LOCUS HSU78516 4278 bp mRNA linear HUM 08-JAN-1999
DEFINITION Homo sapiens cAMP-regulated guanine nucleotide exchange factor II
(cAMP-GEFII) mRNA, complete cds.
ACCESSION U78516
VERSION U78516.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4278)
AUTHORS Kawasaki,H., Springett,G.M., Mochizuki,N., Toki,S., Nakaya,M.,
Matsuda,M., Housman,D.E. and Graybiel,A.M.
TITLE A family of cAMP-binding proteins that directly activate Rap1
JOURNAL Science 282 (5397), 2275-2279 (1998)
PUBMED 9856955
REFERENCE 2 (bases 1 to 4278)
AUTHORS Springett,G.M., Kawasaki,H., Graybiel,A.M. and Housman,D.E.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-1996) Center for Cancer Research, Massachusetts
Institute of Technology, 77 Massachusetts Avenue, E17-540,
Cambridge, MA 02135, USA
COMMENT On Jan 8, 1999 this sequence version replaced gi:4106959.
FEATURES Location/Qualifiers
source 1..4278
/db_xref="H-InvDB:HIT000221424"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31-q32"
gene 1..4278
/gene="cAMP-GEFII"
CDS 109..3144
/gene="cAMP-GEFII"
/codon_start=1
/product="cAMP-regulated guanine nucleotide exchange
factor II"
/protein_id="AAD03422.1"
/translation="MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAF
EKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV
TICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAP
PYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRA
PHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQ
EHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRK
PPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGT
SWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDK
EDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKI
LEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEK
MDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLP
ELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYT
TIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRL
FACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIY
HTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKE
YKNLNSFFAIVMGLSNIAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVA
KLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPD
AAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP"
BASE COUNT 1273 a 903 c 963 g 1139 t
ORIGIN
1 cgggaggagc ggggtccgcg cggcggacga ggcgggggca ggaggcgcag gcagagcgag
61 cgcgggaggt cgccgcagca cagaggacac cgcgcgccgc cgctcaacat ggtcgctgcg
121 cacgctgccc attcttcctc ctctgccgag tggatcgcct gcctggataa aagaccactg
181 gagcgatcca gcgaagatgt ggatataatc ttcactcgac tgaaagaagt taaagctttt
241 gagaaatttc acccaaatct ccttcatcag atttgcttat gtggttatta tgagaatctg
301 gaaaagggaa taacattatt tcgccagggt gatattggaa caaactggta tgctgtcctg
361 gcagggtctt tggatgttaa agtatctgag accagcagtc accaggatgc tgtgaccatc
421 tgtaccctgg gaattgggac ggcctttgga gagtccattc tggacaacac accccgccat
481 gcaaccatcg ttaccaggga gagcagtgaa ctgctccgca tcgagcagaa ggacttcaag
541 gcactatggg agaaatatcg acagtatatg gcaggacttc tggctcctcc ttatggtgtt
601 atggaaacgg gctctaacaa tgacaggatt cctgacaagg agaacacacc tctcattgaa
661 cctcacgttc ctcttcgtcc tgctaacacc attaccaagg tcccttcaga gaagatcctc
721 agagctggaa aaattttacg aaatgccatt ctctctcgag cacctcacat gataagagat
781 agaaaatacc acctaaagac atacagacaa tgctgtgtgg gaactgaact ggtggactgg
841 atgatgcagc agacaccatg tgttcactcc cggactcaag ctgttggcat gtggcaagtc
901 ctgttagaag atggtgttct caaccacgtg gaccaggagc accatttcca agacaaatat
961 ttattctatc gatttctgga tgatgagcac gaggatgccc ctttgcctac tgaggaggag
1021 aagaaggagt gtgatgagga gctccaggac accatgctgc tgctgtcaca gatgggcccc
1081 gacgcccaca tgaggatgat ccttcgcaaa ccacctggcc agaggactgt ggatgaccta
1141 gagattatct atgaggagct tcttcatatt aaagccttat cccatctttc taccacagtg
