LOCUS       HSU62540                6226 bp    mRNA    linear   HUM 13-DEC-2001
DEFINITION  Human anaplastic lymphoma kinase (ALK) mRNA, complete cds.
ACCESSION   U62540
VERSION     U62540.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6226)
  AUTHORS   Morris,S.W., Naeve,C., Mathew,P., James,P.L., Kirstein,M.N., Cui,X.
            and Witte,D.P.
  TITLE     ALK, the chromosome 2 gene locus altered by the t(2;5) in
            non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine
            kinase that is highly related to leukocyte tyrosine kinase (LTK)
  JOURNAL   Oncogene 14 (18), 2175-2188 (1997)
   PUBMED   9174053
REFERENCE   2  (bases 1 to 6226)
  AUTHORS   Morris,S.W., Naeve,C.W., Mathew,P., James,P.L., Kirstein,M.N.,
            Cui,X. and Witte,D.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUN-1996) Experimental Oncology, St. Jude Children's
            Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA
FEATURES             Location/Qualifiers
     source          1..6226
                     /db_xref="H-InvDB:HIT000220727"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23"
     gene            1..6226
                     /gene="ALK"
     CDS             912..5774
                     /gene="ALK"
                     /note="receptor tyrosine kinase"
                     /codon_start=1
                     /product="anaplastic lymphoma kinase"
                     /protein_id="AAB71619.1"
                     /translation="MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGSPLQPREPL
                     SYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLL
                     GPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGE
                     AAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQ
                     IFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEY
                     SPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTIL
                     SPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGR
                     IGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQ
                     LGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKD
                     ARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSL
                     VLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVA
                     FDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVH
                     WLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYG
                     AAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN
                     NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTF
                     HPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWG
                     WETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKV
                     MEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPH
                     LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI
                     MTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ
                     VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL
                     KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP
                     GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
                     EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI
                     ILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER
                     SPAAPPPLPTTSSGKAAKKPTAAEVSVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHG
                     SRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG
                     ASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILK
                     SKNSMNQPGP"
BASE COUNT         1378 a         1746 c         1861 g         1241 t
ORIGIN      
        1 aagcgggggc ggcagcggtg gtagcagctg gtacctcccg ccgcctctgt tcggagggtc
