LOCUS HSU86755 2942 bp mRNA linear HUM 10-APR-1997
DEFINITION Human TNF-alpha converting enzyme mRNA, complete cds.
ACCESSION U86755
VERSION U86755.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2942)
AUTHORS Moss,M.L., Jin,S.-L.C., Milla,M.E., Burkhart,W., Carter,H.L.,
Chen,W.-J., Clay,W.C., Didsbury,J.R., Hassler,D., Hoffman,C.R.,
Kost,T.A., Lambert,M.H., Leesnitzer,M.A., McCauley,P., McGeehan,G.,
Mitchell,J., Moyer,M., Pahel,G., Rocque,W., Overton,L.K.,
Shoenen,F., Seaton,T., Su,J.-L., Warner,J., Willard,D. and
Becherer,J.D.
TITLE Cloning of a disintegrin metalloproteinase that processes precursor
tumour-necrosis factor-alpha
JOURNAL Nature 385 (6618), 733-736 (1997)
PUBMED 9034191
REFERENCE 2 (bases 1 to 2942)
AUTHORS Moss,M.L., Jin,S.-L.C., Milla,M.E., Burkhart,W., Carter,H.L.,
Chen,W.-J., Clay,W.C., Didsbury,J.R., Hassler,D., Hoffman,C.R.,
Kost,T.A., Lambert,M.H., Leesnitzer,M.A., McCauley,P., McGeehan,G.,
Mitchell,J., Moyer,M., Pahel,G., Rocque,W., Overton,L.K.,
Shoenen,F., Seaton,T., Su,J.-L., Warner,J., Willard,D. and
Becherer,J.D.
TITLE Direct Submission
JOURNAL Submitted (23-JAN-1997) Molecular Biochemistry, Glaxo Wellcome
Research and Development Inc., 5 Moore Dr., Research Triangle Park,
NC 27709, USA
FEATURES Location/Qualifiers
source 1..2942
/db_xref="H-InvDB:HIT000221983"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="leukocyte"
CDS 164..2638
/function="processes proTNF-alpha to its mature form"
/note="disintegrin metalloprotease"
/codon_start=1
/product="TNF-alpha converting enzyme"
/protein_id="AAB51586.1"
/translation="MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDI
LSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGK
NESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK
DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADP
DPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG
IQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCL
AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK
TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL
KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTV
CLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFL
RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI
FWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQ
PAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDH
PVTRSEKAASFKLQRQNRVDSKETEC"
BASE COUNT 856 a 587 c 741 g 753 t
ORIGIN
1 cgagcctggc ggtagaatct tcccagtagg cggcgcggga gggaaaagag gattgagggg
61 ctaggccggg cggatcccgt cctcccccga tgtgagcagt tttccgaaac cccgtcaggc
121 gaaggctgcc cagagaggtg gagtcggtag cggggccggg aacatgaggc agtctctcct
181 attcctgacc agcgtggttc ctttcgtgct ggcgccgcga cctccggatg acccgggctt
241 cggcccccac cagagactcg agaagcttga ttctttgctc tcagactacg atattctctc
301 tttatctaat atccagcagc attcggtaag aaaaagagat ctacagactt caacacatgt
361 agaaacacta ctaacttttt cagctttgaa aaggcatttt aaattatacc tgacatcaag
421 tactgaacgt ttttcacaaa atttcaaggt cgtggtggtg gatggtaaaa acgaaagcga
