LOCUS HSU69611 3014 bp mRNA linear HUM 09-APR-1997 DEFINITION Human TNF-alpha converting enzyme mRNA, complete cds. ACCESSION U69611 VERSION U69611.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3014) AUTHORS Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L., Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S., Nelson,N., Bioani,N., Schooley,K.A., Gerhart,M., Davis,R., Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and Cerretti,D.P. TITLE A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells JOURNAL Nature 385 (6618), 729-733 (1997) PUBMED 9034190 REFERENCE 2 (bases 1 to 3014) AUTHORS Cerretti,D.P. TITLE Direct Submission JOURNAL Submitted (06-SEP-1996) Molecular Biology, Immunex Corp., 51 University St., Seattle, WA 98101, USA FEATURES Location/Qualifiers source 1..3014 /db_xref="H-InvDB:HIT000221077" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 115..2589 /note="transmembrane metalloproteinase/disintegrin; adamalysin; TACEA" /codon_start=1 /product="TNF-alpha converting enzyme" /protein_id="AAB51514.1" /translation="MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDI LSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGK NESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK DKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADP DPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG IQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCL AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGK TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTV CLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFL RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI FWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQ PAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDH PVTRSEKAASFKLQRQNRVDSKETEC" misc_feature 2128..2296 /note="encodes transmembrane domain" BASE COUNT 886 a 595 c 735 g 798 t ORIGIN 1 ggattgaggg gctaggccgg gcggatcccg tcctcccccg atgtgagcag ttttccgaaa 61 ccccgtcagg cgaaggctgc ccagagaggt ggagtcggta gcggggccgg gaacatgagg 121 cagtctctcc tattcctgac cagcgtggtt cctttcgtgc tggcgccgcg acctccggat 181 gacccgggct tcggccccca ccagagactc gagaagcttg attctttgct ctcagactac 241 gatattctct ctttatctaa tatccagcag cattcggtaa gaaaaagaga tctacagact 301 tcaacacatg tagaaacact actaactttt tcagctttga aaaggcattt taaattatac 361 ctgacatcaa gtactgaacg tttttcacaa aatttcaagg tcgtggtggt ggatggtaaa 421 aacgaaagcg agtacactgt aaaatggcag gacttcttca ctggacacgt ggttggtgag 481 cctgactcta gggttctagc ccacataaga gatgatgatg ttataatcag aatcaacaca 541 gatggggccg aatataacat agagccactt tggagatttg ttaatgatac caaagacaaa 601 agaatgttag tttataaatc tgaagatatc aagaatgttt cacgtttgca gtctccaaaa 661 gtgtgtggtt atttaaaagt ggataatgaa gagttgctcc caaaagggtt agtagacaga 721 gaaccacctg aagagcttgt tcatcgagtg aaaagaagag ctgacccaga tcccatgaag 781 aacacgtgta aattattggt ggtagcagat catcgcttct acagatacat gggcagaggg 841 gaagagagta caactacaaa ttacttaata gagctaattg acagagttga tgacatctat 901 cggaacactt catgggataa tgcaggtttt aaaggctatg gaatacagat agagcagatt 961 cgcattctca agtctccaca agaggtaaaa cctggtgaaa agcactacaa catggcaaaa 1021 agttacccaa atgaagaaaa ggatgcttgg gatgtgaaga tgttgctaga gcaatttagc 1081 tttgatatag ctgaggaagc atctaaagtt tgcttggcac accttttcac ataccaagat 1141 tttgatatgg gaactcttgg attagcttat gttggctctc ccagagcaaa cagccatgga 1201 ggtgtttgtc caaaggctta ttatagccca gttgggaaga aaaatatcta tttgaatagt 1261 ggtttgacga gcacaaagaa ttatggtaaa accatcctta caaaggaagc tgacctggtt 1321 acaactcatg aattgggaca taattttgga gcagaacatg atccggatgg tctagcagaa 1381 tgtgccccga atgaggacca gggagggaaa tatgtcatgt atcccatagc tgtgagtggc 1441 gatcacgaga acaataagat gttttcaaac tgcagtaaac aatcaatcta taagaccatt 1501 gaaagtaagg cccaggagtg ttttcaagaa cgcagcaata aagtttgtgg gaactcgagg 1561 gtggatgaag gagaagagtg tgatcctggc atcatgtatc tgaacaacga cacctgctgc 1621 aacagcgact gcacgttgaa ggaaggtgtc cagtgcagtg acaggaacag tccttgctgt 1681 aaaaactgtc agtttgagac tgcccagaag aagtgccagg aggcgattaa tgctacttgc 1741 aaaggcgtgt cctactgcac aggtaatagc agtgagtgcc cgcctccagg aaatgctgaa 1801 gatgacactg tttgcttgga tcttggcaag tgtaaggatg ggaaatgcat ccctttctgc 1861 gagagggaac agcagctgga gtcctgtgca tgtaatgaaa ctgacaactc ctgcaaggtg 1921 tgctgcaggg acctttccgg ccgctgtgtg ccctatgtcg atgctgaaca aaagaactta 1981 tttttgagga aaggaaagcc ctgtacagta ggattttgtg acatgaatgg caaatgtgag 2041 aaacgagtac aggatgtaat tgaacgattt tgggatttca ttgaccagct gagcatcaat 2101 acttttggaa agtttttagc agacaacatc gttgggtctg tcctggtttt ctccttgata 2161 ttttggattc ctttcagcat tcttgtccat tgtgtggata agaaattgga taaacagtat 2221 gaatctctgt ctctgtttca ccccagtaac gtcgaaatgc tgagcagcat ggattctgca 2281 tcggttcgca ttatcaaacc ctttcctgcg ccccagactc caggccgcct gcagcctgcc 2341 cctgtgatcc cttcggcgcc agcagctcca aaactggacc accagagaat ggacaccatc 2401 caggaagacc ccagcacaga ctcacatatg gacgaggatg ggtttgagaa ggaccccttc 2461 ccaaatagca gcacagctgc caagtcattt gaggatctca cggaccatcc ggtcaccaga 2521 agtgaaaagg ctgcctcctt taaactgcag cgtcagaatc gtgttgacag caaagaaaca 2581 gagtgctaat ttagttctca gctcttctga cttaagtgtg caaaatattt ttatagattt 2641 gacctacaat caatcacagc ttatattttg tgaagactgg gaagtgactt agcagatgct 2701 ggtcatgtgt ttgaacttcc tgcaggtaaa cagttcttgt gtggtttggc ccttctcctt 2761 ttgaaaaggt aaggtgaagg tgaatctagc ttattttgag gctttcaggt tttagttttt 2821 aaaatatctt ttgacctgtg gtgcaaaagc agaaaataca gctggattgg gttatgagta 2881 tttacgtttt tgtaaattaa tcttttatat tgataacagc actgactagg gaaatgatca 2941 gttttttttt tatacactgt aatgaaccgc tgaatatgag gcatttggca tttatttgtg 3001 atgacaactg gaat //