LOCUS HSU66702 4719 bp mRNA linear HUM 18-OCT-1996
DEFINITION Human phogrin mRNA, complete cds.
ACCESSION U66702
VERSION U66702.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4719)
AUTHORS Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.
TITLE Molecular cloning and characterization of the human transmembrane
protein tyrosine phosphatase homologue, phogrin, an autoantigen of
type 1 diabetes
JOURNAL Biochem. Biophys. Res. Commun. 227 (2), 440-447 (1996)
PUBMED 8878534
REFERENCE 2 (bases 1 to 4719)
AUTHORS Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.
TITLE Direct Submission
JOURNAL Submitted (12-AUG-1996) Barbara Davis Center for Childhood
Diabetes, University of Colorado Health Sciences Center, 4200 East
9th Avenue, Box B-140, Denver, CO 80262, USA
FEATURES Location/Qualifiers
source 1..4719
/db_xref="H-InvDB:HIT000220987"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="islet"
/tissue_type="pancreas"
CDS 15..3062
/note="protein tyrosine phosphatase homolog"
/codon_start=1
/product="phogrin"
/protein_id="AAC50742.1"
/translation="MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEG
LCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQ
YVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEA
LSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGPRTQLREDLLP
RTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMP
RPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAE
LMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEV
HRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQ
TYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEE
EARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVT
TEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLA
CILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRP
EGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLK
NKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHS
DYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQC
YHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDR
GVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEI
DIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ"
BASE COUNT 1057 a 1404 c 1340 g 918 t
ORIGIN
1 aaccggctgc ggggatgggg ccaccgctcc cgctgctgct gctgctactg ctgctgctgc
61 cgccacgcgt cctgcctgcc gccccttcgt ccgtcccccg cggccggcag ctcccggggc
121 gtctgggctg cctgctcgag gagggcctct gcggagcgtc cgaggcctgt gtgaacgatg
181 gagtgtttgg aaggtgccag aaggttccgg caatggactt ttaccgctac gaggtgtcgc
241 ccgtggccct gcagcgcctg cgcgtggcgt tgcagaagct ttccggcaca ggtttcacgt
301 ggcaggatga ctatactcag tatgtgatgg accaggaact tgcagacctc ccgaaaacct
361 acctgaggcg tcctgaagca tccagcccag ccaggccctc aaaacacagc gttggcagcg
421 agaggaggta cagtcgggag ggcggtgctg ccctggccaa cgccctccga cgccacctgc
481 ccttcctgga ggccctgtcc caggccccag cctcagacgt gctcgccagg acccatacgg
541 cgcaggacag accccccgct gagggtgatg accgcttctc cgagagcatc ctgacctatg
601 tggcccacac gtctgcgctg acgtaccctc ccgggccccg gacccagctc cgggaggacc
661 tcctgccgcg gaccctcggc cagctccagc cagatgagct cagccctaag gtggacagtg
721 gtgtggacag acaccatctg atggcggccc tcagtgccta tgctgcccag aggcccccag
781 ctccccccgg ggagggcagc ctggagccac agtaccttct gcgtgcaccc tcaagaatgc
841 ccaggccttt gctggcacca gccgcccccc agaagtggcc ttcacctctg ggagattccg
901 aagacccctc cagcacaggc gatggagcac ggattcatac cctcctgaag gacctgcaga
961 ggcagccggc tgaggtgagg ggcctgagtg gcctggagct ggacggcatg gctgagctga
1021 tggctggcct gatgcaaggc gtggaccatg gagtagctcg aggcagccct gggagagcgg
1081 ccctgggaga gtctggagaa caggcggatg gccccaaggc caccctccgt ggagacagct
1141 ttccagatga cggagtgcag gacgacgatg atagacttta ccaagaggtc caccgtctga
1201 gtgccacact cgggggcctc ctgcaggacc acgggtctcg actcttacct ggagccctcc
1261 cctttgcaag gcccctcgac atggagagga agaagtccga gcaccctgag tcttccctgt
1321 cttcagaaga ggagactgcc ggagtggaga acgtcaagag ccagacgtat tccaaagatc
1381 tgctggggca gcagccgcat tcggagcccg gggccgctgc gtttggggag ctccaaaacc
