LOCUS HSU69612 2877 bp mRNA linear HUM 25-APR-1997 DEFINITION Human TNF-alpha converting enzyme precursor, mRNA, alternatively spliced, complete cds. ACCESSION U69612 VERSION U69612.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2877) AUTHORS Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L., Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S., Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R., Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and Cerretti,D.P. TITLE A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells JOURNAL Nature 385 (6618), 729-733 (1997) PUBMED 9034190 REFERENCE 2 (bases 1 to 2877) AUTHORS Cerretti,D.P. TITLE Direct Submission JOURNAL Submitted (06-SEP-1996) Molecular Biology, Immunex Corp., 51 University St., Seattle, WA 98101, USA FEATURES Location/Qualifiers source 1..2877 /db_xref="H-InvDB:HIT000221078" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 123..2207 /note="transmembrane metalloproteinase/disintegrin; adamalysin; TACEB." /codon_start=1 /product="TNF-alpha converting enzyme precursor" /protein_id="AAB53014.1" /translation="MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDI LSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGK NESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADP DPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG IQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCL AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTV CLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFL RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI FWIPFSILVHCV" sig_peptide 123..173 mat_peptide 174..2204 /product="TNF-alpha converting enzyme" /note="transmembrane metalloproteinase/disintegrin; adamalysin; TACEB" misc_feature 2136..2204 /note="encodes transmembrane domain" BASE COUNT 847 a 572 c 709 g 749 t ORIGIN 1 ggaaaagagg attgaggggc taggccgggc ggatcccgtc ctcccccgat gtgagcagtt 61 ttccgaaacc ccgtcaggcg aaggctgccc agagaggtgg agtcggtagc ggggccggga 121 acatgaggca gtctctccta ttcctgacca gcgtggttcc tttcgtgctg gcgccgcgac 181 ctccggatga cccgggcttc ggcccccacc agagactcga gaagcttgat tctttgctct 241 cagactacga tattctctct ttatctaata tccagcagca ttcggtaaga aaaagagatc 301 tacagacttc aacacatgta gaaacactac taactttttc agctttgaaa aggcatttta 361 aattatacct gacatcaagt actgaacgtt tttcacaaaa tttcaaggtc gtggtggtgg 421 atggtaaaaa cgaaagcgag tacactgtaa aatggcagga cttcttcact ggacacgtgg 481 ttggtgagcc tgactctagg gttctagccc acataagaga tgatgatgtt ataatcagaa 541 tcaacacaga tggggccgaa tataacatag agccactttg gagatttgtt aatgatacca 601 aagacaaaag aatgttagtt tataaatctg aagatatcaa gaatgtttca cgtttgcagt 661 ctccaaaagt gtgtggttat ttaaaagtgg ataatgaaga gttgctccca aaagggttag 721 tagacagaga accacctgaa gagcttgttc atcgagtgaa aagaagagct gacccagatc 781 ccatgaagaa cacgtgtaaa ttattggtgg tagcagatca tcgcttctac agatacatgg 841 gcagagggga agagagtaca actacaaatt acttaataga gctaattgac agagttgatg 901 acatctatcg gaacacttca tgggataatg caggttttaa aggctatgga atacagatag 961 agcagattcg cattctcaag tctccacaag aggtaaaacc tggtgaaaag cactacaaca 1021 tggcaaaaag ttacccaaat gaagaaaagg atgcttggga tgtgaagatg ttgctagagc 1081 aatttagctt tgatatagct gaggaagcat ctaaagtttg cttggcacac cttttcacat 1141 accaagattt tgatatggga actcttggat tagcttatgt tggctctccc agagcaaaca 1201 gccatggagg tgtttgtcca aaggcttatt atagcccagt tgggaagaaa aatatctatt 1261 tgaatagtgg tttgacgagc acaaagaatt atggtaaaac catccttaca aaggaagctg 1321 acctggttac aactcatgaa ttgggacata attttggagc agaacatgat ccggatggtc 1381 tagcagaatg tgccccgaat gaggaccagg gagggaaata tgtcatgtat cccatagctg 1441 tgagtggcga tcacgagaac aataagatgt tttcaaactg cagtaaacaa tcaatctata 1501 agaccattga aagtaaggcc caggagtgtt ttcaagaacg cagcaataaa gtttgtggga 1561 actcgagggt ggatgaagga gaagagtgtg atcctggcat catgtatctg aacaacgaca 1621 cctgctgcaa cagcgactgc acgttgaagg aaggtgtcca gtgcagtgac aggaacagtc 1681 cttgctgtaa aaactgtcag tttgagactg cccagaagaa gtgccaggag gcgattaatg 1741 ctacttgcaa aggcgtgtcc tactgcacag gtaatagcag tgagtgcccg cctccaggaa 1801 atgctgaaga tgacactgtt tgcttggatc ttggcaagtg taaggatggg aaatgcatcc 1861 ctttctgcga gagggaacag cagctggagt cctgtgcatg taatgaaact gacaactcct 1921 gcaaggtgtg ctgcagggac ctttccggcc gctgtgtgcc ctatgtcgat gctgaacaaa 1981 agaacttatt tttgaggaaa ggaaagccct gtacagtagg attttgtgac atgaatggca 2041 aatgtgagaa acgagtacag gatgtaattg aacgattttg ggatttcatt gaccagctga 2101 gcatcaatac ttttggaaag tttttagcag acaacatcgt tgggtctgtc ctggttttct 2161 ccttgatatt ttggattcct ttcagcattc ttgtccattg tgtgtaacgt cgaaatgctg 2221 agcagcatgg attctgcatc ggttcgcatt atcaaaccct ttcctgcgcc ccagactcca 2281 ggccgcctgc agcctgcccc tgtgatccct tcggcgccag cagctccaaa actggaccac 2341 cagagaatgg acaccatcca ggaagacccc agcacagact cacatatgga cgaggatggg 2401 tttgagaagg accccttccc aaatagcagc acagctgcca agtcatttga ggatctcacg 2461 gaccatccgg tcaccagaag tgaaaaggct gcctccttta aactgcagcg tcagaatcgt 2521 gttgacagca aagaaacaga gtgctaattt agttctcagc tcttctgact taagtgtgca 2581 aaatattttt atagatttga cctacaatca atcacagctt atattttgtg aagactggga 2641 agtgacttag cagatgctgg tcatgtgttt gaacttcctg caggtaaaca gttcttgtgt 2701 ggtttggccc ttctcctttt gaaaaggtaa ggtgaaggtg aatctagctt attttgaggc 2761 tttcaggttt tagtttttaa aatatctttt gacctgtggt gcaaaagcag aaaatacagc 2821 tggattgggt tatgagtatt tacgtttttg taaattaatc ttttatattg ataacag //