LOCUS HSU88878 2600 bp mRNA linear HUM 03-SEP-1998
DEFINITION Homo sapiens Toll-like receptor 2 (TLR2) mRNA, complete cds.
ACCESSION U88878
VERSION U88878.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2600)
AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
TITLE A family of human receptors structurally related to Drosophila Toll
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (2), 588-593 (1998)
PUBMED 9435236
REFERENCE 2 (bases 1 to 2600)
AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
TITLE Direct Submission
JOURNAL Submitted (07-FEB-1997) Molecular Biology, DNAX Research Institute,
901 California Ave, Palo Alto, CA 94304, USA
FEATURES Location/Qualifiers
source 1..2600
/db_xref="H-InvDB:HIT000222102"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q32"
/note="cloned using I.M.A.G.E. EST clones #80633 and
#117262 as probes"
gene 1..2600
/gene="TLR2"
CDS 130..2484
/gene="TLR2"
/function="signaling receptor"
/note="type 1 transmembrane receptor; conatains an
extracellular domain largely composed of leucine-rich
repeats and an intracellular segment similar to the
signaling domains of interleukin-1-type receptors, the
intracellular molecule Myd88, and several plant disease
resistance gene products"
/codon_start=1
/product="Toll-like receptor 2"
/protein_id="AAC34133.1"
/translation="MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLN
SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL
EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD
TFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFV
DVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQI
SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSL
TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTL
ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHS
VTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISR
NAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDS
PSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAW
LQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPG
KWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFEENNDAAILILLEPI
EKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS"
BASE COUNT 741 a 539 c 546 g 774 t
ORIGIN
1 ggatccaaag gagacctata gtgactccca ggagctctta gtgaccaagt gaaggtacct
61 gtggggctca ttgtgcccat tgctctttca ctgctttcaa ctggtagttg tgggttgaag
121 cactggacaa tgccacatac tttgtggatg gtgtgggtct tgggggtcat catcagcctc
181 tccaaggaag aatcctccaa tcaggcttct ctgtcttgtg accgcaatgg tatctgcaag
241 ggcagctcag gatctttaaa ctccattccc tcagggctca cagaagctgt aaaaagcctt
301 gacctgtcca acaacaggat cacctacatt agcaacagtg acctacagag gtgtgtgaac
361 ctccaggctc tggtgctgac atccaatgga attaacacaa tagaggaaga ttctttttct
421 tccctgggca gtcttgaaca tttagactta tcctataatt acttatctaa tttatcgtct
481 tcctggttca agcccctttc ttctttaaca ttcttaaact tactgggaaa tccttacaaa
541 accctagggg aaacatctct tttttctcat ctcacaaaat tgcaaatcct gagagtggga
601 aatatggaca ccttcactaa gattcaaaga aaagattttg ctggacttac cttccttgag
661 gaacttgaga ttgatgcttc agatctacag agctatgagc caaaaagttt gaagtcaatt
721 cagaacgtaa gtcatctgat ccttcatatg aagcagcata ttttactgct ggagattttt
781 gtagatgtta caagttccgt ggaatgtttg gaactgcgag atactgattt ggacactttc
841 catttttcag aactatccac tggtgaaaca aattcattga ttaaaaagtt tacatttaga
901 aatgtgaaaa tcaccgatga aagtttgttt caggttatga aacttttgaa tcagatttct
961 ggattgttag aattagagtt tgatgactgt acccttaatg gagttggtaa ttttagagca
1021 tctgataatg acagagttat agatccaggt aaagtggaaa cgttaacaat ccggaggctg
1081 catattccaa ggttttactt attttatgat ctgagcactt tatattcact tacagaaaga
1141 gttaaaagaa tcacagtaga aaacagtaaa gtttttctgg ttccttgttt actttcacaa
1201 catttaaaat cattagaata cttggatctc agtgaaaatt tgatggttga agaatacttg
1261 aaaaattcag cctgtgagga tgcctggccc tctctacaaa ctttaatttt aaggcaaaat
1321 catttggcat cattggaaaa aaccggagag actttgctca ctctgaaaaa cttgactaac
1381 attgatatca gtaagaatag ttttcattct atgcctgaaa cttgtcagtg gccagaaaag
1441 atgaaatatt tgaacttatc cagcacacga atacacagtg taacaggctg cattcccaag
1501 acactggaaa ttttagatgt tagcaacaac aatctcaatt tattttcttt gaatttgccg
1561 caactcaaag aactttatat ttccagaaat aagttgatga ctctaccaga tgcctccctc
1621 ttacccatgt tactagtatt gaaaatcagt aggaatgcaa taactacgtt ttctaaggag
1681 caacttgact catttcacac actgaagact ttggaagctg gtggcaataa cttcatttgc
1741 tcctgtgaat tcctctcctt cactcaggag cagcaagcac tggccaaagt cttgattgat
1801 tggccagcaa attacctgtg tgactctcca tcccatgtgc gtggccagca ggttcaggat
1861 gtccgcctct cggtgtcgga atgtcacagg acagcactgg tgtctggcat gtgctgtgct
1921 ctgttcctgc tgatcctgct cacgggggtc ctgtgccacc gtttccatgg cctgtggtat
1981 atgaaaatga tgtgggcctg gctccaggcc aaaaggaagc ccaggaaagc tcccagcagg
2041 aacatctgct atgatgcatt tgtttcttac agtgagcggg atgcctactg ggtggagaac
2101 cttatggtcc aggagctgga gaacttcaat ccccccttca agttgtgtct tcataagcgg
2161 gacttcattc ctggcaagtg gatcattgac aatatcattg actccattga aaagagccac
2221 aaaactgtct ttgtgctttc tgaaaacttt gtgaagagtg agtggtgcaa gtatgaactg
2281 gacttctccc atttccgtct ttttgaagag aacaatgatg ctgccattct cattcttctg
2341 gagcccattg agaaaaaagc cattccccag cgcttctgca agctgcggaa gataatgaac
2401 accaagacct acctggagtg gcccatggac gaggctcagc gggaaggatt ttgggtaaat
2461 ctgagagctg cgataaagtc ctaggttccc atatttaaga ccagtctttg tctagttggg
2521 atctttatgt cactagttat agttaagttc attcagacat aattatataa aaactacgtg
2581 gatgtaccgt catttgagga
//