LOCUS HSU73338 7224 bp mRNA linear HUM 09-JAN-2007 DEFINITION Human methionine synthase mRNA, complete cds. ACCESSION U73338 VERSION U73338.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7224) AUTHORS Chen,L.H., Liu,M.L., Hwang,H.Y., Chen,L.S., Korenberg,J. and Shane,B. TITLE Human methionine synthase. cDNA cloning, gene localization, and expression JOURNAL J. Biol. Chem. 272 (6), 3628-3634 (1997) PUBMED 9013615 REFERENCE 2 (bases 1 to 7224) AUTHORS Chen,L.H., Liu,M.-L., Hwang,H.-Y., Chen,L.-S., Korenberg,J. and Shane,B. TITLE Direct Submission JOURNAL Submitted (03-OCT-1996) Nutritional Sciences, University of California, 117 Morgan Hall, Berkeley, CA 94720-3104, USA FEATURES Location/Qualifiers source 1..7224 /db_xref="H-InvDB:HIT000221209" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1q42.3-1q43" /tissue_type="liver" /dev_stage="fetus" CDS 395..4192 /EC_number="2.1.1.13" /codon_start=1 /product="methionine synthase" /protein_id="AAB39704.1" /translation="MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQRE KLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTS IAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVE RPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYA PRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGK CTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREI AEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMA GNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATE TDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKE TLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIH KELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKG IEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVM KKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGC NNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPL LIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYE DIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDY IDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARG VVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAP LHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVR RELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLT ESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGY DTD" variation 1004 /note="polymorphism G1004T; creates an amino acid change of Ala to Ser" /replace="t" variation 1158 /note="polymorphism G1158A; creates an amino acid change of Cys to Tyr at amino acid 255" /replace="a" variation 3150 /note="polymorphism A3150G; creates an amino acid change of Asp to Gly at amino acid 919" /replace="g" regulatory 7184..7189 /regulatory_class="polyA_signal_sequence" BASE COUNT 2108 a 1491 c 1761 g 1864 t ORIGIN 1 aaaggttcta aatgtctgcg gggctcagag ccggatgtca cgtcgtcctc ctctgccggt 61 tttctcttgg gtccttttcc gtgccgtccc gcgactccgc ctctggccgc gcgtgtctgg 121 ctgctaggcc gacaccaagg actggccggg tacccgggaa gaaagcacgt gctccagcag 181 ttgccgcgcc cagccccgag agaggcccta gggcgctgcg ggctttcggg gtccgcagtc 241 cccccgcgac gcgagccaac gggaggcgtc aaaagacccg ggccttgtgt ggcaggctcg 301 cctggcgctg gctggcgtgg cccttggccg tcgtcacctg tggagagcac gtcttctctg 361 ccgcgccctc tgcgcaagga ggagactcga caacatgtca cccgcgctcc aagacctgtc 421 gcaacccgaa ggtctgaaga aaaccctgcg ggatgagatc aatgccattc tgcagaagag 481 gattatggtg ctggatggag ggatggggac catgatccag cgggagaagc taaacgaaga 541 acacttccga ggtcaggaat ttaaagatca tgccaggccg ctgaaaggca acaatgacat 601 tttaagtata actcagcctg atgtcattta ccaaatccat aaggaatact tgctggctgg 661 ggcagatatc attgaaacaa atacttttag cagcactagt attgcccaag ctgactatgg 721 ccttgaacac ttggcctacc ggatgaacat gtgctctgca ggagtggcca gaaaagctgc 781 cgaggaggta actctccaga caggaattaa gaggtttgtg gcaggggctc tgggtccgac 841 taataagaca ctctctgtgt ccccatctgt ggaaaggccg gattatagga acatcacatt 901 tgatgagctt gttgaagcat