LOCUS       HSU69612                2877 bp    mRNA    linear   HUM 25-APR-1997
DEFINITION  Human TNF-alpha converting enzyme precursor, mRNA, alternatively
            spliced, complete cds.
ACCESSION   U69612
VERSION     U69612.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L.,
            Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S.,
            Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R.,
            Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and
            Cerretti,D.P.
  TITLE     A metalloproteinase disintegrin that releases tumour-necrosis
            factor-alpha from cells
  JOURNAL   Nature 385 (6618), 729-733 (1997)
   PUBMED   9034190
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Cerretti,D.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-1996) Molecular Biology, Immunex Corp., 51
            University St., Seattle, WA 98101, USA
FEATURES             Location/Qualifiers
     source          1..2877
                     /db_xref="H-InvDB:HIT000221078"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             123..2207
                     /note="transmembrane metalloproteinase/disintegrin;
                     adamalysin; TACEB."
                     /codon_start=1
                     /product="TNF-alpha converting enzyme precursor"
                     /protein_id="AAB53014.1"
                     /translation="MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDI
                     LSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGK
                     NESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK
                     DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADP
                     DPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG
                     IQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCL
                     AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK
                     TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
                     SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL
                     KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTV
                     CLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFL
                     RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI
                     FWIPFSILVHCV"
     sig_peptide     123..173
     mat_peptide     174..2204
                     /product="TNF-alpha converting enzyme"
                     /note="transmembrane metalloproteinase/disintegrin;
                     adamalysin; TACEB"
     misc_feature    2136..2204
                     /note="encodes transmembrane domain"
BASE COUNT          847 a          572 c          709 g          749 t
ORIGIN      
        1 ggaaaagagg attgaggggc taggccgggc ggatcccgtc ctcccccgat gtgagcagtt
       61 ttccgaaacc ccgtcaggcg aaggctgccc agagaggtgg agtcggtagc ggggccggga
      121 acatgaggca gtctctccta ttcctgacca gcgtggttcc tttcgtgctg gcgccgcgac
      181 ctccggatga cccgggcttc ggcccccacc agagactcga gaagcttgat tctttgctct
      241 cagactacga tattctctct ttatctaata tccagcagca ttcggtaaga aaaagagatc
      301 tacagacttc aacacatgta gaaacactac taactttttc agctttgaaa aggcatttta
      361 aattatacct gacatcaagt actgaacgtt tttcacaaaa tttcaaggtc gtggtggtgg
      421 atggtaaaaa cgaaagcgag tacactgtaa aatggcagga cttcttcact ggacacgtgg
      481 ttggtgagcc tgactctagg gttctagccc acataagaga tgatgatgtt ataatcagaa
      541 tcaacacaga tggggccgaa tataacatag agccactttg gagatttgtt aatgatacca
      601 aagacaaaag aatgttagtt tataaatctg aagatatcaa gaatgtttca cgtttgcagt
      661 ctccaaaagt gtgtggttat ttaaaagtgg ataatgaaga gttgctccca aaagggttag
      721 tagacagaga accacctgaa gagcttgttc atcgagtgaa aagaagagct gacccagatc
      781 ccatgaagaa cacgtgtaaa ttattggtgg tagcagatca tcgcttctac agatacatgg
      841 gcagagggga agagagtaca actacaaatt acttaataga gctaattgac agagttgatg
      901 acatctatcg gaacacttca tgggataatg caggttttaa aggctatgga atacagatag
      961 agcagattcg cattctcaag tctccacaag aggtaaaacc tggtgaaaag cactacaaca
     1021 tggcaaaaag ttacccaaat gaagaaaagg atgcttggga tgtgaagatg ttgctagagc
     1081 aatttagctt tgatatagct gaggaagcat ctaaagtttg cttggcacac cttttcacat
     1141 accaagattt tgatatggga actcttggat tagcttatgt tggctctccc agagcaaaca
     1201 gccatggagg tgtttgtcca aaggcttatt atagcccagt tgggaagaaa aatatctatt
     1261 tgaatagtgg tttgacgagc acaaagaatt atggtaaaac catccttaca aaggaagctg
     1321 acctggttac aactcatgaa ttgggacata attttggagc agaacatgat ccggatggtc
     1381 tagcagaatg tgccccgaat gaggaccagg gagggaaata tgtcatgtat cccatagctg
     1441 tgagtggcga tcacgagaac aataagatgt tttcaaactg cagtaaacaa tcaatctata
     1501 agaccattga aagtaaggcc caggagtgtt ttcaagaacg cagcaataaa gtttgtggga
     1561 actcgagggt ggatgaagga gaagagtgtg atcctggcat catgtatctg aacaacgaca
     1621 cctgctgcaa cagcgactgc acgttgaagg aaggtgtcca gtgcagtgac aggaacagtc
     1681 cttgctgtaa aaactgtcag tttgagactg cccagaagaa gtgccaggag gcgattaatg
     1741 ctacttgcaa aggcgtgtcc tactgcacag gtaatagcag tgagtgcccg cctccaggaa
     1801 atgctgaaga tgacactgtt tgcttggatc ttggcaagtg taaggatggg aaatgcatcc
     1861 ctttctgcga gagggaacag cagctggagt cctgtgcatg taatgaaact gacaactcct
     1921 gcaaggtgtg ctgcagggac ctttccggcc gctgtgtgcc ctatgtcgat gctgaacaaa
     1981 agaacttatt tttgaggaaa ggaaagccct gtacagtagg attttgtgac atgaatggca
     2041 aatgtgagaa acgagtacag gatgtaattg aacgattttg ggatttcatt gaccagctga
     2101 gcatcaatac ttttggaaag tttttagcag acaacatcgt tgggtctgtc ctggttttct
     2161 ccttgatatt ttggattcct ttcagcattc ttgtccattg tgtgtaacgt cgaaatgctg
     2221 agcagcatgg attctgcatc ggttcgcatt atcaaaccct ttcctgcgcc ccagactcca
     2281 ggccgcctgc agcctgcccc tgtgatccct tcggcgccag cagctccaaa actggaccac
     2341 cagagaatgg acaccatcca ggaagacccc agcacagact cacatatgga cgaggatggg
     2401 tttgagaagg accccttccc aaatagcagc acagctgcca agtcatttga ggatctcacg
     2461 gaccatccgg tcaccagaag tgaaaaggct gcctccttta aactgcagcg tcagaatcgt
     2521 gttgacagca aagaaacaga gtgctaattt agttctcagc tcttctgact taagtgtgca
     2581 aaatattttt atagatttga cctacaatca atcacagctt atattttgtg aagactggga
     2641 agtgacttag cagatgctgg tcatgtgttt gaacttcctg caggtaaaca gttcttgtgt
     2701 ggtttggccc ttctcctttt gaaaaggtaa ggtgaaggtg aatctagctt attttgaggc
     2761 tttcaggttt tagtttttaa aatatctttt gacctgtggt gcaaaagcag aaaatacagc
     2821 tggattgggt tatgagtatt tacgtttttg taaattaatc ttttatattg ataacag
//