LOCUS HSU78181 3785 bp mRNA linear HUM 08-MAR-1997
DEFINITION Human sodium channel 2 (hBNaC2) mRNA, complete cds.
ACCESSION U78181
VERSION U78181.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3785)
AUTHORS Corey,D.P. and Garcia-Anoveros,J.
TITLE Mechanosensation and the DEG/ENaC ion channels
JOURNAL Science 273 (5273), 323-324 (1996)
PUBMED 8685718
REFERENCE 2 (bases 1 to 3785)
AUTHORS Garcia-Anoveros,J., Derfler,B., Neville-Golden,J., Hyman,B.T. and
Corey,D.P.
TITLE BNaC1 and BNaC2 constitute a new family of human neuronal sodium
channels related to degenerins and epithelial sodium channels
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (4), 1459-1464 (1997)
PUBMED 9037075
REFERENCE 3 (bases 1 to 3785)
AUTHORS Garcia-Anoveros,J., Neville-Golden,J. and Corey,D.P.
TITLE Direct Submission
JOURNAL Submitted (11-NOV-1996) Neurobiology, Massachusetts General
Hospital and Harvard Medical School, 50 Blossom St., Boston, MA
02114, USA
FEATURES Location/Qualifiers
source 1..3785
/db_xref="H-InvDB:HIT000221415"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q12"
/tissue_type="brain"
gene 1..3785
/gene="hBNaC2"
CDS 230..1816
/gene="hBNaC2"
/note="expressed in most or all neurons; alternatively
spliced mRNA deposited under GenBank Accession Number
U78180; sodium channel homolog; member of the DEG/ENaC
superfamily"
/codon_start=1
/product="sodium channel 2"
/protein_id="AAB48981.1"
/translation="MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRA
LWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQ
VSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR
AGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKDGTGNGL
EIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDA
PYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAK
KFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTV
LELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT
YAANILPHHPARGTFEDFTC"
BASE COUNT 816 a 1154 c 1017 g 793 t
ORIGIN
1 gagccagcga gccagcgcgc gcgggcgggc ggacagatcg gagccgagcg gggccgggcg
61 gggcgctccc tgcagggctc tgcgcggcgt gccgcggcgg ccgcgggctc cggccccggg
121 ccatgagccc ctccgcgact cggcgctgag cccgccaccg gtccagcgcc ccaggacccg
181 ccgccggctg ccggcttgcc gaagccccct caggatcccc tcaacaagga tggaactgaa
241 ggccgaggag gaggaggtgg gtggcgtcca gccggtgagc atccaggcct tcgccagcag
301 ctccacactg cacggcctgg cccacatctt ctcctacgag cggctgtctc tgaagcgggc
361 actgtgggcc ctgtgcttcc tgggctcgct ggctgtgctg ctgtgtgtgt gcacggagcg
421 tgtgcagtac tacttccact accaccatgt caccaagctc gacgaggtgg ctgcctctca
481 gcttaccttc cctgctgtca cgctgtgcaa cctcaacgag ttccgcttta gccaagtctc
541 caagaatgac ctgtatcatg ctggggagct gctggccctg ctcaacaaca ggtatgagat
601 accagacaca cagatggcag atgaaaagca gctggagata ctgcaggaca aagccaactt
661 ccgcagcttc aaacccaaac ccttcaacat gcgtgagttc tacgaccgag ctgggcacga
721 cattcgagac atgctgctct cctgccactt ccggggggag gtctgcagcg ctgaagactt
781 caaggtggtc ttcacacgct atggaaagtg ctacacgttc aactcgggcc gagatgggcg
841 gccgcggctg aagaccatga aggatgggac gggcaatggg ctggaaatca tgctggacat
901 ccagcaggac gagtacctgc ctgtgtgggg ggagactgac gagacgtcct tcgaagcagg
961 catcaaagtg cagatccata gtcaggatga acctcctttc atcgaccagc tgggctttgg
1021 cgtggcccca ggcttccaga cctttgtggc ctgccaggag cagcggctca tctacctgcc
