LOCUS HSU71075 5333 bp mRNA linear HUM 16-JAN-1998
DEFINITION Homo sapiens protein tyrosine phosphatase receptor omicron (PTPRO)
mRNA, complete cds.
ACCESSION U71075
VERSION U71075.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5333)
AUTHORS Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S.,
White,R.A., Painter,C., Steinberger,A.A. and Avraham,H.
TITLE Characterization and chromosomal localization of PTPRO, a novel
receptor protein tyrosine phosphatase, expressed in hematopoietic
stem cells
JOURNAL Gene 204 (1-2), 5-16 (1997)
PUBMED 9434160
REFERENCE 2 (bases 1 to 5333)
AUTHORS White,R.A., Avraham,H., Avraham,S. and London,R.
TITLE Direct Submission
JOURNAL Submitted (17-SEP-1996) Genetics, The Children's Mercy Hospital,
2801 Wyandotte Avenue, Kansas City, MO 64108, USA
FEATURES Location/Qualifiers
source 1..5333
/db_xref="H-InvDB:HIT000221138"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p35-pter"
/tissue_type="brain"
gene 1..5333
/gene="PTPRO"
CDS 7..4326
/gene="PTPRO"
/codon_start=1
/product="protein tyrosine phosphatase receptor omicron"
/protein_id="AAC51938.1"
/translation="MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQA
QYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQF
SYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQV
LFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAE
AERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSN
FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEV
HAVSLQTYKLWHLDPDTEYEISVLSRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFA
EIQARQLALQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIK
NLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEE
PQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSV
RARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVY
QVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTVG
DNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQR
SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRS
FTDQSTLQEDERLGLSFMDTHGYSTRGDQRGWGVTEASSLLGGSPRRPCGRKGSPYHT
GQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPAY
DRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVW
QEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERR
GYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTG
CYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETT
IPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRS
MDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSRAFIVTLHPLQSTTPDFWRLVYD
YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN
ISREGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGG
RSGTFCACATVLEIIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGL
ESR"
misc_feature 67..573
/gene="PTPRO"
/note="encodes region similar to memphrin, A5 and mu"
misc_feature 610..825
/gene="PTPRO"
/note="encodes Ig-like region"
misc_feature 859..1143
/gene="PTPRO"
/note="encodes fibronectin type III repeat 1"
misc_feature 1162..1413
/gene="PTPRO"
/note="encodes fibronectin type III repeat 2"
misc_feature 1468..1731
/gene="PTPRO"
/note="encodes fibronectin type III repeat 3"
misc_feature 1780..2022
/gene="PTPRO"
/note="encodes fibronectin type III repeat 4"
misc_feature 2242..2313
/gene="PTPRO"
/note="encodes transmembrane domain"
misc_feature 2704..3423
/gene="PTPRO"
