LOCUS HSU78575 3713 bp mRNA linear HUM 20-DEC-1996
DEFINITION Human 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
mRNA, clone PIP5KIa1, complete cds.
ACCESSION U78575
VERSION U78575.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3713)
AUTHORS Loijens,J.C. and Anderson,R.A.
TITLE Type I phosphatidylinositol-4-phosphate 5-kinases are distinct
members of this novel lipid kinase family
JOURNAL J. Biol. Chem. 271 (51), 32937-32943 (1996)
PUBMED 8955136
REFERENCE 2 (bases 1 to 3713)
AUTHORS Loijens,J.C. and Anderson,R.A.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-1996) Pharmacology, University of Wisconsin -
Madison, 1300 University Ave., Madison, WI 53706, USA
FEATURES Location/Qualifiers
source 1..3713
/db_xref="H-InvDB:HIT000221434"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="PIP5KIa1"
/clone_lib="human fetal brain 5'-stretch cDNA library
(Clontech # HL1149x)"
CDS 401..2050
/EC_number="2.7.1.68"
/note="isoforms, possibly alternatively spliced, encoded
by GenBank Accession Numbers U78576 and U78577"
/codon_start=1
/product="68 kDa type I phosphatidylinositol-4-phosphate
5-kinase alpha"
/protein_id="AAC50910.1"
/translation="MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYAS
GMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYV
VESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIEL
CSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYC
VQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQD
IPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYS
VDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDI
LQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKF
RSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEE
ISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH"
regulatory 3691..3696
/regulatory_class="polyA_signal_sequence"
polyA_site 3713
BASE COUNT 919 a 865 c 882 g 1047 t
ORIGIN
1 attaacaggc cgtggttagg aaggacggag aaggggcgtt cgctcctttg ggacttttca
61 tgcctcgttt ttttttcaga tgtggcttgg tctgggcgca aggtcccagc agccagctta
121 agcttactct tctgtgaaag gggaaagtat cccctgtgga aagcggttaa acttgtggag
181 ggggtgcggg acgtgagttc ttccccatgc caggcgaatg gtgtggcctt gagctggtcc
241 aggagccggc tcgacgtgtc tgagggaggc ccggaggggg cggggaggtg gcccacagaa
301 cgcgggttct gtaaagagac gttgggaaga ttcgattccg agaagaggaa gaaccggatt
361 gaaagagagc caggccgctg agggggaggg ggctgctaag atggcgtcgg cctcctccgg
421 gccgtcgtct tcggtcggtt tttcatcctt tgatcccgcg gtcccttcct gtaccttgtc
481 ctcagcatct ggaatcaaga gacccatggc atctgaggtg ccttatgcct ctggcatgcc
541 catcaagaaa ataggccata gaagtgttga ttcctcagga gagacaacat ataaaaagac
601 aacctcatca gccttgaaag gtgccatcca gttaggcatt acccacactg tggggagcct
661 gagtaccaaa ccagagcgtg atgtcctcat gcaagatttc tacgtggttg agagtatctt
721 ctttcccagt gaagggagca acctgacccc tgctcatcac tacaatgact ttcgtttcaa
781 gacctatgca cctgttgcct tccgctactt ccgggagcta tttggtatcc ggcccgatga
841 ttacttgtat tccctctgca gtgagccgct gattgaactc tgtagctctg gagctagtgg
901 ttccctattc tatgtgtcca gcgacgatga gttcattatt aagacagtcc aacataaaga
961 ggcggaattt ctgcagaagc tgcttccagg atactacatg aacctcaacc agaaccctcg
1021 gactttgctg cctaaattct atggactgta ctgtgtgcag gcaggtggca agaacattcg
