LOCUS HSU79725 2793 bp mRNA linear HUM 04-FEB-1997
DEFINITION Human A33 antigen precursor mRNA, complete cds.
ACCESSION U79725
VERSION U79725.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2793)
AUTHORS Heath,J.K., White,S.J., Johnstone,C.N., Catimel,B., Simpson,R.J.,
Moritz,R.L., Tu,G.-F., Ji,H., Whitehead,R.H., Groenen,L.C.,
Scott,A.M., Ritter,G., Cohen,L., Welt,S., Old,L.J., Nice,E.C. and
Burgess,A.W.
TITLE The human A33 antigen is a transmembrane glycoprotein and a novel
member of the immunoglobulin superfamily
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (2), 469-474 (1997)
PUBMED 9012807
REFERENCE 2 (bases 1 to 2793)
AUTHORS Heath,J.K. and White,S.J.
TITLE Direct Submission
JOURNAL Submitted (26-NOV-1996) Melbourne Branch, Ludwig Institute for
Cancer Research, Post Office Royal Melbourne Hospital, Parkville,
Victoria 3050, Australia
FEATURES Location/Qualifiers
source 1..2793
/db_xref="H-InvDB:HIT000221550"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="LIM1215"
/tissue_type="colon carcinoma"
5'UTR 1..344
CDS 345..1304
/note="intestine-specific antigen; novel member of the
immunoglobulin superfamily; transmembrane protein;
contains an extracellular domain, a transmembrane domain,
and an intracellular domain"
/codon_start=1
/product="A33 antigen precursor"
/protein_id="AAC50957.1"
/translation="MVGKMWPVLWTLCAVRVTVDAISVETPQDVLRASQGKSVTLPCT
YHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASI
TIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQL
TCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEG
TQFCNITVAVRSPSMNVALYVGIAVGVVAALIIIGIIIYCCCCRGKDDNTEDKEDARP
NREAYEEPPEQLRELSREREEEDDYRQEEQRSTGRESPDHLDQ"
sig_peptide 345..407
mat_peptide 408..1301
/product="A33 antigen"
3'UTR 1305..2793
regulatory 2777..2782
/regulatory_class="polyA_signal_sequence"
BASE COUNT 620 a 781 c 730 g 662 t
ORIGIN
1 ctaccccttt gtgagcagtc taggactttg tacacctgtt aagtagggag aaggcagggg
61 aggtggctgg tttaagggga acttgaggga agtagggaag actcctcttg ggacctttgg
121 agtaggtgac acatgagccc agccccagct cacctgccaa tccagctgag gagctcacct
181 gccaatccag ctgaggctgg gcagaggtgg gtgagaagag ggaaaattgc agggacctcc
241 agttgggcca ggccagaagc tgctgtagct ttaaccagac agctcagacc tgtctggagg
301 ctgccagtga caggttaggt ttagggcaga gaagaagcaa gaccatggtg gggaagatgt
361 ggcctgtgtt gtggacactc tgtgcagtca gggtgaccgt cgatgccatc tctgtggaaa
421 ctccgcagga cgttcttcgg gcttcgcagg gaaagagtgt caccctgccc tgcacctacc
481 acacttccac ctccagtcga gagggactta ttcaatggga taagctcctc ctcactcata
541 cggaaagggt ggtcatctgg ccgttttcaa acaaaaacta catccatggt gagctttata
601 agaatcgcgt cagcatatcc aacaatgctg agcagtccga tgcctccatc accattgatc
661 agctgaccat ggctgacaac ggcacctacg agtgttctgt ctcgctgatg tcagacctgg
721 agggcaacac caagtcacgt gtccgcctgt tggtcctcgt gccaccctcc aaaccagaat
781 gcggcatcga gggagagacc ataattggga acaacatcca gctgacctgc caatcaaagg
841 agggctcacc aacccctcag tacagctgga agaggtacaa catcctgaat caggagcagc
901 ccctggccca gccagcctca ggtcagcctg tctccctgaa gaatatctcc acagacacat
961 cgggttacta catctgtacc tccagcaatg aggaggggac gcagttctgc aacatcacgg
1021 tggccgtcag atctccctcc atgaacgtgg ccctgtatgt gggcatcgcg gtgggcgtgg
1081 ttgcagccct cattatcatt ggcatcatca tctactgctg ctgctgccga gggaaggacg
1141 acaacactga agacaaggag gatgcaaggc cgaaccggga agcctatgag gagccaccag
1201 agcagctaag agaactttcc agagagaggg aggaggagga tgactacagg caagaagagc
1261 agaggagcac tgggcgtgaa tccccggacc acctcgacca gtgacaggcc agcagcagag
1321 ggcggcggag gaagggttag gggttcattc tcccgcttcc tggcctccct tctcctttct
1381 aagccctgtt ctcctgtccc tccatcccag acattgatgg ggacatttct tccccagtgt
1441 cagctgtggg gaacatggct ggcctggtaa gggggtccct gtgctgatcc tgctgacctc
1501 actgtcctgt gaagtaaccc ctcctggctg tgacacctgg tgcgggcctg gccctcactc
1561 aagaccaggc tgcagcctcc acttccctcg tagttggcag gagctcctgg aagcacagcg
1621 ctgagcatgg ggcgctccca ctcagaactc tccagggagg cgatgccagc cttggggggt
1681 gggggctgtc ctgctcacct gtgtgcccag cacctggagg ggcaccaggt ggagggtttg
1741 cactccacac atctttcttg aatgaatgaa agaataagtg agtatgcttg ggccctgcat
1801 tggcctggcc tccagctccc actccctttc caacctcact tcccgtagct gccagtatgt
1861 tccaaaccct cctgggaagg ccacctccca ctcctgctgc acaggccctg gggagctttt
1921 gcccacacac tttccatctc tgcctgtcaa tatcgtacct gtccctccag gcccatctca
1981 aatcacaagg atttctctaa ccctatccta attgtccaca tacgtggaaa caatcctgtt
2041 actctgtccc acgtccaatc atgggccaca aggcacagtc ttctgagcga gtgctctcac
2101 tgtattagag cgccagctcc ttggggcagg gcctgggcct catggctttt gctttccctg
2161 aagccctagt agctggcgcc catcctagtg ggcacttaag cttaattggg gaaactgctt
2221 tgattggttg tgccttccct tctctggtct ccttgagatg atcgtagaca cagggatgat
2281 tcccacccaa acccacgtat tcattcagtg agttaaacac gaattgattt aaagtgaaca
2341 cacacaaggg agcttgcttg cagatggtct gagttcttgt gtcctggtaa ttcctctcca
2401 ggccagaata attggcatgt ctcctcaacc cacatggggt tcctggttgt tcctgcatcc
2461 cgatacctca gccctggccc tgcccagccc atttgggctc tggttttctg gtggggctgt
2521 cctgctgccc tcccacagcc tccttctgtt tgtcgagcat ttcttctact cttgagagct
2581 caggcagcgt tagggctgct taggtctcat ggaccagtgg ctggtctcac ccaactgcag
2641 tttactattg ctatcttttc tggatgatca gaaaaataat tccataaatc tattgtctac
2701 ttgcgatttt ttaaaaaatg tatattttta tatatattgt taaatccttt gcttcattcc
2761 aaatgctttc agtaataata aaattgtggg tgg
//