LOCUS       U74612                  3492 bp    mRNA    linear   HUM 21-OCT-2002
DEFINITION  Homo sapiens forkhead box M1A (FOXM1A) mRNA, complete cds.
ACCESSION   U74612
VERSION     U74612.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol. Cell. Biol. 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,R., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-OCT-1996) Biochemistry, University of Illinois at
            Chicago, 1819 West Polk Street, Chicago, IL 60612-7334, USA
FEATURES             Location/Qualifiers
     source          1..3492
                     /db_xref="H-InvDB:HIT000221244"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="HT-29 and Caco-2"
                     /tissue_type="colon carcinoma"
                     /note="Embryonic expression pattern: liver, lung,
                     intestine, kindey, urinary tract; Adult expression
                     pattern: intestine (crypts), colon, testis (spermatocytes
                     and spermatids), and thymus;
                     Induced during liver regeneration - present in HepG2,
                     HeLa, A549 and H441 cell lines"
     gene            1..3492
                     /gene="FOXM1A"
                     /gene_synonym="HFH-11A"
     CDS             115..2520
                     /gene="FOXM1A"
                     /gene_synonym="HFH-11A"
                     /note="hepatocyte nuclear factor-3/fork head homolog 11A;
                     winged helix transcription factor"
                     /codon_start=1
                     /product="forkhead box M1A"
                     /protein_id="AAC51128.1"
                     /translation="MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQA
                     EASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSG
                     PNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALC
                     EQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVK
                     VEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHI
                     AKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQL
                     PEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQ
                     PSVKVPLPLAASLMSSELARHSKRVRIAPKVFGEQVVFGYMSKFFSGDLRDFGTPITS
                     LFNFIFLCLSVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEM
                     PHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVS
                     EMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPAS
                     QLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQ
                     GASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKP
                     GSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIP
                     ELQ"
     misc_feature    820..1155
                     /gene="FOXM1A"
                     /gene_synonym="HFH-11A"
                     /note="Region: winged helix DNA binding domain"
     exon            1090..1134
                     /gene="FOXM1A"
                     /gene_synonym="HFH-11A"
                     /note="exon A1"
                     /number=1
     exon            1384..1497
                     /gene="FOXM1A"
                     /gene_synonym="HFH-11A"
                     /note="exon A2"
                     /number=2
     polyA_site      3475
                     /gene="FOXM1A"
                     /gene_synonym="HFH-11A"
BASE COUNT          856 a         1010 c          867 g          759 t
ORIGIN      
        1 ggttggagga gcccggagcc cgccttcgga gctacggcct aacggcggcg gcgactgcag
       61 tctggagggt ccacacttgt gattctcaat ggagagtgaa aacgcagatt cataatgaaa
      121 actagccccc gtcggccact gattctcaaa agacggaggc tgccccttcc tgttcaaaat
      181 gccccaagtg aaacatcaga ggaggaacct aagagatccc ctgcccaaca ggagtctaat
      241 caagcagagg cctccaagga agtggcagag tccaactctt gcaagtttcc agctgggatc
      301 aagattatta accaccccac catgcccaac acgcaagtag tggccatccc caacaatgct
