LOCUS HSU73727 5589 bp mRNA linear HUM 03-APR-1997
DEFINITION Human receptor protein tyrosine phosphatase hPTP-J precursor, mRNA,
complete cds.
ACCESSION U73727
VERSION U73727.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5589)
AUTHORS Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K.
TITLE Molecular cloning and characterization of a novel human receptor
protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene
expression by PMA and calcium ionophore in Jurkat T lymphoma cells
JOURNAL Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997)
PUBMED 9070223
REFERENCE 2 (bases 1 to 5589)
AUTHORS Wang,B., Kishihara,K., Zhang,T., Hara,H. and Nomoto,K.
TITLE Direct Submission
JOURNAL Submitted (08-OCT-1996) Dept. of Immunology, Medical Institute of
Bioregulation, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82, Japan
FEATURES Location/Qualifiers
source 1..5589
/db_xref="H-InvDB:HIT000221226"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="Jurkat"
/cell_type="peripheral blood lymphocyte"
/tissue_type="skeletal muscle"
CDS 121..4431
/codon_start=1
/product="receptor protein tyrosine phosphatase hPTP-J
precursor"
/protein_id="AAB51343.1"
/translation="MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQA
QYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQF
SYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQV
LFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAE
AERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSN
FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEV
HAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAF
AEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWE
EPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFS
VRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISV
YQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV
GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGDTRLNCIRIARKAACKESKRPLEVSQ
RSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDR
SFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYH
TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPA
YDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCS
SIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR
HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVL
DVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE
FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLP
PDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTS
IVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQ
EGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSG
TFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLESR
"
sig_peptide 121..174
mat_peptide 175..4428
/product="receptor protein tyrosine phosphatase hPTP-J"
misc_feature 178..684
/note="encodes MAM-like domain"
misc_feature 727..933
/note="encodes Ig-like domain"
misc_feature 982..2151
/note="encodes transmembrane ibronectin type-III repeats"
misc_feature 2353..2430
/note="encodes transmembrane region"
misc_feature 2830..3492
/note="encodes PTP domain I"
misc_feature 3697..4377
/note="encodes PTP domain II"
BASE COUNT 1109 a 1777 c 1650 g 1053 t
ORIGIN
1 cagtcccgct ccgcgccgcg ccgctccgct ccggctcggg ctccggctcg cctcgggctg
61 ggctcgggct ccgggggcgg cgtcccgcgc cgggccccgg gacgcggcga tcgtccaacc
