LOCUS HSU86453 5220 bp mRNA linear HUM 07-JUL-1998
DEFINITION Human phosphatidylinositol 3-kinase catalytic subunit p110delta
mRNA, complete cds.
ACCESSION U86453
VERSION U86453.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5220)
AUTHORS Chantry,D., Vojtek,A., Kashishian,A., Holtzman,D.A., Wood,C.,
Gray,P.W., Cooper,J.A. and Hoekstra,M.F.
TITLE p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit
that associates with p85 and is expressed predominantly in
leukocytes
JOURNAL J. Biol. Chem. 272 (31), 19236-19241 (1997)
PUBMED 9235916
REFERENCE 2 (bases 1 to 5220)
AUTHORS Chantry,D., Vojtek,A., Kashishian,A., Holtzman,D., Wood,C.,
Gray,P.W., Cooper,J.A. and Hoekstra,M.
TITLE Direct Submission
JOURNAL Submitted (16-JAN-1997) Leukocyte Biochemistry, ICOS Corporation,
22021 20th Ave. S.E., Bothell, WA 981021, USA
FEATURES Location/Qualifiers
source 1..5220
/db_xref="H-InvDB:HIT000221970"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="macrophage"
CDS 196..3330
/note="PI-3 kinase catalytic subunit"
/codon_start=1
/product="phosphatidylinositol 3-kinase catalytic subunit
p110delta"
/protein_id="AAC25677.1"
/translation="MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLST
IKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLV
AREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWE
AWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMA
CALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGNYPLCQFQYICSCLHSGLTPHLTM
VHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVN
ADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCF
ALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
ELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQ
LQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLY
LLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY
LDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVL
MKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTL
LAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMD
VLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALL
NWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH
FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGL
LFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTK
VNWLAHNVSKDNRQ"
BASE COUNT 1120 a 1525 c 1483 g 1092 t
ORIGIN
1 cagtcgctcc gagcggccgc gagcagagcc gcccagccct gtcagctgcg ccgggacgat
61 aaggagtcag gccagggcgg gatgacactc attgattcta aagcatcttt aatctgccag
121 gcggaggggg ctttgctggt ctttcttgga ctattccaga gaggacaact gtcatctggg
181 aagtaacaac gcaggatgcc ccctggggtg gactgcccca tggaattctg gaccaaggag
241 gagaatcaga gcgttgtggt tgacttcctg ctgcccacag gggtctacct gaacttccct
301 gtgtcccgca atgccaacct cagcaccatc aagcagctgc tgtggcaccg cgcccagtat
361 gagccgctct tccacatgct cagtggcccc gaggcctatg tgttcacctg catcaaccag
421 acagcggagc agcaagagct ggaggacgag caacggcgtc tgtgtgacgt gcagcccttc
