LOCUS HSU69668 7339 bp mRNA linear HUM 26-FEB-1997
DEFINITION Human nuclear pore complex-associated protein TPR (tpr) mRNA,
complete cds.
ACCESSION U69668
VERSION U69668.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7339)
AUTHORS Cordes,V.C., Reidenbach,S., Rackwitz,H.R. and Franke,W.W.
TITLE Identification of protein p270/Tpr as a constitutive component of
the nuclear pore complex-attached intranuclear filaments
JOURNAL J. Cell Biol. 136 (3), 515-529 (1997)
PUBMED 9024684
REFERENCE 2 (bases 1 to 7339)
AUTHORS Cordes,V.C., Hunzicker,A. and Franke,W.W.
TITLE Direct Submission
JOURNAL Submitted (06-SEP-1996) Cell Biology/0110, German Cancer Research
Center, INF 280, Heidelberg 69120, Germany
FEATURES Location/Qualifiers
source 1..7339
/db_xref="H-InvDB:HIT000221080"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
/clone_lib="Uni-ZAPTMXR library, Stratagene"
/dev_stage="fetus"
gene 1..7339
/gene="tpr"
CDS 89..7180
/gene="tpr"
/note="nuclear pore complex-associated protein;
translocated promotor region"
/codon_start=1
/product="Tpr"
/protein_id="AAB48030.1"
/translation="MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHE
KFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIA
QDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKG
ELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNE
ILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH
NELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS
KDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG
MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKA
VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE
EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER
EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV
AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENY
KKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT
SLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEIRAENLKKEKEMLKLSEVRL
SQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE
NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKRHLSNMEVQ
VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSL
EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESME
QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELML
HAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV
CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR
REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL
MKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM
LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL
KAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK
IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLE
SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK
TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI
SRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTAN
IKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQ
EAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHP
QIEPANQELSSNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEA
SDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ
GDYTPMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDEN
DGEHEDYEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGT
ETEESMGGGEGNHRAADSQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRAPQSP
RRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDR
TVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGG
LGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTST
GTLSTTNETATGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQD
PPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHAMGGRGGINRGNIN"
BASE COUNT 2663 a 1364 c 1683 g 1629 t
ORIGIN
1 ccaggcgtct gggtcctgct ggtcttcgcc tttcttctcc gcttctaccc cgtcggccgc
61 tgccactggg gtccctggcc ccaccgacat ggcggcggtg ttgcagcaag tcctggagcg
121 cacggagctg aacaagctgc ccaagtctgt ccagaacaaa cttgaaaagt tccttgctga
181 tcagcaatcc gagatcgatg gcctgaaggg gcggcatgag aaatttaagg tggagagcga
241 acaacagtat tttgaaatag aaaagaggtt gtcccacagt caggagagac ttgtgaatga
301 aacccgagag tgtcaaagct tgcggcttga gctagagaaa ctcaacaatc aactgaaggc
361 actaactgag aaaaacaaag aacttgaaat tgctcaggat cgcaatattg ccattcagag
421 ccaatttaca agaacaaagg aagaattaga agctgagaaa agagacttaa ttagaaccaa
481 tgagagacta tctcaagaac ttgaatactt aacagaggat gttaaacgtc tgaatgaaaa
541 acttaaagaa agcaatacaa caaagggtga acttcagtta aaattggatg aacttcaagc
601 ttctgatgtt tctgttaagt atcgagaaaa acgcttggag caagaaaagg aattgctaca
661 tagtcagaat acatggctga atacagagtt gaaaaccaaa actgatgaac ttctggctct
721 tggaagagaa aaagggaatg agattctaga gcttaaatgt aatcttgaaa ataaaaaaga
781 agaggtttct agactggaag aacaaatgaa tggcttaaaa acatcaaatg aacatcttca
841 aaagcatgtg gaggatctgt tgaccaaatt aaaagaggcc aaggaacaac aggccagtat
901 ggaagagaaa ttccacaatg aattaaatgc ccacataaaa ctttctaatt tgtacaagag
961 tgccgctgat gactcagaag caaagagcaa tgaactaacc cgggcagtag aggaactaca
1021 caaacttttg aaagaagctg gtgaagccaa caaagcaata caagatcatc ttctagaggt
1081 ggagcaatcc aaagatcaaa tggaaaaaga aatgcttgag aaaataggga gattggagaa
1141 ggaattagag aatgcaaatg accttctttc tgccacaaaa cgtaaaggag ccatattgtc
1201 tgaagaagag cttgccgcca tgtctcctac tgcagcagct gtagctaaga tagtgaaacc
1261 tgggatgaaa ctaactgagc tctataatgc ttatgtggaa actcaggatc agttgctttt
1321 ggagaaacta gagaacaaaa gaattaataa gtacctagat gaaatagtga aagaagtgga
1381 agccaaagca ccaattttga aacgccagcg tgaggaatat gaacgtgcac agaaagctgt
1441 agcaagttta tctgttaagc ttgaacaagc tatgaaggag attcagcgat tgcaggagga
1501 cactgataaa gccaacaagc aatcatctgt acttgagaga gataatcgaa gaatggaaat
1561 acaagtaaaa gatctttcac aacagattag agtgcttttg atggaacttg aagaagcaag
1621 gggtaaccac gtaattcgtg atgaggaagt aagctctgct gatataagta gttcatctga
1681 ggtaatatca cagcatctag tatcttacag aaatattgaa gagcttcaac aacaaaatca
1741 acgtctctta gtggccctta gagagcttgg ggaaaccaga gaaagagaag aacaagaaac
1801 aacttcatcc aaaatcactg agcttcagct caaacttgag agtgccctta ctgaactaga
1861 acaactccgc aaatcacgac agcatcaaat gcagcttgtt gattccatag ttcgtcagcg
1921 tgatatgtac cgtattttat tgtcacaaac aacaggagtt gccattccat tacatgcttc
1981 aagcttagat gatgtttctc ttgcatcaac tccaaaacgt ccaagtacat cacagactgt
2041 ttccactcct gctccagtac ctgttattga atcaacagag gctatagagg ctaaggctgc
2101 ccttaaacag ttgcaggaaa tttttgagaa ctacaaaaaa gaaaaagcag aaaatgaaaa
