LOCUS HSU67156 5236 bp mRNA linear HUM 10-DEC-1996
DEFINITION Human mitogen-activated kinase kinase kinase 5 (MAPKKK5) mRNA,
complete cds.
ACCESSION U67156
VERSION U67156.1
KEYWORDS kinase; mitogen-activated; mapk, mapkkk; mekk.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5236)
AUTHORS Wang,X.S., Diener,K., Jannuzzi,D., Trollinger,D., Tan,T.H.,
Lichenstein,H., Zukowski,M. and Yao,Z.
TITLE Molecular cloning and characterization of a novel protein kinase
with a catalytic domain homologous to mitogen-activated protein
kinase kinase kinase
JOURNAL J. Biol. Chem. 271 (49), 31607-31611 (1996)
PUBMED 8940179
REFERENCE 2 (bases 1 to 5236)
AUTHORS Wang,X., Diener,K., Jannuzzi,D., Trollinger,D., Tan,T.H.,
Lichenstein,H., Zukowski,M. and Yao,Z.
TITLE Direct Submission
JOURNAL Submitted (16-AUG-1996) Biology, Amgen Inc., 3200 Walnut Street,
Boulder, CO 80301, USA
FEATURES Location/Qualifiers
source 1..5236
/db_xref="H-InvDB:HIT000221007"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..5236
/gene="MAPKKK5"
CDS 361..4485
/gene="MAPKKK5"
/function="upstream activator of c-Jun kinase pathway"
/note="protein kinase; phosphorylates MKK4 in vitro"
/codon_start=1
/product="mitogen-activated kinase kinase kinase 5"
/protein_id="AAC50894.1"
/translation="MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEH
QLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQ
GQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAF
RQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMIT
PHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESI
LNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLV
ETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCL
VGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSF
ELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPA
WYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEP
TKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFL
YVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGD
RVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQY
LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ
IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPR
GYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAF
ILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVL
VEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSA
PPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHIT
TLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHN
IKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSN
QTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRK
EKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT"
BASE COUNT 1510 a 1139 c 1264 g 1320 t
ORIGIN
1 cgagcgcggc gcccttgagc tgcaccgcgg cgcaggtttg cgagccgact tgtcagccgg
61 ccaagaaaag gaagctccgt cccttcccgc tcacccggct tccccacccc ttgtactcta
121 aactctgcac agggcgagcg gcgcggccac tgatgcgccg aggaggagcg agccgccgcc
181 gggcagcggc gtgccctcgg gggagagggc gccggataag agcggcggcg cggcggcgat
