LOCUS HSU62432 1908 bp mRNA linear HUM 11-JAN-1997
DEFINITION Human nicotinic acetylcholine receptor alpha3 subunit precursor,
mRNA, complete cds.
ACCESSION U62432
VERSION U62432.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1908)
AUTHORS Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
TITLE Comparative structure of human neuronal alpha 2-alpha 7 and beta
2-beta 4 nicotinic acetylcholine receptor subunits and functional
expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
beta 4 subunits
JOURNAL J. Mol. Neurosci. 7 (3), 217-228 (1996)
PUBMED 8906617
REFERENCE 2 (bases 1 to 1908)
AUTHORS Elliott,K.J.
TITLE Direct Submission
JOURNAL Submitted (28-JUN-1996) Kathryn J. Elliott, SIBIA Neurosciences,
Inc., 505 Coast Blvd. So., La Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..1908
/db_xref="H-InvDB:HIT000220716"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="KEalpha3.2"
/cell_line="IMR32"
/cell_type="neuroblastoma"
/clone_lib="SIBIA lambda gt11 library #3 (M. Williams)"
5'UTR 1..189
CDS 190..1704
/codon_start=1
/product="nicotinic acetylcholine receptor alpha3 subunit
precursor"
/protein_id="AAB40110.1"
/translation="MGSGPLSLPLALSPPRLLLLLLSLLPVARASEAEHRLFERLFED
YNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDY
GGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKI
DVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDI
KYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI
SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTT
HTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKE
GYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYI
AENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA"
sig_peptide 190..279
mat_peptide 280..1701
/product="nicotinic acetylcholine receptor alpha3 subunit"
3'UTR 1705..1908
BASE COUNT 427 a 545 c 479 g 457 t
ORIGIN
1 cctgtcctcc cgcgggtccg agggcgctgg aaacccagcg gcggcgaagc ggagaggagc
61 cccgcgcgtc tccgcccgca cggctccagg tctggggtct gcgctggagc cgcgcgggga
121 gaggccgtct ctgcgaccgc cgcgcccgct cccgaccgtc cgggtccgcg gccagcccgg
181 ccaccagcca tgggctctgg cccgctctcg ctgcccctgg cgctgtcgcc gccgcggctg
241 ctgctgctgc tgctgtctct gctgccagtg gccagggcct cagaggctga gcaccgtcta
301 tttgagcggc tgtttgaaga ttacaatgag atcatccggc ctgtagccaa cgtgtctgac
361 ccagtcatca tccatttcga ggtgtccatg tctcagctgg tgaaggtgga tgaagtaaac
421 cagatcatgg agaccaacct gtggctcaag caaatctgga atgactacaa gctgaagtgg
481 aacccctctg actatggtgg ggcagagttc atgcgtgtcc ctgcacagaa gatctggaag
541 ccagacattg tgctgtataa caatgctgtt ggggatttcc aggtggacga caagaccaaa
601 gccttactca agtacactgg ggaggtgact tggatacctc cggccatctt taagagctcc
661 tgtaaaatcg acgtgaccta cttcccgttt gattaccaaa actgtaccat gaagttcggt
721 tcctggtcct acgataaggc gaaaatcgat ctggtcctga tcggctcttc catgaacctc
781 aaggactatt gggagagcgg cgagtgggcc atcatcaaag ccccaggcta caaacacgac
841 atcaagtaca actgctgcga ggagatctac cccgacatca catactcgct gtacatccgg
901 cgcctgccct tgttctacac catcaacctc atcatcccct gcctgctcat ctccttcctc
961 actgtgctcg tcttctacct gccctccgac tgcggtgaga aggtgaccct gtgcatttct
1021 gtcctcctct ccctgacggt gtttctcctg gtgatcactg agaccatccc ttccacctcg
1081 ctggtcatcc ccctgattgg agagtacctc ctgttcacca tgatttttgt aaccttgtcc
1141 atcgtcatca ccgtcttcgt gctcaacgtg cactacagaa ccccgacgac acacacaatg
1201 ccctcatggg tgaagactgt attcttgaac ctgctcccca gggtcatgtt catgaccagg
1261 ccaacaagca acgagggcaa cgctcagaag ccgaggcccc tctacggtgc cgagctctca
1321 aatctgaatt gcttcagccg cgcagagtcc aaaggctgca aggagggcta cccctgccag
1381 gacgggatgt gtggttactg ccaccaccgc aggataaaaa tctccaattt cagtgctaac
1441 ctcacgagaa gctctagttc tgaatctgtt gatgctgtgc tgtccctctc tgctttgtca
1501 ccagaaatca aagaagccat ccaaagtgtc aagtatattg ctgaaaatat gaaagcacaa
1561 aatgaagcca aagagattca agatgattgg aagtatgttg ccatggtgat tgatcgtatt
1621 tttctgtggg ttttcaccct ggtgtgcatt ctagggacag caggattgtt tctgcaaccc
1681 ctgatggcca gggaagatgc ataagcacta agctgtgtgc ctgcctggga gacttccttg
1741 tgtcagggca ggaggaggct gcttcctagt aagaacgtac tttctgttat caagctacca
1801 gctttgtttt tggcatttcg aggtttactt attttccact tatcttggaa tcatgcaaaa
1861 aaaaaatgtc aagagtattt attaccgata aatgaacatt taactagc
//