LOCUS HSU62437 2448 bp mRNA linear HUM 11-JAN-1997
DEFINITION Human nicotinic acetylcholine receptor beta2 subunit precursor,
mRNA, complete cds.
ACCESSION U62437
VERSION U62437.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2448)
AUTHORS Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
TITLE Comparative structure of human neuronal alpha 2-alpha 7 and beta
2-beta 4 nicotinic acetylcholine receptor subunits and functional
expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
beta 4 subunits
JOURNAL J. Mol. Neurosci. 7 (3), 217-228 (1996)
PUBMED 8906617
REFERENCE 2 (bases 1 to 2448)
AUTHORS Elliott,K.J.
TITLE Direct Submission
JOURNAL Submitted (28-JUN-1996) Kathryn J. Elliott, SIBIA Neurosciences,
Inc., 505 Coast Blvd. So., La Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..2448
/db_xref="H-InvDB:HIT000220721"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="Construct Hbeta2.1F (prefrontal cortex Hbeta2.1 +
thalamus Hbeta2.2, Hbeta2.7)"
/tissue_type="prefrontal cortex; thalamus"
/clone_lib="SIBIA lambda gt11 libraries (M. Williams, S.
Ellis)"
5'UTR 1..264
CDS 265..1773
/codon_start=1
/product="nicotinic acetylcholine receptor beta2 subunit
precursor"
/protein_id="AAB40115.1"
/translation="MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNK
LIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNM
KKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVK
HFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD
STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLAL
TVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPW
VKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVN
RASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSED
WKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK"
sig_peptide 265..339
mat_peptide 340..1770
/product="nicotinic acetylcholine receptor beta2 subunit"
3'UTR 1774..2448
BASE COUNT 457 a 801 c 705 g 485 t
ORIGIN
1 ctcctccccc tcaccgtccc aattgtattc cctggaagag cagccggaaa agcctccgcc
61 tgctcatacc aggataggca agaagctggt ttctcctcgc agccggctcc ctgaggccca
121 ggaaccaccg cggcggccgg caccacctgg acccagctcc aggcgggcgc ggcttcagca
181 ccacggacag cgccccaccc gcggccctcc ccccggcggc gcgctccagc cggtgtaggc
241 gaggcagcga gctatgcccg cggcatggcc cggcgctgcg gccccgtggc gctgctcctt
301 ggcttcggcc tcctccggct gtgctcaggg gtgtggggta cggatacaga ggagcggctg
361 gtggagcatc tcctggatcc ttcccgctac aacaagctta tccgcccagc caccaatggc
421 tctgagctgg tgacagtaca gcttatggtg tcactggccc agctcatcag tgtgcatgag
481 cgggagcaga tcatgaccac caatgtctgg ctgacccagg agtgggaaga ttatcgcctc
541 acctggaagc ctgaagagtt tgacaacatg aagaaagttc ggctcccttc caaacacatc
601 tggctcccag atgtggtcct gtacaacaat gctgacggca tgtacgaggt gtccttctat
661 tccaatgccg tggtctccta tgatggcagc atcttctggc tgccgcctgc catctacaag
721 agcgcatgca agattgaagt aaagcacttc ccatttgacc agcagaactg caccatgaag
781 ttccgttcgt ggacctacga ccgcacagag atcgacttgg tgctgaagag tgaggtggcc
841 agcctggacg acttcacacc tagtggtgag tgggacatcg tggcgctgcc gggccggcgc
901 aacgagaacc ccgacgactc tacgtacgtg gacatcacgt atgacttcat cattcgccgc
961 aagccgctct tctacaccat caacctcatc atcccctgtg tgctcatcac ctcgctagcc
1021 atccttgtct tctacctgcc atccgactgt ggcgagaaga tgacgttgtg catctcagtg
1081 ctgctggcgc tcacggtctt cctgctgctc atctccaaga tcgtgcctcc cacctccctc
1141 gacgtgccgc tcgtcggcaa gtacctcatg ttcaccatgg tgcttgtcac cttctccatc
1201 gtcaccagcg tgtgcgtgct caacgtgcac caccgctcgc ccaccacgca caccatggcg
1261 ccctgggtga aggtcgtctt cctggagaag ctgcccgcgc tgctcttcat gcagcagcca
1321 cgccatcatt gcgcccgtca gcgcctgcgc ctgcggcgac gccagcgtga gcgcgagggc
1381 gctggagccc tcttcttccg cgaagcccca ggggccgact cctgcacgtg cttcgtcaac
1441 cgcgcgtcgg tgcaggggtt ggccggggcc ttcggggctg agcctgcacc agtggcgggc
1501 cccgggcgct caggggagcc gtgtggctgt ggcctccggg aggcggtgga cggcgtgcgc
1561 ttcatcgcag accacatgcg gagcgaggac gatgaccaga gcgtgagtga ggactggaag
1621 tacgtcgcca tggtgatcga ccgcctcttc ctctggatct ttgtctttgt ctgtgtcttt
1681 ggcaccatcg gcatgttcct gcagcctctc ttccagaact acaccaccac caccttcctc
1741 cactcagacc actcagcccc cagctccaag tgaggccctt cctcatctcc atgctctttc
1801 accctgccac cctctgctgc acagtagtgt tgggtggagg atggacgagt gagctaccag
1861 gaagaggggc gctgccccca cagatccatc cttttgcttc atctggagtc cctcctcccc
1921 cacgcctcca tccacacaca gcagctccaa cctggaggct ggaccaactg ctttgttttg
1981 gctgctctcc atctcttgta ccagcccagg caatagtgtt gaggagggga gcaaggctgc
2041 taagtggaag acagagatgg cagagccatc caccctgagg agtgacgggc aaggggccag
2101 gaaggggaca ggattgtctg ctgcctccaa gtcatgggag aagaggggta taggacaagg
2161 ggtggaaggg caggagctca caccgcaccg ggctggcctg acacaatggt agctctgaag
2221 ggaggggaag agagaggcct gggtgtgacc tgacacctgc cgctgcttga gtggacagca
2281 gctggactgg gtgggcccca cagtggtcag cgattcctgc caagtagggt ttagccgggc
2341 cccatggtca cagacccctg ggggaggctt ccagctcagt cccacagccc cttgcttcta
2401 agggatccag agacctgctc cagatcctct ttccccactg aagaattc
//