 ttgaaagctg atgagggcaa gaaggaaaca tctccagaat catctctaat tcaagatgag
3481 attgccgtca aattgtcagt ggaaatacct tgcccacctg ctgtttcaga ggctgattta
3541 gccacagatg agagagctga tgtccagatg gaatttattc aggggccaaa agaagaaagc
3601 aaagagaccc cagatatatc catcacgcct tctgatgttg cagagccatt gcatgaaacg
3661 atcgtatctg aaccagcaga gattcagagt gaggaagaag agatagaagc ccagggagaa
3721 tatgataaac tgctcttccg ctcagacacc cttcagataa ctgacctggg tgtctcaggt
3781 gccagggagg aatttgtgga gacctgccca agtgaacaca aaggagtgat tgagtctgtt
3841 gtgaccatcg aggatgattt catcactgta gtgcaaacca caactgatga aggggagtca
3901 gggtcccaca gcgtgcgttt tgcagcccta gagcagcctg aggtggaaag gagaccatct
3961 cctcatgatg aagaagagtt tgaagtagaa gaggcagctg aagcccaggc agaacccaaa
4021 gatggttccc cagaggctcc agcttcccct gagagagaag aggttgcact ttctgaatat
4081 aagacagaaa cctatgacga ttacaaagat gagaccacca ttgacgactc catcatggac
4141 gctgacagcc tctgggtgga cactcaagat gatgatagga gcatcatgac agaacagtta
4201 gaaactattc ctaaagagga gaaagctgaa aaggaagctc ggagatcatc tcttgagaaa
4261 catagaaaag aaaagccttt taaaaccggg agaggcagaa tttccactcc tgaaagaaaa
4321 gtagctaaaa aggaacctag cacagtctcc agagatgaag tgagaaggaa aaaagcagtt
4381 tataagaagg ctgaacttgc taaaaaaaca gaagttcagg cccactctcc ctccaggaaa
4441 ttcattttaa aacctgctat caaatatact agaccaactc atctctcctg tgttaagcgg
4501 aaaaccacag cagcaggtgg ggaatcagct ctggctccca gtgtatttaa acaggcaaag
4561 gacaaagtct ctgacggagt aaccaagagc ccagaaaagc gctcttctct cccaagacct
4621 tcctccattc tccctcctcg gcgaggtgtg tcaggagaca gagatgagaa ttccttctct
4681 ctcaacagtt ctatctcttc ttcagcacgg cggaccacca ggtcagagcc aattcgcaga
4741 gcagggaaga gtggtacctc aacacccact acccctgggt ctactgccat cactcctggc
4801 accccaccaa gttattcttc acgcacacca ggcactcctg gaacccctag ctatcccagg
4861 acccctcaca caccaggaac ccccaagtct gccatcttgg tgccgagtga gaagaaggtc
4921 gccatcatac gtactcctcc aaaatctcct ggactgactc ccaagcagct tcggcttatt
4981 aaccaaccac tgccagacct gaagaatgtc aaatccaaaa tcggatcaac agacaacatc
5041 aaataccagc ctaaaggggg gcaggtacaa attgttacca agaagataga cctaagccat
5101 gtgacatcca aatgtggctc tctgaagaac atccgccaca ggccaggtgg cggacgtgtg
5161 aaaattgaga gtgtaaaact agatttcaaa gaaaaggccc aagctaaagt tggttctctt
5221 gataatgctc atcatgtacc tggaggtggt aatgtcaaga ttgacagcca aaagttgaac
5281 ttcagagagc atgctaaagc ccgtgtggac catggggctg agatcattac acagtcccca
5341 ggcagatcca gcgtggcatc accccgacga ctcagcaatg tctcctcgtc tggaagcatc
5401 aacctgctcg aatctcctca gcttgccact ttggctgagg atgtcactgc tgcactcgct
5461 aagcagggct tgtgaatatt tctcatttag cattgaaata ataatattta ggcatgagct
5521 cttggcagga gtgggctctg agcagttgtt atatcattct ttataaacca taaaataaat
5581 aatctcccgg aattc
//