LOCUS HSU88880 3811 bp mRNA linear HUM 03-SEP-1998
DEFINITION Homo sapiens Toll-like receptor 4 (TLR4) mRNA, complete cds.
ACCESSION U88880
VERSION U88880.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3811)
AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
TITLE A family of human receptors structurally related to Drosophila Toll
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (2), 588-593 (1998)
PUBMED 9435236
REFERENCE 2 (bases 1 to 3811)
AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
TITLE Direct Submission
JOURNAL Submitted (07-FEB-1997) Molecular Biology, DNAX Research Institute,
901 California Ave, Palo Alto, CA 94304, USA
FEATURES Location/Qualifiers
source 1..3811
/db_xref="H-InvDB:HIT000222104"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q32-33"
/note="cloned using I.M.A.G.E. EST clone #202057 as a
probe"
gene 1..3811
/gene="TLR4"
CDS 285..2684
/gene="TLR4"
/function="signaling receptor"
/note="type 1 transmembrane receptor; contains an
extracellular domain largely composed of leucine-rich
repeats and an intracellular segment similar to the
signaling domains of interleukin-1-type receptors, the
intracellular molecule Myd88 and several plant disease
resistance gene products"
/codon_start=1
/product="Toll-like receptor 4"
/protein_id="AAC34135.1"
/translation="MELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLD
LSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLE
NFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQ
MPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRL
VLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLV
SVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPS
LEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHS
NLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPD
IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQV
LDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER
MECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGC
IKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANI
IHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATS
I"
BASE COUNT 1070 a 820 c 784 g 1137 t
ORIGIN
1 acagggccac tgctgctcac agaagcagtg aggatgatgc caggatgatg tctgcctcgc
61 gcctggctgg gactctgatc ccagccatgg ccttcctctc ctgcgtgaga ccagaaagct
121 gggagccctg cgtggagact tggccctaaa ccacacagaa gagctggcat gaaacccaga
181 gctttcagac tccggagcct cagcccttca ccccgattcc attgcttctt gctaaatgct
241 gccgttttat cacggaggtg gttcctaata ttacttatca atgcatggag ctgaatttct
301 acaaaatccc cgacaacctc cccttctcaa ccaagaacct ggacctgagc tttaatcccc
361 tgaggcattt aggcagctat agcttcttca gtttcccaga actgcaggtg ctggatttat
421 ccaggtgtga aatccagaca attgaagatg gggcatatca gagcctaagc cacctctcta
481 ccttaatatt gacaggaaac cccatccaga gtttagccct gggagccttt tctggactat
541 caagtttaca gaagctggtg gctgtggaga caaatctagc atctctagag aacttcccca
601 ttggacatct caaaactttg aaagaactta atgtggctca caatcttatc caatctttca
661 aattacctga gtatttttct aatctgacca atctagagca cttggacctt tccagcaaca
721 agattcaaag tatttattgc acagacttgc gggttctaca tcaaatgccc ctactcaatc
781 tctctttaga cctgtccctg aaccctatga actttatcca accaggtgca tttaaagaaa
841 ttaggcttca taagctgact ttaagaaata attttgatag tttaaatgta atgaaaactt
901 gtattcaagg tctggctggt ttagaagtcc atcgtttggt tctgggagaa tttagaaatg
961 aaggaaactt ggaaaagttt gacaaatctg ctctagaggg cctgtgcaat ttgaccattg
