LOCUS HSU70212 4007 bp mRNA linear HUM 06-JUL-1997
DEFINITION Human SIM1 mRNA, complete cds.
ACCESSION U70212
VERSION U70212.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4007)
AUTHORS Chrast,R., Scott,H.S., Chen,H., Kudoh,J., Rossier,C., Minoshima,S.,
Wang,Y., Shimizu,N. and Antonarakis,S.E.
TITLE Cloning of two human homologs of the Drosophila single-minded gene
SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome
chromosomal region
JOURNAL Genome Res. 7 (6), 615-624 (1997)
PUBMED 9199934
REFERENCE 2 (bases 1 to 4007)
AUTHORS Chrast,R., Rossier,C. and Antonarakis,S.E.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-1996) Medical Genetics, Geneva University Medical
School, 1 rue Michel Servet, Geneva 1211, Switzerland
FEATURES Location/Qualifiers
source 1..4007
/db_xref="H-InvDB:HIT000221095"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q"
gene 1..4007
/gene="SIM1"
CDS 217..2517
/gene="SIM1"
/note="similar to the single-minded protein in Drosophila
melanogaster, SwissProt Accession Number P05709"
/codon_start=1
/product="hSIM1"
/protein_id="AAB62395.1"
/translation="MKEKSKNAARTRREKENSEFYELAKLLPLASAITSQVDKASIIR
LTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIM
YISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSF
FLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP
PSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFH
LRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTD
TEYKGLQLSLDQISASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSG
FHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQFSDRSSLCYGFA
LDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREA
YENSMPHIASVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIET
LIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEVCHGSAL
ANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDI
SPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFD
VTSHLRMQPDPAQGHKGTSVIITNGS"
BASE COUNT 1159 a 967 c 899 g 981 t
ORIGIN
1 ggatccgcgc gaattttcaa agaacatatt ttccgttcac ccccgctggt cttttactgc
61 catcaataca ctgttcttgg tgcaaatacc tcagcctctt tattcaaagt atgttttatg
121 ttttngccaa atatgatctc taattgaaag tttatttttg gttttggatg aatctgcgga
181 gcttaagttg tgagaagaaa gggggaacaa gacacaatga aagaaaagtc caaaaatgct
241 gcgcggacta ggagggagaa ggaaaacagc gaattttatg aactggctaa attactgcct
301 ttggcctcgg ctatcacctc gcaggtggac aaagcatcca taatcagact cacgaccagc
361 tatctcaaaa tgagagtggt gttcccagaa gggctcggcg aggcgtgggg ccactcaagt
421 cggaccagcc ccctggacaa cgttggccga gaactgggct cccatctgct ccagaccctg
481 gatggcttca tcttcgtggt agccccagat gggaagatca tgtacatctc agagacagcc
541 tcagtccact tgggtctttc tcaggtagag ctgaccggaa acagcattta tgaatacatt
601 cacccggcag accacgacga gatgacggcg gtgctcaccg cccatcaacc ctaccactct
661 cacttcgtgc aggagtatga gatcgagcgc tccttcttcc tgaggatgaa gtgcgtcttg
721 gccaagcgta acgccggcct cacctgtggc ggctacaagg tcatccactg cagcggctac
781 ttgaagatcc gccagtacag cctggacatg tcccccttcg acggctgcta ccaaaacgtg
841 ggcctggtgg ccgtgggcca ctcgctgcct cccagcgccg tcacggagat caagctacac
901 agcaatatgt ttatgttccg cgccagcctg gacatgaagc tcatctttct ggactccagg
961 gtggcggagc tgacggggta cgaacctcag gacctgattg agaagactct gtaccaccat
1021 gtgcacggct gcgacacctt ccacctgcgc tgcgcgcacc atttgctgct ggtgaaggga
1081 caggtgacca ccaagtacta caggttcctg gcgaaacacg gcggctgggt atgggtgcaa
1141 agctacgcga ccatcgtgca caacagtcgc tcctccaggc cacactgtat cgtcagcgtc
