LOCUS       HSU73338                7224 bp    mRNA    linear   HUM 09-JAN-2007
DEFINITION  Human methionine synthase mRNA, complete cds.
ACCESSION   U73338
VERSION     U73338.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7224)
  AUTHORS   Chen,L.H., Liu,M.L., Hwang,H.Y., Chen,L.S., Korenberg,J. and
            Shane,B.
  TITLE     Human methionine synthase. cDNA cloning, gene localization, and
            expression
  JOURNAL   J. Biol. Chem. 272 (6), 3628-3634 (1997)
   PUBMED   9013615
REFERENCE   2  (bases 1 to 7224)
  AUTHORS   Chen,L.H., Liu,M.-L., Hwang,H.-Y., Chen,L.-S., Korenberg,J. and
            Shane,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-1996) Nutritional Sciences, University of
            California, 117 Morgan Hall, Berkeley, CA 94720-3104, USA
FEATURES             Location/Qualifiers
     source          1..7224
                     /db_xref="H-InvDB:HIT000221209"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3-1q43"
                     /tissue_type="liver"
                     /dev_stage="fetus"
     CDS             395..4192
                     /EC_number="2.1.1.13"
                     /codon_start=1
                     /product="methionine synthase"
                     /protein_id="AAB39704.1"
                     /translation="MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQRE
                     KLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTS
                     IAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVE
                     RPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYA
                     PRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGK
                     CTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREI
                     AEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMA
                     GNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS
                     SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATE
                     TDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKE
                     TLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIH
                     KELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKG
                     IEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVM
                     KKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGC
                     NNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPL
                     LIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYE
                     DIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDY
                     IDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARG
                     VVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAP
                     LHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVR
                     RELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLT
                     ESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGY
                     DTD"
     variation       1004
                     /note="polymorphism G1004T; creates an amino acid change
                     of Ala to Ser"
                     /replace="t"
