LOCUS HSU85962 8147 bp mRNA linear HUM 22-MAR-1999
DEFINITION Homo sapiens CREB-binding protein mRNA, complete cds.
ACCESSION U85962
VERSION U85962.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8147)
AUTHORS Giles,R.H., Petrij,F., Dauwerse,H.G., den Hollander,A.I.,
Lushnikova,T., van Ommen,G.J., Goodman,R.H., Deaven,L.L.,
Doggett,N.A., Peters,D.J. and Breuning,M.H.
TITLE Construction of a 1.2-Mb contig surrounding, and molecular analysis
of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome
16p13.3
JOURNAL Genomics 42 (1), 96-114 (1997)
PUBMED 9177780
REFERENCE 2 (bases 1 to 8147)
AUTHORS Petrij,F., den Hollander,A.I. and Chrivia,J.C.
TITLE Direct Submission
JOURNAL Submitted (18-JAN-1997) Human Genetics, Leiden University,
Wassenaarseweg 72, Leiden 2333 AL, The Netherlands
REFERENCE 3 (bases 1 to 8147)
AUTHORS Petrij,F.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-1999) Human Genetics, Leiden University,
Wassenaarseweg 72, Leiden 2333 AL, The Netherlands
REMARK Sequence update by submitter
COMMENT On Mar 18, 1999 this sequence version replaced U85962.2.
FEATURES Location/Qualifiers
source 1..8147
/db_xref="H-InvDB:HIT000221959"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
5'UTR 1..818
/note="accuracy of the 5'UTR sequence has not been
confirmed"
CDS 819..8147
/note="CBP; CREBBP"
/codon_start=1
/product="CREB-binding protein"
/protein_id="AAC51331.2"
/translation="MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDEL
IPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQ
AQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVG
LATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGR
GRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPF
GQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGI
VPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVL
NHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPA
SGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQ
PAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGS
NSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDR
RMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQ
PALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMG
PRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQ
FPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPT
PPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQS
TPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRV
PTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGAS
QVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPE
ELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQ
YQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKY
EFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTI
SKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK
ENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSR
FVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
IHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIP
KPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEES
IKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSM
PNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFL
TLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDY
DLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQ
CRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPF
CLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTP
QTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEA
ARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSM
PPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTL
KSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPG
MHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYR
EMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQ
RMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIG
SPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPS
PRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSS
ELSLVGDTTGDTLEKFVEGL"
misc_feature 819..1124
/note="encodes nuclear receptor binding domain; interacts
with RAR, RXR, T3R, GR and TR"
misc_feature 1500..2201
/note="encodes N-terminal transactivation domain (TAD)"
misc_feature 1905..2108
/note="encodes first Cys/His-rich region; interacts with
RXR, Stat2 and HIF-1alpha"
misc_feature 2172..2867
/note="encodes CREB-binding domain; interacts with CREB,
c-Jun, c-Myb/v-Myb, Sap-1a, Tax, Elk-1 and
SREBP-1/SREBP-2"
misc_feature 4140..4328
/note="encodes bromodomain"
misc_feature 4335..6365
/note="encodes histone acetyltransferase domain (HAT)"
misc_feature 4413..5279
/note="encodes second Cys/His-rich region"
misc_feature 4509..4754
/note="encodes TTC finger"
misc_feature 5841..6365
/note="encodes third Cys/His-rich region"
misc_feature 5853..6488
/note="encodes E1A binding domain; interacts with E1A,
c-Fos, TFIIB, pp90rsk, SV40 large T, E2F1/DP1 and MyoD"
misc_feature 5937..6014
/note="encodes second C4 zinc finger"
misc_feature 6129..6131
/note="encodes protein kinase A (PKA) phosphorylation
site"
misc_feature 6363..8045
/note="encodes Gln-rich region; interacts with YY1 and
P/CAF"
misc_feature 6696..6932
/note="encodes C-terminal transactivation domain 1 (TAD)"
misc_feature 6993..7292
/note="encodes C-terminal transactivation domain 2 (TAD);
interacts with p160"
BASE COUNT 1955 a 2636 c 2196 g 1360 t
ORIGIN
1 tccgaattcc ttttttttaa ttgaggaatc aacagccgcc atcttgtcgc ggacccgacc
61 ggggcttcga gcgcgatcta ctcggccccg ccggtcccgg gccccacaac cgcccgcgca
121 ccccgctccg cccggccggc ccgctccgcc cggccctcgg cgcccgcccc ggcggccccg
181 ctcgcctctc ggctcggcct cccggagccc ggcggcggcg gcggcggcag cggcggcggc
241 ggcggcggaa cggggggtgg gggggccgcg gcggcggcgg cgaccccgct cggcgcattg
301 tttttcctca cggcggcggc ggcggcgggc cgcgggccgg gagcggagcc cggagccccc
361 tcgtcgtcgg gccgcgagcg aattcattaa gtggggcgcg gggggggagc gaggcggcgg
421 cggcggcggc accatgttct cggggactgc ctgagccgcc cggccgggcg ccgtcgctgc
481 cagccgggcc cgggggggcg gccgggccgc cggggcgccc ccaccgcgga gtgtcgcgct
541 cgggaggcgg gcaggggatg agggggccgc ggccggcggc ggcggcggcg gccgggggcg
