LOCUS HSU84010 7445 bp mRNA linear HUM 04-MAR-1997
DEFINITION Human glycogen debranching enzyme isoform 4 (AGL) mRNA,
alternatively spliced isoform, complete cds.
ACCESSION U84010
VERSION U84010.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7445)
AUTHORS Bao,Y., Dawsom,T.L. and Chen,Y.-T.
TITLE Human glycogen debranching enzyme gene (AGL): complete structural
organization and characterization of the 5' flanking region
JOURNAL Genomics 38 (1997) In press
REFERENCE 2 (bases 1 to 7445)
AUTHORS Bao,Y., Dawsom,T.L. and Chen,Y.-T.
TITLE Direct Submission
JOURNAL Submitted (07-JAN-1997) Pediatrics, Duke University Medical Center,
Box 3528, Durham, NC 27710, USA
FEATURES Location/Qualifiers
source 1..7445
/db_xref="H-InvDB:HIT000221851"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p21"
gene 1..7445
/gene="AGL"
CDS 479..5077
/gene="AGL"
/EC_number="2.4.1.25"
/note="alternatively spliced isoform"
/codon_start=1
/product="glycogen debranching enzyme isoform 4"
/protein_id="AAB48469.1"
/translation="MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQGKAV
TVYTNYPFPGETFNREKFRSLDWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKS
GGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHF
TPLQTLGLSRSCYSLANQLELNPDFSRPNRKYTWNDVGQLVEKLKKEWNVICITDVVY
NHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWRFSCDVAEGKYKEKGIPALIE
NDHHMNSIRKIIWEDIFPKLKLWEFFQVDVNKAVEQFRRLLTQENRRVTKSDPNQHLT
IIQDPEYRRFGCTVDMNIALTTFIPHDKGPAAIEECCNWFHKRMEELNSEKHRLINYH
QEQAVNCLLGNVFYERLAGHGPKLGPVTRKHPLVTRYFTFPFEEIDFSMEESMIHLPN
KACFLMAHNGWVMGDDPLRNFAEPGSEVYLRRELICWGDSVKLRYGNKPEDCPYLWAH
MKKYTEITATYFQGVRLDNCHSTPLHVAEYMLDAARNLQPNLYVVAELFTGSEDLDNV
FVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDI
THDNECPIVHRSAYDALPSTTIVSMACCASGSTRGYDELVPHQISVVSEERFYTKWNP
EALPSNTGEVNFQSGIIAARCAISKLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIH
QSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTKPYRKDENSING
TPDITVEIREHIQLNESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHA
QVAVGILRNHLTQFSPHFKSGSLAVDNADPILKIPFASLASRLTLAELNQILYRCESE
EKEDGGGCYDIPNWSALKYAGLQGLMSVLAEIRPKNDLGHPFCNNLRSGDWMIDYVSN
RLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDTAWKQMSSFV
QNGSTFVKHLSLGSVQLCGVGKFPSLPILSPALMDVPYRLNEITKEKEQCCVSLAAGL
PHFSSGIFRCWGRDTFIALRGILLITGRYVEARNIILAFAGTLRHGLIPNLLGEGIYA
RYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFEVI
QEAMQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGVDEETGFVYGGNRFNCGTWMDK
MGESDRARNRGIPATPRDGSAVEIVGLSKSAVRWLLELSKKNIFPYHEVTVKRHGKAI
KVSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCDYQLR
PNFTIAMVVAPELFTTEKAGKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDN
YNLAKGFNYHQGPEWLWPIGYFLRAKLYFSRLMGPETTAKTIVLVKNVLSRHYVHLER
SPWKGLPELTNENAQYCPFSCETQAWSIATILETLYDL"
BASE COUNT 2374 a 1260 c 1468 g 2343 t
ORIGIN
1 ctgtctacgg cagctattcc agaggcaaca actgcttccc tctgttctca tctccccatt
61 ggtggctggc gacccgaatt tgggaatggg gagattgccc acctgttatc tttgagcaga
