LOCUS HSU61276 4855 bp mRNA linear HUM 24-APR-2000
DEFINITION Human transmembrane protein Jagged 1 (HJ1) mRNA, complete cds.
ACCESSION U61276
VERSION U61276.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Lindsell,C.E., Shawber,C.J., Boulter,J. and Weinmaster,G.
TITLE Jagged: a mammalian ligand that activates Notch1
JOURNAL Cell 80 (6), 909-917 (1995)
PUBMED 7697721
REFERENCE 2 (bases 1 to 4855)
AUTHORS Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
Artavanis-Tsakonas,S.
TITLE Human ligands of the Notch receptor
JOURNAL Am. J. Pathol. 154 (3), 785-794 (1999)
PUBMED 10079256
REFERENCE 3 (bases 1 to 4855)
AUTHORS Gray,G.E., Mann,R.S., Henrique,D., Ish-Horowicz,D. and
Artavanis-Tsakonas,S.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-1996) Cell Biology, Yale University, 295 Congess
Avenue, New Haven, CT 06510, USA
FEATURES Location/Qualifiers
source 1..4855
/db_xref="H-InvDB:HIT000220686"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..4855
/gene="HJ1"
CDS 371..4027
/gene="HJ1"
/note="contains EGF-like repeats and DSL domain"
/codon_start=1
/product="transmembrane protein Jagged 1"
/protein_id="AAB39007.1"
/translation="MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQN
VNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVI
GGNTFNLKASRGNDPNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGM
INPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNK
TCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGIC
NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE
IAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL
VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDIN
INDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR
FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDH
CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGT
YCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTC
RDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTC
NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCV
DGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ
EVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSG
QSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSP
GLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKE
ITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTA
FYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKM
SKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRD
LESAQSLNRMEYIV"
BASE COUNT 1216 a 1202 c 1306 g 1131 t
ORIGIN
1 gaattcccct cccccctttt tccatgcagc tgatctaaaa gggaataaaa ggctgcgcat
61 aatcataata ataaaagaag gggagcgcga gagaaggaaa gaaagccggg aggtggaaga
121 ggagggggag cgtctcaaag aagcgatcag aataataaaa ggaggccggg ctctttgcct
181 tctggaacgg gccgctcttg aaagggcttt tgaaaagtgg tgttgttttc cagtcgtgca
241 tgctccaatc ggcggagtat attagagccg ggacgcggcc gcaggggcag cggcgacggc
301 agcaccggcg gcagcaccag cgcgaacagc agcggcggcg tcccgagtgc ccgcggcggc
361 gcgcgcagcg atgcgttccc cacggacacg cggccggtcc gggcgccccc taagcctcct
421 gctcgccctg ctctgtgccc tgcgagccaa ggtgtgtggg gcctcgggtc agttcgagtt
481 ggagatcctg tccatgcaga acgtgaacgg ggagctgcag aacgggaact gctgcggcgg
541 cgcccggaac ccgggagacc gcaagtgcac ccgcgacgag tgtgacacat acttcaaagt
601 gtgcctcaag gagtatcagt cccgcgtcac ggccgggggg ccctgcagct tcggctcagg
661 gtccacgcct gtcatcgggg gcaacacctt caacctcaag gccagccgcg gcaacgaccc
721 gaaccgcatc gtgctgcctt tcagtttcgc ctggccgagg tcctatacgt tgcttgtgga
781 ggcgtgggat tccagtaatg acaccgttca acctgacagt attattgaaa aggcttctca
841 ctcgggcatg atcaacccca gccggcagtg gcagacgctg aagcagaaca cgggcgttgc
901 ccactttgag tatcagatcc gcgtgacctg tgatgactac tactatggct ttggctgtaa
961 taagttctgc cgccccagag atgacttctt tggacactat gcctgtgacc agaatggcaa
1021 caaaacttgc atggaaggct ggatgggccc cgaatgtaac agagctattt gccgacaagg
1081 ctgcagtcct aagcatgggt cttgcaaact cccaggtgac tgcaggtgcc agtacggctg
1141 gcaaggcctg tactgtgata agtgcatccc acacccggga tgcgtccacg gcatctgtaa
1201 tgagccctgg cagtgcctct gtgagaccaa ctggggcggc cagctctgtg acaaagatct
1261 caattactgt gggactcatc agccgtgtct caacggggga acttgtagca acacaggccc
1321 tgacaaatat cagtgttcct gccctgaggg gtattcagga cccaactgtg aaattgctga
