LOCUS HSU74382 1929 bp mRNA linear HUM 30-SEP-1999
DEFINITION Human telomeric repeat DNA-binding protein (PIN2) mRNA, complete
cds.
ACCESSION U74382
VERSION U74382.1
KEYWORDS telomere protein; telomere maintenance; mitotic regulator;
NIMA-interacting proteins (Pins); cell cycle regulation.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1929)
AUTHORS Lu,K.P., Hanes,S.D. and Hunter,T.
TITLE A human peptidyl-prolyl isomerase essential for regulation of
mitosis
JOURNAL Nature 380 (6574), 544-547 (1996)
PUBMED 8606777
REFERENCE 2 (bases 1 to 1929)
AUTHORS Shen,M., Haggblom,C., Vogt,M., Hunter,T. and Lu,K.P.
TITLE Characterization and cell cycle regulation of the related human
telomeric proteins Pin2 and TRF1 suggest a role in mitosis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (25), 13618-13623 (1997)
PUBMED 9391075
REFERENCE 3 (bases 1 to 1929)
AUTHORS Lu,K.P. and Hunter,T.
TITLE Direct Submission
JOURNAL Submitted (15-OCT-1996) Molecular Biology and Virology Laboratory,
Salk Institute, 10010 North Torrey Pines Rd, La Jolla, CA 92037,
USA
FEATURES Location/Qualifiers
source 1..1929
/db_xref="H-InvDB:HIT000221240"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa"
gene 1..1929
/gene="PIN2"
CDS 1..1260
/gene="PIN2"
/note="NIMA-interacting protein 2, a potential coordinator
between mitotic progression and telomere homeostasis"
/codon_start=1
/product="telomeric repeat DNA-binding protein"
/protein_id="AAB53363.1"
/translation="MAEDVSSAAPSPRRCADGRDADPTEEQMAETERNDEEQFECQEL
LECQVQVGAPEEEEEEEEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTR
NSAEAIIHGLSSLTACQLRTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGS
IEKEHDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMII
SQKDTFHSFFQHFSYNHMMEKIKSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQD
KPSGNDVEMETEANLDTRKRSHKNLFLSKLQHGTQQQDLNKKERRVGTPQSTKKKKES
RRATESRIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKF
NNRTSVMLKDRWRTMKKLKLISSDSED"
BASE COUNT 618 a 386 c 435 g 490 t
ORIGIN
1 atggcggagg atgtttcctc agcggccccg agcccgcggc ggtgtgcgga tggtagggat
61 gccgacccta ctgaggagca gatggcagaa acagagagaa acgacgagga gcagttcgaa
121 tgccaggaac tgctcgagtg ccaggtgcag gtgggggccc ccgaggagga ggaggaggag
181 gaggaggacg cgggcctggt ggccgaggcc gaggccgtgg ctgccggctg gatgctcgat
241 ttcctctgcc tctctctttg ccgagctttc cgcgacggcc gctccgagga cttccgcagg
301 acccgcaaca gcgcagaggc tattattcat ggactatcca gtctaacagc ttgccagttg
361 agaacgatat acatatgtca gtttttgaca agaattgcag caggaaaaac ccttgatgca
421 cagtttgaaa atgatgaacg aattacaccc ttggaatcag ccctgatgat ttggggttca
481 attgaaaagg aacatgacaa acttcatgaa gaaatacaga atttaattaa aattcaggct
541 atagctgttt gtatggaaaa tggcaacttt aaagaagcag aagaagtctt tgaaagaata
601 tttggtgatc caaattctca tatgcctttc aaaagcaaat tgcttatgat aatctctcag
661 aaagatacat ttcattcctt ttttcaacac ttcagctaca accacatgat ggagaaaatt
721 aagagttatg tgaattatgt gctaagtgaa aaatcatcaa cctttctaat gaaggcagcg
781 gcaaaagtag tagaaagcaa aaggacaaga acaataactt ctcaagataa acctagtggt
841 aatgatgttg aaatggaaac tgaagctaat ttggatacaa gaaaaaggtc tcacaagaat
901 cttttcttat ctaagttgca acatggaacc cagcaacaag accttaataa gaaagaaaga
961 agagtaggaa ctcctcaaag tacaaaaaag aaaaaagaaa gcagaagagc cactgaaagc
1021 agaatacctg tttcaaagag tcagccggta actcctgaaa aacatcgagc tagaaaaaga
1081 caggcatggc tttgggaaga agacaagaat ttgagatctg gcgtgaggaa atatggagag
1141 ggaaactggt ctaaaatact gttgcattat aaattcaaca accggacaag tgtcatgtta
1201 aaagacagat ggaggaccat gaagaaacta aaactgattt cctcagacag cgaagactga
1261 ttgtgtttgt aaaagcttga tgaaaggaca gttaagtatt ttgatcactg cattttgttt
1321 gaaacttgtg tcattgatgt aatttaaaac ttttgtttaa agcattacag tatttttctg
1381 tgaccatcaa ttaatgaggg tttgtgctac cagagttaaa gcatatgcta tcattgtatt
1441 ctttaagaac cttattttga taaaatgtaa atttgttgaa ccctgccaca tttagtatcc
1501 ccacccccaa atcctgttcc aatgaaaaaa ttaaaacctg atacgaaaaa aaaaaaattc
1561 cagttaacct attttgtgtc tgtaggctga cctcaaccct gtaacgtaac ccattaaaat
1621 gaatttcttt ttttttaaga cagagtttct ctctgttgcc caggctggag tgcagtggcg
1681 caatttcagc tcactgaacc tctgcctccc aggtcaagtg attctcctgc ctcagcctct
1741 gagtagctgg gattacaggc acacaccacc agccagctaa tttttgtatt tttagtagag
1801 gcggggtttc accatgctgg tcaggatgtt ctccaactcc tgacttcatg atccacccac
1861 ctcggcctcc caaagtgctg agattacaga cgtgagccac tgcgtcctgc ctaaaatgaa
1921 ttttctaga
//