121 ctaatctctt gtaagcagaa gtgccattcg gagtctccag agccctgtgg cttggggctg
181 ggaatgtccc cctgacttca ggctttccta agtgtattgc ttttctctga gaatggtcta
241 ggtttttaat tttttaattg taagaatctg taatacagca tttttatttc ggtcttattc
301 gttgtgctca aaggcaggaa acaactatta atttgccttc tcgaatctta atagttataa
361 gattcattct ctttcattgc tctgctaggc ataaaacaca cttcgaacat gggtaactca
421 ttcgactgtg gagttctttt aattcttatg aaagatttca aatcctctgg aagccaaaat
481 gggacacagt aaacagattc gaattttact tctgaacgaa atggagaaac tggaaaagac
541 cctcttcaga cttgaacaag ggtatgagct acagttccga ttaggcccaa ctttacaggg
601 aaaagcagtt accgtgtata caaattaccc atttcctgga gaaacattta atagagaaaa
661 attccgttct ctggattggg aaaatccaac agaaagagaa gatgattctg ataaatactg
721 taaacttaat ctgcaacaat ctggttcatt tcagtattat ttccttcaag gaaatgagaa
781 aagtggtgga ggttacatag ttgtggaccc cattttacgt gttggtgctg ataatcatgt
841 gctacccttg gactgtgtta ctcttcagac atttttagct aagtgtttgg gaccttttga
901 tgaatgggaa agcagactta gggttgcaaa agaatcaggc tacaacatga ttcattttac
961 cccattgcag actcttggac tatctaggtc atgctactcc cttgccaatc agttagaatt
1021 aaatcctgac ttttcaagac ctaatagaaa gtatacctgg aatgatgttg gacagctagt
1081 ggaaaaatta aaaaaggaat ggaatgttat ttgtattact gatgttgtct acaatcatac
1141 tgctgctaat agtaaatgga tccaggaaca tccagaatgt gcctataatc ttgtgaattc
1201 tccacactta aaacctgcct gggtcttaga cagagcactt tggcgtttct cctgtgatgt
1261 tgcagaaggg aaatacaaag aaaagggaat acctgctttg attgaaaatg atcaccatat
1321 gaattccatc cgaaaaataa tttgggagga tatttttcca aagcttaaac tctgggaatt
1381 tttccaagta gatgtcaaca aagcggttga gcaatttaga agacttctta cacaagaaaa
1441 taggcgagta accaagtctg atccaaacca acaccttacg attattcaag atcctgaata
1501 cagacggttt ggctgtactg tagatatgaa cattgcacta acgactttca taccacatga
1561 caaggggcca gcagcaattg aagaatgctg taattggttt cataaaagaa tggaggaatt
1621 aaattcagag aagcatcgac tcattaacta tcatcaggaa caggcagtta attgcctttt
1681 gggaaatgtg ttttatgaac gactggctgg ccatggtcca aaactaggac ctgtcactag
1741 aaagcatcct ttagttacca ggtattttac tttcccattt gaagagatag acttctccat
1801 ggaagaatct atgattcatc tgccaaataa agcttgtttt ctgatggcac acaatggatg
1861 ggtaatggga gatgatcctc ttcgaaactt tgctgaaccg ggttcagaag tttacctaag
1921 gagagaactt atttgctggg gagacagtgt taaattacgc tatgggaata aaccagagga
1981 ctgtccttat ctctgggcac acatgaaaaa atacactgaa ataactgcaa cttatttcca
2041 gggagtacgt cttgataact gccactcaac acctcttcac gtagctgagt acatgttgga
2101 tgctgctagg aatttgcaac ccaatttata tgtagtagct gaactgttca caggaagtga
2161 agatctggac aatgtctttg ttactagact gggcattagt tccttaataa gagaggcaat
2221 gagtgcatat aatagtcatg aagagggcag attagtttac cgatatggag gagaacctgt
2281 tggatccttt gttcagccct gtttgaggcc tttaatgcca gctattgcac atgccctgtt
2341 tatggatatt acgcatgata atgagtgtcc tattgtgcat agatcagcgt atgatgctct
2401 tccaagtact acaattgttt ctatggcatg ttgtgctagt ggaagtacaa gaggctatga
2461 tgaattagtg cctcatcaga tttcagtggt ttctgaagaa cggttttaca ctaagtggaa
2521 tcctgaagca ttgccttcaa acacaggtga agttaatttc caaagcggca ttattgcagc