1381 gcacgcctgc ctctctgatc cctgtcacaa cagaggcagc tgtaaggaga cctccctggg
1441 ctttgagtgt gagtgttccc caggctggac cggccccaca tgctctacaa acattgatga
1501 ctgttctcct aataactgtt cccacggggg cacctgccag gacctggtta acggatttaa
1561 gtgtgtgtgc cccccacagt ggactgggaa aacgtgccag ttagatgcaa atgaatgtga
1621 ggccaaacct tgtgtaaacg ccaaatcctg taagaatctc attgccagct actactgcga
1681 ctgtcttccc ggctggatgg gtcagaattg tgacataaat attaatgact gccttggcca
1741 gtgtcagaat gacgcctcct gtcgggattt ggttaatggt tatcgctgta tctgtccacc
1801 tggctatgca ggcgatcact gtgagagaga catcgatgaa tgtgccagca acccctgttt
1861 gaatgggggt cactgtcaga atgaaatcaa cagattccag tgtctgtgtc ccactggttt
1921 ctctggaaac ctctgtcagc tggacatcga ttattgtgag cctaatccct gccagaacgg
1981 tgcccagtgc tacaaccgtg ccagtgacta tttctgcaag tgccccgagg actatgaggg
2041 caagaactgc tcacacctga aagaccactg ccgcacgacc ccctgtgaag tgattgacag
2101 ctgcacagtg gccatggctt ccaacgacac acctgaaggg gtgcggtata tttcctccaa
2161 cgtctgtggt cctcacggga agtgcaagag tcagtcggga ggcaaattca cctgtgactg
2221 taacaaaggc ttcacgggaa catactgcca tgaaaatatt aatgactgtg agagcaaccc
2281 ttgtagaaac ggtggcactt gcatcgatgg tgtcaactcc tacaagtgca tctgtagtga
2341 cggctgggag ggggcctact gtgaaaccaa tattaatgac tgcagccaga acccctgcca
2401 caatgggggc acgtgtcgcg acctggtcaa tgacttctac tgtgactgta aaaatgggtg
2461 gaaaggaaag acctgccact cacgtgacag tcagtgtgat gaggccacgt gcaacaacgg
2521 tggcacctgc tatgatgagg gggatgcttt taagtgcatg tgtcctggcg gctgggaagg
2581 aacaacctgt aacatagccc gaaacagtag ctgcctgccc aacccctgcc ataatggggg
2641 cacatgtgtg gtcaacggcg agtcctttac gtgcgtctgc aaggaaggct gggaggggcc
2701 catctgtgct cagaatacca atgactgcag ccctcatccc tgttacaaca gcggcacctg
2761 tgtggatgga gacaactggt accggtgcga atgtgccccg ggttttgctg ggcccgactg
2821 cagaataaac atcaatgaat gccagtcttc accttgtgcc tttggagcga cctgtgtgga
2881 tgagatcaat ggctaccggt gtgtctgccc tccagggcac agtggtgcca agtgccagga
2941 agtttcaggg agaccttgca tcaccatggg gagtgtgata ccagatgggg ccaaatggga
3001 tgatgactgt aatacctgcc agtgcctgaa tggacggatc gcctgctcaa aggtctggtg
3061 tggccctcga ccttgcctgc tccacaaagg gcacagcgag tgccccagcg ggcagagctg
3121 catccccatc ctggacgacc agtgcttcgt ccacccctgc actggtgtgg gcgagtgtcg
3181 gtcttccagt ctccagccgg tgaagacaaa gtgcacctct gactcctatt accaggataa
3241 ctgtgcgaac atcacattta cctttaacaa ggagatgatg tcaccaggtc ttactacgga
3301 gcacatttgc agtgaattga ggaatttgaa tattttgaag aatgtttccg ctgaatattc
3361 aatctacatc gcttgcgagc cttccccttc agcgaacaat gaaatacatg tggccatttc
3421 tgctgaagat atacgggatg atgggaaccc gatcaaggaa atcactgaca aaataatcga
3481 tcttgttagt aaacgtgatg gaaacagctc gctgattgct gccgttgcag aagtaagagt
3541 tcagaggcgg cctctgaaga acagaacaga tttccttgtt cccttgctga gctctgtctt
3601 aactgtggct tggatctgtt gcttggtgac ggccttctac tggtgcctgc ggaagcggcg
3661 gaagccgggc agccacacac actcagcctc tgaggacaac accaccaaca acgtgcggga
3721 gcagctgaac cagatcaaaa accccattga gaaacatggg gccaacacgg tccccatcaa
3781 ggattacgag aacaagaact ccaaaatgtc taaaataagg acacacaatt ctgaagtaga
3841 agaggacgac atggacaaac accagcagaa agcccggttt gccaagcagc cggcgtacac
3901 gctggtagac agagaagaga agccccccaa cggcacgccg acaaaacacc caaactggac
3961 aaacaaacag gacaacagag acttggaaag tgcccagagc ttaaaccgaa tggagtacat
4021 cgtatagcag accgcgggca ctgccgccgc taggtagagt ctgagggctt gtagttcttt
4081 aaactgtcgt gtcatactcg agtctgaggc cgttgctgac ttagaatccc tgtgttaatt
4141 tagtttgaca agctggctta cactggcaat ggtagttctg tggttggctg ggaaatcgag
4201 tggcgcatct cacagctatg caaaaagcta gtcaacagta cccctggttg tgtgtcccct
4261 tgcagccgac acggtctcgg atcaggctcc caggagctgc ccagccccct ggtactttga
4321 gctcccactt ctgccagatg tctaatggtg atgcagtctt agatcatagt tttatttata
4381 tttattgact cttgagttgt ttttgtatat tggttttatg atgacgtaca agtagttctg
4441 tatttgaaag tgcctttgca gctcagaacc acagcaacga tcacaaatga ctttattatt
4501 tatttttttt aattgtattt ttgttgttgg gggaggggag actttgatgt cagcagttgc
4561 tggtaaaatg aagaatttaa agaaaaaatg tccaaaagta gaactttgta tagttatgta
4621 aataattctt ttttattaat cactgtgtat atttgattta ttaacttaat aatcaagagc
4681 cttaaaacat cattcctttt tatttatatg tatgtgttta gaattgaagg tttttgatag
4741 cattgtaagc gtatggcttt atttttttga actcttctca ttacttgttg cctataagcc
4801 aaaaaggaaa gggtgttttg aaaatagttt attttaaaac aataggatgg gctac
//