241 ggcgcggcgc gcgatggcag ctgcttagcc cggcgggcgc ggagcagccc cgagctgtgg
301 ctggccaggc ggtgcggctg ggcgggggac gccgccgccg ttgctgcccg gcccggagag
361 atgagcacgg aggcggacga aggcatcact ttctctgtgc cacccttcgc cccctcgggc
421 ttctgcacca tccccgaggg cggcatctgc aggaggggag gagcggcggc ggtgggcgag
481 ggcgaggagc accagctgcc accgccgccg ccgggcagct tctggaacgt ggagagcgcc
541 gctgcccctg gcatcggttg tccggcggcc acctcctcga gcagtgccac ccgaggccgg
601 ggcagctctg ttggcggggg cagccgacgg accacggtgg catatgtgat caacgaagcg
661 agccaagggc aactggtggt ggccgagagc gaggccctgc agagcttgcg ggaggcgtgc
721 gagacagtgg gcgccaccct ggaaaccctg cattttggga aactcgactt tggagaaacc
781 accgtgctgg accgctttta caatgcagat attgcggtgg tggagatgag cgatgccttc
841 cggcagccgt ccttgtttta ccaccttggg gtgagagaaa gtttcagcat ggccaacaac
901 atcatcctct actgtgatac taactcggac tctctgcagt cactgaagga aataatttgc
961 cagaagaata ctatgtgcac tgggaactac acctttgttc cttacatgat aactccacat
1021 aacaaagtct actgctgtga cagcagcttc atgaaggggt tgacagagct catgcaaccg
1081 aacttcgagc tgcttcttgg acccatctgc ttacctcttg tggatcgttt tattcaactt
1141 ttgaaggtgg cacaagcaag ttctagccag tacttccggg aatctatact caatgacatc
1201 aggaaagctc gtaatttata cactggtaaa gaattggcag ctgagttggc aagaattcgg
1261 cagcgagtag ataatatcga agtcttgaca gcagatattg tcataaatct gttactttcc
1321 tacagagata tccaggacta tgattctatt gtgaagctgg tagagacttt agaaaaactg
1381 ccaacctttg atttggcctc ccatcaccat gtgaagtttc attatgcatt tgcactgaat
1441 aggagaaatc tccctggtga cagagcaaaa gctcttgata ttatgattcc catggtgcaa
1501 agcgaaggac aagttgcttc agatatgtat tgcctagttg gtcgaatcta caaagatatg
1561 tttttggact ctaatttcac ggacactgaa agcagagacc atggagcttc ttggttcaaa
1621 aaggcatttg aatctgagcc aacactacag tcaggaatta attatgcggt cctcctcctg
1681 gcagctggac accagtttga atcttccttt gagctccgga aagttggggt gaagctaagt
1741 agtcttcttg gtaaaaaggg aaacttggaa aaactccaga gctactggga agttggattt
1801 tttctggggg ccagcgtcct agccaatgac cacatgagag tcattcaagc atctgaaaag
1861 ctttttaaac tgaagacacc agcatggtac ctcaagtcta ttgtagagac aattttaata
1921 tataagcatt ttgtgaaact gaccacagaa cagcctgtgg ccaagcaaga acttgtggac
1981 ttttggatgg atttcctggt cgaggccaca aagacagatg ttactgtggt taggtttcca
2041 gtattaatat tagaaccaac caaaatctat caaccttctt atttgtctat caacaatgaa
2101 gttgaggaaa agacaatctc tatttggcac gtgcttcctg atgacaagaa aggtatacat
2161 gagtggaatt ttagtgcctc ttctgtcagg ggagtgagta tttctaaatt tgaagaaaga
2221 tgctgctttc tttatgtgct tcacaattct gatgatttcc aaatctattt ctgtacagaa
2281 cttcattgta aaaagttttt tgagatggtg aacaccatta ccgaagagaa ggggagaagc
2341 acagaggaag gagactgtga aagtgacttg ctggagtatg actatgaata tgatgaaaat
2401 ggtgacagag tcgttttagg aaaaggcact tatgggatag tctacgcagg tcgggacttg
2461 agcaaccaag tcagaattgc tattaaggaa atcccagaga gagacagcag atactctcag
2521 cccctgcatg aagaaatagc attgcataaa cacctgaagc acaaaaatat tgtccagtat
2581 ctgggctctt tcagtgagaa tggtttcatt aaaatcttca tggagcaggt ccctggagga
2641 agtctttctg ctctccttcg ttccaaatgg ggtccattaa aagacaatga gcaaacaatt
2701 ggcttttata caaagcaaat actggaagga ttaaaatatc tccatgacaa tcagatagtt