1201 aaacgagagt tagcaggtgt tctcattttt gagtctcacg ccaaaggagg gactgtgttg
1261 tttaaccagg gggaagaagg tacctcctgg tacattattc taaaaggatc agtgaatgta
1321 gtcatttacg gcaagggtgt ggtctgcacc ctgcatgaag gagatgactt cggcaagtta
1381 gcactagtga atgatgcccc acgagctgcc tctatcgtct tacgagaaga taactgccat
1441 ttcttaagag tagacaagga ggatttcaac cggatcctaa gggacgtgga ggcgaataca
1501 gtcagactta aagaacatga ccaagatgtc ttggtgctgg agaaggtccc agcagggaac
1561 agagcttcta atcaaggaaa ctcacagcct cagcaaaagt atactgtgat gtcaggaaca
1621 cctgaaaaaa ttttagagca ttttctagaa acaatacgcc ttgaggcaac tttaaatgaa
1681 gcaacagatt ctgttttaaa tgactttatt atgatgcact gtgtttttat gccaaatacc
1741 cagctttgcc cggcactggt ggcccactac cacgcacagc cttcacaagg tacagaacag
1801 gagaaaatgg attatgccct caacaataag aggcgagtca tccgcctggt tctacagtgg
1861 gctgccatgt atggagacct cctgcaagag gatgacgtat ctatggcctt cctggaggag
1921 ttttatgtat ctgtatcaga tgatgcccgg atgattgctg ccctcaagga gcaactgcca
1981 gagttggaga agattgtcaa gcaaatctca gaagatgcaa aggcaccaca aaagaagcac
2041 aaggttcttt tgcaacagtt caatacgggc gatgagagag cccagaagcg ccagcctatc
2101 cgcggctctg atgaagttct gtttaaggtc tattgcatgg accacaccta cacaaccatt
2161 cgggtgccag tggccacttc ggtgaaggaa gtcatcagtg cagttgccga caagctgggc
2221 tccggggagg gcctgatcat agtcaagatg agttccggag gagaaaaggt ggtgctcaaa
2281 cctaatgatg tttcagtatt tacgacgctc accattaatg gacgcctgtt tgcttgcccg
2341 cgagagcaat tcgattcact gactccctta ccagaacagg aaggcccaac tgttggaaca
2401 gtgggaactt ttgaactgat gagctccaaa gatttagcat accagatgac aatttatgat
2461 tgggaactct tcaactgcgt gcatgagctg gagctaatct atcacacatt tggaaggcat
2521 aattttaaaa agaccacagc aaacttggat ttgttcctga ggagatttaa tgaaattcag
2581 ttttgggtcg tcactgagat ctgcctttgt tctcagctca gcaagcgtgt tcagctatta
2641 aaaaaattta ttaagatagc agcccactgt aaggagtata aaaatctgaa ttcctttttt
2701 gccatcgtca tgggactaag taacattgct gtgagccgct tggcactaac gtgggagaaa
2761 ctgccaagca agttcaagaa gttctatgcg gagtttgaaa gtttaatgga cccttcaagg
2821 aaccacaggg cctacaggct gacagtagct aagctggaac ctcctctcat ccccttcatg
2881 cctttgctca ttaaagatat gacatttact catgagggga acaagacgtt cattgacaat
2941 ctagtaaact ttgaaaaaat gcgcatgatt gcaaatacgg ccagaacagt gagatactac
3001 aggagccaac ccttcaatcc tgatgcagct caagctaata agaaccatca ggatgtccgg
3061 agttatgtac ggcaattaaa tgtgattgac aaccagagaa ctttatcaca gatgtcacac
3121 agattagagc ctcgtcgacc atagacattt caaatgccca aagcaacagt ttgtctccag
3181 tccacaatct ttcaaaaatg ccatttatgc tactactgac tgtattgcca ctagagaatt
3241 ctacaaaaca agcaaaaaca catcctgaga cacctcaggg ctgcattcag cttaccagct
3301 acctagcaag agaaggaatt atttgacatg cctaaagctt acacactcta gcttaggaat
3361 ccccagtttg tggctaccct gtttcatttc cacttgtgcc atcttctttg ctgaagtgtt
3421 gaataaggcc cacgtgaaga gtttggtaga aatagccttg tcaagagaac tagcaagccc
3481 ctgacatttt tttctaagag tgtttatggg atgagatgtg ctacaaatgg gatagatttg
3541 gataaaattt taactcaaca tcttgatttg gagcctgggg tttcgggaag gtgttgagga
3601 atctatagaa gtccaaatta taggttgtat tcttccatct tcattgtctt acctctgaag
3661 gaatagaacc tgaccacatt attatgaaac attatggctg tttatgtaat ttagggagga
3721 ctggtctgta atttctgaat gtatatagaa taatatttat gtttacaatg taacttttca
3781 aaatttacaa atcaggatta tatacataag aattccacta agaaatgcca agattcttaa
3841 atttgccagc gttaaagtag aaaataacat ttcagaagag cacaatatgc ataaaacatt
3901 tttcaaaatt gaaatatttt cctgggcatt aaaaaccttt actattggct acaaatttat
3961 tgtacctgat gaaaacatat tttctggact taaatgttat tacaaatatc ttaattttca
4021 gtaattgttt tgcactttca aagattgtaa atagttcatt caatcaatgg tatagagtta
4081 tttatttgct acataataga tactgtgcca aataattact ttttatttat tttatttagt
4141 acgtaatttt gaagtacatt ttttcctgtt ttcacaatta gactacattt aatgtgtagg
4201 aattgtatgt atgtatatct tctgtaaata acatctagta tcttcactaa atataattgt
4261 cgaccgggaa aaaaaaaa
//