LOCUS HSU60669 2424 bp DNA linear HUM 11-FEB-2002
DEFINITION Human 1 alpha,25-dihydroxyvitamin D3 24-hydroxylase (CYP24) gene,
promoter region and partial CDS.
ACCESSION U60669 S78775
VERSION U60669.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2424)
AUTHORS Chen,K.S. and DeLuca,H.F.
TITLE Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase
gene promoter and identification of two vitamin D-responsive
elements
JOURNAL Biochim. Biophys. Acta 1263 (1), 1-9 (1995)
PUBMED 7632726
REFERENCE 2 (bases 1 to 2424)
AUTHORS Chen,K.-S. and DeLuca,H.F.
TITLE Direct Submission
JOURNAL Submitted (13-JUN-1996) Human Oncology, University of Wisconsin,
K4/350, CSC, 600 Highland Ave., Madison, WI 53792, USA
COMMENT On Feb 8, 2002 this sequence version replaced S78775.1.
FEATURES Location/Qualifiers
source 1..2424
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q13.2-13.3"
gene complement(973..2424)
/gene="CYP24"
regulatory complement(973..987)
/regulatory_class="enhancer"
/gene="CYP24"
/note="enhancer 2; VDREd"
regulatory complement(1094..1117)
/regulatory_class="enhancer"
/gene="CYP24"
/note="VDREp"
regulatory 1233..1238
/regulatory_class="TATA_box"
prim_transcript <1263..2424
mRNA join(<1263..1922,2129..2316)
exon 1263..1922
/number=1
CDS join(1664..1922,2129..2184)
/codon_start=1
/product="1 alpha,25-dihydroxyvitamin D3 24-hydroxylase"
/protein_id="AAB03776.1"
/translation="MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVC
PLTAGGETQNAAALPGPTSWPLLASLLPDSLERGSQETARHPGGVPQEVWQDFPHEVG
FL"
intron 1923..2128
/number=1
exon 2129..2316
/number=2
intron 2317..2424
/number=2
BASE COUNT 514 a 781 c 656 g 473 t
ORIGIN
1 aagcttaagt tggactgcaa aagattttta agaaacaaac tagaggctta caaaagaatt
61 taccagggaa ggatttgcca acacttgggg caaaaatgac tgagacacgt aattgaaaag
121 cagggcgagg aaacagaatg tccctcccct cctccctggc tggtggtagt tttgtattgg
181 atcaggttga aaggattcga gccactttaa aacaatcaac aaaaatctcc aacttccgtt
241 cctgaattag caaaagcgtt ctacccttgc cagccgcgat aactctagaa attgtgtatg
301 tttgtcactg gacctgaata ggacgcacct tgggggagag ggggagtact gggggcggtg
361 gtttcaagct ctgtgtgccc ctcctttgca caaggtagtc ggtgtagaag aacagaggcg
421 ggcagtggac ataggggagg tggcccagcc tgaattcaag catcgttggt gcaagccacg
481 ctctcaaggc gcatttccta acttcctaaa gaagtaacaa cagcaactaa cttttattga
541 ctgttgacta tagacaaggc ttcgttgttg ccgctttacg tgcattaatt catttaatct
601 gcaaaacaac caaacatgaa acagcaggaa ggaaattcta caaactctcc ttcttgctca
661 agttaagaaa gtctcctctt ctggtgcatt tcagtaagac tcaaatcctc cccaccctgg
721 gaggcgcaga aagccaaact tcctccaaaa aaaaaaaggc aaaaaaaaaa aaaatcactt
781 cagtccaggc tgggggtatc tggctccccg ggaggcgcgc gggctccccg ggccctggca
841 gacgcggcag cttttctggg cccgcactcg gggacctcgc ccgcccggca tcgcgattgt
901 gcaagcgccg gcggcaacca cggccggctg cggctcctgc gccgggggag ggcggggagg
961 cgcgttcgaa gcacacccgg tgaactccgg cgttcgcatg ccttcctggg ggttatctcc
1021 ggggtggagt gctgccgccc ccaccccacc tcccgcgccc agcgaacata gccccggtca
1081 ccccaggccc ggacgccctc gctcacctcg ctgactccat cctccttcca ccccccctcc
1141 cctgggtccg cgtccctcgg agtctggcca gccgggggcc actccgccct cctctgcgtg
1201 ctcattggcc acccagggca tgctctgtct ccataaatgc atggtccctg ggcataggaa
1261 catggagagg gacaggagga aacgcagcgc cagcagcatc tcatctaccc tccttgacac
1321 ctccccgtgc tccagccaga ccctagaggt cagcttgcgg accaacagga ggactcccag
1381 ctttcccttt tcaagaggtc cccagacacc ggccaccctc ttccagccct gcggccagtg
1441 caaggaggca ccaatgctct gaggctgtcg cgtggtgcag cgtcgagcat cctcgccgag
1501 tccttctgct gcctgtcccg cctcaccccg ctccatcaca ccagctggcc ctctttgctt
1561 ccttttccca gaatcgttaa gccccgactc ccactagcac ctcgtaccaa cctcgcccca
1621 ccccatcctc ctgccttccc gcgctccggt gtcccccgct gccatgagct cccccatcag
1681 caagagccgc tcgcttgccg ccttcctgca gcagctgcgc agtccgaggc agcccccgag
1741 actggtgaca tctacggcgt acacgtcccc tcagccgcga gaggtgccag tctgcccgct
1801 gacagctggt ggcgagactc agaacgcggc cgccctgccg ggccccacca gctggccact
1861 gctggcgagc ctgctgccag attctctgga aagggggtct caagaaacag cacgacaccc
1921 tggtaaaccc ctttttcgcc cctgactctc tcctccctct tcccctccca gtggcgctcc
1981 aaaccctccc cgacatcctt cgccatggtg cttcggcgta tgggcagcga ggtcccggtc
2041 ccctaggagt aaggaggcgg gaggagggaa agcgcttcgg gcacggcgga ggatgcgctg
2101 acaccgcgct gtgcccggcc ggctgcaggt ggagtaccac aagaagtatg gcaagatttt
2161 ccgcatgaag ttgggttcct ttgagtcggt gcacctgggc tcgccatgcc tgctggaagc
2221 gctgtaccgc accgagagcg taccccagcg gctggagatc aaaccgtgga aggcctatcg
2281 cgactaccgc aagaaggcta cgggctgctg atcctggtag tccaatccga gggacctggg
2341 catgcggcca gacctgatga gcctgacggc cgcctggaaa ttgtgaagag gcggagagtt
2401 agagttccct ggggttggaa gctt
//