LOCUS HSU84008 7105 bp mRNA linear HUM 04-MAR-1997
DEFINITION Human glycogen debranching enzyme isoform 2 (AGL) mRNA,
alternatively spliced isoform, complete cds.
ACCESSION U84008
VERSION U84008.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7105)
AUTHORS Bao,Y., Dawsom,T.L. and Chen,Y.-T.
TITLE Human glycogen debranching enzyme gene (AGL): complete structural
organization and characterization of the 5' flanking region
JOURNAL Genomics 38 (1997) In press
REFERENCE 2 (bases 1 to 7105)
AUTHORS Bao,Y., Dawsom,T.L. and Chen,Y.-T.
TITLE Direct Submission
JOURNAL Submitted (07-JAN-1997) Pediatrics, Duke University Medical Center,
Box 3528, Durham, NC 27710, USA
FEATURES Location/Qualifiers
source 1..7105
/db_xref="H-InvDB:HIT000221849"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p21"
gene 1..7105
/gene="AGL"
CDS 139..4737
/gene="AGL"
/EC_number="2.4.1.25"
/note="alternatively spliced isoform"
/codon_start=1
/product="glycogen debranching enzyme isoform 2"
/protein_id="AAB48467.1"
/translation="MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQGKAV
TVYTNYPFPGETFNREKFRSLDWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKS
GGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHF
TPLQTLGLSRSCYSLANQLELNPDFSRPNRKYTWNDVGQLVEKLKKEWNVICITDVVY
NHTAANSKWIQEHPECAYNLVNSPHLKPAWVLDRALWRFSCDVAEGKYKEKGIPALIE
NDHHMNSIRKIIWEDIFPKLKLWEFFQVDVNKAVEQFRRLLTQENRRVTKSDPNQHLT
IIQDPEYRRFGCTVDMNIALTTFIPHDKGPAAIEECCNWFHKRMEELNSEKHRLINYH
QEQAVNCLLGNVFYERLAGHGPKLGPVTRKHPLVTRYFTFPFEEIDFSMEESMIHLPN
KACFLMAHNGWVMGDDPLRNFAEPGSEVYLRRELICWGDSVKLRYGNKPEDCPYLWAH
MKKYTEITATYFQGVRLDNCHSTPLHVAEYMLDAARNLQPNLYVVAELFTGSEDLDNV
FVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDI
THDNECPIVHRSAYDALPSTTIVSMACCASGSTRGYDELVPHQISVVSEERFYTKWNP
EALPSNTGEVNFQSGIIAARCAISKLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIH
QSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTKPYRKDENSING
TPDITVEIREHIQLNESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHA
QVAVGILRNHLTQFSPHFKSGSLAVDNADPILKIPFASLASRLTLAELNQILYRCESE
EKEDGGGCYDIPNWSALKYAGLQGLMSVLAEIRPKNDLGHPFCNNLRSGDWMIDYVSN
RLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDTAWKQMSSFV
QNGSTFVKHLSLGSVQLCGVGKFPSLPILSPALMDVPYRLNEITKEKEQCCVSLAAGL
PHFSSGIFRCWGRDTFIALRGILLITGRYVEARNIILAFAGTLRHGLIPNLLGEGIYA
RYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFEVI
QEAMQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGVDEETGFVYGGNRFNCGTWMDK
MGESDRARNRGIPATPRDGSAVEIVGLSKSAVRWLLELSKKNIFPYHEVTVKRHGKAI
KVSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCDYQLR
PNFTIAMVVAPELFTTEKAGKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDN
YNLAKGFNYHQGPEWLWPIGYFLRAKLYFSRLMGPETTAKTIVLVKNVLSRHYVHLER
SPWKGLPELTNENAQYCPFSCETQAWSIATILETLYDL"
BASE COUNT 2290 a 1195 c 1401 g 2219 t
ORIGIN
