LOCUS HSU70064 7070 bp mRNA linear HUM 29-JAN-1997
DEFINITION Human lysosomal trafficking regulator (LYST) mRNA, partial cds.
ACCESSION U70064
VERSION U70064.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7070)
AUTHORS Barbosa,M.D.F.S., Nguyen,Q.A., Tchernev,V.T., Ashley,J.A.,
Detter,J.C., Blaydes,S.M., Brandt,S.J., Chotai,D., Hodgman,C.,
Solari,R.C.E., Lovett,M. and Kingsmore,S.F.
TITLE Identification of the homologous beige and Chediak-Higashi syndrome
genes
JOURNAL Nature 382 (6588), 262-265 (1996)
PUBMED 8717042
REFERENCE 2 (bases 1 to 7070)
AUTHORS Barbosa,M.D.F.S., Barrat,F.J., Colman,S., Fisher,A., De Saint
Basile,G., Wallace,P. and Kingsmore,S.F.
TITLE LYST
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 7070)
AUTHORS Barbosa,M.D.F.S.
TITLE Direct Submission
JOURNAL Submitted (09-SEP-1996) Medicine, University of Florida, P.O. Box
100221, Gainesville, FL 32610, USA
FEATURES Location/Qualifiers
source 1..7070
/db_xref="H-InvDB:HIT000221093"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q42-43"
/tissue_type="liver"
gene 1..7070
/gene="LYST"
CDS 553..6558
/gene="LYST"
/note="implicated in Chediak-Higashi syndrome"
/codon_start=1
/product="lysosomal trafficking regulator"
/protein_id="AAB41533.1"
/translation="MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQ
YLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPLSA
DIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARK
TQLSTSDSEANSDEKGIAMNKHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDA
MALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCKFDVTLN
HNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHL
LSVDVSTAEMMPENLRKNLTELLRAALKIRICLEKQPDPFAPRQKKTLQEVQEDFVFS
KYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL
QMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSH
FMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASL
SSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLG
GAEISPKIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSG
SEDLLWKWDALKAYQNFVFGEDRLHSIQIANHICNLIQKGNIVVQWKLYNYIFNPVLQ
RGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCN
GVSQIIELNCLNGIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGT
SFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINLFLCVAFLCVSKEAE
SDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYM
LSSVFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQP
KRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSATEAAPEEA
KLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHL
SQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEA
EDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLENLT
QGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLL
GGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTKILLLG
ILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKK
EADRESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKG
KKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALMIQVW
ADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIH
GKISIWVSGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLG
NLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSKYINKEILRCEQIREFF
MTKKDVDIGLLIGSLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSIL
LEPHHLKNLQPTEYKTIQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLI
KYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKL
DVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLL
KAQVVHHFLLTCQVLQEYKEGQLTPMPREMARSFRRKCGQSCT"
BASE COUNT 2169 a 1371 c 1518 g 2012 t
ORIGIN
1 cgcaagggct tctaagaagc catcccaatg accttttggc tttgagaaga gcagtcctca
61 taccagagtg tttggggttt tggcctcttt cagtgtttat tcattcttac gtgggaaagt
121 tgtattccga ggtttctgtg gtgcatgaag cttttgcctt caccatctgt tcccgtgtct
181 tcctcgggtg acatcagagt acagcagtat tttcccttgc catctaatgg ggtttgggct
241 gtttgactca accgtgtgtg ttcctcaatg ccaggggaat aatcctaccc taagtcagct
301 gaacagaagc caggatctaa ctgcaaacaa gagacccagc ttgcttaaca gcatggaaga
361 gaaccagttt ccttgcagct acctgggaag acggttgcta attagcctgc aacaaagagt
421 tccttgctca tctaaaagag gcaatcaccg ttcaggtgaa gctttgttct aagaatattt
481 gtttcatcta gtttatgagt ccaaatgata tagactgtaa atgtcacagc agtggtgaaa
541 gactgctcgg tcatgagcac cgacagtaac tcactggcac gtgaatttct gaccgatgtc
601 aaccggcttt gcaatgcagt ggtccagagg gtggaggcca gggaggaaga agaggaggag
661 acgcacatgg caacccttgg acagtacctt gtccatggtc gaggatttct attacttacc
721 aagctaaatt ctataattga tcaggcattg acatgtagag aagaactcct gactcttctt
781 ctgtctctcc ttccactggt atggaagata cctgtccaag aagaaaaggc aacagatttt
841 aacctaccgc tctcagcaga tataatcctg accaaagaaa agaactcaag ttcacaaaga
901 tccactcagg aaaaattaca tttagaagga agtgccctgt ctagtcaggt ttctgcaaaa
961 gtaaatgttt ttcgaaaaag cagacgacag cgtaaaatta cccatcgcta ttctgtaaga
1021 gatgcaagaa agacacagct ctccacctca gattcagaag ccaattcaga tgaaaaaggc
1081 atagcaatga ataagcatag aaggccccat ctgctgcatc attttttaac atcgtttcct
1141 aaacaagacc accccaaagc taaacttgac cgcttagcaa ccaaagaaca gactcctcca
1201 gatgctatgg ctttggaaaa ttccagagag attattccaa gacaggggtc aaacactgac
1261 attttaagtg agccagctgc cttgtctgtt atcagtaaca tgaacaattc tccatttgac
1321 ttatgtcatg ttttgttatc tttattagaa aaagtttgta agtttgacgt taccttgaat
1381 cataattctc ctttagcagc cagtgtagtg cccacactaa ctgaattcct agcaggcttt
1441 ggggactgct gcagtctgag cgacaacttg gagagtcgag tagtttctgc aggttggacc
1501 gaagaaccgg tggctttgat tcaaaggatg ctctttcgaa cagtgttgca tcttctgtca
1561 gtagatgtta gtactgcaga gatgatgcca gaaaatctta ggaaaaattt aactgaattg
1621 cttagagcag ctttaaaaat tagaatatgc ctagaaaagc agcctgaccc ttttgcacca
1681 agacaaaaga aaacactgca ggaggttcag gaagattttg tgttttcaaa gtatcgtcat
1741 agagcccttc ttttacctga gcttttggaa ggagttcttc agattctgat ctgttgtctt
1801 cagagtgcag cttcaaatcc cttctacttc agtcaagcca tggatttggt tcaagaattc
1861 attcagcatc atggatttaa tttatttgaa acagcagttc ttcaaatgga atggctggtt
1921 ttaagagatg gagttcctcc cgaggcctca gagcatttga aagccctaat aaatagtgtg
1981 atgaaaataa tgagcactgt caaaaaagtg aaatcagagc aacttcatca ttcgatgtgt
2041 acaagaaaaa ggcacagacg atgtgaatat tctcatttta tgcatcatca ccgagatctc