601 ggcggtgagc gctgcggggc gctgttgctg tggctgagat ttggccgccg cctcccccac
661 ccggcctgcg ccctccctct ccctcggcgc ccgcccgcgc cgctcgcggc gcccgcgctc
721 gctcctctcc ctcgcagccg gcagggcccc cgacccccgt ccgggccctc gccggcccgg
781 ccgcccgtgc ccggggctgt tttcgcgagc aggtgaaaat ggctgagaac ttgctggacg
841 gaccgcccaa ccccaaaaga gccaaactca gctcgcccgg tttctcggcg aatgacagca
901 cagattttgg atcattgttt gacttggaaa atgatcttcc tgatgagctg atacccaatg
961 gaggagaatt aggcctttta aacagtggga accttgttcc agatgctgct tccaaacata
1021 aacaactgtc ggagcttcta cgaggaggca gcggctctag tatcaaccca ggaataggaa
1081 atgtgagcgc cagcagcccc gtgcagcagg gcctgggtgg ccaggctcaa gggcagccga
1141 acagtgctaa catggccagc ctcagtgcca tgggcaagag ccctctgagc cagggagatt
1201 cttcagcccc cagcctgcct aaacaggcag ccagcacctc tgggcccacc cccgctgcct
1261 cccaagcact gaatccgcaa gcacaaaagc aagtggggct ggcgactagc agccctgcca
1321 cgtcacagac tggacctggt atctgcatga atgctaactt taaccagacc cacccaggcc
1381 tcctcaatag taactctggc catagcttaa ttaatcaggc ttcacaaggg caggcgcaag
1441 tcatgaatgg atctcttggg gctgctggca gaggaagggg agctggaatg ccgtacccta
1501 ctccagccat gcagggcgcc tcgagcagcg tgctggctga gaccctaacg caggtttccc
1561 cgcaaatgac tggtcacgcg ggactgaaca ccgcacaggc aggaggcatg gccaagatgg
1621 gaataactgg gaacacaagt ccatttggac agccctttag tcaagctgga gggcagccaa
1681 tgggagccac tggagtgaac ccccagttag ccagcaaaca gagcatggtc aacagtttgc
1741 ccaccttccc tacagatatc aagaatactt cagtcaccaa cgtgccaaat atgtctcaga
1801 tgcaaacatc agtgggaatt gtacccacac aagcaattgc aacaggcccc actgcagatc
1861 ctgaaaaacg caaactgata cagcagcagc tggttctact gcttcatgct cataagtgtc
1921 agagacgaga gcaagcaaac ggagaggttc gggcctgctc gctcccgcat tgtcgaacca
1981 tgaaaaacgt tttgaatcac atgacgcatt gtcaggctgg gaaagcctgc caagttgccc
2041 attgtgcatc ttcacgacaa atcatctctc attggaagaa ctgcacacga catgactgtc
2101 ctgtttgcct ccctttgaaa aatgccagtg acaagcgaaa ccaacaaacc atcctggggt
2161 ctccagctag tggaattcaa aacacaattg gttctgttgg cacagggcaa cagaatgcca
2221 cttctttaag taacccaaat cccatagacc ccagctccat gcagcgagcc tatgctgctc
2281 tcggactccc ctacatgaac cagccccaga cgcagctgca gcctcaggtt cctggccagc
2341 aaccagcaca gcctcaaacc caccagcaga tgaggactct caaccccctg ggaaataatc
2401 caatgaacat tccagcagga ggaataacaa cagatcagca gcccccaaac ttgatttcag
2461 aatcagctct tccgacttcc ctgggggcca caaacccact gatgaacgat ggctccaact
2521 ctggtaacat tggaaccctc agcactatac caacagcagc tcctccttct agcaccggtg
2581 taaggaaagg ctggcacgaa catgtcactc aggacctgcg gagccatcta gtgcataaac
2641 tcgtccaagc catcttccca acacctgatc ccgcagctct aaaggatcgc cgcatggaaa
2701 acctggtagc ctatgctaag aaagtggaag gggacatgta cgagtctgcc aacagcaggg
2761 atgaatatta tcacttatta gcagagaaaa tctacaagat acaaaaagaa ctagaagaaa
2821 aacggaggtc gcgtttacat aaacaaggca tcttggggaa ccagccagcc ttaccagccc
2881 cgggggctca gccccctgtg attccacagg cacaacctgt gagacctcca aatggacccc
2941 tgtccctgcc agtgaatcgc atgcaagttt ctcaagggat gaattcattt aaccccatgt
3001 ccttggggaa cgtccagttg ccacaagcac ccatgggacc tcgtgcagcc tccccaatga
3061 accactctgt ccagatgaac agcatgggct cagtgccagg gatggccatt tctccttccc