       61 gcggggcacc gaggtgcttt ccggccgccc tctggtcggc cacccaaagc cgcgggcgct
      121 gatgatgggt gaggaggggg cggcaagatt tcgggcgccc ctgccctgaa cgccctcagc
      181 tgctgccgcc ggggccgctc cagtgcctgc gaactctgag gagccgaggc gccggtgaga
      241 gcaaggacgc tgcaaacttg cgcagcgcgg gggctgggat tcacgcccag aagttcagca
      301 ggcagacagt ccgaagcctt cccgcagcgg agagatagct tgagggtgcg caagacggca
      361 gcctccgccc tcggttcccg cccagaccgg gcagaagagc ttggaggagc cacaaggaac
      421 gcaaaaggcg gccaggacag cgtgcagcag ctgggagccg ccgttctcag ccttaaaagt
      481 tgcagagatt ggaggctgcc ccgagagggg acagacccca gctccgactg cggggggcag
      541 gagaggacgg tacccaactg ccacctccct tcaaccatag tagttcctct gtaccgagcg
      601 cagcgagcta cagacggggg cgcggcactc ggcgcggaga gcgggaggct caaggtccca
      661 gccagtgagc ccagtgtgct tgagtgtctc tggactcgcc cctgagcttc caggtctgtt
      721 tcatttagac tcctgctcgc ctccgtgcag ttgggggaaa gcaagagact tgcgcgcacg
      781 cacagtcctc tggagatcag gtggaaggag ccgctgggta ccaaggactg ttcagagcct
      841 cttcccatct cggggagagc gaagggtgag gctgggcccg gagagcagtg taaacggcct
      901 cctccggcgg gatgggagcc atcgggctcc tgtggctgct gccgctgctg ctttccacgg
      961 cagctgtggg ctccgggatg gggaccggcc agcgcgcggg ctccccagct gcggggtcgc
     1021 cgctgcagcc ccgggagcca ctcagctact cgcgcctgca gaggaagagt ctggcagttg
     1081 acttcgtggt gccctcgctc ttccgtgtct acgcccggga cctactgctg ccaccatcct
     1141 cctcggagct gaaggctggc aggcccgagg cccgcggctc gctagctctg gactgcgccc
     1201 cgctgctcag gttgctgggg ccggcgccgg gggtctcctg gaccgccggt tcaccagccc
     1261 cggcagaggc ccggacgctg tccagggtgc tgaagggcgg ctccgtgcgc aagctccggc
     1321 gtgccaagca gttggtgctg gagctgggcg aggaggcgat cttggagggt tgcgtcgggc
     1381 cccccgggga ggcggctgtg gggctgctcc agttcaatct cagcgagctg ttcagttggt
     1441 ggattcgcca aggcgaaggg cgactgagga tccgcctgat gcccgagaag aaggcgtcgg
     1501 aagtgggcag agagggaagg ctgtccgcgg caattcgcgc ctcccagccc cgccttctct
     1561 tccagatctt cgggactggt catagctcct tggaatcacc aacaaacatg ccatctcctt
     1621 ctcctgatta ttttacatgg aatctcacct ggataatgaa agactccttc cctttcctgt
     1681 ctcatcgcag ccgatatggt ctggagtgca gctttgactt cccctgtgag ctggagtatt
     1741 cccctccact gcatgacctc aggaaccaga gctggtcctg gcgccgcatc ccctccgagg
     1801 aggcctccca gatggacttg ctggatgggc ctggggcaga gcgttctaag gagatgccca
     1861 gaggctcctt tctccttctc aacacctcag ctgactccaa gcacaccatc ctgagtccgt
     1921 ggatgaggag cagcagtgag cactgcacac tggccgtctc ggtgcacagg cacctgcagc
     1981 cctctggaag gtacattgcc cagctgctgc cccacaacga ggctgcaaga gagatcctcc
     2041 tgatgcccac tccagggaag catggttgga cagtgctcca gggaagaatc gggcgtccag
     2101 acaacccatt tcgagtggcc ctggaataca tctccagtgg aaaccgcagc ttgtctgcag
     2161 tggacttctt tgccctgaag aactgcagtg aaggaacatc cccaggctcc aagatggccc
     2221 tgcagagctc cttcacttgt tggaatggga cagtcctcca gcttgggcag gcctgtgact
     2281 tccaccagga ctgtgcccag ggagaagatg agagccagat gtgccggaaa ctgcctgtgg
     2341 gtttttactg caactttgaa gatggcttct gtggctggac ccaaggcaca ctgtcacccc
     2401 acactcctca gtggcaggtc aggaccctaa aggatgcccg gttccaggac caccaagacc
     2461 atgctctatt gctcagtacc actgatgtcc ccgcttctga aagtgctaca gtgaccagtg
     2521 ctacgtttcc tgcaccgatc aagagctctc catgtgagct ccgaatgtcc tggctcattc
     2581 gtggagtctt gaggggaaac gtgtccttgg tgctagtgga gaacaaaacc gggaaggagc
     2641 aaggcaggat ggtctggcat gtcgccgcct atgaaggctt gagcctgtgg cagtggatgg
     2701 tgttgcctct cctcgatgtg tctgacaggt tctggctgca gatggtcgca tggtggggac
     2761 aaggatccag agccatcgtg gcttttgaca atatctccat cagcctggac tgctacctca
     2821 ccattagcgg agaggacaag atcctgcaga atacagcacc caaatcaaga aacctgtttg
     2881 agagaaaccc aaacaaggag ctgaaacccg gggaaaattc accaagacag acccccatct
     2941 ttgaccctac agttcattgg ctgttcacca catgtggggc cagcgggccc catggcccca
     3001 cccaggcaca gtgcaacaac gcctaccaga actccaacct gagcgtggag gtggggagcg
     3061 agggccccct gaaaggcatc cagatctgga aggtgccagc caccgacacc tacagcatct