1081 cccaccctgg ggcacctgca aagctgttac catggactcg gatttggatt tcttcgactc
1141 ctacagcatc actgcctgcc gcatcgactg tgagacgcgc tacctggtgg agaactgcaa
1201 ctgccgcatg gtgcacatgc caggggatgc cccatactgt actccagagc agtacaagga
1261 gtgtgcagat cctgctctgg acttcctggt ggagaaggac caggagtact gcgtgtgtga
1321 aatgccttgc aacctgaccc gctatggcaa agagctgtcc atggtcaaga tccccagcaa
1381 agcctcagcc aagtacctgg ccaagaagtt caacaaatct gagcaataca taggggagaa
1441 catcctggtg ctggacattt tctttgaagt cctcaactat gagaccattg aacagaagaa
1501 ggcctatgag attgcagggc tcctgggtga catcgggggc cagatggggc tgttcatcgg
1561 ggccagcatc ctcacggtgc tggagctctt tgactacgcc tacgaggtca ttaagcacaa
1621 gctgtgccga cgaggaaaat gccagaagga ggccaaaagg agcagtgcgg acaagggcgt
1681 ggccctcagc ctggacgacg tcaaaagaca caacccgtgc gagagccttc ggggccaccc
1741 tgccgggatg acatacgctg ccaacatcct acctcaccat ccggcccgag gcacgttcga
1801 ggactttacc tgctgagccc cgcaggccgc tgaaccaaag gcctagatgg ggaggactag
1861 gagagcgrgg gggcccccag ctgcctcctc acatctgccc tgggractcc ccacactccg
1921 gggcagatct ttcctcttgt ctgtggtaag gaaggagtct tgaccataga gtcctctctc
1981 tgcctctatc ccattcyttt tacatttaac aaaactaatc taaaaaagaa ctaaaaaggg
2041 agaacggggc aagggacctc aggctgcccc tctctcctcc atgctgcctc ccctagctcc
2101 cagcctgaat tctgtctatc tagctgtctg ccatctgagt gtccatctac attctgctgc
2161 caccagtcac caaaggccct tcccagtgag gggtggaagg gatctctggg gtctggaatt
2221 tggccccaaa ccagagaatg taccttaagg gggagggcta gtgtggggga gggaggcttc
2281 cccagcctta agagaccctc tcagcccagt gactgtcccc aaacccaagt ctcctggcag
2341 gaactaaaac ctcagcccca ctctctcaca ccatgtggaa tctcgtgggg gtcggggatc
2401 cccttaagaa gtggtaatgg ggacaagatg cggccctggt gctgtaggct acatcctgat
2461 acctataagt tcacccccac cccacagctg ctggagagaa atcccaagag gcagcccttc
2521 ctcaccatcc cattaaagac ckggctggtt agcgtccagc tcagggagaa gggcgctagt
2581 gcctaacctc actggtccct ctcccggagg cccttgtaga gggccacgtc cataaatttt
2641 cttatggaac tctcccacat cctcttcccc aacttcattt gcttctctca acaacctcat
2701 ctgcattttc tatttctata tgatacagac tctatattgc tatatctctg tatatacttt
2761 cccagccctg tctgtctcca ccccatcccc tcttgtctct gagaaccatt ctcccacccc
2821 aagttccacc ttctatgttt ctactccctc cctggtctct gaatgcctty gcctgtataa
2881 agagttggac tctctcccct ggtgtctgta ctgtgtacac acatccctct gagaagcaca
2941 aggagacgac acgcgcattg taacctttgc actgtctcag tggcgacaaa ggaagctgtg
3001 aatcacaagc tctgcctctt tctggcctca ccctctcccc caacccgggc accctcggcc
3061 ctccctgcag ccttaacatt ctcttcccct gctcctccta tcccattgcc ctctgcccag
3121 ctgacagtgg catccccagg gaaggggttg ctgtagagat agcccccacc caggggatgg
3181 aggtctaccc tggacactaa gccaagtgtg tcagagacag aagggagctg gggattggcg
3241 actcctgaag ttggggcagt gggatgctga caggcagaag ctgaggtcct cagtcagtgg
3301 cctttcctcc ttctgggtgc ccagccccct ttcctcacct gatacccaag cccaccactt
3361 ttattttctg gtgaggtggg tttgggagga aagagaggcc tagaggagga gttgaaagct
3421 ctgctgttgt ctcaccctat cttaatgaga gacaagtgag gtggagggcc tgccccccct
3481 ccctccacca gacactcctt ccaggcctga gccccaaccc ctcttcaggc cttccttccc
3541 tagctgtgtc ttggtcttca atcccagaac aggacctgtg agcagctgca ttggcctgga
3601 gctggagagt aaggctgtag gatctttgga atctcttggt tcctaagagt ttcctcagag
3661 atcatacctc cccagaggga agcaggaatg aggccaaaaa gtgtgcattg gataggggaa
3721 cagcaggcag ggctctgggt gacgcatgcc tctggtctaa taaactgggt ttcaaccaaa
3781 aaaaa
//