LOCUS HSU63420 2905 bp mRNA linear HUM 15-NOV-1996
DEFINITION Human Sp140 protein (Sp140) mRNA, complete cds.
ACCESSION U63420
VERSION U63420.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2905)
AUTHORS Bloch,D.B., de la Monte,S.M., Guigaouri,P., Filippov,A. and
Bloch,K.D.
TITLE Identification and characterization of a leukocyte-specific
component of the nuclear body
JOURNAL J. Biol. Chem. 271 (46), 29198-29204 (1996)
PUBMED 8910577
REFERENCE 2 (bases 1 to 2905)
AUTHORS Bloch,D.B., de la Monte,S.M., Guigaouri,P., Filippov,A. and
Bloch,K.D.
TITLE Direct Submission
JOURNAL Submitted (10-JUL-1996) Harvard Medical School, Massachusetts
General Hospital, Arthritis Research, 8th Floor, Charlestown Navy
Yard, Massachusetts General Hospital East, 149 13th St.,
Charlestown, MA 02129, USA
FEATURES Location/Qualifiers
source 1..2905
/db_xref="H-InvDB:HIT000220772"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="Sp140.1; Sp140.2"
/cell_line="HEpG2; HUVEC"
/cell_type="umbilical vein endothelial"
/tissue_type="placenta"
gene 1..2905
/gene="Sp140"
CDS 107..2368
/gene="Sp140"
/note="similar to autoantigen Sp100"
/codon_start=1
/product="Sp140 protein"
/protein_id="AAC50817.1"
/translation="MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFR
FFRENKVEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSEL
EKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPY
GKQENSNACHEMDDIAVPQEALSSSARCEPGFSSESCEQLALPKAGGGDAEDAPSLLP
VSCKLAIQIDEGESEEMPKLLPYDTEETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSD
DCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSA
YENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRRKKRGHG
WSRMRMRRQKNSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGRKRGKPGTRFTQSDR
AAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGILHKKKLQQGILVKCIQTEDGKW
FTPTEFEIKGGHARSKNWRLSVRCGGWPLRWLMENGFLPDPPRIRYRKKKRILKSQNN
SSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKES
PGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLK
EPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNF
KEVFAIQETNGNN"
misc_feature 1140..1200
/gene="Sp140"
/note="encodes presumed nuclear localization sequence"
misc_feature 1735..1857
/gene="Sp140"
/note="encodes zinc-finger motif"
misc_feature 2041..2145
/gene="Sp140"
/note="encodes bromodomain"
BASE COUNT 874 a 610 c 760 g 661 t
ORIGIN
1 gtgctctttg actgagcacc gaggggcagt tggcagcttc acctcagagc tgcaggaagg
61 aacggggcag tgaaaatcga atcgggtgtg atcctaggcc aagctcatgg cccagcaggg
121 ccagcagggg caaatggcaa gtggagacag caatctcaac ttcaggatgg tcgcagagat
181 ccagaacgta gagggtcaga acctgcagga gcaggtttgc cctgagccca ttttcaggtt
241 cttcagagaa aacaaggtgg agattgcaag tgcaataaca aggccatttc ctttccttat
301 gggcctccga gaccgctcct tcatctccga gcagatgtat gaacattttc aagaagcttt
361 tagaaacctg gtcccagtga caagagtgat gtattgtgta ctcagtgaac tggagaagac
421 atttggctgg tcacatctgg aagcattgtt cagcaggatt aacctgatgg cctatcctga