3121 gaatgcctca gcctccgaac atgatgggtg cacacaccaa caacatgatg gcccaggcgc
3181 ccgctcagag ccagtttctg ccacagaacc agttcccgtc atccagcggg gcgatgagtg
3241 tgggcatggg gcagccgcca gcccaaacag gcgtgtcaca gggacaggtg cctggtgctg
3301 ctcttcctaa ccctctcaac atgctggggc ctcaggccag ccagctacct tgccctccag
3361 tgacacagtc accactgcac ccaacaccgc ctcctgcttc cacggctgct ggcatgccat
3421 ctctccagca cacgacacca cctgggatga ctcctcccca gccagcagct cccactcagc
3481 catcaactcc tgtgtcgtct tccgggcaga ctcccacccc gactcctggc tcagtgccca
3541 gtgctaccca aacccagagc acccctacag tccaggcagc agcccaggcc caggtgaccc
3601 cgcagcctca aaccccagtt cagcccccgt ctgtggctac ccctcagtca tcgcagcaac
3661 agccgacgcc tgtgcacgcc cagcctcctg gcacaccgct ttcccaggca gcagccagca
3721 ttgataacag agtccctacc ccctcctcgg tggccagcgc agaaaccaat tcccagcagc
3781 caggacctga cgtacctgtg ctggaaatga agacggagac ccaagcagag gacactgagc
3841 ccgatcctgg tgaatccaaa ggggagccca ggtctgagat gatggaggag gatttgcaag
3901 gagcttccca agttaaagaa gaaacagaca tagcagagca gaaatcagaa ccaatggaag
3961 tggatgaaaa gaaacctgaa gtgaaagtag aagttaaaga ggaagaagag agtagcagta
4021 acggcacagc ctctcagtca acatctcctt cgcagccgcg caaaaaaatc tttaaaccag
4081 aggagttacg ccaggccctc atgccaaccc tagaagcact gtatcgacag gacccagagt
4141 cattaccttt ccggcagcct gtagatcccc agctcctcgg aattccagac tattttgaca
4201 tcgtaaagaa tcccatggac ctctccacca tcaagcggaa gctggacaca gggcaatacc
4261 aagagccctg gcagtacgtg gacgacgtct ggctcatgtt caacaatgcc tggctctata
4321 atcgcaagac atcccgagtc tataagtttt gcagtaagct tgcagaggtc tttgagcagg
4381 aaattgaccc tgtcatgcag tcccttggat attgctgtgg acgcaagtat gagttttccc
4441 cacagacttt gtgctgctat gggaagcagc tgtgtaccat tcctcgcgat gctgcctact
4501 acagctatca gaataggtat catttctgtg agaagtgttt cacagagatc cagggcgaga
4561 atgtgaccct gggtgacgac ccttcacagc cccagacgac aatttcaaag gatcagtttg
4621 aaaagaagaa aaatgatacc ttagaccccg aacctttcgt tgattgcaag gagtgtggcc
4681 ggaagatgca tcagatttgc gttctgcact atgacatcat ttggccttca ggttttgtgt
4741 gcgacaactg cttgaagaaa actggcagac ctcgaaaaga aaacaaattc agtgctaaga
4801 ggctgcagac cacaagactg ggaaaccact tggaagaccg agtgaacaaa tttttgcggc
4861 gccagaatca ccctgaagcc ggggaggttt ttgtccgagt ggtggccagc tcagacaaga
4921 cggtggaggt caagcccggg atgaagtcac ggtttgtgga ttctggggaa atgtctgaat
4981 ctttcccata tcgaaccaaa gctctgtttg cttttgagga aattgacggc gtggatgtct
5041 gcttttttgg aatgcacgtc caagaatacg gctctgattg cccccctcca aacacgaggc
5101 gtgtgtacat ttcttatctg gatagtattc atttcttccg gccacgttgc ctccgcacag
5161 ccgtttacca tgagatcctt attggatatt tagagtatgt gaagaaatta gggtatgtga
5221 cagggcacat ctgggcctgt cctccaagtg aaggagatga ttacatcttc cattgccacc
5281 cacctgatca aaaaataccc aagccaaaac gactgcagga gtggtacaaa aagatgctgg
5341 acaaggcgtt tgcagagcgg atcatccatg actacaagga tattttcaaa caagcaactg
5401 aagacaggct caccagtgcc aaggaactgc cctattttga aggtgatttc tggcccaatg
5461 tgttagaaga gagcattaag gaactagaac aagaagaaga ggagaggaaa aaggaagaga
5521 gcactgcagc cagtgaaacc actgagggca gtcagggcga cagcaagaat gccaagaaga
5581 agaacaacaa gaaaaccaac aagaacaaaa gcagcatcag ccgcgccaac aagaagaagc
