LOCUS HSU75743 7122 bp mRNA linear HUM 06-JUN-1997
DEFINITION Human methionine synthase mRNA, complete cds.
ACCESSION U75743
VERSION U75743.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7122)
AUTHORS Li,Y.N., Gulati,S., Baker,P.J., Brody,L.C., Banerjee,R. and
Kruger,W.D.
TITLE Cloning, mapping and RNA analysis of the human methionine synthase
gene
JOURNAL Hum. Mol. Genet. 5 (12), 1851-1858 (1996)
PUBMED 8968735
REFERENCE 2 (bases 1 to 7122)
AUTHORS Li,Y.N., Gulati,S., Baker,P.J., Brody,L.C., Banerjee,R. and
Kruger,W.D.
TITLE Direct Submission
JOURNAL Submitted (23-OCT-1996) Population Science, Fox Chase Cancer
Center, 7701 Burholme Ave., Philadelphia, PA 19111, USA
FEATURES Location/Qualifiers
source 1..7122
/db_xref="H-InvDB:HIT000221272"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q42-44"
/cell_type="lymphoid"
/note="composite cDNA"
CDS 287..4084
/note="similar to Escherichia coli methionine synthase
encoded by GenBank Accession Number J04975"
/codon_start=1
/product="methionine synthase"
/protein_id="AAB58906.1"
/translation="MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQRE
KLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTS
IAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVE
RPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYA
PRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLYIGLNCALGAAEMRPFIEIIGK
CTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREI
AEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMA
GNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS
SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATE
TDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKE
TLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIH
KELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKG
IEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVM
KKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGC
NNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPL
LIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYE
DIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDY
IDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARG
VVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAP
LHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVR
RELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLT
ESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGY
DTD"
BASE COUNT 2112 a 1450 c 1728 g 1832 t
ORIGIN
1 gcgcgtgtct ggctgctagg ccgacaccaa ggactggccg ggtacccggg aagaaagcac
61 gtgctccagc agttgccgcg cccagccccg agagaggccc tagggcgctg cgggctttcg
121 gggtccgcag tccccccgcg acgcgagcca acgggaggcg tcaaaagacc cgggccttgt
181 gtggcaggct cgcctggcgc tggctggcgt ggcccttggc cgtcgtcacc tgtggagagc
241 acgtcttctc tgccgcgccc tctgcgcaag gaggagactc gacaacatgt cacccgcgct
301 ccaagacctg tcgcaacccg aaggtctgaa gaaaaccctg cgggatgaga tcaatgccat
361 tctgcagaag aggattatgg tgctggatgg agggatgggg accatgatcc agcgggagaa
421 gctaaacgaa gaacacttcc gaggtcagga atttaaagat catgccaggc cgctgaaagg
481 caacaatgac attttaagta taactcagcc tgatgtcatt taccaaatcc ataaggaata
541 cttgctggct ggggcagata tcattgaaac aaatactttt agcagcacta gtattgccca
601 agctgactat ggccttgaac acttggccta ccggatgaac atgtgctctg caggagtggc
661 cagaaaagct gccgaggagg taactctcca gacaggaatt aagaggtttg tggcaggggc
721 tctgggtccg actaataaga cactctctgt gtccccatct gtggaaaggc cggattatag
781 gaacatcaca tttgatgagc ttgttgaagc ataccaagag caggccaaag gacttctgga
841 tggcggggtt gatatcttac tcattgaaac tatttttgat actgccaatg ccaaggcagc
901 cttgtttgca ctccaaaatc tttttgagga gaaatatgct ccccggccta tctttatttc
961 agggacgatc gttgataaaa gtgggcggac tctttccgga cagacaggag agggatttgt