2161 aatacaaaat gagcagcttg agaaacttca agaacaagtt acagatttgc gatcacaaaa
2221 taccaaaatt tctacccagc tagattttgc ttctaaacgt tatgaaatgc tgcaagataa
2281 tgttgaagga tatcgtcgag aaataacatc acttcatgag agaaatcaga aactcactgc
2341 cacaactcaa aagcaagaac agattatcaa tacgatgact caagatttga gaggagcaaa
2401 tgagaagcta gctgtcgcag aaataagagc agaaaatttg aagaaggaaa aggaaatgct
2461 taaattgtct gaagttcgtc tttctcagca aagagagtct ttgttagctg aacaaagggg
2521 gcaaaactta ctgctaacta atctgcaaac aattcaggga atactggagc gatctgaaac
2581 agaaaccaaa caaaggctta gtagccagat agaaaaactg gaacatgaga tctctcatct
2641 aaagaagaag ttggaaaatg aggtggaaca aaggcataca cttactagaa atctagatgt
2701 tcaactttta gatacaaaga gacaactgga tacagagaca aatcttcatc ttaacacaaa
2761 agaactatta aaaaatgctc aaaaagaaat tgccacattg aaacggcacc tcagtaatat
2821 ggaagtccaa gttgcttctc agtcttcaca gagaactggt aaaggtcagc ctagcaacaa
2881 agaagatgtg gatgatcttg tgagtcagct aagacagaca gaagagcagg tgaatgactt
2941 aaaggagaga ctcaaaacaa gtacgagcaa tgtggaacaa tatcaagcaa tggttactag
3001 tttagaagaa tccctgaaca aggaaaaaca ggtgacagaa gaagtgcgta agaatattga
3061 agttcgttta aaagagtcag ctgaatttca gacacagttg gaaaagaagt tgatggaagt
3121 agagaaggaa aaacaagaac ttcaggatga taaaagaaga gccatagaga gcatggaaca
3181 acagttatct gaattgaaga aaacactttc tagtgttcag aatgaagtac aagaagctct
3241 tcagagagca agcacagctt taagtaatga gcagcaagcc agacgtgact gtcaggaaca
3301 agctaaaata gctgtggaag ctcagaataa gtatgagaga gaattgatgc tgcatgctgc
3361 tgatgttgaa gctctacaag ctgcgaagga gcaggtttca aaaatggcat cagtccgtca
3421 gcatttggaa gaaacaacac agaaagcaga atcacagttg ttggagtgta aagcatcttg
3481 ggaggaaaga gagagaatgt taaaggatga agtttccaaa tgtgtatgtc gctgtgaaga
3541 tctggagaaa caaaacagat tacttcatga tcagatcgaa aaattaagtg acaaggtcgt
3601 tgcctctgtg aaggaaggtg tacaaggtcc actgaatgta tctctcagtg aagaaggaaa
3661 atctcaagaa caaattttgg aaattctcag atttatacga cgagaaaaag aaattgctga
3721 aactaggttt gaggtggctc aggttgagag tctgcgttat cgacaaaggg ttgaactttt
3781 agaaagagag ctgcaggaac tgcaagatag tctaaatgct gaaagggaga aagtccaggt
3841 aactgcaaaa acaatggctc agcatgaaga actgatgaag aaaactgaaa caatgaatgt
3901 agttatggag accaataaaa tgctaagaga agagaaggag agactagaac aggatctaca
3961 gcaaatgcaa gcaaaggtga ggaaactgga gttagatatt ttacccttac aagaagcaaa
4021 tgctgagctg agtgagaaaa gcggtatgtt gcaggcagag aagaagctct tagaagagga
4081 tgtcaaacgt tggaaagcac gtaaccagca tctagtaagt caacagaaag atccagatac
4141 agaagaatat cggaagctcc tttctgaaaa ggaagttcat actaagcgta ttcaacaatt
4201 gacagaagaa attggtagac ttaaagctga aattgcaaga tcaaatgcat ctttgactaa
4261 caaccagaac ttaattcaga gtctgaagga agatctaaat aaagtaagaa ctgaaaagga
4321 aaccatccag aaggacttag atgccaaaat aattgatatc caagaaaaag tcaaaactat
4381 tactcaagtt aagaaaattg gacgtaggta caagactcaa tatgaagaac ttaaagcaca
4441 acaggataag gttatggaga catcggctca gtcctctgga gaccatcagg agcagcatgt
4501 ttcagtccag gaaatgcagg aactcaaaga aacgctcaac caagctgaaa caaaatcaaa
4561 atcacttgaa agtcaagtag agaatctgca gaagacatta tctgaaaaag agacagaagc
4621 aagaaatctc caggaacaga ctgtgcaact tcagtctgaa ctttcacgac ttcgtcagga
4681 tcttcaagat agaaccacac aggaggagca gctccgacaa cagataactg aaaaggaaga