accaagagca ggccaaagga cttctggatg gcggggttga 961 tatcttactc attgaaacta tttttgatac tgccaatgcc aaggcagcct tgtttgcact 1021 ccaaaatctt tttgaggaga aatatgctcc ccggcctatc tttatttcag ggacgatcgt 1081 tgataaaagt gggcggactc tttccggaca gacaggagag ggatttgtca tcagcgtgtc 1141 tcatggagaa ccactctgca ttggattaaa ttgtgctttg ggtgcagctg aaatgagacc 1201 ttttattgaa ataattggaa aatgtacaac agcctatgtc ctctgttatc ccaatgcagg 1261 tcttcccaac acctttggtg actatgatga aacgccttct atgatggcca agcacctaaa 1321 ggattttgct atggatggct tggtcaatat agttggagga tgctgtgggt caacaccaga 1381 tcatatcagg gaaattgctg aagctgtgaa aaattgtaag cctagagttc cacctgccac 1441 tgcttttgaa ggacatatgt tactgtctgg tctagagccc ttcaggattg gaccgtacac 1501 caactttgtt aacattggag agcgctgtaa tgttgcagga tcaaggaagt ttgctaaact 1561 catcatggca ggaaactatg aagaagcctt gtgtgttgcc aaagtgcagg tggaaatggg 1621 agcccaggtg ttggatgtca acatggatga tggcatgcta gatggtccaa gtgcaatgac 1681 cagattttgc aacttaattg cttccgagcc agacatcgca aaggtacctt tgtgcatcga 1741 ctcctccaat tttgctgtga ttgaagctgg gttaaagtgc tgccaaggga agtgcattgt 1801 caatagcatt agtctgaagg aaggagagga cgacttcttg gagaaggcca ggaagattaa 1861 aaagtatgga gctgctatgg tggtcatggc ttttgatgaa gaaggacagg caacagaaac 1921 agacacaaaa atcagagtgt gcacccgggc ctaccatctg cttgtgaaaa aactgggctt 1981 taatccaaat gacattattt ttgaccctaa tatcctaacc attgggactg gaatggagga 2041 acacaacttg tatgccatta attttatcca tgcaacaaaa gtcattaaag aaacattacc 2101 tggagccaga ataagtggag gtctttccaa cttgtccttc tccttccgag gaatggaagc 2161 cattcgagaa gcaatgcatg gggttttcct ttaccatgca atcaagtctg gcatggacat 2221 ggggatagtg aatgctggaa acctccctgt gtatgatgat atccataagg aacttctgca 2281 gctctgtgaa gatctcatct ggaataaaga ccctgaggcc actgagaagc tcttacgtta 2341 tgcccagact caaggcacag gagggaagaa agtcattcag actgatgagt ggagaaatgg 2401 ccctgtcgaa gaacgccttg agtatgccct tgtgaagggc attgaaaaac atattattga 2461 ggatactgag gaagccaggt taaaccaaaa aaaatatccc cgacctctca atataattga 2521 aggacccctg atgaatggaa tgaaaattgt tggtgatctt tttggagctg gaaaaatgtt 2581 tctacctcag gttataaagt cagcccgggt tatgaagaag gctgttggcc accttatccc 2641 tttcatggaa aaagaaagag aagaaaccag agtgcttaac ggcacagtag aagaagagga 2701 cccttaccag ggcaccatcg tgctggccac tgttaaaggc gacgtgcacg acataggcaa 2761 gaacatagtt ggagtagtcc ttggctgcaa taatttccga gttattgatt taggagtcat 2821 gactccatgt gataagatac tgaaagctgc tcttgaccac aaagcagata taattggcct 2881 gtcaggactc atcactcctt ccctggatga aatgattttt gttgccaagg aaatggagag 2941 attagctata aggattccat tgttgattgg aggagcaacc acttcaaaaa cccacacagc 3001 agttaaaata gctccgagat acagtgcacc tgtaatccat gtcctggacg cgtccaagag 3061 tgtggtggtg tgttcccagc tgttagatga aaatctaaag gatgaatact ttgaggaaat 3121 catggaagaa tatgaagata ttagacagga ccattatgag tctctcaagg agaggagata 3181 cttaccctta agtcaagcca gaaaaagtgg tttccaaatg gattggctgt ctgaacctca 3241 cccagtgaag cccacgttta ttgggaccca ggtctttgaa gactatgacc tgcagaagct 3301 ggtggactac attgactgga agcctttctt tgatgtctgg cagctccggg gcaagtaccc 3361 gaatcgaggc tttcccaaga tatttaacga caaaacagta ggtggagagg ccaggaaggt 3421 ctacgatgat gcccacaata tgctgaacac actgattagt caaaagaaac tccgggcccg 3481 gggtgtggtt gggttctggc cagcacagag tatccaagac gacattcacc tgtacgcgga 3541 ggctgctgtg ccccaggctg cagagcccat agccaccttc tatgggttaa ggcaacaggc 3601 tgagaaggac tctgccagca cggagccata ctactgcctc tcagacttca tcgctccctt 3661 gcattctggc atccgtgact acctgggcct gtttgccgtt gcctgctttg gggtagaaga 3721 gctgagcaag gcctatgagg atgatggtga cgactacagc agcatcatgg tcaaggcgct 3781 gggggaccgg ctggcagagg cctttgcaga agagctccat gaaagagttc gccgagaact 3841 gtgggcctac tgtggcagtg agcagctgga cgtcgcagac ctgcgcaggc tgcggtacaa 3901 gggcatccgc ccggctcctg gctaccccag ccagcccgac cacaccgaga agctcaccat 3961 gtggagactt gcagacatcg agcagtctac aggcattagg ttaacagaat cattagcaat 4021 ggcacctgct tcagcagtct caggcctcta cttctccaat ttgaagtcca aatattttgc 