     3121 cgggctacgg agctgctggc gggaaaggcg ggaagaacac catgatgcgg tcccacggcg
     3181 tgtctgtgct gggcatcttc aacctggaga aggatgacat gctgtacatc ctggttgggc
     3241 agcagggaga ggacgcctgc cccagtacaa accagttaat ccagaaagtc tgcattggag
     3301 agaacaatgt gatagaagaa gaaatccgtg tgaacagaag cgtgcatgag tgggcaggag
     3361 gcggaggagg agggggtgga gccacctacg tatttaagat gaaggatgga gtgccggtgc
     3421 ccctgatcat tgcagccgga ggtggcggca gggcctacgg ggccaagaca gacacgttcc
     3481 acccagagag actggagaat aactcctcgg ttctagggct aaacggcaat tccggagccg
     3541 caggtggtgg aggtggctgg aatgataaca cttccttgct ctgggccgga aaatctttgc
     3601 aggagggtgc caccggagga cattcctgcc cccaggccat gaagaagtgg gggtgggaga
     3661 caagaggggg tttcggaggg ggtggagggg ggtgctcctc aggtggagga ggcggaggat
     3721 atataggcgg caatgcagcc tcaaacaatg accccgaaat ggatggggaa gatggggttt
     3781 ccttcatcag tccactgggc atcctgtaca ccccagcttt aaaagtgatg gaaggccacg
     3841 gggaagtgaa tattaagcat tatctaaact gcagtcactg tgaggtagac gaatgtcaca
     3901 tggaccctga aagccacaag gtcatctgct tctgtgacca cgggacggtg ctggctgagg
     3961 atggcgtctc ctgcattgtg tcacccaccc cggagccaca cctgccactc tcgctgatcc
     4021 tctctgtggt gacctctgcc ctcgtggccg ccctggtcct ggctttctcc ggcatcatga
     4081 ttgtgtaccg ccggaagcac caggagctgc aagccatgca gatggagctg cagagccctg
     4141 agtacaagct gagcaagctc cgcacctcga ccatcatgac cgactacaac cccaactact
     4201 gctttgctgg caagacctcc tccatcagtg acctgaagga ggtgccgcgg aaaaacatca
     4261 ccctcattcg gggtctgggc catggcgcct ttggggaggt gtatgaaggc caggtgtccg
     4321 gaatgcccaa cgacccaagc cccctgcaag tggctgtgaa gacgctgcct gaagtgtgct
     4381 ctgaacagga cgaactggat ttcctcatgg aagccctgat catcagcaaa ttcaaccacc
     4441 agaacattgt tcgctgcatt ggggtgagcc tgcaatccct gccccggttc atcctgctgg
     4501 agctcatggc ggggggagac ctcaagtcct tcctccgaga gacccgccct cgcccgagcc
     4561 agccctcctc cctggccatg ctggaccttc tgcacgtggc tcgggacatt gcctgtggct
     4621 gtcagtattt ggaggaaaac cacttcatcc accgagacat tgctgccaga aactgcctct
     4681 tgacctgtcc aggccctgga agagtggcca agattggaga cttcgggatg gcccgagaca
     4741 tctacagggc gagctactat agaaagggag gctgtgccat gctgccagtt aagtggatgc
     4801 ccccagaggc cttcatggaa ggaatattca cttctaaaac agacacatgg tcctttggag
     4861 tgctgctatg ggaaatcttt tctcttggat atatgccata ccccagcaaa agcaaccagg
     4921 aagttctgga gtttgtcacc agtggaggcc ggatggaccc acccaagaac tgccctgggc
     4981 ctgtataccg gataatgact cagtgctggc aacatcagcc tgaagacagg cccaactttg
     5041 ccatcatttt ggagaggatt gaatactgca cccaggaccc ggatgtaatc aacaccgctt
     5101 tgccgataga atatggtcca cttgtggaag aggaagagaa agtgcctgtg aggcccaagg
     5161 accctgaggg ggttcctcct ctcctggtct ctcaacaggc aaaacgggag gaggagcgca
     5221 gcccagctgc cccaccacct ctgcctacca cctcctctgg caaggctgca aagaaaccca
     5281 cagctgcaga ggtctctgtt cgagtcccta gagggccggc cgtggaaggg ggacacgtga
     5341 atatggcatt ctctcagtcc aaccctcctt cggagttgca caaggtccac ggatccagaa
     5401 acaagcccac cagcttgtgg aacccaacgt acggctcctg gtttacagag aaacccacca
     5461 aaaagaataa tcctatagca aagaaggagc cacacgacag gggtaacctg gggctggagg
     5521 gaagctgtac tgtcccacct aacgttgcaa ctgggagact tccgggggcc tcactgctcc
     5581 tagagccctc ttcgctgact gccaatatga aggaggtacc tctgttcagg ctacgtcact
     5641 tcccttgtgg gaatgtcaat tacggctacc agcaacaggg cttgccctta gaagccgcta
     5701 ctgcccctgg agctggtcat tacgaggata ccattctgaa aagcaagaat agcatgaacc
     5761 agcctgggcc ctgagctcgg tcgcacactc acttctcttc cttgggatcc ctaagaccgt
     5821 ggaggagaga gaggcaatgg ctccttcaca aaccagagac caaatgtcac gttttgtttt
     5881 gtgccaacct attttgaagt accaccaaaa aagctgtatt ttgaaaatgc tttagaaagg
     5941 ttttgagcat gggttcatcc tattctttcg aaagaagaaa atatcataaa aatgagtgat
     6001 aaatacaagg cccagatgtg gttgcataag gtttttatgc atgtttgttg tatacttcct
     6061 tatgcttctt ttaaattgtg tgtgctctgc ttcaatgtag tcagaattag ctgcttctat
     6121 gtttcatagt tggggtcata gatgtttcct tgccttgttg atgtggacat gagccatttg
     6181 aggggagagg gaacggaaat aaaggagtta tttgtaatga ctaaaa
//