1 ctgtctacgg cagctattcc agaggcaaca actgcttccc tctgttctca tctccccatt
61 ggtggctggc gacccgaatt tgggaatggg gagattgccc acctgttatc tttgagcaga
121 ctaatctctt aagccaaaat gggacacagt aaacagattc gaattttact tctgaacgaa
181 atggagaaac tggaaaagac cctcttcaga cttgaacaag ggtatgagct acagttccga
241 ttaggcccaa ctttacaggg aaaagcagtt accgtgtata caaattaccc atttcctgga
301 gaaacattta atagagaaaa attccgttct ctggattggg aaaatccaac agaaagagaa
361 gatgattctg ataaatactg taaacttaat ctgcaacaat ctggttcatt tcagtattat
421 ttccttcaag gaaatgagaa aagtggtgga ggttacatag ttgtggaccc cattttacgt
481 gttggtgctg ataatcatgt gctacccttg gactgtgtta ctcttcagac atttttagct
541 aagtgtttgg gaccttttga tgaatgggaa agcagactta gggttgcaaa agaatcaggc
601 tacaacatga ttcattttac cccattgcag actcttggac tatctaggtc atgctactcc
661 cttgccaatc agttagaatt aaatcctgac ttttcaagac ctaatagaaa gtatacctgg
721 aatgatgttg gacagctagt ggaaaaatta aaaaaggaat ggaatgttat ttgtattact
781 gatgttgtct acaatcatac tgctgctaat agtaaatgga tccaggaaca tccagaatgt
841 gcctataatc ttgtgaattc tccacactta aaacctgcct gggtcttaga cagagcactt
901 tggcgtttct cctgtgatgt tgcagaaggg aaatacaaag aaaagggaat acctgctttg
961 attgaaaatg atcaccatat gaattccatc cgaaaaataa tttgggagga tatttttcca
1021 aagcttaaac tctgggaatt tttccaagta gatgtcaaca aagcggttga gcaatttaga
1081 agacttctta cacaagaaaa taggcgagta accaagtctg atccaaacca acaccttacg
1141 attattcaag atcctgaata cagacggttt ggctgtactg tagatatgaa cattgcacta
1201 acgactttca taccacatga caaggggcca gcagcaattg aagaatgctg taattggttt
1261 cataaaagaa tggaggaatt aaattcagag aagcatcgac tcattaacta tcatcaggaa
1321 caggcagtta attgcctttt gggaaatgtg ttttatgaac gactggctgg ccatggtcca
1381 aaactaggac ctgtcactag aaagcatcct ttagttacca ggtattttac tttcccattt
1441 gaagagatag acttctccat ggaagaatct atgattcatc tgccaaataa agcttgtttt
1501 ctgatggcac acaatggatg ggtaatggga gatgatcctc ttcgaaactt tgctgaaccg
1561 ggttcagaag tttacctaag gagagaactt atttgctggg gagacagtgt taaattacgc
1621 tatgggaata aaccagagga ctgtccttat ctctgggcac acatgaaaaa atacactgaa
1681 ataactgcaa cttatttcca gggagtacgt cttgataact gccactcaac acctcttcac
1741 gtagctgagt acatgttgga tgctgctagg aatttgcaac ccaatttata tgtagtagct
1801 gaactgttca caggaagtga agatctggac aatgtctttg ttactagact gggcattagt
1861 tccttaataa gagaggcaat gagtgcatat aatagtcatg aagagggcag attagtttac
1921 cgatatggag gagaacctgt tggatccttt gttcagccct gtttgaggcc tttaatgcca
1981 gctattgcac atgccctgtt tatggatatt acgcatgata atgagtgtcc tattgtgcat
2041 agatcagcgt atgatgctct tccaagtact acaattgttt ctatggcatg ttgtgctagt
2101 ggaagtacaa gaggctatga tgaattagtg cctcatcaga tttcagtggt ttctgaagaa
2161 cggttttaca ctaagtggaa tcctgaagca ttgccttcaa acacaggtga agttaatttc
2221 caaagcggca ttattgcagc caggtgtgct atcagtaaac ttcatcagga gcttggagcc
2281 aagggtttta ttcaggtgta tgtggatcaa gttgatgaag acatagtggc agtaacaaga
2341 cactcaccta gcatccatca gtctgttgtg gctgtatcta gaactgcttt caggaatccc
