LOCUS HSU84487 3310 bp mRNA linear HUM 14-MAR-1997
DEFINITION Human CX3C chemokine precursor, mRNA, alternatively spliced,
complete cds.
ACCESSION U84487
VERSION U84487.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3310)
AUTHORS Bazan,J.F., Bacon,K.B., Hardiman,G., Wang,W., Soo,K., Rossi,D.,
Greaves,D.R., Zlotnik,A. and Schall,T.J.
TITLE A new class of membrane-bound chemokine with a CX3C motif
JOURNAL Nature 385 (6617), 640-644 (1997)
PUBMED 9024663
REFERENCE 2 (bases 1 to 3310)
AUTHORS Bazan,J.F., Bacon,K.B., Hardiman,G., Wang,W., Rossi,D.,
Greaves,D.R., Zlotnik,A. and Schall,T.J.
TITLE Direct Submission
JOURNAL Submitted (07-JAN-1997) Molecular Biology, DNAX Research Institute,
901 California Ave., Palo Alto, CA 94304-1104, USA
FEATURES Location/Qualifiers
source 1..3310
/db_xref="H-InvDB:HIT000221867"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 80..1273
/note="membrane-tethered chemokine module"
/codon_start=1
/product="CX3C chemokine precursor"
/protein_id="AAB49679.1"
/translation="MAPISLSWLLRLATFCHLTVLLAGQHHGVTKCNITCSKMTSKIP
VALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNGGT
FEKQIGEVKPRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTG
VTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSSAPHQPGPSLWAEAKTSEA
PSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQSPRPENSLEREEMGPVPAHTDAFQ
DWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHATMDPQRLGVLITPVPDA
QAATRRQAVGLLAFLGLLFCLGVAMFTYQSLQGCPRKMAGEMAEGLRYIPRSCGSNSY
VLVPV"
sig_peptide 80..151
mat_peptide 152..1270
/product="CX3C chemokine"
misc_feature 152..379
/note="encodes chemokine module"
misc_feature 380..1102
/note="encodes glycosylation stalk"
misc_feature 1103..1159
/note="encodes transmembrane helix"
misc_feature 1160..1270
/note="encodes intracellular domain"
3'UTR 1274..3310
/note="alternatively spliced; short transcript deposited
as GenBank Accession Number U91835"
BASE COUNT 659 a 1051 c 916 g 682 t
ORIGIN
1 ggcacgaggg cactgagctc tgccgcctgg ctctagccgc ctgcctggcc cccgccggga
61 ctcttgccca ccctcagcca tggctccgat atctctgtcg tggctgctcc gcttggccac
121 cttctgccat ctgactgtcc tgctggctgg acagcaccac ggtgtgacga aatgcaacat
181 cacgtgcagc aagatgacat caaagatacc tgtagctttg ctcatccact atcaacagaa
241 ccaggcatca tgcggcaaac gcgcaatcat cttggagacg agacagcaca ggctgttctg
301 tgccgacccg aaggagcaat gggtcaagga cgcgatgcag catctggacc gccaggctgc
361 tgccctaact cgaaatggcg gcaccttcga gaagcagatc ggcgaggtga agcccaggac
421 cacccctgcc gccgggggaa tggacgagtc tgtggtcctg gagcccgaag ccacaggcga
481 aagcagtagc ctggagccga ctccttcttc ccaggaagca cagagggccc tggggacctc
541 cccagagctg ccgacgggcg tgactggttc ctcagggacc aggctccccc cgacgccaaa
601 ggctcaggat ggagggcctg tgggcacgga gcttttccga gtgcctcccg tctccactgc
661 cgccacgtgg cagagttctg ctccccacca acctgggccc agcctctggg ctgaggcaaa
721 gacctctgag gccccgtcca cccaggaccc ctccacccag gcctccactg cgtcctcccc
781 agccccagag gagaatgctc cgtctgaagg ccagcgtgtg tggggtcagg gacagagccc