481 ctgcccgtcc tgcgcctggt ggcccgtgag ggcgaccgcg tgaagaagct catcaactca
541 cagatcagcc tcctcatcgg caaaggcctc cacgagtttg actccttgtg cgacccagaa
601 gtgaacgact ttcgcgccaa gatgtgccaa ttctgcgagg aggcggccgc ccgccggcag
661 cagctgggct gggaggcctg gctgcagtac agtttccccc tgcagctgga gccctcggct
721 caaacctggg ggcctggtac cctgcggctc ccgaaccggg cccttctggt caacgttaag
781 tttgagggca gcgaggagag cttcaccttc caggtgtcca ccaaggacgt gccgctggcg
841 ctgatggcct gtgccctgcg gaagaaggcc acagtgttcc ggcagccgct ggtggagcag
901 ccggaagact acacgctgca ggtgaacggc aggcatgagt acctgtatgg caactacccg
961 ctctgccagt tccagtacat ctgcagctgc ctgcacagtg ggttgacccc tcacctgacc
1021 atggtccatt cctcctccat cctcgccatg cgggatgagc agagcaaccc tgccccccag
1081 gtccagaaac cgcgtgccaa accacctccc attcctgcga agaagccttc ctctgtgtcc
1141 ctgtggtccc tggagcagcc gttccgcatc gagctcatcc agggcagcaa agtgaacgcc
1201 gacgagcgga tgaagctggt ggtgcaggcc gggcttttcc acggcaacga gatgctgtgc
1261 aagacggtgt ccagctcgga ggtgagcgtg tgctcggagc ccgtgtggaa gcagcggctg
1321 gagttcgaca tcaacatctg cgacctgccc cgcatggccc gtctctgctt tgcgctgtac
1381 gccgtgatcg agaaagccaa gaaggctcgc tccaccaaga agaagtccaa gaaggcggac
1441 tgccccattg cctgggccaa cctcatgctg tttgactaca aggaccagct taagaccggg
1501 gaacgctgcc tctacatgtg gccctccgtc ccagatgaga agggcgagct gctgaacccc
1561 acgggcactg tgcgcagtaa ccccaacacg gatagcgccg ctgccctgct catctgcctg
1621 cccgaggtgg ccccgcaccc cgtgtactac cccgccctgg agaagatctt ggagctgggg
1681 cgacacagcg agtgtgtgca tgtcaccgag gaggagcagc tgcagctgcg ggaaatcctg
1741 gagcggcggg ggtctgggga gctgtatgag cacgagaagg acctggtgtg gaagctgcgg
1801 catgaagtcc aggagcactt cccggaggcg ctagcccggc tgctgctggt caccaagtgg
1861 aacaagcatg aggatgtggc ccagatgctc tacctgctgt gctcctggcc ggagctgccc
1921 gtcctgagcg ccctggagct gctagacttc agcttccccg attgccacgt aggctccttc
1981 gccatcaagt cgctgcggaa actgacggac gatgagctgt tccagtacct gctgcagctg
2041 gtgcaggtgc tcaagtacga gtcctacctg gactgcgagc tgaccaaatt cctgctggac
2101 cgggccctgg ccaaccgcaa gatcggccac ttccttttct ggcacctccg ctccgagatg
2161 cacgtgccgt cggtggccct gcgcttcggc ctcatcctgg aggcctactg caggggcagc
2221 acccaccaca tgaaggtgct gatgaagcag ggggaagcac tgagcaaact gaaggccctg
2281 aatgacttcg tcaagctgag ctctcagaag acccccaagc cccagaccaa ggagctgatg
2341 cacttgtgca tgcggcagga ggcctaccta gaggccctct cccacctgca gtccccactc
2401 gaccccagca ccctgctggc tgaagtctgc gtggagcagt gcaccttcat ggactccaag
2461 atgaagcccc tgtggatcat gtacagcaac gaggaggcag gcagcggcgg cagcgtgggc
2521 atcatcttta agaacgggga tgacctccgg caggacatgc tgaccctgca gatgatccag
2581 ctcatggacg tcctgtggaa gcaggagggg ctggacctga ggatgacccc ctatggctgc
2641 ctccccaccg gggaccgcac aggcctcatt gaggtggtac tccgttcaga caccatcgcc
2701 aacatccaac tcaacaagag caacatggca gccacagccg ccttcaacaa ggatgccctg
2761 ctcaactggc tgaagtccaa gaacccgggg gaggccctgg atcgagccat tgaggagttc