4741 aaaaaccaga aaggctattg tagcagcaaa gtcaaaaatt gcacacttag ctggtgtaaa
4801 agatcagcta actaaagaaa atgaggagct taaacaaagg aatggagcct tagatcagca
4861 gaaagatgaa ttggatgttc gcattactgc gctaaagtcc caatatgaag gtcgaattag
4921 tcgcttggaa agagaactca gggagcatca agagagacac cttgagcaga gagatgagcc
4981 tcaagaacct tctaataagg tccctgaaca gcagagacag atcacattga aaacaactcc
5041 agcttctggt gaaagaggaa ttgccagcac atcagaccca ccaacagcca atatcaagcc
5101 aactcctgtt gtgtctactc caagtaaagt gacagctgca gctatggctg gaaataagtc
5161 aacacccagg gctagtatcc gcccaatggt tacacctgca actgttacaa atcccactac
5221 taccccaaca gctacagtga tgcccactac acaagtggaa tcacaggaag ctatgcagtc
5281 agaagggcct gtggaacatg ttccagtttt tggaagcaca agtggatccg ttcgttctac
5341 tagtcctaat gtccagcctt ctatctctca acctatttta actgttcagc aacaaacaca
5401 ggctacagct tttgtgcaac ccactcaaca gagtcatcct cagattgagc ctgccaatca
5461 agagttatct tcaaacatag tagaggttgt tcagagttca ccagttgagc ggccttctac
5521 ttccacagca gtatttggca cagtttcggc tacccccagt tcttctttgc caaagcgtac
5581 acgtgaagag gaagaggata gcaccataga agcatcagac caagtctctg atgatacagt
5641 ggaaatgcct cttccaaaga agttgaaaag tgtcacacct gtgggaactg aggaagaagt
5701 tatggcagaa gaaagtactg atggagaggt agagactcag gtatacaacc aggattctca
5761 agattccatt ggagaaggag ttacccaggg agattataca cctatggaag acagtgaaga
5821 aacctctcag tctctacaaa tagatcttgg gccacttcaa tcagatcagc agacgacaac
5881 ttcatcccag gatggtcaag gcaaaggaga tgatgtcatt gtaattgaca gtgatgatga
5941 agaagaggat gatgatgaaa atgatggaga acatgaggat tatgaagagg atgaggaaga
6001 tgatgatgat gatgaagatg acacagggat gggagatgag ggtgaagata gtaatgaagg
6061 aactggtagt gccgatggca atgatggtta tgaagctgat gatgctgagg gtggtgatgg
6121 gactgatcca ggtacagaaa cagaagaaag tatgggtgga ggtgaaggta atcacagagc
6181 tgctgattct caaaacagtg gtgaaggaaa tacaggtgct gcagaatctt ctttttctca
6241 ggaggtttct agagaacaac agccatcatc agcatctgaa agacaggccc ctcgagcacc
6301 tcagtcaccg agacgcccac cacatccact tcccccaaga ctgaccattc atgccccacc
6361 tcaggagttg ggaccaccag ttcagagaat tcagatgacc cgaaggcagt ctgtaggacg
6421 tggccttcag ttgactccag gaataggtgg catgcaacag catttttttg atgatgaaga
6481 cagaacagtt ccaagtactc caactcttgt ggtgccacat cgtactgatg gatttgctga
6541 agcaattcat tcgccgcagg ttgctggtgt ccctagattc cggtttgggc cacctgaaga
6601 tatgccacaa acaagttcta gtcactctga tcttggccag cttgcttctc aaggaggttt
6661 aggaatgtat gaaacacccc tgttcctagc tcatgaagaa gagtcaggtg gccgaagtgt
6721 tcccactact ccactacaag tagcagcccc agtgactgta tttactgaga gcaccacctc
6781 tgatgcttcg gaacatgcct ctcaatctgt tccaatggtg actacatcca ctggcacttt
6841 atctacaaca aatgaaacag caacaggtga tgatggagat gaagtatttg tggaggcaga
6901 atctgaaggt attagttcag aagcaggcct agaaattgat agccagcagg aagaagagcc
6961 ggttcaagca tctgatgagt cagatctccc ctccaccagc caggatcctc cttctagctc
7021 atctgtagat actagtagta gtcaaccaaa gcctttcaga cgagtaagac ttcagacaac
7081 attgagacaa ggtgtccgtg gtcgtcagtt taacagacag agaggtgtga gccatgcaat
7141 gggagggaga ggaggaataa acagaggaaa tattaattaa atggtctgta aacaataaca
7201 actgtgaata agattatcaa atctgtttta gtgtaatgat tgtcaagttt aaaaacattt
7261 ttatatataa actggtatac tcatgtcaat attctttatt aataaaatgt ttttcagtgt
7321 caaaaaaaaa aaaaaaaaa
//