1021 catcagcgtg tctcatggag aaccactcta cattggatta aattgtgctt tgggtgcagc
1081 tgaaatgaga ccttttattg aaataattgg aaaatgtaca acagcctatg tcctctgtta
1141 tcccaatgca ggtcttccca acacctttgg tgactatgat gaaacgcctt ctatgatggc
1201 caagcaccta aaggattttg ctatggatgg cttggtcaat atagttggag gatgctgtgg
1261 gtcaacacca gatcatatca gggaaattgc tgaagctgtg aaaaattgta agcctagagt
1321 tccacctgcc actgcttttg aaggacatat gttactgtct ggtctagagc ccttcaggat
1381 tggaccgtac accaactttg ttaacattgg agagcgctgt aatgttgcag gatcaaggaa
1441 gtttgctaaa ctcatcatgg caggaaacta tgaagaagcc ttgtgtgttg ccaaagtgca
1501 ggtggaaatg ggagcccagg tgttggatgt caacatggat gatggcatgc tagatggtcc
1561 aagtgcaatg accagatttt gcaacttaat tgcttccgag ccagacatcg caaaggtacc
1621 tttgtgcatc gactcctcca attttgctgt gattgaagct gggttaaagt gctgccaagg
1681 gaagtgcatt gtcaatagca ttagtctgaa ggaaggagag gacgacttct tggagaaggc
1741 caggaagatt aaaaagtatg gagctgctat ggtggtcatg gcttttgatg aagaaggaca
1801 ggcaacagaa acagacacaa aaatcagagt gtgcacccgg gcctaccatc tgcttgtgaa
1861 aaaactgggc tttaatccaa atgacattat ttttgaccct aatatcctaa ccattgggac
1921 tggaatggag gaacacaact tgtatgccat taattttatc catgcaacaa aagtcattaa
1981 agaaacatta cctggagcca gaataagtgg aggtctttcc aacttgtcct tctccttccg
2041 aggaatggaa gccattcgag aagcaatgca tggggttttc ctttaccatg caatcaagtc
2101 tggcatggac atggggatag tgaatgctgg aaacctccct gtgtatgatg atatccataa
2161 ggaacttctg cagctctgtg aagatctcat ctggaataaa gaccctgagg ccactgagaa
2221 gctcttacgt tatgcccaga ctcaaggcac aggagggaag aaagtcattc agactgatga
2281 gtggagaaat ggccctgtcg aagaacgcct tgagtatgcc cttgtgaagg gcattgaaaa
2341 acatattatt gaggatactg aggaagccag gttaaaccaa aaaaaatatc cccgacctct
2401 caatataatt gaaggacccc tgatgaatgg aatgaaaatt gttggtgatc tttttggagc
2461 tggaaaaatg tttctacctc aggttataaa gtcagcccgg gttatgaaga aggctgttgg
2521 ccaccttatc cctttcatgg aaaaagaaag agaagaaacc agagtgctta acggcacagt
2581 agaagaagag gacccttacc agggcaccat cgtgctggcc actgttaaag gcgacgtgca
2641 cgacataggc aagaacatag ttggagtagt ccttggctgc aataatttcc gagttattga
2701 tttaggagtc atgactccat gtgataagat actgaaagct gctcttgacc acaaagcaga
2761 tataattggc ctgtcaggac tcatcactcc ttccctggat gaaatgattt ttgttgccaa
2821 ggaaatggag agattagcta taaggattcc attgttgatt ggaggagcaa ccacttcaaa
2881 aacccacaca gcagttaaaa tagctccgag atacagtgca cctgtaatcc atgtcctgga
2941 cgcgtccaag agtgtggtgg tgtgttccca gctgttagat gaaaatctaa aggatgaata
3001 ctttgaggaa atcatggaag aatatgaaga tattagacag gaccattatg agtctctcaa
3061 ggagaggaga tacttaccct taagtcaagc cagaaaaagt ggtttccaaa tggattggct
3121 gtctgaacct cacccagtga agcccacgtt tattgggacc caggtctttg aagactatga
3181 cctgcagaag ctggtggact acattgactg gaagcctttc tttgatgtct ggcagctccg
3241 gggcaagtac ccgaatcgag gctttcccaa gatatttaac gacaaaacag taggtggaga
3301 ggccaggaag gtctacgatg atgcccacaa tatgctgaac acactgatta gtcaaaagaa
3361 actccgggcc cggggtgtgg ttgggttctg gccagcacag agtatccaag acgacattca
3421 cctgtacgca gaggctgctg tgccccaggc tgcagagccc atagccacct tctatgggtt
3481 aaggcaacag gctgagaagg actctgccag cacggagcca tactactgcc tctcagactt
3541 catcgctccc ttgcattctg gcatccgtga ctacctgggc ctgtttgccg ttgcctgctt
3601 tggggtagaa gagctgagca aggcctatga ggatgatggt gacgactaca gcagcatcat
3661 ggtcaaggcg ctgggggacc ggctggcaga ggcctttgca gaagagctcc atgaaagagt
3721 tcgccgagaa ctgtgggcct actgtggcag tgagcagctg gacgtcgcag acctgcgcag
3781 gctgcggtac aagggcatcc gcccggctcc tggctacccc agccagcccg accacaccga
3841 gaagctcacc atgtggagac tcgcagacat cgagcagtct acaggcatta ggttaacaga
3901 atcattagca atggcacctg cttcagcagt ctcaggcctc tacttctcca atttgaagtc
3961 caaatatttt gctgtgggga agatttccaa ggatcaggtt gaggattatg cattgaggaa
4021 gaacatatct gtggctgagg ttgagaaatg gcttggaccc attttgggat atgatacaga