2401 aagacttcat tttacagcaa ggaagtgcct caaatgtgca tccctggcaa aattgaagaa
2461 gtagttcttg aagctagaac tattgagaga aacacgaaac cttataggaa ggatgagaat
2521 tcaatcaatg gaacaccaga tatcacagta gaaattagag aacatattca gcttaatgaa
2581 agtaaaattg ttaaacaagc tggagttgcc acaaaagggc ccaatgaata tattcaagaa
2641 atagaatttg aaaacttgtc tccaggaagt gttattatat tcagagttag tcttgatcca
2701 catgcacaag tcgctgttgg aattcttcga aatcatctga cacaattcag tcctcacttt
2761 aaatctggca gcctagctgt tgacaatgca gatcctatat taaaaattcc ttttgcttct
2821 cttgcctcca gattaacttt ggctgagcta aatcagatcc tttaccgatg tgaatcagaa
2881 gaaaaggaag atggtggagg gtgctatgac ataccaaact ggtcagccct taaatatgca
2941 ggtcttcaag gtttaatgtc tgtattggca gaaataagac caaagaatga cttggggcat
3001 cctttttgta ataatttgag atctggagat tggatgattg actatgtcag taaccggctt
3061 atttcacgat caggaactat tgctgaagtt ggtaaatggt tgcaggctat gttcttctac
3121 ctgaagcaga tcccacgtta ccttatccca tgttactttg atgctatatt aattggtgca
3181 tataccactc ttctggatac agcatggaag cagatgtcaa gctttgttca gaatggttca
3241 acctttgtga aacacctttc attgggttca gttcaactgt gtggagtagg aaaattccct
3301 tccctgccaa ttctttcacc tgccctaatg gatgtacctt ataggttaaa tgagatcaca
3361 aaagaaaagg agcaatgttg tgtttctcta gctgcaggct tacctcattt ttcttctggt
3421 attttccgct gctggggaag ggatactttt attgcactta gaggtatact gctgattact
3481 ggacgctatg tagaagccag gaatattatt ttagcatttg cgggtaccct gaggcatggt
3541 ctcattccta atctactggg tgaagggatt tatgccagat acaattgtcg ggatgctgtg
3601 tggtggtggc tgcagtgtat ccaggattac tgtaaaatgg ttccaaatgg tctagacatt
3661 ctcaagtgcc cagtttccag aatgtatcct acagatgatt ctgctccttt gcctgctggc
3721 acactggatc agccattgtt tgaagtcata caggaagcaa tgcaaaaaca catgcagggc
3781 atacagttcc gagaaaggaa tgctggtccc cagatagatc gaaacatgaa ggacgaaggt
3841 tttaatataa ctgcaggagt tgatgaagaa acaggatttg tttatggagg aaatcgtttc
3901 aattgtggca catggatgga taaaatggga gaaagtgaca gagctagaaa cagaggaatc
3961 ccagccacac caagagatgg gtctgctgtg gaaattgtgg gcctgagtaa atctgctgtt
4021 cgctggttgc tggaattatc caaaaaaaat attttccctt atcatgaagt cacagtaaaa
4081 agacatggaa aggctataaa ggtctcatat gatgagtgga acagaaaaat acaagacaac
4141 tttgaaaagc tatttcatgt ttccgaagac ccttcagatt taaatgaaaa gcatccaaat
4201 ctggttcaca aacgtggcat atacaaagat agttatggag cttcaagtcc ttggtgtgac
4261 tatcagctca ggcctaattt taccatagca atggttgtgg cccctgagct ctttactaca
4321 gaaaaagcag ggaaagcttt ggagattgca gaaaaaaaat tgcttggtcc ccttggcatg
4381 aaaactttag atccagatga tatggtttac tgtggaattt atgacaatgc attagacaat
4441 gacaactaca atcttgctaa aggtttcaat tatcaccaag gacctgagtg gctgtggcct
4501 attgggtatt ttcttcgtgc aaaattatat ttttccagat tgatgggccc ggagactact
4561 gcaaagacta tagttttggt taaaaatgtt ctttcccgac attatgttca tcttgagaga
4621 tccccttgga aaggacttcc agaactgacc aatgagaatg cccagtactg tcctttcagc
4681 tgtgaaacac aagcctggtc aattgctact attcttgaga cactttatga tttatagttt