2581 caggtgtgct atcagtaaac ttcatcagga gcttggagcc aagggtttta ttcaggtgta
2641 tgtggatcaa gttgatgaag acatagtggc agtaacaaga cactcaccta gcatccatca
2701 gtctgttgtg gctgtatcta gaactgcttt caggaatccc aagacttcat tttacagcaa
2761 ggaagtgcct caaatgtgca tccctggcaa aattgaagaa gtagttcttg aagctagaac
2821 tattgagaga aacacgaaac cttataggaa ggatgagaat tcaatcaatg gaacaccaga
2881 tatcacagta gaaattagag aacatattca gcttaatgaa agtaaaattg ttaaacaagc
2941 tggagttgcc acaaaagggc ccaatgaata tattcaagaa atagaatttg aaaacttgtc
3001 tccaggaagt gttattatat tcagagttag tcttgatcca catgcacaag tcgctgttgg
3061 aattcttcga aatcatctga cacaattcag tcctcacttt aaatctggca gcctagctgt
3121 tgacaatgca gatcctatat taaaaattcc ttttgcttct cttgcctcca gattaacttt
3181 ggctgagcta aatcagatcc tttaccgatg tgaatcagaa gaaaaggaag atggtggagg
3241 gtgctatgac ataccaaact ggtcagccct taaatatgca ggtcttcaag gtttaatgtc
3301 tgtattggca gaaataagac caaagaatga cttggggcat cctttttgta ataatttgag
3361 atctggagat tggatgattg actatgtcag taaccggctt atttcacgat caggaactat
3421 tgctgaagtt ggtaaatggt tgcaggctat gttcttctac ctgaagcaga tcccacgtta
3481 ccttatccca tgttactttg atgctatatt aattggtgca tataccactc ttctggatac
3541 agcatggaag cagatgtcaa gctttgttca gaatggttca acctttgtga aacacctttc
3601 attgggttca gttcaactgt gtggagtagg aaaattccct tccctgccaa ttctttcacc
3661 tgccctaatg gatgtacctt ataggttaaa tgagatcaca aaagaaaagg agcaatgttg
3721 tgtttctcta gctgcaggct tacctcattt ttcttctggt attttccgct gctggggaag
3781 ggatactttt attgcactta gaggtatact gctgattact ggacgctatg tagaagccag
3841 gaatattatt ttagcatttg cgggtaccct gaggcatggt ctcattccta atctactggg
3901 tgaagggatt tatgccagat acaattgtcg ggatgctgtg tggtggtggc tgcagtgtat
3961 ccaggattac tgtaaaatgg ttccaaatgg tctagacatt ctcaagtgcc cagtttccag
4021 aatgtatcct acagatgatt ctgctccttt gcctgctggc acactggatc agccattgtt
4081 tgaagtcata caggaagcaa tgcaaaaaca catgcagggc atacagttcc gagaaaggaa
4141 tgctggtccc cagatagatc gaaacatgaa ggacgaaggt tttaatataa ctgcaggagt
4201 tgatgaagaa acaggatttg tttatggagg aaatcgtttc aattgtggca catggatgga
4261 taaaatggga gaaagtgaca gagctagaaa cagaggaatc ccagccacac caagagatgg
4321 gtctgctgtg gaaattgtgg gcctgagtaa atctgctgtt cgctggttgc tggaattatc
4381 caaaaaaaat attttccctt atcatgaagt cacagtaaaa agacatggaa aggctataaa
4441 ggtctcatat gatgagtgga acagaaaaat acaagacaac tttgaaaagc tatttcatgt
4501 ttccgaagac ccttcagatt taaatgaaaa gcatccaaat ctggttcaca aacgtggcat
4561 atacaaagat agttatggag cttcaagtcc ttggtgtgac tatcagctca ggcctaattt
4621 taccatagca atggttgtgg cccctgagct ctttactaca gaaaaagcag ggaaagcttt
4681 ggagattgca gaaaaaaaat tgcttggtcc ccttggcatg aaaactttag atccagatga
4741 tatggtttac tgtggaattt atgacaatgc attagacaat gacaactaca atcttgctaa
4801 aggtttcaat tatcaccaag gacctgagtg gctgtggcct attgggtatt ttcttcgtgc
4861 aaaattatat ttttccagat tgatgggccc ggagactact gcaaagacta tagttttggt
4921 taaaaatgtt ctttcccgac attatgttca tcttgagaga tccccttgga aaggacttcc
