LOCUS HSU62540 6226 bp mRNA linear HUM 13-DEC-2001 DEFINITION Human anaplastic lymphoma kinase (ALK) mRNA, complete cds. ACCESSION U62540 VERSION U62540.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6226) AUTHORS Morris,S.W., Naeve,C., Mathew,P., James,P.L., Kirstein,M.N., Cui,X. and Witte,D.P. TITLE ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK) JOURNAL Oncogene 14 (18), 2175-2188 (1997) PUBMED 9174053 REFERENCE 2 (bases 1 to 6226) AUTHORS Morris,S.W., Naeve,C.W., Mathew,P., James,P.L., Kirstein,M.N., Cui,X. and Witte,D.P. TITLE Direct Submission JOURNAL Submitted (28-JUN-1996) Experimental Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA FEATURES Location/Qualifiers source 1..6226 /db_xref="H-InvDB:HIT000220727" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2p23" gene 1..6226 /gene="ALK" CDS 912..5774 /gene="ALK" /note="receptor tyrosine kinase" /codon_start=1 /product="anaplastic lymphoma kinase" /protein_id="AAB71619.1" /translation="MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGSPLQPREPL SYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLL GPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGE AAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQ IFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEY SPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTIL SPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGR IGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQ LGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKD ARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSL VLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVA FDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVH WLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYG AAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTF HPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWG WETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKV MEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPH LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI MTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI ILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER SPAAPPPLPTTSSGKAAKKPTAAEVSVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHG SRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG ASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILK SKNSMNQPGP" BASE COUNT 1378 a 1746 c 1861 g 1241 t ORIGIN 1 aagcgggggc ggcagcggtg gtagcagctg gtacctcccg ccgcctctgt tcggagggtc 61 gcggggcacc gaggtgcttt ccggccgccc tctggtcggc cacccaaagc cgcgggcgct 121 gatgatgggt gaggaggggg cggcaagatt tcgggcgccc ctgccctgaa cgccctcagc 181 tgctgccgcc ggggccgctc cagtgcctgc gaactctgag gagccgaggc gccggtgaga 241 gcaaggacgc tgcaaacttg cgcagcgcgg gggctgggat tcacgcccag aagttcagca 301 ggcagacagt ccgaagcctt cccgcagcgg agagatagct tgagggtgcg caagacggca 361 gcctccgccc tcggttcccg cccagaccgg gcagaagagc ttggaggagc cacaaggaac 421 gcaaaaggcg gccaggacag cgtgcagcag ctgggagccg ccgttctcag ccttaaaagt 481 tgcagagatt ggaggctgcc ccgagagggg acagacccca gctccgactg cggggggcag 541 gagaggacgg tacccaactg ccacctccct tcaaccatag tagttcctct gtaccgagcg 601 cagcgagcta cagacggggg cgcggcactc ggcgcggaga gcgggaggct caaggtccca 661 gccagtgagc ccagtgtgct tgagtgtctc tggactcgcc cctgagcttc caggtctgtt 721 tcatttagac