LOCUS HSU88540 2366 bp mRNA linear HUM 03-SEP-1998
DEFINITION Homo sapiens Toll-like receptor 1 (TLR1) mRNA, complete cds.
ACCESSION U88540
VERSION U88540.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2366)
AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
TITLE A family of human receptors structurally related to Drosophila Toll
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (2), 588-593 (1998)
PUBMED 9435236
REFERENCE 2 (bases 1 to 2366)
AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
TITLE Direct Submission
JOURNAL Submitted (04-FEB-1997) Molecular Biology, DNAX Research Institute,
901 California Ave., Palo Alto, CA 94304, USA
FEATURES Location/Qualifiers
source 1..2366
/db_xref="H-InvDB:HIT000222084"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p14"
/cell_type="erythroleukemic TF-1 cells"
gene 1..2366
/gene="TLR1"
CDS 1..2361
/gene="TLR1"
/function="signaling receptor"
/note="type 1 transmembrane receptor with an extracellular
domain largely composed of leucine-rich repeats and an
intracellular segment with similarity to the signaling
domains of interleukin-1-type receptors, the intracellular
molecule Myd88 and several plant disease resistance gene
products"
/codon_start=1
/product="Toll-like receptor 1"
/protein_id="AAC34137.1"
/translation="MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLS
QKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSH
NKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIA
HLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLEL
SNIKCVLEDNKCSYFLSILAKLQTNPKLSSLTLNNIETTWNSFIRILQLVWHTTVWYF
SISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVS
GTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAE
MTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVL
DLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSAD
FFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTL
LKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRAR
NIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVEN
IITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIP
SSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK"
BASE COUNT 722 a 487 c 446 g 711 t
ORIGIN
1 atgactagca tcttccattt tgccattatc ttcatgttaa tacttcagat cagaatacaa
61 ttatctgaag aaagtgaatt tttagttgat aggtcaaaaa acggtctcat ccacgttcct
121 aaagacctat cccagaaaac aacaatctta aatatatcgc aaaattatat atctgagctt
181 tggacttctg acatcttatc actgtcaaaa ctgaggattt tgataatttc tcataataga
241 atccagtatc ttgatatcag tgttttcaaa ttcaaccagg aattggaata cttggatttg
301 tcccacaaca agttggtgaa gatttcttgc caccctactg tgaacctcaa gcacttggac
361 ctgtcattta atgcatttga tgccctgcct atatgcaaag agtttggcaa tatgtctcaa
421 ctaaaatttc tggggttgag caccacacac ttagaaaaat ctagtgtgct gccaattgct
481 catttgaata tcagcaaggt cttgctggtc ttaggagaga cttatgggga aaaagaagac
541 cctgagggcc ttcaagactt taacactgag agtctgcaca ttgtgttccc cacaaacaaa
601 gaattccatt ttattttgga tgtgtcagtc aagactgtag caaatctgga actatctaat
661 atcaaatgtg tgctagaaga taacaaatgt tcttacttcc taagtattct ggcgaaactt
721 caaacaaatc caaagttatc aagtcttacc ttaaacaaca ttgaaacaac ttggaattct
781 ttcattagga tcctccagct ggtttggcat acaactgtat ggtatttctc aatttcaaac
841 gtgaagctac agggtcagct ggacttcaga gattttgatt attctggcac ttccttgaag
901 gccttgtcta tacaccaagt tgtcagcgat gtgttcggtt ttccgcaaag ttatatctat
961 gaaatctttt cgaatatgaa catcaaaaat ttcacagtgt ctggtacacg catggtccac
1021 atgctttgcc catccaaaat tagcccgttc ctgcatttgg atttttccaa taatctctta
1081 acagacacgg tttttgaaaa ttgtgggcac cttactgagt tggagacact tattttacaa
1141 atgaatcaat taaaagaact ttcaaaaata gctgaaatga ctacacagat gaagtctctg
1201 caacaattgg atattagcca gaattctgta agctatgatg aaaagaaagg agactgttct
1261 tggactaaaa gtttattaag tttaaatatg tcttcaaata tacttactga cactattttc
1321 agatgtttac ctcccaggat caaggtactt gatcttcaca gcaataaaat aaagagcatt
1381 cctaaacaag tcgtaaaact ggaagctttg caagaactca atgttgcttt caattcttta
1441 actgaccttc ctggatgtgg cagctttagc agcctttctg tattgatcat tgatcacaat
1501 tcagtttccc acccatcagc tgatttcttc cagagctgcc agaagatgag gtcaataaaa
1561 gcaggggaca atccattcca atgtacctgt gagctaggag aatttgtcaa aaatatagac
1621 caagtatcaa gtgaagtgtt agagggctgg cctgattctt ataagtgtga ctacccggaa
1681 agttatagag gaaccctact aaaggacttt cacatgtctg aattatcctg caacataact
1741 ctgctgatcg tcaccatcgt tgccaccatg ctggtgttgg ctgtgactgt gacctccctc
1801 tgcatctact tggatctgcc ctggtatctc aggatggtgt gccagtggac ccagacccgg
1861 cgcagggcca ggaacatacc cttagaagaa ctccaaagaa atctccagtt tcatgcattt
1921 atttcatata gtgggcacga ttctttctgg gtgaagaatg aattattgcc aaacctagag
1981 aaagaaggta tgcagatttg ccttcatgag agaaactttg ttcctggcaa gagcattgtg
2041 gaaaatatca tcacctgcat tgagaagagt tacaagtcca tctttgtttt gtctcccaac
2101 tttgtccaga gtgaatggtg ccattatgaa ctctactttg cccatcacaa tctctttcat
2161 gaaggatcta atagcttaat cctgatcttg ctggaaccca ttccgcagta ctccattcct
2221 agcagttatc acaagctcaa aagtctcatg gccaggagga cttatttgga atggcccaag
2281 gaaaagagca aacgtggcct tttttgggct aacttaaggg cagccattaa tattaagctg
2341 acagagcaag caaagaaata gtctag
//