LOCUS HSU67733 4240 bp mRNA linear HUM 21-MAY-1997
DEFINITION Human cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase
PDE2A3 (PDE2A) mRNA, complete cds.
ACCESSION U67733
VERSION U67733.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4240)
AUTHORS Rosman,G.J., Martins,T.J., Sonnenburg,W.K., Beavo,J.A., Ferguson,K.
and Loughney,K.
TITLE Isolation and characterization of human cDNAs encoding a
cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase
JOURNAL Gene 191 (1), 89-95 (1997)
PUBMED 9210593
REFERENCE 2 (bases 1 to 4240)
AUTHORS Rosman,G.J., Martins,T.J., Sonnenburg,W.K., Beavo,J.A., Ferguson,K.
and Loughney,K.
TITLE Direct Submission
JOURNAL Submitted (21-AUG-1996) Icos Corporation, 22021 20th Ave. S.E.,
Bothell, WA 98021, USA
FEATURES Location/Qualifiers
source 1..4240
/db_xref="H-InvDB:HIT000221019"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..4240
/gene="PDE2A"
CDS 162..2987
/gene="PDE2A"
/function="cGMP-stimulated 3',5'-cyclic nucleotide
phosphodiesterase"
/note="PDE2 family; splice variant 3"
/codon_start=1
/product="PDE2A3"
/protein_id="AAC51320.1"
/translation="MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCA
DSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELP
QEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAA
VILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQK
GGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSC
KVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVP
VISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCE
CQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVV
DDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIK
NENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHL
ANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ
DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLE
DIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNT
HGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRL
LLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIP
ELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLD
FLDEEYEVPDLDGTRAPINGCCSLDAE"
BASE COUNT 902 a 1260 c 1202 g 876 t
ORIGIN
1 cagcagagct ggattggggt gttgagtcca ggctgagtag ggggcagccc actgctcttg
61 gtccctgtgc ctgctggggg tgccctgccc tgaactccag gcagcgggga cagggcgagg
121 tgccacctta gtctggctgg ggaggcggac gatgaggagt gatggggcag gcatgcggcc
181 actccatcct ctgcaggagc cagcagtacc cggcagcgcg accggctgag ccgcggggcc
241 agcaggtctt cctcaagccg gacgagccgc cgccgccgcc gcagccatgc gccgacagcc
301 tgcaggacgc cttgctgagt ctgggctctg tcatcgacat ttcaggcctg caacgtgctg
361 tcaaggaggc cctgtcagct gtgctccccc gagtggaaac tgtctacacc tacctactgg
421 atggtgagtc ccagctggtg tgtgaggacc ccccacatga gctgccccag gaggggaaag
481 tccgggaggc tatcatctcc cagaagcggc tgggctgcaa tgggctgggc ttctcagacc
541 tgccagggaa gcccttggcc aggctggtgg ctccactggc tcctgatacc caagtgctgg
601 tcatgccgct agcggacaag gaggctgggg ccgtggcagc tgtcatcttg gtgcactgtg
661 gccagctgag tgataatgag gaatggagcc tgcaggcggt ggagaagcat accctggtcg
721 ccctgcggag ggtgcaggtc ctgcagcagc gcgggcccag ggaggctccc cgagccgtcc
781 agaacccccc ggaggggacg gcggaagacc agaagggcgg ggcggcgtac accgaccgcg
841 accgcaagat cctccaactg tgcggggaac tctacgacct ggatgcctct tccctgcagc
901 tcaaagtgct ccaatacctg cagcaggaga cccgggcatc ccgctgctgc ctcctgctgg
961 tgtcggagga caatctccag ctttcttgca aggtcatcgg agacaaagtg ctcggggaag
1021 aggtcagctt tcccttgaca ggatgcctgg gccaggtggt ggaagacaag aagtccatcc
1081 agctgaagga cctcacctcc gaggatgtac aacagctgca gagcatgttg ggctgtgagc
1141 tgcaggccat gctctgtgtc cctgtcatca gccgggccac tgaccaggtg gtggccttgg
1201 cctgcgcctt caacaagcta gaaggagact tgttcaccga cgaggacgag catgtgatcc