tcctgctcgc ctccgtgcag ttgggggaaa gcaagagact tgcgcgcacg 781 cacagtcctc tggagatcag gtggaaggag ccgctgggta ccaaggactg ttcagagcct 841 cttcccatct cggggagagc gaagggtgag gctgggcccg gagagcagtg taaacggcct 901 cctccggcgg gatgggagcc atcgggctcc tgtggctgct gccgctgctg ctttccacgg 961 cagctgtggg ctccgggatg gggaccggcc agcgcgcggg ctccccagct gcggggtcgc 1021 cgctgcagcc ccgggagcca ctcagctact cgcgcctgca gaggaagagt ctggcagttg 1081 acttcgtggt gccctcgctc ttccgtgtct acgcccggga cctactgctg ccaccatcct 1141 cctcggagct gaaggctggc aggcccgagg cccgcggctc gctagctctg gactgcgccc 1201 cgctgctcag gttgctgggg ccggcgccgg gggtctcctg gaccgccggt tcaccagccc 1261 cggcagaggc ccggacgctg tccagggtgc tgaagggcgg ctccgtgcgc aagctccggc 1321 gtgccaagca gttggtgctg gagctgggcg aggaggcgat cttggagggt tgcgtcgggc 1381 cccccgggga ggcggctgtg gggctgctcc agttcaatct cagcgagctg ttcagttggt 1441 ggattcgcca aggcgaaggg cgactgagga tccgcctgat gcccgagaag aaggcgtcgg 1501 aagtgggcag agagggaagg ctgtccgcgg caattcgcgc ctcccagccc cgccttctct 1561 tccagatctt cgggactggt catagctcct tggaatcacc aacaaacatg ccatctcctt 1621 ctcctgatta ttttacatgg aatctcacct ggataatgaa agactccttc cctttcctgt 1681 ctcatcgcag ccgatatggt ctggagtgca gctttgactt cccctgtgag ctggagtatt 1741 cccctccact gcatgacctc aggaaccaga gctggtcctg gcgccgcatc ccctccgagg 1801 aggcctccca gatggacttg ctggatgggc ctggggcaga gcgttctaag gagatgccca 1861 gaggctcctt tctccttctc aacacctcag ctgactccaa gcacaccatc ctgagtccgt 1921 ggatgaggag cagcagtgag cactgcacac tggccgtctc ggtgcacagg cacctgcagc 1981 cctctggaag gtacattgcc cagctgctgc cccacaacga ggctgcaaga gagatcctcc 2041 tgatgcccac tccagggaag catggttgga cagtgctcca gggaagaatc gggcgtccag 2101 acaacccatt tcgagtggcc ctggaataca tctccagtgg aaaccgcagc ttgtctgcag 2161 tggacttctt tgccctgaag aactgcagtg aaggaacatc cccaggctcc aagatggccc 2221 tgcagagctc cttcacttgt tggaatggga cagtcctcca gcttgggcag gcctgtgact 2281 tccaccagga ctgtgcccag ggagaagatg agagccagat gtgccggaaa ctgcctgtgg 2341 gtttttactg caactttgaa gatggcttct gtggctggac ccaaggcaca ctgtcacccc 2401 acactcctca gtggcaggtc aggaccctaa aggatgcccg gttccaggac caccaagacc 2461 atgctctatt gctcagtacc actgatgtcc ccgcttctga aagtgctaca gtgaccagtg 2521 ctacgtttcc tgcaccgatc aagagctctc catgtgagct ccgaatgtcc tggctcattc 2581 gtggagtctt gaggggaaac gtgtccttgg tgctagtgga gaacaaaacc gggaaggagc 2641 aaggcaggat ggtctggcat gtcgccgcct atgaaggctt gagcctgtgg cagtggatgg 2701 tgttgcctct cctcgatgtg tctgacaggt tctggctgca gatggtcgca tggtggggac 2761 aaggatccag agccatcgtg gcttttgaca atatctccat cagcctggac tgctacctca 2821 ccattagcgg agaggacaag atcctgcaga atacagcacc caaatcaaga aacctgtttg 2881 agagaaaccc aaacaaggag ctgaaacccg gggaaaattc accaagacag acccccatct 2941 ttgaccctac agttcattgg ctgttcacca catgtggggc cagcgggccc catggcccca 3001 cccaggcaca gtgcaacaac gcctaccaga actccaacct gagcgtggag gtggggagcg 3061 agggccccct gaaaggcatc cagatctgga aggtgccagc caccgacacc tacagcatct 3121 cgggctacgg agctgctggc gggaaaggcg ggaagaacac catgatgcgg tcccacggcg 3181 tgtctgtgct gggcatcttc aacctggaga aggatgacat gctgtacatc ctggttgggc 3241 agcagggaga ggacgcctgc cccagtacaa accagttaat ccagaaagtc tgcattggag 3301 agaacaatgt gatagaagaa gaaatccgtg tgaacagaag cgtgcatgag tgggcaggag 3361 gcggaggagg agggggtgga gccacctacg tatttaagat gaaggatgga gtgccggtgc 3421 ccctgatcat tgcagccgga ggtggcggca gggcctacgg ggccaagaca gacacgttcc 3481 