LOCUS       HSU70312                1719 bp    mRNA    linear   HUM 06-JAN-2005
DEFINITION  Homo sapiens integrin binding protein Del-1 (Del1) mRNA, complete
            cds.
ACCESSION   U70312
VERSION     U70312.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Hidai,C., Zupancic,T., Penta,K., Mikhail,A., Kawana,M.,
            Quertermous,E.E., Aoka,Y., Fukagawa,M., Matsui,Y., Platika,D.,
            Auerbach,R., Hogan,B.L., Snodgrass,R. and Quertermous,T.
  TITLE     Cloning and characterization of developmental endothelial locus-1:
            an embryonic endothelial cell protein that binds the alphavbeta3
            integrin receptor
  JOURNAL   Genes Dev. 12 (1), 21-33 (1998)
   PUBMED   9420328
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Hidai,C., Zupancic,T.J., Penta,K., Mikhail,A., Kawana,M.,
            Quertermous,E.E., Fukagawa,M., Matsui,Y., Hogan,B.L.M.,
            Snodgrass,H.R. and Quertermous,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-1996) Molecular Biology, Progenitor Inc., 1507
            Chambers Rd., Columbus, OH 43212, USA
FEATURES             Location/Qualifiers
     source          1..1719
                     /db_xref="H-InvDB:HIT000221105"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14"
                     /cell_type="endothelial"
                     /tissue_type="lung"
                     /dev_stage="fetus"
     gene            1..1719
                     /gene="Del1"
                     /note="developmentally regulated; activated during
                     embryogenesis; expressed in extraembryonic mesoderm,
                     within yolk sac blood islands, in angioblasts and early
                     endothelial cells, in the developing heart, lungs and
                     kidney, and in developing bone and developing eye"
     CDS             111..1553
                     /gene="Del1"
                     /standard_name="developmental endothelial locus 1"
                     /note="modular extracellular matrix protein; contains
                     three EGF-like repeats and two discoidin I-like domains;
                     the second EGF-like repeat contains an RGD integrin
                     binding motif that appears to be a ligand for alpha-v
                     beta-3 integrin receptor; similar to the fate determinant
                     notch proteins and to coagulation factors IX, V, and VIII;
                     the domain structure of Del-1 is similar to the milk fat
                     globule membrane proteins BA46 and MFG-E8"
                     /codon_start=1
                     /product="integrin binding protein Del-1"
                     /protein_id="AAC02648.1"
                     /translation="MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADG
                     SFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIG
                     YVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSG
                     PLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQI
                     NLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNID
                     NNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQ
                     ITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGII
                     TQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPP
                     IYARHIRILPWSWYGRITLRSELLGCTEEE"
BASE COUNT          496 a          376 c          414 g          433 t
ORIGIN      
        1 gaattcttta gtaggggcgg agtctgctgc tgccctgcgc tgccacctcg gctacactgc
       61 cctccgcgac gacccctgac cagccggggt cacgtccggg agacgggatc atgaagcgct
      121 cggtagccgt ctggctcttg gtcgggctca gcctcggtgt cccccagttc ggcaaaggtg
      181 atatttgtga tcccaatcca tgtgaaaatg gaggtatctg tttgccagga ttggctgatg
      241 gttccttttc ctgtgagtgt ccagatggct tcacagaccc caactgttct agtgttgtgg
      301 aggttgcatc agatgaagaa gaaccaactt cagcaggtcc ctgcactcct aatccatgcc
      361 ataatggagg aacctgtgaa ataagtgaag cataccgagg ggatacattc ataggctatg
      421 tttgtaaatg tccccgagga tttaatggga ttcactgtca gcacaacata aatgaatgcg
      481 aagttgagcc ttgcaaaaat ggtggaatat gtacagatct tgttgctaac tattcctgtg
      541 agtgcccagg cgaatttatg ggaagaaatt gtcaatacaa atgctcaggc ccactgggaa
      601 ttgaaggtgg aattatatca aaccagcaaa tcacagcttc ctctactcac cgagctcttt
      661 ttggactcca aaaatggtat ccctactatg cacgtcttaa taagaagggg cttataaatg
      721 cgtggacagc tgcagaaaat gacagatggc cgtggattca gataaatttg caaaggaaaa
      781 tgagagttac tggtgtgatt acccaaggag ccaagaggat tggaagccca gagtatataa
      841 aatcctacaa aattgcctac agtaatgatg gaaagacttg ggcaatgtac aaagtgaaag
      901 gcaccaatga agacatggtg tttcgtggaa acattgataa caacactcca tatgctaact
      961 ctttcacacc ccccataaaa gctcagtatg taagactcta tccccaagtt tgtcgaagac
     1021 attgcacttt gcgaatggaa cttcttggct gtgaactgtc gggttgttct gagcctctgg
     1081 gtatgaaatc aggacatata caagactatc agatcactgc ctccagcatc ttcagaacgc
     1141 tcaacatgga catgttcact tgggaaccaa ggaaagctcg gctggacaag caaggcaaag
     1201 tgaatgcctg gacctctggc cacaatgacc agtcacaatg gttacaggtg gatcttcttg
     1261 ttccaaccaa agtgactggc atcattacac aaggagctaa agattttggt catgtacagt
     1321 ttgttggctc ctacaaactg gcttacagca atgatggaga acactggact gtataccagg
     1381 atgaaaagca aagaaaagat aaggttttcc agggaaattt tgacaatgac actcacagaa
     1441 aaaatgtcat cgaccctccc atctatgcac gacacataag aatccttcct tggtcctggt
     1501 acgggaggat cacattgcgg tcagagctgc tgggctgcac agaggaggaa tgaggggagg
     1561 ctacatttca caaccctctt ccctatttcc ctaaaagtat ctccatggaa tgaactgtgc
     1621 aaaatctgta ggaaactgaa tggttttttt ttttttttca tgaaaaagtg ctcaaattat
     1681 ggtaggcaac taacggtgtt tttaaggggg ccggaattc
//