LOCUS HSU68485 1921 bp mRNA linear HUM 27-APR-1999
DEFINITION Homo sapiens bridging integrator protein-1 (BIN1) mRNA, complete
cds.
ACCESSION U68485
VERSION U68485.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1921)
AUTHORS Sakamuro,D., Elliott,K.J., Wechsler-Reya,R. and Prendergast,G.C.
TITLE BIN1 is a novel MYC-interacting protein with features of a tumour
suppressor
JOURNAL Nat. Genet. 14 (1), 69-77 (1996)
PUBMED 8782822
REFERENCE 2 (bases 1 to 1921)
AUTHORS Sakamuro,D., Elliott,K.J., Wechsler-Reya,R. and Prendergast,G.C.
TITLE Direct Submission
JOURNAL Submitted (29-AUG-1996) Wistar Institute, 3601 Spruce Street,
Philadelphia, PA 19104, USA
REFERENCE 3 (bases 1 to 1921)
AUTHORS Sakamuro,D., Elliott,K.J., Wechsler-Reya,R. and Prendergast,G.C.
TITLE Direct Submission
JOURNAL Submitted (27-MAY-1998) Wistar Institute, 3601 Spruce Street,
Philadelphia, PA 19104, USA
REMARK Sequence update by submitter
COMMENT On May 27, 1998 this sequence version replaced gi:1710134.
FEATURES Location/Qualifiers
source 1..1921
/db_xref="H-InvDB:HIT000221050"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q14"
/tissue_type="skeletal muscle"
gene 1..1921
/gene="BIN1"
CDS 47..1411
/gene="BIN1"
/function="associates with the N-terminal transactivation
domain of MYC in a manner requiring the integrity of the
conserved MYC box regions 1 and 2 (MB1, MB2)"
/codon_start=1
/product="bridging integrator protein-1"
/protein_id="AAC17461.1"
/translation="MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQF
EQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANK
IAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESL
QTAKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLE
ENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPRKKSKLFSRLRRKKNSDNAPAK
GNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAG
AQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDY
TATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFT
ERVP"
BASE COUNT 468 a 537 c 593 g 323 t
ORIGIN
1 ccccgcgcga gagcggccct tgccaccggg cgaggcctgc gccgcgatgg cagagatggg
61 cagtaaaggg gtgacggcgg gaaagatcgc cagcaacgtg cagaagaagc tcacccgcgc
121 gcaggagaag gttctccaga agctggggaa ggcagatgag accaaggatg agcagtttga
181 gcagtgcgtc cagaatttca acaagcagct gacggagggc acccggctgc agaaggatct
241 ccggacctac ctggcctccg tcaaagccat gcacgaggct tccaagaagc tgaatgagtg
301 tctgcaggag gtgtatgagc ccgattggcc cggcagggat gaggcaaaca agatcgcaga
361 gaacaacgac ctgctgtgga tggattacca ccagaagctg gtggaccagg cgctgctgac
421 catggacacg tacctgggcc agttccccga catcaagtca cgcattgcca agcgggggcg
481 caagctggtg gactacgaca gtgcccggca ccactacgag tcccttcaaa ctgccaaaaa
541 gaaggatgaa gccaaaattg ccaaggccga ggaggagctc atcaaagccc agaaggtgtt
601 tgaggagatg aatgtggatc tgcaggagga gctgccgtcc ctgtggaaca gccgcgtagg
661 tttctacgtc aacacgttcc agagcatcgc gggcctggag gaaaacttcc acaaggagat
721 gagcaagctc aaccagaacc tcaatgatgt gctggtcggc ctggagaagc aacacgggag
781 caacaccttc acggtcaagg cccagcccag aaagaaaagt aaactgtttt cgcggctgcg
841 cagaaagaag aacagtgaca acgcgcctgc aaaagggaac aagagccctt cgcctccaga
901 tggctcccct gccgccaccc ccgagatcag agtcaaccac gagccagagc cggccggcgg
961 ggccacgccc ggggccaccc tccccaagtc cccatctcag ccagcagagg cctcggaggt
1021 ggcgggtggg acccaacctg cggctggagc ccaggagcca ggggagacgg cggcaagtga
1081 agcagcctcc agctctcttc ctgctgtcgt ggtggagacc ttcccagcaa ctgtgaatgg
1141 caccgtggag ggcggcagtg gggccgggcg cttggacctg cccccaggtt tcatgttcaa
1201 ggtacaggcc cagcacgact acacggccac tgacacagac gagctgcagc tcaaggctgg
1261 tgatgtggtg ctggtgatcc ccttccagaa ccctgaagag caggatgaag gctggctcat
1321 gggcgtgaag gagagcgact ggaaccagca caaggagctg gagaagtgcc gtggcgtctt
1381 ccccgagaac ttcactgaga gggtcccatg acggcggggc ccaggcagcc tccgggcgtg
1441 tgaagaacac ctcctcccga aaaatgtgtg gttctttttt ttgttttgtt ttcgtttttc
1501 atcttttgaa gagcaaaggg aaatcaagag gagaccccca ggcagagggg cgttctccca
1561 aagtttaggt cgttttccaa agagccgcgt cccggcaagt ccggcggaat tcaccagtgt
1621 tcctgaagct gctgtgtcct ctagttgagt ttctggcgcc cctgcctgtg cccgcatgtg
1681 tgcctggccg cagggcgggg ctgggggctg ccgagccacc atacttaact gaagcttcgg
1741 ccgcaccacc cggggaaggg tcctcttttc ctggcagctg ctgtgggtgg ggcccagaca
1801 ccagcctagc ctgctctgcc ccgcagacgg tctgtgtgct gtttgaaaat aaatcttagt
1861 gttcaaaaca aaatgaaaca aaaaaaaaaa tgataaaaac tctcaaaaaa acaaggaatt
1921 c
//