     variation       1158
                     /note="polymorphism G1158A; creates an amino acid change
                     of Cys to Tyr at amino acid 255"
                     /replace="a"
     variation       3150
                     /note="polymorphism A3150G; creates an amino acid change
                     of Asp to Gly at amino acid 919"
                     /replace="g"
     regulatory      7184..7189
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT         2108 a         1491 c         1761 g         1864 t
ORIGIN      
        1 aaaggttcta aatgtctgcg gggctcagag ccggatgtca cgtcgtcctc ctctgccggt
       61 tttctcttgg gtccttttcc gtgccgtccc gcgactccgc ctctggccgc gcgtgtctgg
      121 ctgctaggcc gacaccaagg actggccggg tacccgggaa gaaagcacgt gctccagcag
      181 ttgccgcgcc cagccccgag agaggcccta gggcgctgcg ggctttcggg gtccgcagtc
      241 cccccgcgac gcgagccaac gggaggcgtc aaaagacccg ggccttgtgt ggcaggctcg
      301 cctggcgctg gctggcgtgg cccttggccg tcgtcacctg tggagagcac gtcttctctg
      361 ccgcgccctc tgcgcaagga ggagactcga caacatgtca cccgcgctcc aagacctgtc
      421 gcaacccgaa ggtctgaaga aaaccctgcg ggatgagatc aatgccattc tgcagaagag
      481 gattatggtg ctggatggag ggatggggac catgatccag cgggagaagc taaacgaaga
      541 acacttccga ggtcaggaat ttaaagatca tgccaggccg ctgaaaggca acaatgacat
      601 tttaagtata actcagcctg atgtcattta ccaaatccat aaggaatact tgctggctgg
      661 ggcagatatc attgaaacaa atacttttag cagcactagt attgcccaag ctgactatgg
      721 ccttgaacac ttggcctacc ggatgaacat gtgctctgca ggagtggcca gaaaagctgc
      781 cgaggaggta actctccaga caggaattaa gaggtttgtg gcaggggctc tgggtccgac
      841 taataagaca ctctctgtgt ccccatctgt ggaaaggccg gattatagga acatcacatt
      901 tgatgagctt gttgaagcat accaagagca ggccaaagga cttctggatg gcggggttga
      961 tatcttactc attgaaacta tttttgatac tgccaatgcc aaggcagcct tgtttgcact
     1021 ccaaaatctt tttgaggaga aatatgctcc ccggcctatc tttatttcag ggacgatcgt
     1081 tgataaaagt gggcggactc tttccggaca gacaggagag ggatttgtca tcagcgtgtc
     1141 tcatggagaa ccactctgca ttggattaaa ttgtgctttg ggtgcagctg aaatgagacc
     1201 ttttattgaa ataattggaa aatgtacaac agcctatgtc ctctgttatc ccaatgcagg
     1261 tcttcccaac acctttggtg actatgatga aacgccttct atgatggcca agcacctaaa
     1321 ggattttgct atggatggct tggtcaatat agttggagga tgctgtgggt caacaccaga
     1381 tcatatcagg gaaattgctg aagctgtgaa aaattgtaag cctagagttc cacctgccac
     1441 tgcttttgaa ggacatatgt tactgtctgg tctagagccc ttcaggattg gaccgtacac
     1501 caactttgtt aacattggag agcgctgtaa tgttgcagga tcaaggaagt ttgctaaact
     1561 catcatggca ggaaactatg aagaagcctt gtgtgttgcc aaagtgcagg tggaaatggg
     1621 agcccaggtg ttggatgtca acatggatga tggcatgcta gatggtccaa gtgcaatgac
     1681 cagattttgc aacttaattg cttccgagcc agacatcgca aaggtacctt tgtgcatcga
     1741 ctcctccaat tttgctgtga ttgaagctgg gttaaagtgc tgccaaggga agtgcattgt
     1801 caatagcatt agtctgaagg aaggagagga cgacttcttg gagaaggcca ggaagattaa
     1861 aaagtatgga gctgctatgg tggtcatggc ttttgatgaa gaaggacagg caacagaaac
     1921 agacacaaaa atcagagtgt gcacccgggc ctaccatctg cttgtgaaaa aactgggctt
     1981 taatccaaat gacattattt ttgaccctaa tatcctaacc attgggactg gaatggagga
     2041 acacaacttg tatgccatta attttatcca tgcaacaaaa gtcattaaag aaacattacc