5641 ccagcatgcc caacgtgtcc aatgacctgt cccagaagct gtatgccacc atggagaagc
5701 acaaggaggt cttcttcgtg atccacctgc acgctgggcc tgtcatcaac accctgcccc
5761 ccatcgtcga ccccgacccc ctgctcagct gtgacctcat ggatgggcgc gacgccttcc
5821 tcaccctcgc cagagacaag cactgggagt tctcctcctt gcgccgctcc aagtggtcca
5881 cgctctgcat gctggtggag ctgcacaccc agggccagga ccgctttgtc tacacctgca
5941 acgagtgcaa gcaccacgtg gagacgcgct ggcactgcac tgtgtgcgag gactacgacc
6001 tctgcatcaa ctgctataac acgaagagcc atgcccataa gatggtgaag tgggggctgg
6061 gcctggatga cgagggcagc agccagggcg agccacagtc aaagagcccc caggagtcac
6121 gccggctgag catccagcgc tgcatccagt cgctggtgca cgcgtgccag tgccgcaacg
6181 ccaactgctc gctgccatcc tgccagaaga tgaagcgggt ggtgcagcac accaagggct
6241 gcaaacgcaa gaccaacggg ggctgcccgg tgtgcaagca gctcatcgcc ctctgctgct
6301 accacgccaa gcactgccaa gaaaacaaat gccccgtgcc cttctgcctc aacatcaaac
6361 acaagctccg ccagcagcag atccagcacc gcctgcagca ggcccagctc atgcgccggc
6421 ggatggccac catgaacacc cgcaacgtgc ctcagcagag tctgccttct cctacctcag
6481 caccgcccgg gacccccaca cagcagccca gcacacccca gacgccgcag ccccctgccc
6541 agccccaacc ctcacccgtg agcatgtcac cagctggctt ccccagcgtg gcccggactc
6601 agccccccac cacggtgtcc acagggaagc ctaccagcca ggtgccggcc cccccacccc
6661 cggcccagcc ccctcctgca gcggtggaag cggctcggca gatcgagcgt gaggcccagc
6721 agcagcagca cctgtaccgg gtgaacatca acaacagcat gcccccagga cgcacgggca
6781 tggggacccc ggggagccag atggcccccg tgagcctgaa tgtgccccga cccaaccagg
6841 tgagcgggcc cgtcatgccc agcatgcctc ccgggcagtg gcagcaggcg ccccttcccc
6901 agcagcagcc catgccaggc ttgcccaggc ctgtgatatc catgcaggcc caggcggccg
6961 tggctgggcc ccggatgccc agcgtgcagc cacccaggag catctcaccc agcgctctgc
7021 aagacctgct gcggaccctg aagtcgccca gctcccctca gcagcaacag caggtgctga
7081 acattctcaa atcaaacccg cagctaatgg cagctttcat caaacagcgc acagccaagt
7141 acgtggccaa tcagcccggc atgcagcccc agcctggcct ccagtcccag cccggcatgc
7201 aaccccagcc tggcatgcac cagcagccca gcctgcagaa cctgaatgcc atgcaggctg
7261 gcgtgccgcg gcccggtgtg cctccacagc agcaggcgat gggaggcctg aacccccagg
7321 gccaggcctt gaacatcatg aacccaggac acaaccccaa catggcgagt atgaatccac
7381 agtaccgaga aatgttacgg aggcagctgc tgcagcagca gcagcaacag cagcagcaac
7441 aacagcagca acagcagcag cagcaaggga gtgccggcat ggctgggggc atggcggggc
7501 acggccagtt ccagcagcct caaggacccg gaggctaccc accggccatg cagcagcagc
7561 agcgcatgca gcagcatctc cccctccagg gcagctccat gggccagatg gcggctcaga
7621 tgggacagct tggccagatg gggcagccgg ggctgggggc agacagcacc cccaacatcc
7681 agcaagccct gcagcagcgg attctgcagc aacagcagat gaagcagcag attgggtccc
7741 caggccagcc gaaccccatg agcccccagc aacacatgct ctcaggacag ccacaggcct
7801 cgcatctccc tggccagcag atcgccacgt cccttagtaa ccaggtgcgg tctccagccc
7861 ctgtccagtc tccacggccc cagtcccagc ctccacattc cagcccgtca ccacggatac
7921 agccccagcc ttcgccacac cacgtctcac cccagactgg ttccccccac cccggactcg
7981 cagtcaccat ggccagctcc atagatcagg gacacttggg gaaccccgaa cagagtgcaa
8041 tgctccccca gctgaacacc cccagcagga gtgcgctgtc cagcgaactg tccctggtcg
8101 gggacaccac gggggacacg ctagagaagt ttgtggaggg cttgtag
//