2101 tcaggtcttc tggtttcggc ttttaaaaac caggtttcca aaaacccatt tgaagagact
2161 gcagatggag atgtttatta tcctgagcgg tgctgttgca ttgcagtgtg tgcccatcag
2221 tgcttgcgct tactacagca ggcttccttg agcagcactt gtgtccagat cctatcgggt
2281 gttcataaca ttggaatatg ctgttgtatg gatcccaaat ctgtaatcat tcctttgctc
2341 catgctttta aattgccagc actgaaaaat tttcagcagc atatattgaa tatccttaac
2401 aaacttattt tggatcagtt aggaggagca gagatatcac caaaaattaa aaaagcagct
2461 tgtaatattt gtactgttga ctctgaccaa ctagcccaat tagaagagac actgcaggga
2521 aacttatgtg atgctgaact ctcctcaagt ttatccagtc cttcttacag atttcaaggg
2581 atcctgccca gcagtggatc tgaagatttg ttgtggaaat gggatgcttt aaaggcttat
2641 cagaactttg tttttggaga agacagatta catagtatac agattgcaaa tcacatttgc
2701 aatttaatcc agaaaggcaa tatagttgtt cagtggaaat tatataatta catatttaat
2761 cctgtgctcc aaagaggagt tgaattagca catcattgtc aacacctaag cgttacttca
2821 gctcaaagtc atgtatgtag ccatcataac cagtgcttgc ctcaggacgt gcttcagatt
2881 tatgtaaaaa ctctgcctat cctgcttaaa tccagggtaa taagagattt gtttttgagt
2941 tgtaatggag taagtcaaat aatcgaatta aattgcttaa atggtattcg aagtcattct
3001 ctaaaagcat ttgaaactct gataatcagc ctaggggagc aacagaaaga tgcctcagtt
3061 ccagatattg atgggataga cattgaacag aaggagttgt cctctgtaca tgtgggtact
3121 tcttttcatc atcagcaagc ttattcagat tctcctcaga gtctcagcaa attttatgct
3181 ggcctcaaag aagcttatcc aaagagacgg aagactgtta accaagatgt tcatatcaac
3241 acaataaacc tattcctctg tgtggctttt ttatgcgtaa gtaaagaagc agagtctgac
3301 agggagtcgg ccaatgactc agaagatact tctggctatg acagcacagc cagcgagcct
3361 ttaagtcata tgctgccatg tatatctctc gagagccttg tcttgccttc tcctgaacat
3421 atgcaccaag cagcagacat ttggtctatg tgtcgttgga tctacatgtt gagttcagtg
3481 ttccagaaac agttttatag gcttggtggt ttccgagtat gccataagtt aatatttatg
3541 ataatacaga aactgttcag aagtcacaaa gaggagcaag gaaaaaagga gggagataca
3601 agtgtaaatg aaaaccagga tttaaacaga atttctcaac ctaagagaac tatgaaggaa
3661 gatttattat ctttggctat aaaaagtgac cccataccat cagaactagg tagtctaaaa
3721 aagagtgctg acagtttagg taaattagag ttacagcata tttcttccat aaatgtggaa
3781 gaagtttcag ctactgaagc cgctcccgag gaagcaaagc tatttacaag tcaagaaagt
3841 gagacctcac ttcaaagtat acgacttttg gaagcccttc tggccatttg tcttcatggt
3901 gccagaacta gtcaacagaa gatggaattg gagttaccta atcagaactt gtctgtggaa
3961 agtatattat ttgaaatgag ggaccatctt tcccagtcaa aggtgattga aacacaacta
4021 gcaaagcctt tatttgatgc cctgcttcga gttgccctcg ggaattattc agcagatttt
4081 gaacataatg atgctatgac tgagaagagt catcaatctg cagaagaatt gtcatcccag
4141 cctggtgatt tttcagaaga agctgaggat tctcagtgtt gtagttttaa acttttagtt
4201 gaagaagaag gttacgaagc agatagtgaa agcaatcctg aagatggcga aacccaggat
4261 gatggggtag acttaaagtc tgaaacagaa ggtttcagtg catcaagcag tccaaatgac
4321 ttactcgaaa acctcactca aggggaaata atttatcctg agatttgtat gctggaatta
4381 aatttgcttt ctgctagtaa agccaaactt gatgtgcttg cccatgtatt tgagagtttt
4441 ttgaaaatta ttaggcagaa agaaaagaat gtttttctgc tcatgcaaca gggaactgtg
4501 aaaaatcttt taggagggtt cttgagtatt ttaacacagg atgattctga ttttcaagca
