LOCUS HSU79734 4714 bp mRNA linear HUM 06-MAY-1997
DEFINITION Human huntingtin interacting protein (HIP1) mRNA, complete cds.
ACCESSION U79734
VERSION U79734.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4714)
AUTHORS Kalchman,M.A., Koide,H.B., McCutcheon,K., Graham,R.K., Nichol,K.,
Nishiyama,K., Kazemi-Esfarjani,P., Lynn,F.C., Wellington,C.,
Metzler,M., Goldberg,Y.P., Kanazawa,I., Geitz,R.D. and Hayden,M.R.
TITLE HIP1, a human homologue of S. cerevisiae Sla2p, interacts with
membrane-associated huntingtin in the brain
JOURNAL Nat. Genet. 16 (1), 44-53 (1997)
PUBMED 9140394
REFERENCE 2 (bases 1 to 4714)
AUTHORS Kalchman,M.A., Nichol,K., Graham,R.K., Geitz,R.D. and Hayden,M.R.
TITLE Direct Submission
JOURNAL Submitted (24-NOV-1996) Medical Genetics, University of British
Columbia, #416-2125 East Mall, NCE Building, Vancouver, BC V6T 1Z4,
Canada
FEATURES Location/Qualifiers
source 1..4714
/db_xref="H-InvDB:HIT000221551"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q11.2"
gene 1..4714
/gene="HIP1"
CDS 245..2989
/gene="HIP1"
/note="putative orf; similar to SLA2 Saccharomyces
cerevisiae, encoded by Genbank Accession Number Z22811,
and ZK370.3 protein in Caenorhabditis elegans, encoded by
Genbank Accession Number M98552"
/codon_start=1
/product="huntingtin interacting protein 1"
/protein_id="AAC51257.1"
/translation="MSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSD
RQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPL
IQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFK
RLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQN
LFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQ
RVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEI
ERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELED
SLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAEL
EKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAA
EQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLL
HSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLEN
ADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEML
SKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYA
KNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAAS
KVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQ
EMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE
"
BASE COUNT 1230 a 1258 c 1250 g 976 t
ORIGIN
1 cagcatcaat aaggccatta atacgcagga agtggctgta aaggaaaaac acgccagaac
61 gtgcatactg ggcacccacc atgagaaagg ggcacagacc ttctggtctg ttgtcaaccg
121 cctgcctctg tctagcaacg cagtgctctg ctggaagttc tgccatgtgt tccacaaact
181 cctccgagat ggacacccga acgtcctgaa ggactctctg agatacagaa atgaattgag
241 tgacatgagc aggatgtggg gccacctgag cgaggggtat ggccagctgt gcagcatcta
301 cctgaaactg ctaagaacca agatggagta ccacaccaaa aatcccaggt tcccaggcaa
361 cctgcagatg agtgaccgcc agctggacga ggctggagaa agtgacgtga acaacttttt
421 ccagttaaca gtggagatgt ttgactacct ggagtgtgaa ctcaacctct tccaaacagt
481 attcaactcc ctggacatgt cccgctctgt gtccgtgacg gcagcagggc agtgccgcct
541 cgccccgctg atccaggtca tcttggactg cagccacctt tatgactaca ctgtcaagct
601 tctcttcaaa ctccactcct gcctcccagc tgacaccctg caaggccacc gggaccgctt
661 catggagcag tttacaaagt tgaaagatct gttctaccgc tccagcaacc tgcagtactt
721 caagcggctc attcagatcc cccagctgcc tgagaaccca cccaacttcc tgcgagcctc
781 agccctgtca gaacatatca gccctgtggt ggtgatccct gcagaggcct catcccccga
841 cagcgagcca gtcctagaga aggatgacct catggacatg gatgcctctc agcagaattt
901 atttgacaac aagtttgatg acatctttgg cagttcattc agcagtgatc ccttcaattt
961 caacagtcaa aatggtgtga acaaggatga gaaggaccac ttaattgagc gactatacag
1021 agagatcagt ggattgaagg cacagctaga aaacatgaag actgagagcc agcgggttgt
1081 gctgcagctg aagggccacg tcagcgagct ggaagcagat ctggccgagc agcagcacct
1141 gcggcagcag gcggccgacg actgtgaatt cctgcgggca gaactggacg agctcaggag
1201 gcagcgggag gacaccgaga aggctcagcg gagcctgtct gagatagaaa ggaaagctca
1261 agccaatgaa cagcgatata gcaagctaaa ggagaagtac agcgagctgg ttcagaacca
1321 cgctgacctg ctgcggaaga atgcagaggt gaccaaacag gtgtccatgg ccagacaagc