481 tttaaacgag atttacagaa gcttccagaa tgtatgctat gaacactcac ctctccaaat
541 gaataatgta aacgatttag aagatagacc cagattacta ccatatggta aacaagagaa
601 cagcaatgcc tgtcatgaaa tggatgatat agcagtgcct caggaagcct tgagctcctc
661 ggcaaggtgt gagccaggtt tctcttcaga gtcttgtgag cagttagctc tcccaaaggc
721 tggtggagga gatgctgaag atgcacccag cctactacca gtgtcctgta aacttgctat
781 acaaatagat gaaggagaat cagaagaaat gcccaagtta ctgccttatg atacagaaga
841 gacctttgat ctaaaaactc cccaagtcac taatgaagga gaaccagaga aggggctctg
901 tctactacca ggtgaaggag aagagggcag tgatgactgt tcggaaatgt gtgatggaga
961 agagcgccag gaagcctcta gctccctagc aagacgtggg tcagtgtcta gtgaactaga
1021 aaatcaccca atgaatgaag aaggagaatc agaagagctt gcttctagcc tgctatatga
1081 taatgtacca ggagcggagc aatcagcata tgaaaatgag aagtgttcct gtgtcatgtg
1141 tttctcagaa gaggtgccag gaagcccaga agcaaggacg gaaagtgatc aagcgtgtgg
1201 cacaatggat actgtggata ttgcaaacaa ctccactttg ggaaaaccca agaggaaaag
1261 aagaaaaaag agggggcatg gctggagcag aatgagaatg agaaggcaga aaaacagcca
1321 acaaaatgat aatagcaaag ccgacggcca ggtggtctcc agtgaaaaga aggcgaacgt
1381 gaatctgaaa gacctttcca agattagggg gagaaagaga ggcaaacctg gaacccgctt
1441 cactcagagt gacagagctg cacagaaaag agtccgatca agagcttcaa gaaagcacaa
1501 agatgaaact gtggatttta aggctccttt gcttccagtg acctgtggtg gggtgaaggg
1561 aattttacat aagaagaaat tgcagcaagg aatcttggtg aagtgtatac agactgagga
1621 tggaaaatgg ttcaccccca cggaatttga aatcaaagga ggccatgcaa gatcaaagaa
1681 ctggaggctg agtgtgcgct gtggcgggtg gcccctacga tggctgatgg agaatggatt
1741 tctgcctgat cctccaagaa tacgttacag gaaaaaaaag agaatactga agtctcaaaa
1801 caatagctca gttgaccctt gtatgagaaa cctggatgag tgtgaggtgt gccgggacgg
1861 aggggagctg ttctgttgcg acacttgttc aagagtcttc catgaggact gtcacatccc
1921 gcctgtggaa gctgagagga ccccgtggaa ttgcatcttc tgcaggatga aggagtctcc
1981 gggaagccaa cagtgttgtc aggaatctga ggtcctggag aggcagatgt gtcctgagga
2041 acagttgaaa tgtgagttcc tcctcttgaa agtctattgc tgttctgaga gctccttttt
2101 tgccaagatt ccatactatt attatattag agaggcgtgt caaggcctga aggagcccat
2161 gtggttggat aaaatcaaga aaaggctgaa tgagcacggt tacccccaag tggaggggtt
2221 tgtacaagac atgcgcctca tcttccagaa ccacagggcc tcttacaagt acaaggattt
2281 tggccaaatg ggatttagac tggaggctga gtttgagaag aatttcaagg aagtgtttgc
2341 tattcaggaa acaaatggga acaattgact ggattagtgg atgctgaaag cattcagcaa
2401 atggcaccct aaaatatgcc gctggtttgc cactgacttc aaaatgaggt cacttgggca
2461 cagcacatgc agggaggggc ttttctctga gcctccttca tctgcccaaa gacaaatcct
2521 caaaaggaaa ttcaatcatc atgaatcaca accccaagta tctcatcagc cagggaagag
2581 taagtgggat cacagggaag gatgttggca gcgacaccat cccatacagg ctcttacctc
2641 ttctcctgag ggctgctcca gacaacattt attacccaga agaccttttg tctgaaaacc
2701 agccaagctt tattcaggac acacttcttg ccttcacttt cccacttccg tggccacctc
2761 catgcagaag ccctaagccc acattctttc aatagctcac ggtggtgcat gagtgtccat
2821 catctgactc ttctcggagt ctcatatttt gtgggactcc tgtgcaaaca tatgttatta
2881 aaattttttt cctcctgtaa aggaa
//