2821 accctctcct gtgctggcta ttgtgtggcc acatatgtgc tgggcattgg cgatcggcac
2881 agcgacaaca tcatgatccg agagagtggg cagctgttcc acattgattt tggccacttt
2941 ctggggaatt tcaagaccaa gtttggaatc aaccgcgagc gtgtcccatt catcctcacc
3001 tatgactttg tccatgtgat tcagcagggg aagactaata atagtgagaa atttgaacgg
3061 ttccggggct actgtgaaag ggcctacacc atcctgcggc gccacgggct tctcttcctc
3121 cacctctttg ccctgatgcg ggcggcaggc ctgcctgagc tcagctgctc caaagacatc
3181 cagtatctca aggactccct ggcactgggg aaaacagagg aggaggcact gaagcacttc
3241 cgagtgaagt ttaacgaagc cctccgtgag agctggaaaa ccaaagtgaa ctggctggcc
3301 cacaacgtgt ccaaagacaa caggcagtag tggctcctcc cagccctggg cccaagagga
3361 ggcggctgcg ggtcgtgggg accaagcaca ttggtcctaa aggggctgaa gagcctgaac
3421 tgcacctaac gggaaagaac cgacatggct gccttttgtt tacactggtt atttatttat
3481 gacttgaaat agtttaagga gctaaacagc cataaacgga aacgcctcct tcattcagcg
3541 gcggtgctgg gccccccgag gctgcacctg gctctcggct gaggattgtc accccaagtc
3601 ttccagctgg tggatctggg cccagcaaag actgttctcc tcccgaggga accttcttcc
3661 caggcctccc gccagactgc ctgggtcctg gcgcctggcg gtcacctggt gcctactgtc
3721 cgacaggatg cctcgatcct cgtgcgaccc accctgtgta tcctccctag actgagttct
3781 ggcagctccc cgaggcagcc ggggtaccct ctagattcag ggatgcttgc tctccacttt
3841 tcaagtgggt cttgggtacg agaattccct catctttctc tactgtaaag tgattttgtt
3901 tgcaggtaag aaaataatag atgactcacc acacctctac ggctggggag atcaggccca
3961 gccccataaa ggagaatcta cgctggtcct caggacgtgt taaagagatc tgggcctcat
4021 gtagctcacc ccggtcacgc atgaaggcaa aagcaggtca gaagcgaata ctctgccatt
4081 atctcaaaaa tctttttttt tttttttttg agatggggtc ttcctctgtt gcccaggctg
4141 gagtgcagtg gtgcaatctt ggctcactgt aacctccgcc tcccaggttc aagtgattct
4201 tcttgcctca gcctcctgag tagctgggat tacaggtgtg caccacccgt acccagctaa
4261 tttttgtatt ttagtagaga cgggggtttc accatgttgg ctgggctggt ctcgaactcc
4321 tgacctcagg tgatccaccc gcctgagcct cccaaagtgc tgggattaca ggcatgagcc
4381 accacgcccg gcccactctg ccattgtcta agccacctct gaaagcaggt tttaacaaaa
4441 ggatgaggcc agaactcttc cagaaccatc acctttggga acctgctgtg agagtgctga
4501 ggtaccagaa gtgtgagaac gagggggcgt gctgggatct ttctctctga ctatacttag
4561 tttgaaatgg tgcaggctta gtcttaagcc tccaaaggcc tggatttgag cagctttaga
4621 aatgcaggtt ctagggcttc tcccagcctt cagaagccaa ctaactctgc agatggggct
4681 aggactgtgg gcttttagca gcccacaggt gatcctaaca tatcaggcca tggactcagg
4741 acctgcccgg tgatgctgtt gatttctcaa aggtcttcca aaactcaaca gagccagaag
4801 tagccgcccg ctcagcggct caggtgccag ctctgttctg attcaccagg ggtccgtcag
4861 tagtcattgc cacccgcggg gcacctccct ggccacacgc ctgttcccag caagtgctga
4921 aactcactag accgtctgcc tgtttcgaaa tggggaaagc cgtgcgtgcg cgttatttat
4981 ttaagtgcgc ctgtgtgcgc gggtgtggga gcacactttg caaagccaca gcgtttctgg
5041 ttttgggtgt acagtcttgt gtgcctggcg agaagaatat tttctatttt tttaagtcat
5101 ttcatgtttc tgtctgggga aggcaagtta gttaagtatc actgatgtgg gttgagacca
5161 gcactctgtg aaaccttgaa atgagaagta aaggcagatg aaaagaaaaa aaaaaaaaaa
//