     2101 tggagccaga ataagtggag gtctttccaa cttgtccttc tccttccgag gaatggaagc
     2161 cattcgagaa gcaatgcatg gggttttcct ttaccatgca atcaagtctg gcatggacat
     2221 ggggatagtg aatgctggaa acctccctgt gtatgatgat atccataagg aacttctgca
     2281 gctctgtgaa gatctcatct ggaataaaga ccctgaggcc actgagaagc tcttacgtta
     2341 tgcccagact caaggcacag gagggaagaa agtcattcag actgatgagt ggagaaatgg
     2401 ccctgtcgaa gaacgccttg agtatgccct tgtgaagggc attgaaaaac atattattga
     2461 ggatactgag gaagccaggt taaaccaaaa aaaatatccc cgacctctca atataattga
     2521 aggacccctg atgaatggaa tgaaaattgt tggtgatctt tttggagctg gaaaaatgtt
     2581 tctacctcag gttataaagt cagcccgggt tatgaagaag gctgttggcc accttatccc
     2641 tttcatggaa aaagaaagag aagaaaccag agtgcttaac ggcacagtag aagaagagga
     2701 cccttaccag ggcaccatcg tgctggccac tgttaaaggc gacgtgcacg acataggcaa
     2761 gaacatagtt ggagtagtcc ttggctgcaa taatttccga gttattgatt taggagtcat
     2821 gactccatgt gataagatac tgaaagctgc tcttgaccac aaagcagata taattggcct
     2881 gtcaggactc atcactcctt ccctggatga aatgattttt gttgccaagg aaatggagag
     2941 attagctata aggattccat tgttgattgg aggagcaacc acttcaaaaa cccacacagc
     3001 agttaaaata gctccgagat acagtgcacc tgtaatccat gtcctggacg cgtccaagag
     3061 tgtggtggtg tgttcccagc tgttagatga aaatctaaag gatgaatact ttgaggaaat
     3121 catggaagaa tatgaagata ttagacagga ccattatgag tctctcaagg agaggagata
     3181 cttaccctta agtcaagcca gaaaaagtgg tttccaaatg gattggctgt ctgaacctca
     3241 cccagtgaag cccacgttta ttgggaccca ggtctttgaa gactatgacc tgcagaagct
     3301 ggtggactac attgactgga agcctttctt tgatgtctgg cagctccggg gcaagtaccc
     3361 gaatcgaggc tttcccaaga tatttaacga caaaacagta ggtggagagg ccaggaaggt
     3421 ctacgatgat gcccacaata tgctgaacac actgattagt caaaagaaac tccgggcccg
     3481 gggtgtggtt gggttctggc cagcacagag tatccaagac gacattcacc tgtacgcgga
     3541 ggctgctgtg ccccaggctg cagagcccat agccaccttc tatgggttaa ggcaacaggc
     3601 tgagaaggac tctgccagca cggagccata ctactgcctc tcagacttca tcgctccctt
     3661 gcattctggc atccgtgact acctgggcct gtttgccgtt gcctgctttg gggtagaaga
     3721 gctgagcaag gcctatgagg atgatggtga cgactacagc agcatcatgg tcaaggcgct
     3781 gggggaccgg ctggcagagg cctttgcaga agagctccat gaaagagttc gccgagaact
     3841 gtgggcctac tgtggcagtg agcagctgga cgtcgcagac ctgcgcaggc tgcggtacaa
     3901 gggcatccgc ccggctcctg gctaccccag ccagcccgac cacaccgaga agctcaccat
     3961 gtggagactt gcagacatcg agcagtctac aggcattagg ttaacagaat cattagcaat
     4021 ggcacctgct tcagcagtct caggcctcta cttctccaat ttgaagtcca aatattttgc
     4081 tgtggggaag atttccaagg atcaggttga ggattatgca ttgaggaaga acatatctgt
     4141 ggctgaggtt gagaaatggc ttggacccat tttgggatat gatacagact aacttttttt
     4201 ttttttgcct tttttattct tgatgatcct caaggaaata caacctaggg tgccttaaaa
     4261 ataacaacaa caaaaaacct gtgtgcatct ggctgacact tccctgcttc tggttttcga
     4321 agactattta gtggaacctt gtagaggagc agggtcttcc tgcagtgcct ggaaaacagg
     4381 cgctgttttt ttgggacctt gcgtgaagag cagtgagcag ggttcctgtg gtttccctgg
     4441 tccctctgag atggggacag actgaagaca gaggtcgttt gatttcaaag caagtcaacc
     4501 tgcttttttc tgtttttaca gtggaatcta ggaggccact tagtcgtctt tttttcctct
     4561 tagaagaaaa gcctgaaact gagttgaata gagaagtgtg accctgtgac aaaatgatac
     4621 tgtgagaaat ggggcatttt aatctaagtg gttataacag tggattctga cggggaaggt
