LOCUS HSU73377 3664 bp mRNA linear HUM 21-MAR-1997
DEFINITION Human p66shc (SHC) mRNA, complete cds.
ACCESSION U73377
VERSION U73377.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3664)
AUTHORS Migliaccio,E., Mele,S., Salcini,A.E., Pelicci,G., Lai,K.M.,
Superti-Furga,G., Pawson,T., Di Fiore,P.P., Lanfrancone,L. and
Pelicci,P.G.
TITLE Opposite effects of the p52shc/p46shc and p66shc splicing isoforms
on the EGF receptor-MAP kinase-fos signalling pathway
JOURNAL EMBO J. 16 (4), 706-716 (1997)
PUBMED 9049300
REFERENCE 2 (bases 1 to 3664)
AUTHORS Migliaccio,E., Mele,S., Salcini,A.E., Pelicci,G., Venus Lai,K.,
Superti-Furga,G., Pawson,T., Di Fiore,P.P. and Pelicci,P.G.
TITLE Direct Submission
JOURNAL Submitted (04-OCT-1996) Experimental Oncology, European Institute
of Oncology, Via Ripamonti 435, Milano 20141, Italy
FEATURES Location/Qualifiers
source 1..3664
/db_xref="H-InvDB:HIT000221210"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21"
gene 1..3664
/gene="SHC"
CDS 195..1946
/gene="SHC"
/note="alternatively spliced isoform in GenBank Accession
Number X68148"
/codon_start=1
/product="p66shc"
/protein_id="AAB49972.1"
/translation="MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGP
ILPPLPGDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIDGAAMPES
GPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGV
SYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSS
ILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAY
VAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDG
SAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA
TLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAI
NGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDF
LVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI
ISAGSELCLQQPVERKL"
misc_feature 195..524
/gene="SHC"
/note="encodes collagen-homology region 2"
misc_feature 1224..1655
/gene="SHC"
/note="encodes collagen-homology region 1"
misc_feature 1656..1943
/gene="SHC"
/note="encodes SH2 domain"
BASE COUNT 786 a 1059 c 977 g 842 t
ORIGIN
1 atggggcctg aaactgtctg ggtctgagct ggggagcgga agccacttgt ccctctccct
61 ccccaggact tctgtgactc ctgggccaca gaggtccaac cagggtaagg gcctggggat
121 accccctgcc tggccccctt gcccaaactg gcaggggggc caggctgggc agcagcccct
181 ctttcacctc aactatggat ctcctgcccc ccaagcccaa gtacaatcca ctccggaatg
241 agtctctgtc atcgctggag gaaggggctt ctgggtccac ccccccggag gagctgcctt
301 ccccatcagc ttcatccctg gggcccatcc tgcctcctct gcctggggac gatagtccca
361 ctaccctgtg ctccttcttc ccccggatga gcaacctgag gctggccaac ccggctgggg
421 ggcgcccagg gtctaagggg gagccaggaa gggcagctga tgatggggag gggatcgatg
481 gggcagccat gccagagtca ggccccctac ccctcctcca ggacatgaac aagctgagtg
541 gaggcggcgg gcgcaggact cgggtggaag ggggccagct tgggggcgag gagtggaccc
601 gccacgggag ctttgtcaat aagcccacgc ggggctggct gcatcccaac gacaaagtca
661 tgggacccgg ggtttcctac ttggttcggt acatgggttg tgtggaggtc ctccagtcaa
721 tgcgtgccct ggacttcaac acccggactc aggtcaccag ggaggccatc agtctggtgt
781 gtgaggctgt gccgggtgct aagggggcga caaggaggag aaagccctgt agccgcccgc
841 tcagctctat cctggggagg agtaacctga aatttgctgg aatgccaatc actctcaccg
901 tctccaccag cagcctcaac ctcatggccg cagactgcaa acagatcatc gccaaccacc