4561 tgccagagag tattggtgga tcttttggta tctttgatga gttcaagaac atgttcagaa
4621 gagctaaccc ttcttttgag aatatttctg gagaaatctc cttgtacaaa aattcttctt
4681 ctgggtattc tgaaaattat tgaaagtgat actactatga gcccttcaca gtatctaacc
4741 ttccctttac tgcacgctcc aaatttaagc aacggtgttt catcacaaaa gtatcctggg
4801 attttaaaca gtaaggccat gggtttattg agaagagcac gagtttcacg gagcaagaaa
4861 gaggctgata gagagagttt tccccatcgg ctgctttcat cttggcacat agccccagtc
4921 cacctgccgt tgctggggca aaactgctgg ccacacctat cagaaggttt cagtgtttcc
4981 ctgtggttta atgtggagtg tatccatgaa gctgagagta ctacagaaaa aggaaagaag
5041 ataaagaaaa gaaacaaatc attaatttta ccagatagca gttttgatgg tacagagagc
5101 gacagaccag aaggtgcaga gtacataaat cctggtgaaa gactcataga agaaggatgt
5161 attcatataa tttcactggg atccaaagcg ttgatgatcc aagtgtgggc tgatccccac
5221 aatgccactc ttatctttcg tgtgtgcatg gattcaaatg atgacatgaa agctgtttta
5281 ctagcacagg ttgaatcaca ggagaatatt ttcctcccaa gcaaatggca acatttagta
5341 ctcacctact tacagcagcc ccaagggaaa aggaggattc atgggaaaat ctccatatgg
5401 gtctctggac agaggaagcc tgatgttact ttggatttta tgcttccaag aaaaacaagt
5461 ttgtcatctg atagcaataa aacattttgc atgattggcc attgtttatc atcccaagaa
5521 gagtttttgc agttggctgg aaaatgggac ctgggaaatt tgcttctctt caacggagct
5581 aaggttggtt cacaagaggc cttttatctg tatgcttgtg gacccaacca tacatctgta
5641 atgccatgta agtatggcaa gccagtcaat gactactcca aatatattaa taaagaaatt
5701 ttgcgatgtg aacaaatcag agaatttttt atgaccaaga aagatgtgga tattggtctc
5761 ttaattggaa gtctttcagt tgtttataca acttactgtc ctgctcagta taccatctat
5821 gaaccagtga ttagacttaa aggtcaaatg aaaacccaac tctctcaaag acccttcagc
5881 tcaaaagaag ttcagagcat cttattagaa cctcatcatc taaagaatct ccaacctact
5941 gaatataaaa ctattcaagg cattctgcac gaaattggtg gaactggcat atttgttttt
6001 ctctttgcca gggttgttga actcagtagc tgtgaagaaa ctcaagcatt agcactgcga
6061 gttatactct cattaattaa atacaaccaa caaagagtac atgaattaga aaattgtaat
6121 ggactttcta tgattcatca ggtgttgatc aaacaaaaat gcattgttgg gttttacatt
6181 ttgaagaccc ttcttgaagg atgctgtggt gaagatatta tttatatgaa tgagaatgga
6241 gagtttaagt tggatgtaga ctctaatgct ataatccaag atgttaagct gttagaggaa
6301 ctattgcttg actggaagat atggagtaaa gcagagcaag gtgtttggga aactttgcta
6361 gcagctctag aagtcctcat cagagcagat caccaccagc agatgtttaa tattaagcag
6421 ttattgaaag ctcaagtggt tcatcacttt ctactgactt gtcaggtttt gcaggaatac
6481 aaagaggggc aactcacacc catgccccga gagatggcaa gatctttcag gagaaagtgc
6541 ggtcaatcat gtacctgagg cattccagca gtggaggaag gtcccttatg agccctggat
6601 ttatggtaat aagcccatct ggttttactg cttcaccata tgaaggagag aattcctcta
6661 atattattcc acaacagatg gccgcccata tgctgcgttc tagaagccta ccagcattcc
6721 ctacttcttc actactaacg caatcacaaa aactgactgg aagtttgggt tgtagtatcg
6781 acaggttaca aaatattgca gatacttatg ttgccaccca atcaaagaaa caaaattctt
6841 tggggagttc cgacacactg aaaaaaggca aagaggacgc attcatcagt agctgtgagt
6901 ctgcaaaaac tgtttgtgaa atggaagctg tcctctcagc ccaggtctct gtcagtgatg
6961 tcccaaaggg agtgctggga tttccagtgg tcaaagcaga tcataaacag ttgggagcag
7021 aacccaggtc agaagatgac agtcctgggg atgagtcctg cccacgccga
//