1261 agcactgctt ccactacacc agcaccgtgc tcaccagcac cctggccttc cagaaggaac
1321 agaaactcaa gtgtgagtgc caggctcttc tccaagtggc aaagaacctc ttcacccacc
1381 tggatgacgt ctctgtcctg ctccaggaga tcatcacgga ggccagaaac ctcagcaacg
1441 cagagatctg ctctgtgttc ctgctggatc agaatgagct ggtggccaag gtgttcgacg
1501 ggggcgtggt ggatgatgag agctatgaga tccgcatccc ggccgatcag ggcatcgcgg
1561 gacacgtggc gaccacgggc cagatcctga acatccctga cgcatatgcc catccgcttt
1621 tctaccgcgg cgtggacgac agcaccggct tccgcacgcg caacatcctc tgcttcccca
1681 tcaagaacga gaaccaggag gtcatcggtg tggccgagct ggtgaacaag atcaatgggc
1741 catggttcag caagttcgac gaggacctgg cgacggcctt ctccatctac tgcggcatca
1801 gcatcgccca ttctctccta tacaaaaaag tgaatgaggc tcagtatcgc agccacctgg
1861 ccaatgagat gatgatgtac cacatgaagg tctccgacga tgagtatacc aaacttctcc
1921 atgatgggat ccagcctgtg gctgccattg actccaattt tgcaagtttc acctataccc
1981 ctcgttccct gcccgaggat gacacgtcca tggccatcct gagcatgctg caggacatga
2041 atttcatcaa caactacaaa attgactgcc cgaccctggc ccggttctgt ttgatggtga
2101 agaagggcta ccgggatccc ccctaccaca actggatgca cgccttttct gtctcccact
2161 tctgctacct gctctacaag aacctggagc tcaccaacta cctcgaggac atcgagatct
2221 ttgccttgtt tatttcctgc atgtgtcatg acctggacca cagaggcaca aacaactctt
2281 tccaggtggc ctcgaaatct gtgctggctg cgctctacag ctctgagggc tccgtcatgg
2341 agaggcacca ctttgctcag gccatcgcca tcctcaacac ccacggctgc aacatctttg
2401 atcatttctc ccggaaggac tatcagcgca tgctggatct gatgcgggac atcatcttgg
2461 ccacagacct ggcccaccat ctccgcatct tcaaggacct ccagaagatg gctgaggtgg
2521 gctacgaccg aaacaacaag cagcaccaca gacttctcct ctgcctcctc atgacctcct
2581 gtgacctctc tgaccagacc aagggctgga agactacgag aaagatcgcg gagctgatct
2641 acaaagaatt cttctcccag ggagacctgg agaaggccat gggcaacagg ccgatggaga
2701 tgatggaccg ggagaaggcc tatatccctg agctgcaaat cagcttcatg gagcacattg
2761 caatgcccat ctacaagctg ttgcaggacc tgttccccaa agcggcagag ctgtacgagc
2821 gcgtggcctc caaccgtgag cactggacca aggtgtccca caagttcacc atccgcggcc
2881 tcccaagtaa caactcgctg gacttcctgg atgaggagta cgaggtgcct gatctggatg
2941 gcactagggc ccccatcaat ggctgctgca gccttgatgc tgagtgatcc cctccaggac
3001 acttccctgc ccaggccacc tcccacagcc ctccactggt ctggccagat gcactgggaa
3061 cagagccacg ggtcctgggt cctagaccag gacttcctgt gtgaccctgg acaagtacta
3121 ccttcctggg cctcagcttt ctcgtctgta taatggaagc aagacttcca acctcacgga
3181 gactttgtaa tttgcttctc tgagagcaca ggggtgacca atgagcagtg ggccctactc
3241 tgcacctctg accacacctt ggcaagtctt tcccaagcca ttctttgtct gagcagcttg
3301 atggtttctc cttgccccat ttctgcccca ccagatcttt gctcctttcc ctttgaggac
3361 tcccaccctt tgggtctcca ggatcctcat ggaaggggaa ggtgagacat ctgagtgagc
3421 agagtgtggc atcttggaaa cagtccttag ttctgtggga ggactagaaa cagccgcggc
3481 gaaggccccc tgaggaccac tactatactg atggtgggat tgggacctgg gggatacagg
3541 ggccccagga agaagctggc cagaggggca gctcagtgct ctgcagagag gggccctggg
3601 gagaagcagg atgggattga tgggcaggag ggatccccgc actgggagac aggcccaggt
3661 atgaatgagc cagccatgct tcctcctgcc tgtgtgacgc tgggcgagtc tcttcccctg
3721 tctgggccaa acagggagcg ggtaagacaa tccatgctct aagatccatt ttagatcaat
3781 gtctaaaata gctctatggc tctgcggagt cccagcagag gctatggaat gtttctgcaa
3841 ccctaaggca cagagagcca accctgagtg tctcagaggc cccctgagtg ttccccttgg
3901 cctgagcccc ttacccattc ctgcagccag tgagagacct ggcctcagcc tggcagcgct
3961 ctcttcaagg ccatatccac ctgtgccctg gggcttggga gaccccatag gccgggactc
4021 ttgggtcagc ccgccactgg cttctctctt tttctccgtt tcattctgtg tgcgttgtgg
4081 ggtgggggag ggggtccacc tgccttacct ttctgagttg cctttagaga gatgcgtttt
4141 tctaggactc tgtgcaactg tcgtatatgg tcccgtgggc tgaccgcttt gtacatgaga
4201 ataaatctat ttctttctac caaaaaaaaa aaaaaaaaaa
//