LOCUS       HSU84401                2364 bp    mRNA    linear   HUM 02-FEB-1997
DEFINITION  Human smoothened mRNA, complete cds.
ACCESSION   U84401
VERSION     U84401.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2364)
  AUTHORS   Stone,D., Hynes,M., Armanini,M., Swanson,T., Gu,Q., Johnson,R.,
            Scott,M., Pennica,D., Goddard,A., Phillips,H., Noll,M., Hooper,J.,
            de Sauvage,F.J. and Rosenthal,A.
  TITLE     The tumour-suppressor gene patched encodes a candidate receptor for
            Sonic hedgehog
  JOURNAL   Nature 384 (6605), 129-134 (1996)
   PUBMED   8906787
REFERENCE   2  (bases 1 to 2364)
  AUTHORS   Stone,D., Hynes,M., Armanini,M., Swanson,T., Gu,Q., Johnson,R.,
            Scott,M., Pennica,D., Goddard,A., Phillips,H., Noll,M., Hooper,J.,
            de Sauvage,F.J. and Rosenthal,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JAN-1997) Molecular Oncology, Genentech Inc., 460 Pt
            San Bruno Blvd., South San Francisco, CA 94404, USA
FEATURES             Location/Qualifiers
     source          1..2364
                     /db_xref="H-InvDB:HIT000221863"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             1..2364
                     /function="candidate receptor for Sonic hedgehog"
                     /codon_start=1
                     /product="smoothened"
                     /protein_id="AAB41788.1"
                     /translation="MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSA
                     GGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEA
                     HGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERE
                     RGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQ
                     NPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFV
                     GSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVV
                     LTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFV
                     GYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETML
                     RLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCE
                     IKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKS
                     KMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTK
                     MVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEV
                     CPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPE
                     PSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF"
BASE COUNT          412 a          764 c          721 g          467 t
ORIGIN      
        1 atggccgctg cccgcccagc gcgggggccg gagctcccgc tcctggggct gctgctgctg
       61 ctgctgctgg gggacccggg ccggggggcg gcctcgagcg ggaacgcgac cgggcctggg
      121 cctcggagcg cgggcgggag cgcgaggagg agcgcggcgg tgactggccc tccgccgccg
      181 ctgagccact gcggccgggc tgccccctgc gagccgctgc gctacaacgt gtgcctgggc
      241 tcggtgctgc cctacggggc cacctccaca ctgctggccg gagactcgga ctcccaggag
      301 gaagcgcacg gcaagctcgt gctctggtcg ggcctccgga atgccccccg ctgctgggca
      361 gtgatccagc ccctgctgtg tgccgtatac atgcccaagt gtgagaatga ccgggtggag
      421 ctgcccagcc gtaccctctg ccaggccacc cgaggcccct gtgccatcgt ggagagggag
      481 cggggctggc ctgacttcct gcgctgcact cctgaccgct tccctgaagg ctgcacgaat
      541 gaggtgcaga acatcaagtt caacagttca ggccagtgcg aagtgccctt ggttcggaca
      601 gacaacccca agagctggta cgaggacgtg gagggctgcg gcatccagtg ccagaacccg
      661 ctcttcacag aggctgagca ccaggacatg cacagctaca tcgcggcctt cggggccgtc
      721 acgggcctct gcacgctctt caccctggcc acattcgtgg ctgactggcg gaactcgaat
      781 cgctaccctg ctgttattct cttctacgtc aatgcgtgct tctttgtggg cagcattggc
      841 tggctggccc agttcatgga tggtgcccgc cgagagatcg tctgccgtgc agatggcacc
      901 atgaggcttg gggagcccac ctccaatgag actctgtcct gcgtcatcat ctttgtcatc
      961 gtgtactacg ccctgatggc tggtgtggtt tggtttgtgg tcctcaccta tgcctggcac
     1021 acttccttca aagccctggg caccacctac cagcctctct cgggcaagac ctcctacttc
     1081 cacctgctca cctggtcact cccctttgtc ctcactgtgg caatccttgc tgtggcgcag
     1141 gtggatgggg actctgtgag tggcatttgt tttgtgggct acaagaacta ccgataccgt
     1201 gcgggcttcg tgctggcccc aatcggcctg gtgctcatcg tgggaggcta cttcctcatc
     1261 cgaggagtca tgactctgtt ctccatcaag agcaaccacc ccgggctgct gagtgagaag
     1321 gctgccagca agatcaacga gaccatgctg cgcctgggca tttttggctt cctggccttt
     1381 ggctttgtgc tcattacctt cagctgccac ttctacgact tcttcaacca ggctgagtgg
     1441 gagcgcagct tccgggacta tgtgctatgt caggccaatg tgaccatcgg gctgcccacc
     1501 aagcagccca tccctgactg tgagatcaag aatcgcccga gccttctggt ggagaagatc
     1561 aacctgtttg ccatgtttgg aactggcatc gccatgagca cctgggtctg gaccaaggcc
     1621 acgctgctca tctggaggcg tacctggtgc aggttgactg ggcagagtga cgatgagcca
     1681 aagcggatca agaagagcaa gatgattgcc aaggccttct ctaagcggca cgagctcctg
     1741 cagaacccag gccaggagct gtccttcagc atgcacactg tgtcccacga cgggcccgtg
     1801 gcgggcttgg cctttgacct caatgagccc tcagctgatg tctcctctgc ctgggcccag
     1861 catgtcacca agatggtggc tcggagagga gccatactgc cccaggatat ttctgtcacc
     1921 cctgtggcaa ctccagtgcc cccagaggaa caagccaacc tgtggctggt tgaggcagag
     1981 atctccccag agctgcagaa gcgcctgggc cggaagaaga agaggaggaa gaggaagaag
     2041 gaggtgtgcc cgctggcgcc gccccctgag cttcaccccc ctgcccctgc ccccagtacc
     2101 attcctcgac tgcctcagct gccccggcag aaatgcctgg tggctgcagg tgcctgggga
     2161 gctggggact cttgccgaca gggagcgtgg accctggtct ccaacccatt ctgcccagag
     2221 cccagtcccc ctcaggatcc atttctgccc agtgcaccgg cccccgtggc atgggctcat
     2281 ggccgccgac agggcctggg gcctattcac tcccgcacca acctgatgga cacagaactc
     2341 atggatgcag actcggactt ctga
//