/note="encodes protein tyrosine phosphatase domain 1"
misc_feature 3598..4323
/gene="PTPRO"
/note="encodes protein tyrosine phosphatase domain 2"
BASE COUNT 1061 a 1691 c 1581 g 998 t
ORIGIN
1 ccaaccatgg cccgtgccca ggcgctcgtg ctggcactca ccttccagct ctgcgcgccg
61 gagaccgaga ctccggcagc tggctgcacc ttcgaggagg caagtgaccc agcagtgccc
121 tgcgagtaca gccaggccca gtacgatgac ttccagtggg agcaagtgcg aatccaccct
181 ggcacccggg cacctgcgga cctgccccac ggctcctact tgatggtcaa cacttcccag
241 catgccccag gccagcgagc ccatgtcatc ttccagagcc tgagcgagaa tgatacccac
301 tgtgtgcagt tcagctactt cctgtacagc cgggacgggc acagcccggg caccctgggc
361 gtctacgtgc gcgttaatgg gggccccctg ggcagtgctg tgtggaatat gactggatcc
421 cacggccgtc agtggcacca ggctgagctg gctgtcagca ctttctggcc caatgaatat
481 caggtgctgt ttgaggccct catctcccca gaccgcaggg gctacatggg cctagatgac
541 atcctgcttc tcagctaccc ctgcgcaaag gccccacact tctcccgcct gggcgacgtg
601 gaggtcaacg cgggccagaa cgcgtcgttc cagtgcatgg ccgcgggcag agcggccgag
661 gccgaacgct tcctcttgca acggcagagc ggggcgctgg tgccggcggc gggcgtgcgg
721 cacatcagcc accggcgctt cctggccact ttcccgctgg ctgccgtgag ccgcgccgag
781 caggacctgt accgctgtgt gtcccaggcc ccgcgcggcg cgggcgtctc taacttcgcg
841 gagctcatcg tcaaggagcc cccaactccc atcgcgcccc cacagctgct gcgtgctggc
901 cccacctacc tcatcatcca gctcaacacc aactccatca ttggcgacgg gccgatcgtg
961 cgcaaggaga ttgagtaccg catggcgcgc gggccctggg ctgaggtgca cgccgtcagc
1021 ctgcagacct acaagctgtg gcacctcgac cccgacacag agtatgagat cagcgtgctc
1081 tcacgtcccg gagacggcgg cactggccgc cctgggccac ccctcatcag ccgcaccaaa
1141 tgcgcagagc ccatgagggc ccccaaaggc ttggcttttg ctgagatcca ggcccgtcag
1201 ctggccctgc agtgggaacc actgggctac aacgtgacgc gttgccacac ctatactgtg
1261 tcgctgtgct atcactacac cctgggcagc agccacaacc agaccatccg agagtgtgtg
1321 aagacagagc aaggtgtcag ccgctacacc atcaagaacc tgctgcccta tcggaacgtt
1381 cacgtgaggc ttgtcctcac taaccctgag gggcgcaaag agggcaagga ggtcactttc
1441 cagacggatg aggatgtgcc cagtgggatt gcagccgagt ccctgacctt cactccactg
1501 gaggacatga tcttcctcaa gtgggaggag ccccaggagc ccaatggtct catcacccag
1561 tatgagatca gctaccagag catcgagtca tcagacccgg cagtgaacgt gccaggccca
1621 cgacgtacca tctccaagct ccgcaatgag acctaccatg tcttctccaa cctgcaccca
1681 ggcaccacct acctgttctc cgtgcgggcc cgcacaggca aaggcttcgg ccaggcggca
1741 ctcactgaga taaccactaa catctctgct cccagctttg attatgccga catgccgtca
1801 cccctgggcg agtctgagaa caccatcacc gtgctgctga ggccggcaca gggccgcggt
1861 gcgcccatca gtgtgtacca ggtgattgtg gaggaggagc gggcgcggag gctgcggcgg
1921 gagccaggtg gacaggactg cttcccagtg ccattgacct tcgaggcggc gctggcccga
1981 ggcctggtgc actacttcgg ggccgaactg gcggccagca gtctacctga ggccatgccc
2041 tttaccgtgg gtgacaacca gacctaccga ggcttctgga acccaccact tgagcctagg
2101 aaggcctatc tcatctactt ccaggcagca agccacctga agggggagac ccggctgaat
2161 tgcatccgca ttgccaggaa agctgcctgc aaggaaagca agcggcccct ggaggtgtcc
2221 cagagatcgg aggagatggg gcttatcctg ggcatctgtg caggggggct tgctgtcctc
2281 atccttctcc tgggtgccat cattgtcatc atccgcaaag ggaagccggt gaacatgacc
2341 aaggccaccg tcaactaccg ccaggagaag acacacatga tgagcgccgt ggaccgcagc
2401 ttcacagacc agagcaccct gcaggaggac gagcggctgg gcctgtcctt catggacacc
2461 catggctaca gcacccgggg agaccagcgc ggctgggggg tcactgaggc cagcagcctc
2521 ctggggggct ccccgaggcg tccctgtggc cggaagggct ccccatacca cacggggcag
2581 ctgcaccctg cggtgcgtgt cgcagacctt ctgcagcaca tcaaccagat gaagacggcc