4741 attacagata ttaagtatgc aattactgta ttataggatg caaggtcatc atatgtaaat
4801 gctatatgca caggctcaag ttgttttaaa aatctcattt attataatat tgatgctcaa
4861 ttaggtaaga ttgtaaaagc attgattttt tttaatgtac agaggtagat ttcaatttga
4921 atcagaaaga aatatcatta ccaatgaaat gtgtttgagt tcagtaagaa ttattcaaat
4981 gcctagaaat ccatagtttg gaaaataaaa atcatgtcat cttctatttg tacagaaatg
5041 aaaataaaat atgaaaataa tgaaagaaat gaaaagatag cttttaattg tggtatatat
5101 aatcttcagt aacaatacat actgaatacg ctgtggttca ttaatattaa caccacgtac
5161 tatagtattc ttagaataca gtgctcactg catttaataa atatttaata aatgatgaat
5221 gatagaagtt tccatctaca atatatgttc ctaaatggag cacagatgtt caaactatgc
5281 tttcattttt tcactgatat attaattttt gtgtaatgaa tgccaacagt atattttata
5341 tgatttactt atgtgaggaa acatgcaaag cattaggaaa tttatttcct aaaaacagtt
5401 ttgtaaaatt agtattgagt tctattgagt attataagat agcttacatt ttcaaaatgg
5461 aaattgtcgg tcatatttct agaactttaa agaaaaaaga atgttatatt agttttctaa
5521 aactcaacta tctttagtca tgttcaaaaa tctattgcta gatcatagta gatactggtt
5581 ttctattaac tcaaaaccta cattgacaag tttaacattg agaagaatct taacaaaaat
5641 atggatatga attcagtaga tatcttaaat tcaataaaat cactggaagt ttttcatgat
5701 aacttatttt aagatgcctt aaaaatctta aagtcacaaa aggaaaaagg tttttaacat
5761 ttacatgagt taacattttt tcatagaact tatttcctag atagaatttt ttactgtttt
5821 ttactgtttt cttaagaaaa cagttaaatc attatgcatt cagttggaag aaagtagtgg
5881 caagaattct ttcattgcta tataatattc agtggctcat ttatacctaa taaaataatg
5941 gtattttaaa ataatgctac tttcaaagta gcattttttt agttagttta caggttacat
6001 acccaaaacc ttaactatga ctaagaaatt aaagaagaaa accagcaaac taaaacttct
6061 gggcagcaaa aatatataaa tgcttcagat gtcaaatacc catgcttgaa agctcgtgta
6121 atttacttta agattatctg cctgctcttc ttcaaagctg accttgcttt agaaatagtt
6181 ttaactagct tagttttctg gtttccaaaa ctaaaataga ttaaatccta caaatttaag
6241 gacagttgtg acagtaatct gaccactatc tataaataca ttggacattg gtttccaaat
6301 ctccctttct cttcagttcc ttccttgttc aatatatacc cttctctaaa ctgtgcgggt
6361 aaaaggaatg actgtccttg agagaaccat tagtttatca aaggtttatg tagttttgtt
6421 gctgtaccct aactttgata ttcagggagg taggaaaggt aacagaaaac cagcatattt
6481 aatcaaagca agaagtaatc gctgacagtt aaatgtgacc aaaaaaatta aaagttcaca
6541 atttttttaa tgtagccatt tggggttatc tctagtaagg cagataccca cgttggtaaa
6601 tttttaggat attgtgttgc actagaaaac taagtggttc atatttctaa tgaggaagat
6661 taatgaaaga acattgttat attctgcgtg gtatatttta aagtttaaga aggcatgtta
6721 aacattattt cctctatggt agttaaaata cagaattaga tttttaacag gtgtcatttg
6781 actaaacgtt tcggtagaat gcttcatact tgagtgatgc tggataaggt attgtatttc
6841 aacaatggac tatgccttgg tttttcacta atcaaaatca aaattactct ttaacatgat
6901 aaatgaattt accagtttag tatgctgtgg tattttaata agttttcaaa gataattggg
6961 aaaacatgag actggtcata ttgatgaata ttgtaacatg tgaattgtga tccatttctg
7021 atatgtcttg aactactgtg tctagtaggc aaatgtcatt gttacctctg tgtgttaaga
7081 aaataaaaat attttctaaa ggtcg
//