2761 caccgggaca taaagggtga caatgtgttg attaatacct acagtggtgt tctcaagatc
2821 tctgacttcg gaacatcaaa gaggcttgct ggcataaacc cctgtactga aacttttact
2881 ggtaccctcc agtatatggc accagaaata atagataaag gaccaagagg ctacggaaaa
2941 gcagcagaca tctggtctct gggctgtaca atcattgaaa tggccacagg aaaaccccca
3001 ttttatgaac tgggagaacc acaagcagct atgttcaagg tgggaatgtt taaagtccac
3061 cctgagatcc cagagtccat gtctgcagag gccaaggcat tcatactgaa atgttttgaa
3121 ccagatcctg acaagagagc ctgtgctaac gacttgcttg ttgatgagtt tttaaaagtt
3181 tcaagcaaaa agaaaaagac acaacctaag ctttcagctc tttcagctgg atcaaatgaa
3241 tatctcagga gtatatcctt gccggtacct gtgctggtgg aggacaccag cagcagcagt
3301 gagtacggct cagtttcacc cgacacggag ttgaaagtgg accccttctc tttcaaaaca
3361 agagccaagt cctgcggaga aagagatgtc aagggaattc ggacactctt tttgggcatt
3421 ccagatgaga attttgaaga tcacagtgct cctccttccc ctgaagaaaa agattctgga
3481 ttcttcatgc tgaggaagga cagtgagagg cgagctaccc ttcacaggat cctgacggaa
3541 gaccaagaca aaattgtgag aaacctaatg gaatctttag ctcagggggc tgaagaaccg
3601 aaactaaaat gggaacacat cacaaccctc attgcaagcc tcagagaatt tgtgagatcc
3661 actgaccgaa aaatcatagc caccacactg tcaaagctga aactggagct ggacttcgac
3721 agccatggca ttagccaagt ccaggtggta ctctttggtt ttcaagatgc tgtcaataaa
3781 gttcttcgga atcataacat caagccgcac tggatgtttg ccttagacag tatcattcgg
3841 aaggcggtac agacagccat taccatcctg gttccagaac taaggccaca tttcagcctt
3901 gcatctgaga gtgatactgc tgatcaagaa gacttggatg tagaagatga ccatgaggaa
3961 cagccttcaa atcaaactgt ccgaagacct caggctgtca ttgaagatgc tgtggctacc
4021 tcaggcgtga gcacgctcag ttctactgtg tctcatgatt cccagagtgc tcaccggtca
4081 ctgaatgtac agcttggaag gatgaaaata gaaaccaata gattactgga agaattggtt
4141 cggaaagaga aagaattaca agcactcctt catcgagcta ttgaagaaaa agaccaagaa
4201 attaaacacc tgaagcttaa gtcccaaccc atagaaattc ctgaattgcc tgtatttcat
4261 ctaaattctt ctggcacaaa tactgaagat tctgaactta ccgactggct gagagtgaat
4321 ggagctgatg aagacactat aagccggttt ttggctgaag attatacact attggatgtt
4381 ctctactatg ttacacgtga tgacttaaaa tgcttgagac taaggggagg gatgctgtgc
4441 acactgtgga aggctatcat tgactttcga aacaaacaga cttgactgtt gctcaatcta
4501 atcttcgatg gaaattctaa aaattaatac agagctgatc ttcttggggg tgggaaaatc
4561 gaagggagar gagaaaggcg ctgcmcttta aatccagtat ttgtttactc atgttaaaaa
4621 aaaaaaaaac agacaaaaca cactgaaatt tcctaactac atctatttct ataattttta
4681 aggactnttc ataaggactc ttaaaataat cctgaacatt agaaccctaa tgttcaggaa
4741 gattttaatc taagcatttt tatggaaata tttttaatgc agcagctatt gcacttcagc
4801 caaatgttta tttcacacaa aacggatgta acattcatgt gatcgtgcac ccactggaca
4861 aaccaaaatg tgaccataac tgtttaggtt ctgtgtgttt gtaatatgtc taataatctg
4921 gagtagaaat gcgtaatttc aattactgta taaagtttat gtttttttaa gtgtgcagaa
4981 tctgagagca atggttttta cttctctgtg ttaattgtaa tattgactct attttgtaac
5041 ttaagtttct gacctgtcgt acatttgttt gagtcgttta tgtactactg aactgtacca
5101 gttgcacatg cttgaactgt agtaatgtta gcttgttcta aagctatcca ttgtgtcata
5161 tttactctaa aaattaaaga gactctcaac aaaaaaaaaa aaaaaaaaaa accatggtac
5221 ccggatcctc gaattc
//