121 atggcccgtg cccaggcgct cgtgctggca ctcaccttcc agctctgcgc gccggagacc
181 gagactccgg cagctggctg caccttcgag gaggcaagtg acccagcagt gccctgcgag
241 tacagccagg cccagtacga tgacttccag tgggagcaag tgcgaatcca ccctggcacc
301 cgggcacctg cggacctgcc ccacggctcc tacttgatgg tcaacacttc ccagcatgcc
361 ccaggccagc gagcccatgt catcttccag agcctgagcg agaatgatac ccactgtgtg
421 cagttcagct acttcctgta cagccgggac gggcacagcc cgggcaccct gggcgtctac
481 gtgcgcgtta atgggggccc cctgggcagt gctgtgtgga atatgactgg atcccacggc
541 cgtcagtggc accaggctga gctggctgtc agcactttct ggcccaatga atatcaggtg
601 ctgtttgagg ccctcatctc cccagaccgc aggggctaca tgggcctaga tgacatcctg
661 cttctcagct acccctgcgc aaaggcccca cacttctccc gcctgggcga cgtggaggtc
721 aacgcgggcc agaacgcgtc gttccagtgc atggccgcgg gcagagcggc cgaggccgaa
781 cgcttcctct tgcaacggca gagcggggcg ctggtgccgg cggcgggcgt gcggcacatc
841 agccaccggc gcttcctggc cactttcccg ctggctgccg tgagccgcgc cgagcaggac
901 ctgtaccgct gtgtgtccca ggccccgcgc ggcgcgggcg tctctaactt cgcggagctc
961 atcgtcaagg agcccccaac tcccatcgcg cccccacagc tgctgcgtgc tggccccacc
1021 tacctcatca tccagctcaa caccaactcc atcattggcg acgggccgat cgtgcgcaag
1081 gagattgagt accgcatggc gcgcgggccc tgggctgagg tgcacgccgt cagcctgcag
1141 acctacaagc tgtggcacct cgaccccgac acagagtatg agatcagcgt gctgctcacg
1201 cgtcccggag acggcggcac tggccgccct gggccacccc tcatcagccg caccaaatgc
1261 gcagagccca tgagggcccc caaaggcctg gcttttgctg agatccaggc ccgtcagctg
1321 accctgcagt gggaaccact gggctacaac gtgacgcgtt gccacaccta tactgtgtcg
1381 ctgtgctatc actacaccct gggcagcagc cacaaccaga ccatccgaga gtgtgtgaag
1441 acagagcaag gtgtcagccg ctacaccatc aagaacctgc tgccctatcg gaacgttcac
1501 gtgaggcttg tcctcactaa ccctgagggg cgcaaagagg gcaaggaggt cactttccag
1561 acggatgagg atgtgcccag tgggattgca gccgagtccc tgaccttcac tccactggag
1621 gacatgatct tcctcaagtg ggaggagccc caggagccca atggtctcat cacccagtat
1681 gagatcagct accagagcat cgagtcatca gacccggcag tgaacgtgcc aggcccacga
1741 cgtaccatct ccaagctccg caatgagacc taccatgtct tctccaacct gcacccaggc
1801 accacctacc tgttctccgt gcgggcccgc acaggcaaag gcttcggcca ggcggcactc
1861 actgagataa ccactaacat ctctgctccc agctttgatt atgccgacat gccgtcaccc
1921 ctgggcgagt ctgagaacac catcaccgtg ctgctgaggc cggcacaggg ccgcggtgcg
1981 cccatcagtg tgtaccaggt gattgtggag gaggagcggg cgcggaggct gcggcgggag
2041 ccaggtggac aggactgctt cccagtgcca ttgaccttcg aggcggcgct ggcccgaggc
2101 ctggtgcact acttcggggc cgaactggcg gccagcagtc tacctgaggc catgcccttt
2161 accgtgggtg acaaccagac ctaccgaggc ttctggaacc caccacttga gcctaggaag
2221 gcctatctca tctacttcca ggcagcaagc cacctgaagg gggatacccg gctgaattgc
2281 atccgcattg ccaggaaagc tgcctgcaag gaaagcaagc ggcccctgga ggtgtcccag
2341 agatcggagg agatggggct tatcctgggc atctgtgcag gggggcttgc tgtcctcatc
2401 cttctcctgg gtgccatcat tgtcatcatc cgcaaaggga agccggtgaa catgaccaag
2461 gccaccgtca actaccgcca ggagaagaca cacatgatga gcgccgtgga ccgcagcttc
2521 acagaccaga gcaccctgca ggaggacgag cggctgggcc tgtccttcat ggacacccat
2581 ggctacagca cccggggaga ccagcgcagc ggtggggtca ctgaggccag cagcctcctg
2641 gggggctccc cgaggcgtcc ctgtggccgg aagggctccc cataccacac ggggcagctg
2701 caccctgcgg tgcgtgtcgc agaccttctg cagcacatca accagatgaa gacggccgag
2761 ggttacggct tcaagcagga gtatgagagc ttctttgaag gctgggacgc cacaaagaag
2821 aaagacaagg tcaagggcag ccggcaggag ccaatgcctg cctatgatcg gcaccgagtg