1381 ccaggtagat ttggaacgag agaaaaaaga gctggaggat tcgttggagc gcatcagtga
1441 ccagggccag cggaagactc aagaacagct ggaagttcta gagagcttga agcaggaact
1501 tgccacaagc caacgggagc ttcaggttct gcaaggcagc ctggaaactt ctgcccagtc
1561 agaagcaaac tgggcagccg agttcgccga gctagagaag gagcgggaca gcctggtgag
1621 tggcgcagct catagggagg aggaattatc tgctcttcgg aaagaactgc aggacactca
1681 gctcaaactg gccagcacag aggaatctat gtgccagctt gccaaagacc aacgaaaaat
1741 gcttctggtg gggtccagga aggctgcgga gcaggtgata caagacgccc tgaaccagct
1801 tgaagaacct cctctcatca gctgcgctgg gtctgcagat cacctcctct ccacggtcac
1861 atccatttcc agctgcatcg agcaactgga gaaaagctgg agccagtatc tggcctgccc
1921 agaagacatc agtggacttc tccattccat aaccctgctg gcccacttga ccagcgacgc
1981 cattgctcat ggtgccacca cctgcctcag agccccacct gagcctgccg actcactgac
2041 cgaggcctgt aagcagtatg gcagggaaac cctcgcctac ctggcctccc tggaggaaga
2101 gggaagcctt gagaatgccg acagcacagc catgaggaac tgcctgagca agatcaaggc
2161 catcggcgag gagctcctgc ccaggggact ggacatcaag caggaggagc tgggggacct
2221 ggtggacaag gagatggcgg ccacttcagc tgctattgaa actgccacgg ccagaataga
2281 ggagatgctc agcaaatccc gagcaggaga cacaggagtc aaattggagg tgaatgaaag
2341 gatccttggt tgctgtacca gcctcatgca agctattcag gtgctcatcg tggcctctaa
2401 ggacctccag agagagattg tggagagcgg caggggtaca gcatccccta aagagtttta
2461 tgccaagaac tctcgatgga cagaaggact tatctcagcc tccaaggctg tgggctgggg
2521 agccactgtc atggtggatg cagctgatct ggtggtacaa ggcagaggga aatttgagga
2581 gctaatggtg tgttctcatg aaattgctgc tagcacagcc cagcttgtgg ctgcatccaa
2641 ggtgaaagct gataaggaca gccccaacct agcccagctg cagcaggcct ctcggggagt
2701 gaaccaggcc actgccggcg ttgtggcctc aaccatttcc ggcaaatcac agatcgaaga
2761 gacagacaac atggacttct caagcatgac gctgacacag atcaaacgcc aagagatgga
2821 ttctcaggtt agggtgctag agctagaaaa tgaattgcag aaggagcgtc aaaaactggg
2881 agagcttcgg aaaaagcact acgagcttgc tggtgttgct gagggctggg aagaaggaac
2941 agaggcatct ccacctacac tgcaagaagt ggtaaccgaa aaagaataga gccaaaccaa
3001 caccccatat gtcagtgtaa atccttgtta cctatctcgt gtgtgttatt tccccagcca
3061 caggccaaat ccttggagtc ccaggggcag ccacaccact gccattaccc agtgccgagg
3121 acatgcatga cacttcccaa agactccctc catagcgaca ccctttctgt ttggacccat
3181 ggtcatctct gttcttttcc cgcctcccta gttagcatcc aggctggcca gtgctgccca
3241 tgagcaagcc taggtacgaa gaggggtggt ggggggcagg gccactcaac agagaggacc
3301 aacatccagt cctgctgact atttgacccc cacaacaatg ggtatcctta atagaggagc
3361 tgcttgttgt ttgttgacag cttggaaagg gaagatctta tgccttttct tttctgtttt
3421 cttctcagtc ttttcagttt catcatttgc acaaacttgt gagcatcaga gggctgatgg
3481 attccaaacc aggacactac cctgagatct gcacagtcag aaggacggca ggagtgtcct
3541 ggctgtgaat gccaaagcca ttctccccct ctttgggcag tgccatggat ttccactgct
3601 tcttatggtg gttggttggg ttttttggtt ttgttttttt tttttaagtt tcactcacat
3661 agccaactct cccaaagggc acacccctgg ggctgagtct ccagggcccc ccaactgtgg
3721 tagctccagc gatggtgctg cccaggcctc tcggtgctcc atctccgcct ccacactgac
3781 caagtgctgg cccacccagt ccatgctcca gggtcaggcg gagctgctga gtgacagctt
3841 tcctcaaaaa gcagaaggag agtgagtgcc tttccctcct aaagctgaat cccggcggaa
3901 agcctctgtc cgcctttaca agggagaaga caacagaaag agggacaaga gggttcacac
3961 agcccagttc ccgtgacgag gctcaaaaac ttgatcacat gcttgaatgg agctggtgag
4021 atcaacaaca ctacttccct gccggaatga actgtccgtg aatggtctct gtcaagcggg
4081 ccgtctccct tggcccagag acggagtgtg ggagtgattc ccaactcctt tctgcagacg
4141 tctgccttgg catcctcttg aataggaaga tcgttccact ttctacgcaa ttgacaaacc
4201 cggaagatca gatgcaattg ctcccatcag ggaagaaccc tatacttggt ttgctaccct
4261 tagtatttat tactaacctc ccttaagcag caacagccta caaagagatg cttggagcaa
4321 tcagaacttc aggtgtgact ctagcaaagc tcatctttct gcccggctac atcagccttc
4381 aagaatcaga agaaagccaa ggtgctggac tgttactgac ttggatccca aagcaaggag
4441 atcatttgga gctcttgggt cagagaaaat gagaaaggac agagccagcg gctccaactc
4501 ctttcagcca catgccccag gctctcgctg ccctgtggac aggatgagga cagagggcac
4561 atgaacagct tgccagggat gggcagccca acagcacttt tcctcttcta gatggacccc
4621 agcatttaag tgaccttctg atcttgggaa aacagcgtct tccttcttta tctatagcaa
4681 ctcattggtg gtagccatca agcacttcgg aatt
//