1201 aactatgtcc tcacagacac agaatacaaa gggctgcagc tctccctgga tcagatctca
1261 gcctccaaac cagccttctc ctataccagc agctccaccc ccaccatgac tgacaacaga
1321 aagggggcca aatcccggct ctccagctca aagtcaaaat ccaggacttc cccataccct
1381 cagtattcgg gatttcacac agaaagatcg gaatctgatc atgacagcca gtggggcgga
1441 agtcccttga ccgacacggc ctctccgcag cttctggacc ccgccgatag gcctggctcc
1501 cagcacgacg catcgtgcgc ctacagacag ttttcggacc gcagctctct ctgctatggc
1561 tttgcgcttg accactcgag gctggtggaa gagaggcatt tccataccca ggcctgtgaa
1621 ggaggccgat gtgaggcagg caggtacttc ctgggaacgc cgcaggccgg gagggagccc
1681 tggtggggct ctcgcgcagc cttgcccctg acaaaggcct ccccagaaag cagagaagcc
1741 tatgaaaaca gcatgcctca catcgcttca gtccacagga tccatgggcg aggtcattgg
1801 gatgaagata gtgtggtcag ttctccagac cctgggtcgg ccagtgaatc aggtgaccga
1861 tatcgtactg agcagtatca aagtagccca catgaaccca gcaaaattga aactcttata
1921 agagccactc agcaaatgat taaagaagaa gagaacagat tacagctaag gaaagccccc
1981 tcagaccaac tggcttccat taatggggct gggaaaaaac actccctgtg ttttgcaaac
2041 taccaacagc ccccaccaac aggtgaagtc tgccatggct ctgctcttgc caacacttca
2101 ccatgtgacc atatccagca gagagaggga aaaatgttga gcccccatga aaatgactat
2161 gacaacagtc ccaccgcact atctcggata agtagtccca attcggatcg catttcaaaa
2221 tccagtttga tcctagctaa agactatctg cattcggata tatctcctca tcagacagca
2281 ggagaccacc ctactgtctc tccaaactgc tttggctctc accggcagta ttttgacaag
2341 catgcttaca cattaactgg atatgccctg gagcacttat atgacagcga aaccattaga
2401 aactattcct tgggctgtaa tggctcacac tttgatgtaa cttcccatct gaggatgcaa
2461 ccagacccag cacaaggaca caagggaaca tctgttataa taaccaacgg aagctgatgt
2521 tttgctgaaa tattttgttc tttaaggatc tctgaaacat atttatagtt taatacccca
2581 ttaccagcat ttactatgcc acagattgtt agagagtata acttaagtta ctgggtattt
2641 gatacgtgtt cctataaaat caaagaaaac atagcactag cattcagggt tatacacaga
2701 aaagggagct aaattgaata cacaaatttc ccctctaatt atatgggaac cagaatagat
2761 aaattttgac ttgaaaaata ttcatgtaga tcaagtgtgc atatatacta catgagagga
2821 ctgatgaatg acaacattgc attgtgacta tccagtgatc ctcaaacaca caaactatta
2881 cttacaaact gcggtataca ttttacatat ggaaatatag gctatgtaat gtaaatacat
2941 caaaaatggg taattttctt tgactctgtc acactaaact tcttaacgaa atttccattc
3001 ccaaaataac tgagaaagag agagatacat cttataaact gacttctttg tggtttcaaa
3061 tcagccagct catttggttc aggcataaat tagagaaatg gttctggata tggtgcaaaa
3121 atgagttttc acctggtatc cattataaac aatcaggaag aggtaatttt tcaccttgct
3181 tttcagttag acaaggacca ggattgcact gacatggcgc tgagggtttt tctaagtaag
3241 aacactgaga tattgggaca cacatcaaaa acctggagtg ctcaattgga agtagttcta
3301 tgaatatgga aaggccagag gcagagtgaa ataaaatgct atctcaaagt ttaacacaat
3361 ttaagggctc agcataagta aacaacatat ttggggtttg cttgtaaaac caactaaata
3421 aaaaattcaa accaattcac ccagaaaaaa gaccaatagg tgcaaaaata aaaggaaaac
3481 cagtgaagtg ccacatgaca gcagtgttaa gtgtttgaaa acgtttcaaa gcacatatgt
3541 gccaatgtga caacatgtgg aaagcctcag gagagagtct aagataaaag cttaggctga
3601 tagacaagta gttaagagct aagagcagta ctctgaagga ataggcaaaa tgtttatttt
3661 ccttattgtt tgtaaacaac aaacttggtc ttacatctgt gtggtatagt agaaaggcca
3721 gctgactaga tctctggatt ctaattttgg ccctacctgt aacttaattt tgtgaccaca
3781 gttgtaccat tcaccgtgcc tgggctctag tttcctggtt tgtaaggcag ccccagcgtt
3841 catgttctgt gatagagcag aactgaactt attacctaat taactctctg ctatgagttg
3901 tcaagactga tcattctgtt ttttctgtac acagaagttt agatgctttg tgacttaagc
3961 aggtgtgtgg gctcctttag gcaggttaca gttaatttct agagtcg
//