LOCUS HSU70312 1719 bp mRNA linear HUM 06-JAN-2005 DEFINITION Homo sapiens integrin binding protein Del-1 (Del1) mRNA, complete cds. ACCESSION U70312 VERSION U70312.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1719) AUTHORS Hidai,C., Zupancic,T., Penta,K., Mikhail,A., Kawana,M., Quertermous,E.E., Aoka,Y., Fukagawa,M., Matsui,Y., Platika,D., Auerbach,R., Hogan,B.L., Snodgrass,R. and Quertermous,T. TITLE Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor JOURNAL Genes Dev. 12 (1), 21-33 (1998) PUBMED 9420328 REFERENCE 2 (bases 1 to 1719) AUTHORS Hidai,C., Zupancic,T.J., Penta,K., Mikhail,A., Kawana,M., Quertermous,E.E., Fukagawa,M., Matsui,Y., Hogan,B.L.M., Snodgrass,H.R. and Quertermous,T. TITLE Direct Submission JOURNAL Submitted (10-SEP-1996) Molecular Biology, Progenitor Inc., 1507 Chambers Rd., Columbus, OH 43212, USA FEATURES Location/Qualifiers source 1..1719 /db_xref="H-InvDB:HIT000221105" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5q14" /cell_type="endothelial" /tissue_type="lung" /dev_stage="fetus" gene 1..1719 /gene="Del1" /note="developmentally regulated; activated during embryogenesis; expressed in extraembryonic mesoderm, within yolk sac blood islands, in angioblasts and early endothelial cells, in the developing heart, lungs and kidney, and in developing bone and developing eye" CDS 111..1553 /gene="Del1" /standard_name="developmental endothelial locus 1" /note="modular extracellular matrix protein; contains three EGF-like repeats and two discoidin I-like domains; the second EGF-like repeat contains an RGD integrin binding motif that appears to be a ligand for alpha-v beta-3 integrin receptor; similar to the fate determinant notch proteins and to coagulation factors IX, V, and VIII; the domain structure of Del-1 is similar to the milk fat globule membrane proteins BA46 and MFG-E8" /codon_start=1 /product="integrin binding protein Del-1" /protein_id="AAC02648.1" /translation="MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADG SFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIG YVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSG PLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQI NLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNID NNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQ ITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGII TQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPP IYARHIRILPWSWYGRITLRSELLGCTEEE" BASE COUNT 496 a 376 c 414 g 433 t ORIGIN 1 gaattcttta gtaggggcgg agtctgctgc tgccctgcgc tgccacctcg gctacactgc 61 cctccgcgac gacccctgac cagccggggt cacgtccggg agacgggatc atgaagcgct 121 cggtagccgt ctggctcttg gtcgggctca gcctcggtgt cccccagttc ggcaaaggtg 181 atatttgtga tcccaatcca tgtgaaaatg gaggtatctg tttgccagga ttggctgatg 241 gttccttttc ctgtgagtgt ccagatggct tcacagaccc caactgttct agtgttgtgg 301 aggttgcatc agatgaagaa gaaccaactt cagcaggtcc ctgcactcct aatccatgcc 361 ataatggagg aacctgtgaa ataagtgaag cataccgagg ggatacattc ataggctatg 421 tttgtaaatg tccccgagga tttaatggga ttcactgtca gcacaacata aatgaatgcg 481 aagttgagcc ttgcaaaaat ggtggaatat gtacagatct tgttgctaac tattcctgtg 541 agtgcccagg cgaatttatg ggaagaaatt gtcaatacaa atgctcaggc ccactgggaa 601 ttgaaggtgg aattatatca aaccagcaaa tcacagcttc ctctactcac cgagctcttt 661 ttggactcca aaaatggtat ccctactatg cacgtcttaa taagaagggg cttataaatg 721 cgtggacagc tgcagaaaat gacagatggc cgtggattca gataaatttg caaaggaaaa 781 tgagagttac tggtgtgatt acccaaggag ccaagaggat tggaagccca gagtatataa 841 aatcctacaa aattgcctac agtaatgatg gaaagacttg ggcaatgtac aaagtgaaag 901 gcaccaatga agacatggtg tttcgtggaa acattgataa caacactcca tatgctaact 961 ctttcacacc ccccataaaa gctcagtatg taagactcta tccccaagtt tgtcgaagac 1021 attgcacttt gcgaatggaa cttcttggct gtgaactgtc gggttgttct gagcctctgg 1081 gtatgaaatc aggacatata caagactatc agatcactgc ctccagcatc ttcagaacgc 1141 tcaacatgga catgttcact tgggaaccaa ggaaagctcg gctggacaag caaggcaaag 1201 tgaatgcctg gacctctggc cacaatgacc agtcacaatg gttacaggtg gatcttcttg 1261 ttccaaccaa agtgactggc atcattacac aaggagctaa agattttggt catgtacagt 1321 ttgttggctc ctacaaactg gcttacagca atgatggaga acactggact gtataccagg 1381 atgaaaagca aagaaaagat aaggttttcc agggaaattt tgacaatgac actcacagaa 1441 aaaatgtcat cgaccctccc atctatgcac gacacataag aatccttcct tggtcctggt 1501 acgggaggat cacattgcgg tcagagctgc tgggctgcac agaggaggaa tgaggggagg 1561 ctacatttca caaccctctt ccctatttcc ctaaaagtat ctccatggaa tgaactgtgc 1621 aaaatctgta ggaaactgaa tggttttttt ttttttttca tgaaaaagtg ctcaaattat 1681 ggtaggcaac taacggtgtt tttaaggggg ccggaattc //