841 caggccagag aactctctgg agcgggagga gatgggtccc gtgccagcgc acacggatgc
901 cttccaggac tgggggcctg gcagcatggc ccacgtctct gtggtccctg tctcctcaga
961 agggaccccc agcagggagc cagtggcttc aggcagctgg acccctaagg ctgaggaacc
1021 catccatgcc accatggacc cccagaggct gggcgtcctt atcactcctg tccctgacgc
1081 ccaggctgcc acccggaggc aggcggtggg gctgctggcc ttccttggcc tcctcttctg
1141 cctgggggtg gccatgttca cctaccagag cctccagggc tgccctcgaa agatggcagg
1201 agagatggcg gagggccttc gctacatccc ccggagctgt ggtagtaatt catatgtcct
1261 ggtgcccgtg tgaactcctc tggcctgtgt ctagttgttt gattcagaca gctgcctggg
1321 atccctcatc ctcataccca cccccaccca agggcctggc ctgagctggg atgattggag
1381 gggggaggtg ggatcctcca ggtgcacaag ctccaagctc ccaggcattc cccaggaggc
1441 cagccttgac cattctccac cttccaggga cagagggggt ggcctcccaa ctcaccccag
1501 ccccaaaact ctcctctgct gctggctggt tagaggttcc ctttgacgcc atcccagccc
1561 caatgaacaa ttatttatta aatgcccagc cccttctgac ccatgctgcc ctgtgagtac
1621 tacagtcctc ccatctcaca catgagcatc aggccaggcc ctctgcccac tccctgcaac
1681 ctgattgtgt ctcttggtcc tgctgcagtt gccagtcacc ccggccacct gcggtgctat
1741 ctcccccagc cccatcctct gtacagagcc cacgccccca ctggtgacat gtcttttctt
1801 gcatgaggct agtgtggtgt ttcctgggca ctgcttccag tgaggctctg cccttggtta
1861 ggsattgtgg gaaggggaga taagggtatc tggtgacttt cctctttggt ctacactgtg
1921 ctgagtctga aggctgggtt ctgatcctag ttccaccatc aagccaccaa catactccca
1981 tctgtgaaag gaaagaggga ggtaaggaat acctgtcccc ctgacaacac tcattgacct
2041 gaggcccttc tctccagccc ctggatgcag cctcacagtc cttaccagca gagcacctta
2101 gacagtccct gccaatggac taacttgtct ttggaccctg aggcccagag ggcctgcarg
2161 ggagtgagtt gatagcacag accctgccct gtgggccccc aaatggaaat gggcagagca
2221 gagaccatcc ctgaaggccc cgcccaggct tagtcactga gacagcccgg gctctgcttc
2281 ccatcacccg ctaagaggga gggagggctc cagacacatg tccaagaagc ccaggaaagg
2341 ctccaggagc agccacattc ctgatgcttc ttcagagact cctgcaggca gccaggccac
2401 aagacccttg tggtcccacc ccacacacgc cagattcttt cctgaggctg ggctcccttc
2461 ccacctctct cactccttga aaacactgtt ctctgccctc caagaccttc tccttcacct
2521 ttgtccccac cgcagacagg accaggggat ttccatgatg ttttccatga gtcccctgtt
2581 tgtttctgaa agggacgcta cccgggaagg gggctgggac atgggaaagg ggaagttgta
2641 ggcataaagt caggggttcc cttttttggc tgctgaaggc tcgagcatgc ctggatgggg
2701 ctgcaccggc tggcctggcc cctcagggtc cctggtggca gctcacctct cccttggatt
2761 gtccccgacc cttgccgtct acctgagggg cctcttatgg gctgggttct acccaggtgc
2821 taggaacact ccttcacaga tgggtgcttg gaggaaggaa acccagctct ggtccataga
2881 gagcaaaacg ctgtgctgcc ctgcccaccc tggcctctgc actcccctgc tgggtgtggc
2941 gcagcatatt caggaagctc agggccctgg ctcaggtggg gtcactctgg cagctcagag
3001 agggtgggag tgggtccaat gcactttgtt ctggctcttc caggctggga gagcctttca
3061 ggggtgggac accctgtgat ggggccctgc ctcctttgtg aggaagccgc tggggccagt
3121 tggtccccct tccatggact ttgttagttt ctccaagcag gacatggaca aggatgatct
3181 aggaagactt tggaaagagt aggaagactt tggaaagact tttccaaccc tcatcaccaa
3241 cgtctgtgcc attttgtatt ttactaataa aatttaaaag tcttgtgaaa aaaaaaaaaa
3301 aaaaaaaaaa
//