acccagagag actggagaat aactcctcgg ttctagggct aaacggcaat tccggagccg 3541 caggtggtgg aggtggctgg aatgataaca cttccttgct ctgggccgga aaatctttgc 3601 aggagggtgc caccggagga cattcctgcc cccaggccat gaagaagtgg gggtgggaga 3661 caagaggggg tttcggaggg ggtggagggg ggtgctcctc aggtggagga ggcggaggat 3721 atataggcgg caatgcagcc tcaaacaatg accccgaaat ggatggggaa gatggggttt 3781 ccttcatcag tccactgggc atcctgtaca ccccagcttt aaaagtgatg gaaggccacg 3841 gggaagtgaa tattaagcat tatctaaact gcagtcactg tgaggtagac gaatgtcaca 3901 tggaccctga aagccacaag gtcatctgct tctgtgacca cgggacggtg ctggctgagg 3961 atggcgtctc ctgcattgtg tcacccaccc cggagccaca cctgccactc tcgctgatcc 4021 tctctgtggt gacctctgcc ctcgtggccg ccctggtcct ggctttctcc ggcatcatga 4081 ttgtgtaccg ccggaagcac caggagctgc aagccatgca gatggagctg cagagccctg 4141 agtacaagct gagcaagctc cgcacctcga ccatcatgac cgactacaac cccaactact 4201 gctttgctgg caagacctcc tccatcagtg acctgaagga ggtgccgcgg aaaaacatca 4261 ccctcattcg gggtctgggc catggcgcct ttggggaggt gtatgaaggc caggtgtccg 4321 gaatgcccaa cgacccaagc cccctgcaag tggctgtgaa gacgctgcct gaagtgtgct 4381 ctgaacagga cgaactggat ttcctcatgg aagccctgat catcagcaaa ttcaaccacc 4441 agaacattgt tcgctgcatt ggggtgagcc tgcaatccct gccccggttc atcctgctgg 4501 agctcatggc ggggggagac ctcaagtcct tcctccgaga gacccgccct cgcccgagcc 4561 agccctcctc cctggccatg ctggaccttc tgcacgtggc tcgggacatt gcctgtggct 4621 gtcagtattt ggaggaaaac cacttcatcc accgagacat tgctgccaga aactgcctct 4681 tgacctgtcc aggccctgga agagtggcca agattggaga cttcgggatg gcccgagaca 4741 tctacagggc gagctactat agaaagggag gctgtgccat gctgccagtt aagtggatgc 4801 ccccagaggc cttcatggaa ggaatattca cttctaaaac agacacatgg tcctttggag 4861 tgctgctatg ggaaatcttt tctcttggat atatgccata ccccagcaaa agcaaccagg 4921 aagttctgga gtttgtcacc agtggaggcc ggatggaccc acccaagaac tgccctgggc 4981 ctgtataccg gataatgact cagtgctggc aacatcagcc tgaagacagg cccaactttg 5041 ccatcatttt ggagaggatt gaatactgca cccaggaccc ggatgtaatc aacaccgctt 5101 tgccgataga atatggtcca cttgtggaag aggaagagaa agtgcctgtg aggcccaagg 5161 accctgaggg ggttcctcct ctcctggtct ctcaacaggc aaaacgggag gaggagcgca 5221 gcccagctgc cccaccacct ctgcctacca cctcctctgg caaggctgca aagaaaccca 5281 cagctgcaga ggtctctgtt cgagtcccta gagggccggc cgtggaaggg ggacacgtga 5341 atatggcatt ctctcagtcc aaccctcctt cggagttgca caaggtccac ggatccagaa 5401 acaagcccac cagcttgtgg aacccaacgt acggctcctg gtttacagag aaacccacca 5461 aaaagaataa tcctatagca aagaaggagc cacacgacag gggtaacctg gggctggagg 5521 gaagctgtac tgtcccacct aacgttgcaa ctgggagact tccgggggcc tcactgctcc 5581 tagagccctc ttcgctgact gccaatatga aggaggtacc tctgttcagg ctacgtcact 5641 tcccttgtgg gaatgtcaat tacggctacc agcaacaggg cttgccctta gaagccgcta 5701 ctgcccctgg agctggtcat tacgaggata ccattctgaa aagcaagaat agcatgaacc 5761 agcctgggcc ctgagctcgg tcgcacactc acttctcttc cttgggatcc ctaagaccgt 5821 ggaggagaga gaggcaatgg ctccttcaca aaccagagac caaatgtcac gttttgtttt 5881 gtgccaacct attttgaagt accaccaaaa aagctgtatt ttgaaaatgc tttagaaagg 5941 ttttgagcat gggttcatcc tattctttcg aaagaagaaa atatcataaa aatgagtgat 6001 aaatacaagg cccagatgtg gttgcataag gtttttatgc atgtttgttg tatacttcct 6061 tatgcttctt ttaaattgtg tgtgctctgc ttcaatgtag tcagaattag ctgcttctat 6121 gtttcatagt tggggtcata gatgtttcct tgccttgttg atgtggacat gagccatttg 6181 aggggagagg gaacggaaat aaaggagtta tttgtaatga ctaaaa //