2881 aaactgcacc cgatgctggg agaccccaat gccgactaca ttaatgccaa ctacatagat
2941 ggttaccaca ggtcaaacca cttcatagcc actcaagggc cgaagcctga gatggtctat
3001 gacttctggc gtatggtgtg gcaggagcac tgttccagca tcgtcatgat caccaagctg
3061 gtcgaggtgg gcagggtgaa atgctcacgg tactggccgg aggactcaga cacctacggg
3121 gacatcaaga ttatgctggt gaagacagag accctggctg agtatgtcgt gcgcactttt
3181 gccctggagc ggagaggcta ctctgcccgg cacgaggtcc gccagttcca cttcacagcg
3241 tggccagagc atggcgtccc ctaccatgcc acggggctgc tggctttcat ccggcgcgtg
3301 aaggcctcca ccccacctga tgccgggccc attgtcatcc actgcagcgc gggcaccggc
3361 cgcacaggtt gctatatcgt cctggatgtg atgctggaca tggcagagtg tgagggcgtc
3421 gtggacattt acaactgtgt gaagactctc tgctcccggc gtgtcaacat gatccagact
3481 gaggagcagt acatcttcat tcatgatgca atcctggagg cctgcctgtg tggggagacc
3541 accatccctg tcagtgagtt caaggccacc tacaaggaga tgatccgcat tgatcctcag
3601 agtaattcct cccagctgcg ggaagagttc cagacgctga actcggtcac cccgccgctg
3661 gacgtggagg agtgcagcat cgccctgttg ccccggaacc gtgacaagaa ccgcagcatg
3721 gacgtcctgc cgcccgaccg ctgcctgccc ttcctcatct ccactgatgg ggactccaac
3781 aactacatta atgcagccct gactgacagc tacacacgga gtgcggcctt catcgtgacc
3841 ctgcacccgc tgcagagcac cacgcccgac ttctggcggc tggtctacga ttacgggtgc
3901 acctccatcg tcatgctcaa ccagctgaac cagtccaact ccgcctggcc ctgcctgcag
3961 tactggccag agccaggccg gcagcaatat ggcctcatgg aggtggagtt tatgtcgggc
4021 acagctgatg aagacttagt ggctcgagtc ttccgggtgc agaacatctc tcggttgcag
4081 gaggggcacc tgctggtgcg gcacttccag ttcctgcgct ggtctgcata ccgggacaca
4141 cctgactcca agaaggcctt cttgcacctg ctggctgagg tggacaagtg gcaggccgag
4201 agtggggatg ggcgcaccat cgtgcactgc ctaaacgggg gaggacgcag cggcaccttc
4261 tgcgcctgcg ccacggtcct ggagatgatc cgctgccaca acttggtgga cgttttcttt
4321 gctgccaaaa ccctccggaa ctacaaaccc aacatggtgg agaccatgga tcagtaccac
4381 ttttgctacg atgtggccct ggagtacttg gaggggctgg agtcaagata gcggggccct
4441 ggcctggggc acccactgca cactcagggc cagacccacc atcctggact ggcgaggaag
4501 atcagtgcct cctgctctgc ccaaacacac tcccatgggg caagcactgg agtggatgct
4561 gggctatctt gctccccctt ccactgtggg cagggccttt cgcttgtccc atgggcgggt
4621 ggtgggccaa ggaggagctt agcaagtctg cagcccagcc ccacctccat agggtcctgc
4681 aggcctgtgc tgagaggcct ggtgctgcct ggcagagtga caaaggctca ggacggctgg
4741 ctctggggga ctcaggccaa gccccttggc accatcctgg cttttggcag ggatgagtga
4801 ggccctgcag agagcatccc aggccaaggt tcccactcag cctgccccct ctgcatgtgg
4861 gtagaggatg tactgggact tggcatttag gattccatct ggcccagccc ctgaaggtcc
4921 tggggaagca ggtctcaatt ctgaatagcc agtggggcac actgactgtc ctccccaggg
4981 gaactgcagc gccctcctcc ccactgcccc ctgcagcccc tgagatattt tgctcactat
5041 ccctccccac ttgcttccct gatatgtgct ctgagcttcc ctgaaccagg atctgcctat
5101 tactgctgtg ccccatgggg ggctccttcc ctgcctgacc cactgttgca gaatgaagtc
5161 acctcgcccc cctcttcctt taatcttcag gcctcactgg cctgtcctgc tcagcttggg
5221 ccagtgacaa tctgcaaggc tgaacaacag cccctggggt tgaggcccct gtggctcctg
5281 gtcaggctgc ccgttgtggg gaggggcagt attagagcag ggctggtcat accctctgga
5341 gttcagagga agaggtagga ccagtgcttt tttgtttctt ttgttatttt tggttgggtg
5401 ggtgggaagg tctctttaaa atggggcagg ccacaccccc attccgtgcc tcaatttccc
5461 catctgtaaa ctgtagatat gactactgac ctacctcgca gggggctgtg gggaggcata
5521 agctgatgtt tgtaaagcgc tttgtaaata aacgtgctct ctgaatgcca aaaaaaaaaa
5581 aaaaaaaaa
//