LOCUS HSU76833 2366 bp mRNA linear HUM 14-AUG-1997 DEFINITION Human integral membrane serine protease Seprase mRNA, complete cds. ACCESSION U76833 VERSION U76833.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2366) AUTHORS Goldstein,L.A., Ghersi,G., Pineiro-Sanchez,M.L., Salamone,M., Yeh,Y., Flessate,D. and Chen,W.T. TITLE Molecular cloning of seprase: a serine integral membrane protease from human melanoma JOURNAL Biochim. Biophys. Acta 1361 (1), 11-19 (1997) PUBMED 9247085 REFERENCE 2 (bases 1 to 2366) AUTHORS Goldstein,L.A., Ghersi,G., Pineiro-Sanchez,M.L., Salamone,M., Yeh,Y., Flessate,D. and Chen,W.-T. TITLE Direct Submission JOURNAL Submitted (31-OCT-1996) Cell Biology, Georgetown University Medical School, 3970 Reservoir Road N.W., Washington, DC 20007, USA FEATURES Location/Qualifiers source 1..2366 /db_xref="H-InvDB:HIT000221322" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="amelanotic melanoma; LOX" CDS 49..2331 /note="170 kDa homodimeric gelatinase; member of the nonclassical serine hydrolase family; synthesized by RT-PCR using Fibroblast Activation Protein alpha (FAP alpha) primers" /codon_start=1 /product="integral membrane serine protease Seprase" /protein_id="AAC51668.1" /translation="MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTL KDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASN YGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGS KLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNG KFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVG PQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPK TQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITS GKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQY YTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEI KKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEG MVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWS YGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTV MARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLS TNHLYTHMTHFLKQCFSLSD" BASE COUNT 761 a 448 c 489 g 668 t ORIGIN 1 ccacgctctg aagacagaat tagctaactt tcaaaaacat ctggaaaaat gaagacttgg 61 gtaaaaatcg tatttggagt tgccacctct gctgtgcttg ccttattggt gatgtgcatt 121 gtcttacgcc cttcaagagt tcataactct gaagaaaata caatgagagc actcacactg 181 aaggatattt taaatggaac attttcttat aaaacatttt ttccaaactg gatttcagga 241 caagaatatc ttcatcaatc tgcagataac aatatagtac tttataatat tgaaacaggg 301 caatcatata ccattttgag taatagaacc atgaaaagtg tgaatgcttc aaattacggc 361 ttatcacctg atcggcaatt tgtatatcta gaaagtgatt attcaaagct ttggagatac 421 tcttacacag caacatatta catctatgac cttagcaatg gagaatttgt aagaggaaat 481 gagcttcctc gtccaattca gtatttatgc tggtcgcctg ttgggagtaa attagcatat 541 gtctatcaaa acaatatcta tttgaaacaa agaccaggag atccaccttt tcaaataaca 601 tttaatggaa gagaaaataa aatatttaat ggaatcccag actgggttta tgaagaggaa 661 atgcttgcta caaaatatgc tctctggtgg tctcctaatg gaaaattttt ggcatatgcg 721 gaatttaatg atacggatat accagttatt gcctattcct attatggcga tgaacaatat 781 cctagaacaa taaatattcc atacccaaag gctggagcta agaatcccgt tgttcggata 841 tttattatcg ataccactta ccctgcgtat gtaggtcccc aggaagtgcc tgttccagca 901 atgatagcct caagtgatta ttatttcagt tggctcacgt gggttactga tgaacgagta 961 tgtttgcagt ggctaaaaag agtccagaat gtttcggtcc tgtctatatg tgacttcagg 1021 gaagactggc agacatggga ttgtccaaag acccaggagc atatagaaga aagcagaact 1081 ggatgggctg gtggattctt tgtttcaaca ccagttttca gctatgatgc catttcgtac 1141 tacaaaatat ttagtgacaa ggatggctac aaacatattc actatatcaa agacactgtg 1201 gaaaatgcta ttcaaattac aagtggcaag tgggaggcca taaatatatt cagagtaaca 1261 caggattcac tgttttattc tagcaatgaa tttgaagaat accctggaag aagaaacatc 1321 tacagaatta gcattggaag ctatcctcca agcaagaagt gtgttacttg ccatctaagg 1381 aaagaaaggt gccaatatta cacagcaagt ttcagcgact acgccaagta ctatgcactt 1441 gtctgctacg gcccaggcat ccccatttcc acccttcatg atggacgcac tgatcaagaa 1501 attaaaatcc tggaagaaaa caaggaattg gaaaatgctt tgaaaaatat ccagctgcct 1561 aaagaggaaa ttaagaaact tgaagtagat gaaattactt tatggtacaa gatgattctt 1621 cctcctcaat ttgacagatc aaagaagtat cccttgctaa ttcaagtgta tggtggtccc 1681 tgcagtcaga gtgtaaggtc tgtatttgct gttaattgga tatcttatct tgcaagtaag 1741 gaagggatgg tcattgcctt ggtggatggt cgaggaacag ctttccaagg tgacaaactc 1801 ctctatgcag tgtatcgaaa gctgggtgtt tatgaagttg aagaccagat tacagctgtc 1861 agaaaattca tagaaatggg tttcattgat gaaaaaagaa tagccatatg gggctggtcc 1921 tatggaggat acgtttcatc actggccctt gcatctggaa ctggtctttt caaatgtggt 1981 atagcagtgg ctccagtctc cagctgggaa tattacgcgt ctgtctacac agagagattc 2041 atgggtctcc caacaaagga tgataatctt gagcactata agaattcaac tgtgatggca 2101 agagcagaat atttcagaaa tgtagactat cttctcatcc acggaacagc agatgataat 2161 gtgcactttc agaactcagc acagattgct aaagctctgg ttaatgcaca agtggatttc 2221 caggcaatgt ggtactctga ccagaaccac ggcttatccg gcctgtccac gaaccactta 2281 tacacccaca tgacccactt cctaaagcag tgtttctctt tgtcagacta aaaacgatgc 2341 agatgcaagc ctgtatcaga atctga //