1441 agatgcctgg gccctcgaag gaggagcaga gccttccagc gggtgctcag gaggccctca
1501 gcgacggcct gcaattggag gtccagcctt ccgaggaaga ggcgcggggc tacatcgtga
1561 cagacagaga ccccctgcgc cccgaggaag gaaggcggct ggtggaggac gtcgcccgcc
1621 tcctgcaggt gcccagcagt gcgttcgctg acgtggaggt tctcggacca gcagtgacct
1681 tcaaagtgag cgccaatgtc caaaacgtga ccactgagga tgtggagaag gccacagttg
1741 acaacaaaga caaactggag gaaacctctg gactgaaaat tcttcaaacc ggagtcgggt
1801 cgaaaagcaa actcaagttc ctgcctcctc aggcggagca agaagactcc accaagttca
1861 tcgcgctcac cctggtctcc ctcgcctgca tcctgggcgt cctcctggcc tctggcctca
1921 tctactgcct ccgccatagc tctcagcaca ggctgaagga gaagctctcg ggactagggg
1981 gcgacccagg tgcagatgcc actgccgcct accaggagct gtgccgccag cgtatggcca
2041 cgcggccacc agaccgacct gagggcccgc acacgtcacg catcagcagc gtctcatccc
2101 agttcagcga cgggccgatc cccagcccct ccgcacgcag cagcgcctca tcctggtccg
2161 aggagcctgt gcagtccaac atggacatct ccaccggcca catgatcctg tcctacatgg
2221 aggaccacct gaagaacaag aaccggctgg agaaggagtg ggaagcgctg tgcgcctacc
2281 aggcggagcc caacagctcg ttcgtggccc agagggagga gaacgtgccc aagaaccgct
2341 ccctggctgt gctgacctat gaccactccc gggtcctgct gaaggcggag aacagccaca
2401 gccactcaga ctacatcaac gctagcccca tcatggatca cgacccgagg aaccccgcgt
2461 acatcgccac ccagggaccg ctgcccgcca ccgtggctga cttttggcag atggtgtggg
2521 agagcggctg cgtggtgatc gtcatgctga cacccctcgc ggagaacggc gtccggcagt
2581 gctaccacta ctggccggat gaaggctcca atctctacca catctatgag gtgaacctgg
2641 tctccgagca catctggtgt gaggacttcc tggtgaggag cttctatctg aagaacctgc
2701 agaccaacga gacgcgcacc gtgacgcagt tccacttcct gagttggtat gaccgaggag
2761 tcccttcctc ctcaaggtcc ctcctggact tccgcagaaa agtaaacaaa tgctacaggg
2821 gccgttcttg tccgataatt gttcattgca gtgacggtgc aggccggagc ggcacctacg
2881 tcctgatcga catggttctc aacaagatgg ccaaaggtgc taaagagatt gatatcgcag
2941 cgaccctgga gcacttgagg gaccagagac ccggcatggt ccagacgaag gagcagtttg
3001 agttcgcgct gacagccgtg gctgaggagg tgaacgccat cctcaaggcc cttccccagt
3061 gagcggcagc gtcaggggcc tcaggggagc ccccacccca cggatgttgt caggaatcat
3121 gatctgactt taattgtgtg tcttctatta taactgcata gtaatagggc ccttagctct
3181 cccgtagtca gcgcagttta gcagttaaaa gtgtattttt gtttaatcaa acaataataa
3241 agagagattt gtggaaaaat ccagttacgg gtggagggga atcggttcat caattttcac
3301 ttgcttaaaa aaaatacttt ttcttaaagc acccgttcac cttcttggtt gaagttgtgt
3361 taacaatgca gtagccagca cgttcgaggc ggtttccagg aagagtgtgc ttgtcatctg
3421 ccactttcgg gagggtggat ccactgtgca ggagtggccg gggaagctgg cagcactcag
3481 tgaggccgcc cggcacacaa ggcacgtttg gcatttctct ttgagagagt ttatcattgg
3541 gagaagccgc ggggacagaa ctgaacgtcc tgcagcttcg gggcaagtga gacaatcaca
3601 gctcctcgct gcgtctccat caacactgcg ccgggtacca tggacggccc cgtcagccac
3661 accggtcagc ccaagcagag tgattcaggg gctccccggg ggcagacacc tgtgcacccc
3721 atgagtagtg cccacttgag gctggcactc ccctgacctc acctttgcaa agttacagat
3781 gcaccccaac attgagatgt gtttttaatg ttaaaatatt gatttctacg ttatgaaaac
3841 agatgccccc gtgaatgctt acctgtgaga taaccacaac caggaagaac aaatctgggc
3901 attgagcaag ctatgagggt ccccgggagc acacgaaccc tgccaggccc ccgctggctc
3961 ctccaggcac gtcccggacc tgtggggccc cagagagggg acatttccct cctgggagag
4021 aaggagatca gggcaactcg gagagggctg cgagcatttc cctcccggga gaggaaatca
4081 gggcgacctg cacgcactgc gtagagcctg gaagggaagt gagaaaccag ccgaccggcc
4141 ctgcccctct tcccgggatc acttaatgaa ccacgtgttt tgacatcatg ttaacctaag
4201 cacgtacaga tgattccgga tttgacaaaa taacatttga gtatccgatt cgccatcacc
4261 cctacccccg aaataggaca actcacttca ttgaccagga tgatcacatg gaaggcggcg
4321 cagaggcagc tgtgtgggct gcagatttcc tgtgtggggt tcagcgtata aaacgcacct
4381 ccatcccgcc cttcccacag cattcctcca tcttagatag atggtactct ccaaaggccc
4441 taccagaggg aacacggcct actgagcgga cagaatgatg ccaaaatatt gcttatgtct
4501 ctacatggta ttgtaatgaa tatctgcttt aatatagcta tcatttcttt tccaaaatta
4561 cttctcttta tctggaattt aattaatcga aatgaattta tctgaatata ggaagcatat
4621 gcctacttgt aatttctaac tacttatgtt tgaagagaaa cctccggtgt gagatataca
4681 aatatattta attgtgtcat attaaacttc ccggaattc
//