1081 gattgtggtg atgaacaatc ttttaccaag atcggtaaaa atgcatatca aatatgacct
1141 caaaggctca acctacaaac ggcgggcttc ccagaaagag cgagagaagc ctcttcccac
1201 atttaaagac ctagacttct tacaagacat ccctgatggt ctttttttgg atgctgacat
1261 gtacaacgct ctctgtaaga ccctgcagcg tgactgtttg gtgctgcaga gcttcaagat
1321 aatggattac agcctcttga tgtcaatcca taatatagat catgcacaac gagagccctt
1381 aagcagtgaa acacagtact cagttgatac tcgaagaccg gccccccaaa aggctctgta
1441 ttccacagcc atggaatcca tccagggaga ggctcgacgg ggtggtacca tggagactga
1501 tgaccatatg ggtggcatcc ctgcccggaa tagtaaaggg gaaaggcttc tgctttatat
1561 tggcatcatt gacattctac agtcttacag gtttgttaag aagttggagc actcttggaa
1621 agccctggta catgacggag acactgtctc agtgcatcgc ccaggcttct acgctgaacg
1681 gttccagcgc ttcatgtgca acacagtatt taagaagatt cccttgaagc cttctccttc
1741 caaaaagttt cggtctggct catctttctc tcggcgagca ggctccagtg gcaactcctg
1801 cattacttac cagccatcgg tctctgggga acacaaggca caagtgacaa caaaggcaga
1861 agtggagcca ggcgttcacc ttggtcgtcc tgatgtttta cctcagactc cacctttgga
1921 ggaaatcagt gagggctcgc ctattcctga ccccagtttc tcacctctag ttggagagac
1981 tttgcaaatg ctaactacaa gtacaacctt ggaaaagctt gaagttgcag agtcagagtt
2041 cacccattaa gcgcaaagcc tcagaagacc tggaacaaga ttctgccatc tctgtgatcc
2101 caagatgtca gcccttgccc cagcaatgct gaattttctt ctacttggtc atcaaaaaag
2161 gagtgtaata gaagtgaggg gagctgctcc tccatcttct tcctgaagaa gaaccttctc
2221 tccttcctct tcctcatgaa tgggccttag tgcctcagag agttgaggac cgcagcatcc
2281 cctccactcc agagttgggt ggtacggatt ttcaactggc caaccctttg cctccactat
2341 tgaatttttt tcagaccccc attcttcatg ctggaaatgg gattgctgga cttggcagct
2401 ttctttcccc tcgtctttga ctaggaaccg gactcttaat ttcctcagga cagactagct
2461 ggcacattat ccctacctta gttctttctc tctgactcct ggaagaatac tcctgtaatc
2521 tctgtaaagg tttttggggg ataagggtgt ttaaccacct cccagctttc ttcttctttt
2581 ttttttctga aaaaaggaaa aagcacacag cacacaattt caagccattt tcagatcaga
2641 actccagaag tgttgacaag atgcctattc gtagagttcc ctcagaagag ccatggtgtt
2701 tatgaagaga agagtagtga ttgctctgcc agaagcagct cctctttaaa ctcctcctct
2761 cttgatgaat ttcttaaggc tgaaggaatg aagagagtgg gacatggggt aatctttatc
2821 ccttttgtta aaacaggagg cagccatggg ctgggagatc atagcccttc ctaggcagaa
2881 tcctgttcac tgccaggcta tagtaattat tactattttg caatttgaaa tatattctgg
2941 ttgtttttct aaatgtgaag acttaccaaa tgaattttag atcattctcc agaggagatt
3001 ttttttgctc ttctcatctt ttccaacagt gttctcctgt ttgtggagct aaggtaaaga
3061 ggggacactt ctgtctgttt aacagacagt ccatatctgt gaggccagca aatattttct
3121 taaactcatg gggagacagc agattcttgc cttggtgagg tcattgctgt gccatatgtc
3181 ctacccccct gtcttcatgc agggaagttg gaaatggggg ctacatatgc cctctcctcc
3241 ccgtctacaa gagttgtggt tttccatctg atccttccac tcttgtcagg ggaagaaggg
3301 ggcctggtat ctcaggcaga ttgttgaatt cctgttctat cccttctcta tcccaccctg
3361 ccttgataat atgttagccc ataccccaaa taactgtcta tattagacac ccccagccag
3421 tttctggctg cctgtctttg ctgccatgtt ttttacaaga aggaaagaat tcttgctatt
3481 tttttttcat aatttactat ttatgatgta tttaagtgtt ttattaagga cagagttctg
3541 ttaggggtgg gagggaatat ttgagggagg gctgggtctt agggaaagga atggggaagc
3601 aacattttta ttaagtgtta ctatttgcct ctactttgta ttgttcagaa atggcaaata
3661 caatataaaa gtgatatatg gttttaatgt aataaacttt aatgagttat tta
//