4081 ctaacttttt ttttttttgc cttttttatt cttgatgatc ctcaaggaaa tacaacctag
4141 ggtgccttaa aaataacaac aacaaaaaac ctgtgtgcat ctggctgaca cttacctgct
4201 tctggttttc gaagactatt tagtggaacc ttgtagagga gcagggtctt cctgcagtgc
4261 ctggaaaaca ggcgctgttt ttttgggacc ttgcgtgaag agcagtgagc agggttcctg
4321 tggtttccct ggtccctctg agatggggac agactgaaga cagaggtcgt ttgatttcaa
4381 agcaagtcaa cctgcttttt tctgttttta cagtggaatc taggaggcca cttagtcgtc
4441 tttttttcct cttagaagaa aagcctgaaa ctgagttgaa tagagaagtg tgaccctgtg
4501 acaaaatgat actgtgaaaa atggggcatt ttaatctaag tggttataac agtggattct
4561 gacggggaag gtgtagctct gttctcttcg gaagacctcg ttttctaaag gctggactaa
4621 atggctgcag aactcccttt ggcaaaaggc atgcgctcac tgcttgcttg tcagaaacac
4681 tgaagccatt tgccccagtg tggtcaagca gccatgcttt ctgggcattt tcgtcctccc
4741 ataatttcat atttccgtac ccctgaggaa acaaaaagga aatgaggaga gaaagttact
4801 gttaagggtg gttaacattt tttttgtttt gttttgtttt ggtttttttt ttttgagaca
4861 gagtctggct ctgtcgccca ggctggagtg caggggcgca atctcggctc atagcaagct
4921 ccgcctcctg ggttcatgcc attctcctgc ctcagcctcc agagtagctg ggactacagg
4981 tgcccaccac cacacccggc taattttttg tgtttttaca aaatacaaaa aagtagagac
5041 aggatttcac tgtgttagcc aggatggtct tgatctcccg acctcgtgat ctgcccacct
5101 cagcctccca aaatgctggg attacaggcg tgagccaccg agcctggccg gttaacatct
5161 tttaattgtt tccaggattg agcaggttct cagctgggct ctgatatccc gtgcggagtt
5221 ggacaagtgg gcagcataaa gtcactcatt tcttaccatt ttattcccct caattctcaa
5281 tatattcagt aatgaagaat ggtgccacca ctcaagcaac aagcctcaaa ctcaaccatg
5341 tcatcttttt cttggatgat tgcagttatt tcaaaaattt gcatgcaaaa tatacactca
5401 tcctacttca agatggtggt ggcaatagtc aggagaaggt aacattggag tcctggtttg
5461 attcgaagga tgaagacgaa gaagcaaggg aggaacaaat gaagaaccat ctttgttcat
5521 gaataggaat attcaagatt ataaaggtat caggtctcct aaaattgatc tatggattta
5581 ataccatttt caatggaaat tccaacagat tttattgaat gaaacaagca ggtgtttata
5641 tggagtagca aaggacttaa aattaccaaa tgcttctaaa tatgaaggag aggttgggga
5701 cacgcaccct atgtgatacc aagttttatt gtcaagacag tgtcatggtg cagaggtagg
5761 cattctgagc aggggaacaa aataagggcc tagaaactca cccgtgcata tgttgacctt
5821 tgcaaaatga cctggtgaca tggcaagtca gtggggacag gaaggaccac tccctaagta
5881 atcccagaac aatggctatt catgtgggaa aaaaagaaat tttactttct ctcaccttac
5941 ctggtgataa gttccaaata tgttaagggc tttaatacaa aaagcaaaaa ttgtcagtgt
6001 ttggatgaaa aaagccttag ggcaggaaag aatctcttga gacataaagt agtaatcata
6061 aaggacaaga tggttaagtc aattctgtta aaactcaagg cttatattaa gcaaacactt
6121 gaagtgagaa gatgatccac aacttgagaa gacatttata atacaaataa ctgatgaagg
6181 attcataatc acaaatatag agaattccta tttaaaaaaa tagaaaaata gtgaagacta
6241 cacaagagga aatagggctt ttaaataaat agatgttctg tagcattggt cagggaaata
6301 tgaattagga ccacaatgag attccatttt atatccataa gatttgcaaa ggttgggtct
6361 gacagtacca gttgttagat ctgtagggac ttgtacaaca ttgtggatgt gtaaacaggc
6421 accactgctt taaaaaacaa ttatccctta cagacttgaa catttgcaga cgttatgatc
6481 ttgcttccaa ctcccacctg tatgtccagc aaactcttgc atgtggccac taggaggaat
6541 gtgtaagaat gttcatagtt acatatttat aatagttaat aactggaaaa agtgaaatgt
6601 atgtctgtct acaggaaaat aggtgaataa ttagatatat atattcattc tacgggatat
6661 tattcagtag tggaaatgag tgaactacag ctatacctca caataagaat gaatctcaga
6721 aaatattaag gaaaaaagca agtttgaaga gaccacatgg ggcgtactat ttttattggg
6781 cccaaaaaca agcaaaacca aagaatatgt agtctaagca tacgtataca ataaaactat
6841 gctattaaaa aaaaaaggta actgataaac caaaattgag catagtaatt acccacagaa
6901 ggaggaagtg gaagggacag gagcacatag gtagatgcca agttatgcag ctgttctggt
6961 tcctcctggt aggcttacaa gtgtttacta tatgctatta atacattata ctttataact
7021 aatagataac agttttttac atattaaata tgttctactt aaatatatta taaaaaataa
7081 aggcaaagtg gaatgtttaa aaaaaaaaaa aaaaaaaaaa aa
//