     4681 gtagctctgt tctcttcgga agacctcgtt ttctaaaggc tggactaaat ggctgcagaa
     4741 ctccctttgg caaaaggcat gcgctcactg cttgcttgtc agaaacactg aagccatttg
     4801 ccccagtgtg gtcaagcagc catgctttct gggcattttc gtcctcccat aatttcatat
     4861 ttccgtaccc ctgaggaaac aaaaaggaaa tgaggagaga aagttactgt taagggtggt
     4921 taacattttt tttgttttgt tttgttttgg tttttttttt tttgagacag agtctggctc
     4981 tgtcgcccag gctggagtgc aggggcgcaa tctcggctca tagcaagctc cgcctcctgg
     5041 gttcatgcca ttctcctgcc tcagcctcca gagtagctgg gactacaggt gcccgccacc
     5101 acacccggct aattttttgt gtttttacaa aatacaaaaa agtagagaca ggatttcact
     5161 gtgttagcca ggatggtctt gatctcccga cctcgtgatc tgcccacctc agcctcccaa
     5221 aatgctggga ttacaggcgt gagccaccga gcctggccgg ttaacatctt ttaattgttt
     5281 ccaggattga gcaggttctc agctgggctc tgatatcccg tgcggagttg gacaagtggg
     5341 cagcataaag tcactcattt cttaccattt tattcccctc aattctcaat atattcagta
     5401 atgaagaatg gtgccaccac tcaagcaaca agcctcaaac tcacccatgt catctttttc
     5461 ttggatgatt gcagttattt caaaaatttg catgcaaaat atacactcat cctacttcaa
     5521 gatggtggtg gcaatagtca ggagaaggta gcattggagt cctggtttga ttcgaaggat
     5581 gaagacgaag aagcaaggga ggaacaaatg aagaaccatc tttgttcatg aataggaata
     5641 ttcaagatta taaaggtatc aggtctccta aaattgatct atggatttaa taccattttc
     5701 aatggaaatt ccaacagatt ttattgaatg aaacaagcag gtgtttatat ggagtagcaa
     5761 aggacttaaa attaccaaat gcttctaaat atgaaggaga ggttggggac acgcacccta
     5821 tgtgatacca agttttattg tcaagacagt gtcatggtgc agaggtaggc attctgagca
     5881 ggggaacaaa ataagggcct agaaactcac ccgtgcatat gttgaccttt gcaaaatgac
     5941 ctggtgacat ggcaagtcag tggggacagg aaggaccact ccctaagtaa tcccagaaca
     6001 atggctattc atgtgggaaa aaaagaaatt ttactttctc tcaccttacc tggtgataag
     6061 ttccaaatat gttaagggct ttaatacaaa aagcaaaaat tgtcagtgtt tggatgaaaa
     6121 aagccttagg gcaggaaaga atctcttgag acataaagta gtaatcataa aggacaagat
     6181 ggttaagtca attctgttaa aactcaaggc ttatattaag caaacacttg aagtgagaag
     6241 atgatccaca acttgagaag acatttataa tacaaataac tgatgaagga ttcataatca
     6301 caaatataga gaattcctat ttaaaaaaat agaaaaatag tgaagactac acaagaggaa
     6361 atagggcttt taaataaata gatgttctgt agcattggtc agggaaatat gaattaggac
     6421 cacaatgaga ttccatttta tatccataag atttgcaaag gttgggtctg acagtaccag
     6481 ttgttagatc tgtagggact tgtacaacat tgtggatgtg taaacaggca ccactgcttt
     6541 aaaaaacaat tatcccttac agacttgaac atttgcagac cttatgatct tgcttccaac
     6601 tcccacctgt atgtccagca aactcttgca tgtggccact aggaggaatg tgtaagaatg
     6661 ttcatagtta catatttata atagttaata actggaaaaa gtgaaatgta tgtctgtcta
     6721 caggaaaata ggtgaataat tagatatatg tattcattct acgggatatt attcagtagt
     6781 ggaaatgagt gaactacagc tatacctcac aataagaatg aatctcagaa aatattaagg
     6841 aaaaaagcaa gtttgaagag accacatggg gcgtactatt tttattgagc ccaaaaacaa
     6901 gcaaaaccaa agaatatgta gtctaagcat acgtatacaa taaaactatg ctattaaaaa
     6961 aaaaggtaac tgataaacca aaattgagca tagtaattac ccacagaagg aggaagtgga
     7021 agggacagga gcacataggt agatgccaag ttatgcagct gttctggttc ctcctggtag
     7081 gcttacaagt gtttactata tgctattaat acattatact ttataactaa tagataacag
     7141 ttttttacat attaaatatg ttctacttaa atatattata aaaaataaag gcaaagtgga
     7201 atgataacct aaaaaaaaaa aaaa
//