2641 gagggttacg gcttcaagca ggagtacgag agcttctttg aaggctggga cgccacaaag
2701 aagaaagaca aggtcaaggg cagccggcag gagccaatgc ctgcctatga tcggcaccga
2761 gtgaaactgc acccgatgct gggagacccc aatgccgact acattaatgc caactacata
2821 gatattcgga taaaccgaga aggttaccac aggtcaaacc acttcatagc cactcaaggg
2881 ccgaagcctg agatggtcta tgacttctgg cgtatggtgt ggcaggagca ctgttccagc
2941 atcgtcatga tcaccaagct ggtcgaggtg ggcagggtga aatgctcacg gtactggccg
3001 gaggactcag acacctacgg ggacatcaag attatgctgg tgaagacaga gaccctggct
3061 gagtatgtcg tgcgcacttt tgccctggag cggagaggct actctgcccg gcacgaggtc
3121 cgccagttcc acttcacagc gtggccagag catggcgtcc cctaccatgc cacggggctg
3181 ctggctttca tccggcgcgt gaaggcttcc accccacctg atgccgggcc cattgtcatc
3241 cactgcagcg cgggcaccgg ccgcacaggt tgctatatcg tcctggatgt gatgctggac
3301 atggcagagt gtgagggcgt cgtggacatt tacaactgtg tgaagactct ctgctcccgg
3361 cgtgtcaaca tgatccagac tgaggagcag tacatcttca ttcatgatgc aatcctggag
3421 gcctgcctgt gtggggagac caccatccct gtcagtgagt tcaaggccac ctacaaggag
3481 atgatccgca ttgatcctca gagtaattcc tcccagctgc gggaagagtt ccagacgctg
3541 aactcggtca ccccgccgct ggacgtggag gagtgcagca tcgccctgtt gccccggaac
3601 cgcgacaaga accgcagcat ggacgtcctg ccgcccgacc gctgcctgcc cttcctcatc
3661 tccactgatg gggactccaa caactacatt aatgcagccc tgactgacag ctacacacgg
3721 agtcgtgcct tcatcgtgac cctgcacccg ctgcagagca ccacgcccga cttctggcgg
3781 ctggtctacg attacgggtg cacctccatc gtcatgctca accagctgaa ccagtccaac
3841 tccgcctggc cctgcctgca gtactggcca gagccaggcc ggcagcaata tggcctcatg
3901 gaggtggagt ttatgtcggg cacagctgat gaagacttag tggctcgagt cttccgggtg
3961 cagaacatct ctcgggaggg gcacctgctg gtgcggcact tccagttcct gcgctggtct
4021 gcataccggg acacacctga ctccaagaag gccttcttgc acctgctggc tgaggtggac
4081 aagtggcagg ccgagagtgg ggatgggcgc accatcgtgc actgcctaaa cgggggagga
4141 cgcagcggca ccttctgcgc ctgcgccacg gtcctggaga tcatccgctg ccacaacttg
4201 gtggacgttt tctttgctgc caaaaccctc cggaactaca aacccaacat ggtggagacc
4261 atggatcagt accacttttg ctacgatgtg gccctggagt acttggaggg gctggagtca
4321 agatagcggg gccctggcct ggggcaccca ctgcacactc agggccagac ccaccatcct
4381 ggactggcga ggaagatcag tgcctcctgc tctgcccaaa cacactccca tgggggcaag
4441 cactgggagt ggatgctggg ctatcttgct cccccttcca ctgtgggcag ggcctttcgc
4501 ttgtcccatg ggcgggtggt gggccaagga ggagcttagc aagtctgcag cccagcccca
4561 cctccatagg gtcctgcagg cctgtgctga gaggcctggt gctgcctggc agagtgacaa
4621 aggctcagga cggctggctc tgggggactc aggccaagcc ccttggcacc atctggcttt
4681 tggcagggat gagtgaggcc ctgcagagag catcccaggc caaggttccc actcagcctg
4741 ccccctctgc atgtgggtag aggatgtact gggacttggc atttaggatt ccatctggcc
4801 cagcccctga aggtcctggg gaagcaggac tcaattctga atagccagtg gggcacactg
4861 actgtcctcc ccaggggaac tgcagcgccc tcctggggac tgccccctgc agcccctgag
4921 atattttgct cactatccct ccccacttgc ttccctgaat atgtgcctgt gagcttccct
4981 gaaccaggat ctgcctatta ctgctgtgcc ccatgggggg ctccttccct gcctgaccca
5041 ctgttgcaga atgaagtcac ctcgcccccc tcttccttta atcttcaggc ctcactggcc
5101 tgtcctgctc agcttgggcc agtgacaatc tgcaaggctg aacaacagcc cctggngttg
5161 aggcccctgt nctcctggtc aggctgcccg ttgtggggag gggcagtgtt agagcagggc
5221 tggtcatacc ctctggagtt cagaggaaga ggtaggacca gtgctttttt ggttctttgg
5281 tattttgggt gggtgggtgg gaagtctctt taaatggggc aggcacaccc cat
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