1021 aagaattccg attagcatac ttagactact acctcgatga tattattgac ttatttaatt
1081 gtttgacaaa tgtttcttca ttttccctgg tgagtgtgac tattgaaagg gtaaaagact
1141 tttcttataa tttcggatgg caacatttag aattagttaa ctgtaaattt ggacagtttc
1201 ccacattgaa actcaaatct ctcaaaaggc ttactttcac ttccaacaaa ggtgggaatg
1261 ctttttcaga agttgatcta ccaagccttg agtttctaga tctcagtaga aatggcttga
1321 gtttcaaagg ttgctgttct caaagtgatt ttgggacaac cagcctaaag tatttagatc
1381 tgagcttcaa tggtgttatt accatgagtt caaacttctt gggcttagaa caactagaac
1441 atctggattt ccagcattcc aatttgaaac aaatgagtga gttttcagta ttcctatcac
1501 tcagaaacct catttacctt gacatttctc atactcacac cagagttgct ttcaatggca
1561 tcttcaatgg cttgtccagt ctcgaagtct tgaaaatggc tggcaattct ttccaggaaa
1621 acttccttcc agatatcttc acagagctga gaaacttgac cttcctggac ctctctcagt
1681 gtcaactgga gcagttgtct ccaacagcat ttaactcact ctccagtctt caggtactaa
1741 atatgagcca caacaacttc ttttcattgg atacgtttcc ttataagtgt ctgaactccc
1801 tccaggttct tgattacagt ctcaatcaca taatgacttc caaaaaacag gaactacagc
1861 attttccaag tagtctagct ttcttaaatc ttactcagaa tgactttgct tgtacttgtg
1921 aacaccagag tttcctgcaa tggatcaagg accagaggca gctcttggtg gaagttgaac
1981 gaatggaatg tgcaacacct tcagataagc agggcatgcc tgtgctgagt ttgaatatca
2041 cctgtcagat gaataagacc atcattggtg tgtcggtcct cagtgtgctt gtagtatctg
2101 ttgtagcagt tctggtctat aagttctatt ttcacctgat gcttcttgct ggctgcataa
2161 agtatggtag aggtgaaaac atctatgatg cctttgttat ctactcaagc caggatgagg
2221 actgggtaag gaatgagcta gtaaagaatt tagaagaagg ggtgcctcca tttcagctct
2281 gccttcacta cagagacttt attcccggtg tggccattgc tgccaacatc atccatgaag
2341 gtttccataa aagccgaaag gtgattgttg tggtgtccca gcacttcatc cagagccgct
2401 ggtgtatctt tgaatatgag attgctcaga cctggcagtt tctgagcagt cgtgctggta
2461 tcatcttcat tgtcctgcag aaggtggaga agaccctgct caggcagcag gtggagctgt
2521 accgccttct cagcaggaac acttacctgg agtgggagga cagtgtcctg gggcggcaca
2581 tcttctggag acgactcaga aaagccctgc tggatggtaa atcatggaat ccagaaggaa
2641 cagtgggtac aggatgcaat tggcaggaag caacatctat ctgaagagga aaaataaaaa
2701 cctcctgagg catttcttgc ccagctgggt ccaacacttg ttcagttaat aagtattaaa
2761 tgctgccaca tgtcaggcct tatgctaagg gtgagtaatt ccatggtgca ctagatatgc
2821 agggctgcta atctcaagga gcttccagtg cagagggaat aaatgctaga ctaaaataca
2881 gagtcttcca ggtgggcatt tcaaccaact cagtcaagga acccatgaca aagaaagtca
2941 tttcaactct tacctcatca agttgaataa agacagagaa aacagaaaga gacattgttc
3001 ttttcctgag tcttttgaat ggaaattgta ttatgttata gccatcataa aaccattttg
3061 gtagttttga ctgaactggg tgttcacttt ttcctttttg attgaataca atttaaattc
3121 tacttgatga ctgcagtcgt caaggggctc ctgatgcaag atgccccttc cattttaagt
3181 ctgtctcctt acagaggtta aagtctaatg gctaattcct aaggaaacct gattaacaca
3241 tgctcacaac catcctggtc attctcgaac atgttctatt ttttaactaa tcacccctga
3301 tatattttta tttttatata tccagttttc atttttttac gtcttgccta taagctaata
3361 tcataaataa ggttgtttaa gacgtgcttc aaatatccat attaaccact atttttcaag
3421 gaagtatgga aaagtacact ctgtcacttt gtcactcgat gtcattccaa agttattgcc
3481 tactaagtaa tgactgtcat gaaagcagca ttgaaataat ttgtttaaag ggggcactct
3541 tttaaacggg aagaaaattt ccgcttcctg gtcttatcat ggacaatttg ggctataggc
3601 atgaaggaag tgggattacc tcaggaagtc accttttctt gattccagaa acatatgggc
3661 tgataaaccc ggggtgacct catgaaatga gttgcagcag atgtttattt ttttcagaac
3721 aagtgatgtt tgatggacct atgaatctat ttagggagac acagatggct gggatccctc
3781 ccctgtaccc ttctcactga caggagaact a
//