      361 aatattcaca gcatcatcac agcactgact gccaagggaa aagagagtgg cagtagtggg
      421 cccaacaaat tcatcctcat cagctgtggg ggagccccaa ctcagcctcc aggactccgg
      481 cctcaaaccc aaaccagcta tgatgccaaa aggacagaag tgaccctgga gaccttggga
      541 ccaaaacctg cagctaggga tgtgaatctt cctagaccac ctggagccct ttgcgagcag
      601 aaacgggaga cctgtgcaga tggtgaggca gcaggctgca ctatcaacaa tagcctatcc
      661 aacatccagt ggcttcgaaa gatgagttct gatggactgg gctcccgcag catcaagcaa
      721 gagatggagg aaaaggagaa ttgtcacctg gagcagcgac aggttaaggt tgaggagcct
      781 tcgagaccat cagcgtcctg gcagaactct gtgtctgagc ggccacccta ctcttacatg
      841 gccatgatac aattcgccat caacagcact gagaggaagc gcatgacttt gaaagacatc
      901 tatacgtgga ttgaggacca ctttccctac tttaagcaca ttgccaagcc aggctggaag
      961 aactccatcc gccacaacct ttccctgcac gacatgtttg tccgggagac gtctgccaat
     1021 ggcaaggtct ccttctggac cattcacccc agtgccaacc gctacttgac attggaccag
     1081 gtgtttaagc cactggaccc agggtctcca caattgcccg agcacttgga atcacagcag
     1141 aaacgaccga atccagagct ccgccggaac atgaccatca aaaccgaact ccccctgggc
     1201 gcacggcgga agatgaagcc actgctacca cgggtcagct catacctggt acctatccag
     1261 ttcccggtga accagtcact ggtgttgcag ccctcggtga aggtgccatt gcccctggcg
     1321 gcttccctca tgagctcaga gcttgcccgc catagcaagc gagtccgcat tgcccccaag
     1381 gtttttgggg aacaggtggt gtttggttac atgagtaagt tctttagtgg cgatctgcga
     1441 gattttggta cacccatcac cagcttgttt aattttatct ttctttgttt atcagtgctg
     1501 ctagctgagg aggggatagc tcctctttct tctgcaggac cagggaaaga ggagaaactc
     1561 ctgtttggag aagggttttc tcctttgctt ccagttcaga ctatcaagga ggaagaaatc
     1621 cagcctgggg aggaaatgcc acacttagcg agacccatca aagtggagag ccctcccttg
     1681 gaagagtggc cctccccggc cccatctttc aaagaggaat catctcactc ctgggaggat
     1741 tcgtcccaat ctcccacccc aagacccaag aagtcctaca gtgggcttag gtccccaacc
     1801 cggtgtgtct cggaaatgct tgtgattcaa cacagggaga ggagggagag gagccggtct
     1861 cggaggaaac agcatctact gcctccctgt gtggatgagc cggagctgct cttctcagag
     1921 gggcccagta cttcccgctg ggccgcagag ctcccgttcc cagcagactc ctctgaccct
     1981 gcctcccagc tcagctactc ccaggaagtg ggaggacctt ttaagacacc cattaaggaa
     2041 acgctgccca tctcctccac cccgagcaaa tctgtcctcc ccagaacccc tgaatcctgg
     2101 aggctcacgc ccccagccaa agtaggggga ctggatttca gcccagtaca aacctcccag
     2161 ggtgcctctg accccttgcc tgaccccctg gggctgatgg atctcagcac cactcccttg
     2221 caaagtgctc ccccccttga atcaccgcaa aggctcctca gttcagaacc cttagacctc
     2281 atctccgtcc cctttggcaa ctcttctccc tcagatatag acgtccccaa gccaggctcc
     2341 ccggagccac aggtttctgg ccttgcagcc aatcgttctc tgacagaagg cctggtcctg
     2401 gacacaatga atgacagcct cagcaagatc ctgctggaca tcagctttcc tggcctggac
     2461 gaggacccac tgggccctga caacatcaac tggtcccagt ttattcctga gctacagtag
     2521 agccctgccc ttgcccctgt gctcaagctg tccaccatcc cgggcactcc aaggctcagt
     2581 gcaccccaag cctctgagtg aggacagcag gcagggactg ttctgctcct catagctccc
     2641 tgctgcctga ttatgcaaaa gtagcagtca caccctagcc actgctggga ccttgtgttc
     2701 cccaagagta tctgattcct ctgctgtccc tgccaggagc tgaagggtgg gaacaacaaa
     2761 ggcaatggtg aaaagagatt aggaaccccc cagcctgttt ccattctctg cccagcagtc
     2821 tcttaccttc cctgatcttt gcagggtggt ccgtgtaaat agtataaatt ctccaaatta
     2881 tcctctaatt ataaatgtaa gcttatttcc ttagatcatt atccagagac tgccagaagg
     2941 tgggtaggat gacctggggt ttcaattgac ttctgttcct tgcttttagt tttgatagaa
     3001 gggaagacct gcagtgcacg gtttcttcca ggctgaggta cctggatctt gggttcttca
     3061 ctgcagggac ccagacaagt ggatctgctt gccagagtcc tttttgcccc tccctgccac
     3121 ctccccgtgt ttccaagtca gctttcctgc aagaagaaat cctggttaaa aaagtctttt
     3181 gtattgggtc aggagttgaa tttggggtgg gaggatggat gcaactgaag cagagtgtgg
     3241 gtgcccagat gtgcgctatt agatgtttct ctgataatgt ccccaatcat accagggaga
     3301 ctggcattga cgagaactca ggtggaggct tgagaaggcc gaaagggccc ctgacctgcc
     3361 tggcttcctt agcttgcccc tcagctttgc aaagagccac cctaggcccc agctgaccgc
     3421 atgggtgtga gccagcttga gaacactaac tactcaataa aagcgaaggt ggacaaaaaa
     3481 aaaaaaaaaa aa
//