481 gtacactgta aaatggcagg acttcttcac tggacacgtg gttggtgagc ctgactctag
541 ggttctagcc cacataagag atgatgatgt tataatcaga atcaacacag atggggccga
601 atataacata gagccacttt ggagatttgt taatgatacc aaagacaaaa gaatgttagt
661 ttataaatct gaagatatca agaatgtttc acgtttgcag tctccaaaag tgtgtggtta
721 tttaaaagtg gataatgaag agttgctccc aaaagggtta gtagacagag aaccacctga
781 agagcttgtt catcgagtga aaagaagagc tgacccagat cccatgaaga acacgtgtaa
841 attattggtg gtagcagatc atcgcttcta cagatacatg ggcagagggg aagagagtac
901 aactacaaat tacttaatag agctaattga cagagttgat gacatctatc ggaacacttc
961 atgggataat gcaggtttta aaggctatgg aatacagata gagcagattc gcattctcaa
1021 gtctccacaa gaggtaaaac ctggtgaaaa gcactacaac atggcaaaaa gttacccaaa
1081 tgaagaaaag gatgcttggg atgtgaagat gttgctagag caatttagct ttgatatagc
1141 tgaggaagca tctaaagttt gcttggcaca ccttttcaca taccaagatt ttgatatggg
1201 aactcttgga ttagcttatg ttggctctcc cagagcaaac agccatggag gtgtttgtcc
1261 aaaggcttat tatagcccag ttgggaagaa aaatatctat ttgaatagtg gtttgacgag
1321 cacaaagaat tatggtaaaa ccatccttac aaaggaagct gacctggtta caactcatga
1381 attgggacat aattttggag cagaacatga tccggatggt ctagcagaat gtgccccgaa
1441 tgaggaccag ggagggaaat atgtcatgta tcccatagct gtgagtggcg atcacgagaa
1501 caataagatg ttttcaaact gcagtaaaca atcaatctat aagaccattg aaagtaaggc
1561 ccaggagtgt tttcaagaac gcagcaataa agtttgtggg aactcgaggg tggatgaagg
1621 agaagagtgt gatcctggca tcatgtatct gaacaacgac acctgctgca acagcgactg
1681 cacgttgaag gaaggtgtcc agtgcagtga caggaacagt ccttgctgta aaaactgtca
1741 gtttgagact gcccagaaga agtgccagga ggcgattaat gctacttgca aaggcgtgtc
1801 ctactgcaca ggtaatagca gtgagtgccc gcctccagga aatgctgaag atgacactgt
1861 ttgcttggat cttggcaagt gtaaggatgg gaaatgcatc cctttctgcg agagggaaca
1921 gcagctggag tcctgtgcat gtaatgaaac tgacaactcc tgcaaggtgt gctgcaggga
1981 cctttctggc cgctgtgtgc cctatgtcga tgctgaacaa aagaacttat ttttgaggaa
2041 aggaaagccc tgtacagtag gattttgtga catgaatggc aaatgtgaga aacgagtaca
2101 ggatgtaatt gaacgatttt gggatttcat tgaccagctg agcatcaata cttttggaaa
2161 gtttttagca gacaacatcg ttgggtctgt cctggttttc tccttgatat tttggattcc
2221 tttcagcatt cttgtccatt gtgtggataa gaaattggat aaacagtatg aatctctgtc
2281 tctgtttcac cccagtaacg tcgaaatgct gagcagcatg gattctgcat cggttcgcat
2341 tatcaaaccc tttcctgcgc cccagactcc aggccgcctg cagcctgccc ctgtgatccc
2401 ttcggcgcca gcagctccaa aactggacca ccagagaatg gacaccatcc aggaagaccc
2461 cagcacagac tcacatatgg acgaggatgg gtttgagaag gaccccttcc caaatagcag
2521 cacagctgcc aagtcatttg aggatctcac ggaccatccg gtcaccagaa gtgaaaaggc
2581 tgcctccttt aaactgcagc gtcagaatcg tgttgacagc aaagaaacag agtgctaatt
2641 tagttctcag ctcttctgac ttaagtgtgc aaaatatttt tatagatttg acctacaatc
2701 aatcacagct tatattttgt gaagactggg aagtgactta gcagatgctg gtcatgtgtt
2761 tggaacttcc tgcaggtaaa cagttcttgt gtgggtttgg gcccntctcc ttttggaaaa
2821 ggtaagggtg aaggtgaatc ttgcttattn tgggggtttc aggtttnagt ttttaaaata
2881 tcttttggac ctgtgggtgn aaaagcagaa atacagntgg attgggttat gagtatttac
2941 gt
//