LOCUS HSU83410 2832 bp mRNA linear HUM 03-APR-1997
DEFINITION Human CUL-2 (cul-2) mRNA, complete cds.
ACCESSION U83410
VERSION U83410.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2832)
AUTHORS Pause,A., Lee,S., Worrell,R.A., Chen,D.Y., Burgess,W.H.,
Linehan,W.M. and Klausner,R.D.
TITLE The von Hippel-Lindau tumor-suppressor gene product forms a stable
complex with human CUL-2, a member of the Cdc53 family of proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (6), 2156-2161 (1997)
PUBMED 9122164
REFERENCE 2 (bases 1 to 2832)
AUTHORS Pause,A.
TITLE Direct Submission
JOURNAL Submitted (30-DEC-1996) CBMB, NICHD, NIH, 18 Library Drive,
Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..2832
/db_xref="H-InvDB:HIT000221821"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="kidney"
gene 1..2832
/gene="cul-2"
CDS 147..2384
/gene="cul-2"
/note="Cullin family member; Cdc53 homolog; VHL tumor
suppressor protein binding protein"
/codon_start=1
/product="CUL-2"
/protein_id="AAC51190.1"
/translation="MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYA
LCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMD
CLYRYLSTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILI
RMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEY
YKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQ
FLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQEN
MPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLA
KYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQ
IYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKM
NYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMIN
HDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQA
AIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADE
YSYVA"
BASE COUNT 935 a 534 c 576 g 787 t
ORIGIN
1 gcgagctgac agccgccgcc gccgccgcct ccgcccacct tcctcgccgg ggcttcgtct
61 ttcactcctt cgggctgcct ccccctcccc ttgtcccctg ccccttgccc tgcttctgca
121 gaagatttca acactacact tgcacaatgt ctttgaaacc aagagtagta gattttgatg
181 aaacatggaa caaacttttg acgacaataa aagccgtggt catgttggaa tacgtcgaaa
241 gagcaacatg gaatgaccgt ttctcagata tctatgcttt atgtgtggcc tatcctgaac
301 cccttggaga aagactttat acagaaacta agattttttt ggaaaatcat gttcggcatt
361 tgcataagag agttttggag tcagaagaac aagtacttgt tatgtatcat aggtactggg
421 aagaatacag caagggtgca gactatatgg actgcttata taggtatctc agcacccagt
481 ttattaaaaa gaataaatta acagaagcgg accttcagta tggctatggt ggtgtagata
541 tgaatgaacc acttatggaa ataggagagc tagcattgga tatgtggagg aaattgatgg
601 ttgaaccact tcaggccatc cttatccgaa tgctgctccg agaaatcaaa aatgatcgtg
661 gtggagaaga cccaaaccag aaagtaatcc atggggttat taactccttt gttcatgttg
721 aacagtataa gaaaaaattc cccttaaagt tttatcagga aatttttgag tctccctttc
781 tgactgaaac aggagagtat tacaaacaag aagcttcaaa tttattacaa gaatcaaact
841 gctcacagta tatggaaaag gttttaggta gattaaaaga tgaagaaatt cgatgtcgaa
901 aatacctaca tccaagttca tatactaagg tgattcatga atgtcaacaa cgaatggtag
961 cagaccactt acagttttta catgcagaat gtcataatat aattcgacaa gagaaaaaaa
1021 atgacatggc aaatatgtac gtcttactcc gtgctgtgtc cactggttta cctcatatga
1081 ttcaggagct gcaaaaccac atccatgatg agggccttcg agcaaccagc aaccttactc
1141 aggaaaacat gccaacacta tttgtggagt cagttttgga agtgcatggt aaatttgttc
1201 agcttatcaa cactgttttg aatggtgatc agcattttat gagtgcgttg gataaggccc
1261 ttacgtcagt tgtaaattac agagaaccta agtctgtttg caaagcacct gaactgcttg
1321 ctaagtactg tgacaactta ctgaagaagt cagcgaaagg gatgacagag aatgaagtgg
1381 aagacaggct tacgagcttc atcacagtgt tcaaatacat tgatgacaag gacgtctttc
1441 aaaagttcta cgcaagaatg ctggcaaaac gtttaattca tgggttatcc atgtctatgg
1501 actctgaaga agccatgatc aacaaattaa agcaagcctg tggttatgag tttaccagca
1561 agctacatcg gatgtataca gatatgagtg tcagcgctga tctcaacaat aagttcaaca
1621 attttatcaa aaaccaagac acagtaatag atttgggaat tagttttcaa atatatgttc
1681 tacaggctgg tgcgtggcct cttactcagg ctccttcatc tacgtttgca attccccagg
1741 aattagaaaa aagtgtacag atgtttgaat tattttatag ccaacatttc agtggaagga
1801 aacttacatg gttacattat ctgtgtacag gtgaagttaa aatgaactat ttgggcaaac
1861 catatgtagc catggttaca acataccaaa tggcagttct tcttgccttt aacaacagtg
1921 aaactgtcag ttataaagag cttcaggaca gcactcagat gaatgaaaag gaactgacaa
1981 aaacaatcaa atcattactt gatgtgaaaa tgattaacca tgattcagaa aaggaagata
2041 ttgatgcaga atcttcgttt tcattaaata tgaactttag cagtaaaaga acaaaattta
2101 aaattactac atcaatgcag aaagacacac cacaagaaat ggagcagact agaagtgcag
2161 ttgatgagga ccggaaaatg tatctccaag ctgctatagt tcgtatcatg aaagcacgaa
2221 aagtgcttcg gcacaatgcc cttattcaag aggtgattag ccagtcaaga gctaggttta
2281 atcccagtat cagcatgatt aagaagtgta ttgaagttct gatagacaaa caatacatag
2341 aacgcagcca ggcgtcggca gatgaataca gctacgtcgc gtgatgtcgc tctcctccag
2401 cgtggtgtga gaagatcatt gccatcacca tttggtgtgt tcctgtggga aaaagcagga
2461 ctgtgcctcc ataatttggt catttggcag cccctgtttt ctgctgttta caacatcacc
2521 agtgccacgt catgagcgtc aaagaaaatg cctagagata tttcaagctc atgacattat
2581 gacatttctt aaaactttat taaaagaatg agtgaagtat tgctgaaaag tggaaaatcg
2641 gttgggtacc atgctttttc tccccttcac gtttgcagtt gatgtgtctt tttttttttt
2701 tttaatgtat cttaaaggac ataaaattta aaaacttaaa tattgtaata tgacagataa
2761 cctaataatt gtatctacat taaaatgaca aacatgatac tgctgcttgt caaataaaaa
2821 aaaaaaaaaa aa
//