4081 tgtggggaag atttccaagg atcaggttga ggattatgca ttgaggaaga acatatctgt 4141 ggctgaggtt gagaaatggc ttggacccat tttgggatat gatacagact aacttttttt 4201 ttttttgcct tttttattct tgatgatcct caaggaaata caacctaggg tgccttaaaa 4261 ataacaacaa caaaaaacct gtgtgcatct ggctgacact tccctgcttc tggttttcga 4321 agactattta gtggaacctt gtagaggagc agggtcttcc tgcagtgcct ggaaaacagg 4381 cgctgttttt ttgggacctt gcgtgaagag cagtgagcag ggttcctgtg gtttccctgg 4441 tccctctgag atggggacag actgaagaca gaggtcgttt gatttcaaag caagtcaacc 4501 tgcttttttc tgtttttaca gtggaatcta ggaggccact tagtcgtctt tttttcctct 4561 tagaagaaaa gcctgaaact gagttgaata gagaagtgtg accctgtgac aaaatgatac 4621 tgtgagaaat ggggcatttt aatctaagtg gttataacag tggattctga cggggaaggt 4681 gtagctctgt tctcttcgga agacctcgtt ttctaaaggc tggactaaat ggctgcagaa 4741 ctccctttgg caaaaggcat gcgctcactg cttgcttgtc agaaacactg aagccatttg 4801 ccccagtgtg gtcaagcagc catgctttct gggcattttc gtcctcccat aatttcatat 4861 ttccgtaccc ctgaggaaac aaaaaggaaa tgaggagaga aagttactgt taagggtggt 4921 taacattttt tttgttttgt tttgttttgg tttttttttt tttgagacag agtctggctc 4981 tgtcgcccag gctggagtgc aggggcgcaa tctcggctca tagcaagctc cgcctcctgg 5041 gttcatgcca ttctcctgcc tcagcctcca gagtagctgg gactacaggt gcccgccacc 5101 acacccggct aattttttgt gtttttacaa aatacaaaaa agtagagaca ggatttcact 5161 gtgttagcca ggatggtctt gatctcccga cctcgtgatc tgcccacctc agcctcccaa 5221 aatgctggga ttacaggcgt gagccaccga gcctggccgg ttaacatctt ttaattgttt 5281 ccaggattga gcaggttctc agctgggctc tgatatcccg tgcggagttg gacaagtggg 5341 cagcataaag tcactcattt cttaccattt tattcccctc aattctcaat atattcagta 5401 atgaagaatg gtgccaccac tcaagcaaca agcctcaaac tcacccatgt catctttttc 5461 ttggatgatt gcagttattt caaaaatttg catgcaaaat atacactcat cctacttcaa 5521 gatggtggtg gcaatagtca ggagaaggta gcattggagt cctggtttga ttcgaaggat 5581 gaagacgaag aagcaaggga ggaacaaatg aagaaccatc tttgttcatg aataggaata 5641 ttcaagatta taaaggtatc aggtctccta aaattgatct atggatttaa taccattttc 5701 aatggaaatt ccaacagatt ttattgaatg aaacaagcag gtgtttatat ggagtagcaa 5761 aggacttaaa attaccaaat gcttctaaat atgaaggaga ggttggggac acgcacccta 5821 tgtgatacca agttttattg tcaagacagt gtcatggtgc agaggtaggc attctgagca 5881 ggggaacaaa ataagggcct agaaactcac ccgtgcatat gttgaccttt gcaaaatgac 5941 ctggtgacat ggcaagtcag tggggacagg aaggaccact ccctaagtaa tcccagaaca 6001 atggctattc atgtgggaaa aaaagaaatt ttactttctc tcaccttacc tggtgataag 6061 ttccaaatat gttaagggct ttaatacaaa aagcaaaaat tgtcagtgtt tggatgaaaa 6121 aagccttagg gcaggaaaga atctcttgag acataaagta gtaatcataa aggacaagat 6181 ggttaagtca attctgttaa aactcaaggc ttatattaag caaacacttg aagtgagaag 6241 atgatccaca acttgagaag acatttataa tacaaataac tgatgaagga ttcataatca 6301 caaatataga gaattcctat ttaaaaaaat agaaaaatag tgaagactac acaagaggaa 6361 atagggcttt taaataaata gatgttctgt agcattggtc agggaaatat gaattaggac 6421 cacaatgaga ttccatttta tatccataag atttgcaaag gttgggtctg acagtaccag 6481 ttgttagatc tgtagggact tgtacaacat tgtggatgtg taaacaggca ccactgcttt 6541 aaaaaacaat tatcccttac agacttgaac atttgcagac cttatgatct tgcttccaac 6601 tcccacctgt atgtccagca aactcttgca tgtggccact aggaggaatg tgtaagaatg 6661 ttcatagtta catatttata atagttaata actggaaaaa gtgaaatgta tgtctgtcta 6721 caggaaaata ggtgaataat tagatatatg tattcattct acgggatatt attcagtagt 6781 ggaaatgagt gaactacagc tatacctcac aataagaatg aatctcagaa aatattaagg 6841 aaaaaagcaa gtttgaagag accacatggg gcgtactatt tttattgagc ccaaaaacaa 6901 gcaaaaccaa agaatatgta gtctaagcat acgtatacaa taaaactatg ctattaaaaa 6961 aaaaggtaac tgataaacca aaattgagca tagtaattac ccacagaagg aggaagtgga 7021 agggacagga gcacataggt agatgccaag ttatgcagct gttctggttc ctcctggtag 7081 gcttacaagt gtttactata tgctattaat acattatact ttataactaa tagataacag 7141 ttttttacat attaaatatg ttctacttaa atatattata aaaaataaag gcaaagtgga 7201 atgataacct aaaaaaaaaa aaaa //