4981 agaactgacc aatgagaatg cccagtactg tcctttcagc tgtgaaacac aagcctggtc
5041 aattgctact attcttgaga cactttatga tttatagttt attacagata ttaagtatgc
5101 aattactgta ttataggatg caaggtcatc atatgtaaat gctatatgca caggctcaag
5161 ttgttttaaa aatctcattt attataatat tgatgctcaa ttaggtaaga ttgtaaaagc
5221 attgattttt tttaatgtac agaggtagat ttcaatttga atcagaaaga aatatcatta
5281 ccaatgaaat gtgtttgagt tcagtaagaa ttattcaaat gcctagaaat ccatagtttg
5341 gaaaataaaa atcatgtcat cttctatttg tacagaaatg aaaataaaat atgaaaataa
5401 tgaaagaaat gaaaagatag cttttaattg tggtatatat aatcttcagt aacaatacat
5461 actgaatacg ctgtggttca ttaatattaa caccacgtac tatagtattc ttagaataca
5521 gtgctcactg catttaataa atatttaata aatgatgaat gatagaagtt tccatctaca
5581 atatatgttc ctaaatggag cacagatgtt caaactatgc tttcattttt tcactgatat
5641 attaattttt gtgtaatgaa tgccaacagt atattttata tgatttactt atgtgaggaa
5701 acatgcaaag cattaggaaa tttatttcct aaaaacagtt ttgtaaaatt agtattgagt
5761 tctattgagt attataagat agcttacatt ttcaaaatgg aaattgtcgg tcatatttct
5821 agaactttaa agaaaaaaga atgttatatt agttttctaa aactcaacta tctttagtca
5881 tgttcaaaaa tctattgcta gatcatagta gatactggtt ttctattaac tcaaaaccta
5941 cattgacaag tttaacattg agaagaatct taacaaaaat atggatatga attcagtaga
6001 tatcttaaat tcaataaaat cactggaagt ttttcatgat aacttatttt aagatgcctt
6061 aaaaatctta aagtcacaaa aggaaaaagg tttttaacat ttacatgagt taacattttt
6121 tcatagaact tatttcctag atagaatttt ttactgtttt ttactgtttt cttaagaaaa
6181 cagttaaatc attatgcatt cagttggaag aaagtagtgg caagaattct ttcattgcta
6241 tataatattc agtggctcat ttatacctaa taaaataatg gtattttaaa ataatgctac
6301 tttcaaagta gcattttttt agttagttta caggttacat acccaaaacc ttaactatga
6361 ctaagaaatt aaagaagaaa accagcaaac taaaacttct gggcagcaaa aatatataaa
6421 tgcttcagat gtcaaatacc catgcttgaa agctcgtgta atttacttta agattatctg
6481 cctgctcttc ttcaaagctg accttgcttt agaaatagtt ttaactagct tagttttctg
6541 gtttccaaaa ctaaaataga ttaaatccta caaatttaag gacagttgtg acagtaatct
6601 gaccactatc tataaataca ttggacattg gtttccaaat ctccctttct cttcagttcc
6661 ttccttgttc aatatatacc cttctctaaa ctgtgcgggt aaaaggaatg actgtccttg
6721 agagaaccat tagtttatca aaggtttatg tagttttgtt gctgtaccct aactttgata
6781 ttcagggagg taggaaaggt aacagaaaac cagcatattt aatcaaagca agaagtaatc
6841 gctgacagtt aaatgtgacc aaaaaaatta aaagttcaca atttttttaa tgtagccatt
6901 tggggttatc tctagtaagg cagataccca cgttggtaaa tttttaggat attgtgttgc
6961 actagaaaac taagtggttc atatttctaa tgaggaagat taatgaaaga acattgttat
7021 attctgcgtg gtatatttta aagtttaaga aggcatgtta aacattattt cctctatggt
7081 agttaaaata cagaattaga tttttaacag gtgtcatttg actaaacgtt tcggtagaat
7141 gcttcatact tgagtgatgc tggataaggt attgtatttc aacaatggac tatgccttgg
7201 tttttcacta atcaaaatca aaattactct ttaacatgat aaatgaattt accagtttag
7261 tatgctgtgg tattttaata agttttcaaa gataattggg aaaacatgag actggtcata
7321 ttgatgaata ttgtaacatg tgaattgtga tccatttctg atatgtcttg aactactgtg
7381 tctagtaggc aaatgtcatt gttacctctg tgtgttaaga aaataaaaat attttctaaa
7441 ggtcg
//