961 acatgcaatc tatctcattt gcatccggcg gggatccgga cacagccgag tatgtcgcct
1021 atgttgccaa agaccctgtg aatcagagag cctgccacat tctggagtgt cccgaagggc
1081 ttgcccagga tgtcatcagc accattggcc aggccttcga gttgcgcttc aaacaatacc
1141 tcaggaaccc acccaaactg gtcacccctc atgacaggat ggctggcttt gatggctcag
1201 catgggatga ggaggaggaa gagccacctg accatcagta ctataatgac ttcccgggga
1261 aggaaccccc cttggggggg gtggtagaca tgaggcttcg ggaaggagcc gctccagggg
1321 ctgctcgacc cactgcaccc aatgcccaga cccccagcca cttgggagct acattgcctg
1381 taggacagcc tgttggggga gatccagaag tccgcaaaca gatgccacct ccaccaccct
1441 gtccaggcag agagcttttt gatgatccct cctatgtcaa cgtccagaac ctagacaagg
1501 cccggcaagc agtgggtggt gctgggcccc ccaatcctgc tatcaatggc agtgcacccc
1561 gggacctgtt tgacatgaag cccttcgaag atgctcttcg ggtgcctcca cctccccagt
1621 cggtgtccat ggctgagcag ctccgagggg agccctggtt ccatgggaag ctgagccggc
1681 gggaggctga ggcactgctg cagctcaatg gggacttctt ggtacgggag agcacgacca
1741 cacctggcca gtatgtgctc actggcttgc agagtgggca gcctaagcat ttgctactgg
1801 tggaccctga gggtgtggtt cggactaagg atcaccgctt tgaaagtgtc agtcacctta
1861 tcagctacca catggacaat cacttgccca tcatctctgc gggcagcgaa ctgtgtctac
1921 agcaacctgt ggagcggaaa ctgtgatctg ccctagcgct ctcttccaga agatgccctc
1981 caatcctttc caccctattc cctaactctc gggacctcgt ttgggagtgt tctgtgggct
2041 tggccttgtg tcagagctgg gagtagcatg gactctgggt ttcatatcca gctgagtgag
2101 agggtttgag tcaaaagcct gggtgagaat cctgcctctc cccaaacatt aatcaccaaa
2161 gtattaatgt acagagtggc ccctcacctg ggcctttcct gtgccaacct gatgcccctt
2221 ccccaagaag gtgagtgctt gtcatggaaa atgtcctgtg gtgacaggcc cagtggaaca
2281 gtcacccttc tgggcaaggg ggaacaaatc acacctctgg gcttcagggt atcccagacc
2341 cctctcaaca cccgcccccc ccatgtttaa actttgtgcc tttgaccatc tcttaggtct
2401 aatgatattt tatgcaaaca gttcttggac ccctgaattc ttcaatgaca gggatgccaa
2461 caccttcttg gcttctggga cctgtgttct tgctgagcac cctctccggt ttgggttggg
2521 ataacagagg caggagtggc agctgtcccc tctccctggg gatatgcaac ccttagagat
2581 tgccccagag ccccactccc ggccaggcgg gagatggacc cctcccttgc tcagtgcctc
2641 ctggccgggg cccctcaccc caaggggtct gtatatacat ttcataaggc ctgccctccc
2701 atgttgcatg cctatgtact ctgcgccaaa gtgcagccct tcctcctgaa gcctctgccc
2761 tgcctccctt tctgggaggg cggggtgggg gtgactgaat ttgggcctct tgtacagtta
2821 actctcccag gtggattttg tggaggtgag aaaaggggca ttgagactat aaagcagtag
2881 acaatcccca cataccatct gtagagttgg aactgcattc ttttaaagtt ttatatgcat
2941 atattttagg gctgctagac ttactttcct attttctttt ccattgctta ttcttgagca
3001 caaaatgata atcaattatt acatttatac atcacctttt tgacttttcc aagccctttt
3061 acagctcttg gcattttcct cgcctaggcc tgtgaggtaa ctgggatcgc accttttata
3121 ccagagacct gaggcagatg aaatttattt ccatctagga ctagaaaaac ttgggtctct
3181 taccgcgaga ctgagaggca gaagtcagcc cgaatgcctg tcagtttcat ggaggggaaa
3241 cgcaaaacct gcagttcctg agtaccttct acaggcccgg cccagcctag gcccggggtg
3301 gccacaccac agcaagccgg ccccccctct tttggccttg tggataaggg agagttgacc
3361 gttttcatcc tggcctcctt ttgctgtttg gatgtttcca cgggtctcac ttataccaaa
3421 gggaaaactc ttcattaaag tccgtatttc ttctaaaaaa aaaaaaaaaa aaatacattt
3481 atacatcacc tttttgactt ttccaagccc ttttacagct cttggcattt tcctcgccta
3541 ggcctgtgag gtaactggga tcgcaccttt tataccagag acctgaggca gatgaaattt
3601 atttccatct aggactagaa aaacttgggt ctcttaccgc gagactgaga ggcagaagtc
3661 agcc
//