LOCUS HSU60521 1963 bp mRNA linear HUM 25-OCT-1996
DEFINITION Human protease proMch6 (Mch6) mRNA, complete cds.
ACCESSION U60521
VERSION U60521.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1001)
AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
TITLE CPP32, a novel human apoptotic protein with homology to
Caenorhabditis elegans cell death protein Ced-3 and mammalian
interleukin-1 beta-converting enzyme
JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994)
PUBMED 7983002
REFERENCE 2 (bases 1 to 1963)
AUTHORS Srinivasula,S.M., Fernandes-Alnemri,T., Zangrilli,J., Robertson,N.,
Armstrong,R.C., Wang,L., Trapani,J.A., Tomaselli,K.J., Litwack,G.
and Alnemri,E.S.
TITLE The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and
the lamin-cleaving enzyme Mch2alpha are substrates for the
apoptotic mediator CPP32
JOURNAL J. Biol. Chem. 271 (43), 27099-27106 (1996)
PUBMED 8900201
REFERENCE 3 (bases 1 to 1963)
AUTHORS Alnemri,E.S.
TITLE Direct Submission
JOURNAL Submitted (11-JUN-1996) Emad S. Alnemri, Pharmacology, Thomas
Jefferson University, Jefferson Cancer Institute, 233 S. Tenth
Street, Philadelphia, PA 19107, USA
FEATURES Location/Qualifiers
source 1..1963
/db_xref="H-InvDB:HIT000220639"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="Mch6-1A"
/cell_line="Jurkat"
/cell_type="T-lymphocyte"
/clone_lib="Human Jurkat T-lymphocyte lambda Uni-ZAP XR
cDNA library"
gene 1..1963
/gene="Mch6"
CDS 46..1296
/gene="Mch6"
/function="cysteine protease which is activated by CPP32
and granzyme B"
/experiment="experimental evidence, no additional details
recorded"
/note="prodomain of this protease is similar to the CED-3
prodomain; proMch6 is a new member of the
aspartate-specific cysteine protease family"
/citation=[1]
/codon_start=1
/product="proMch6"
/protein_id="AAC50776.1"
/translation="MDEADRRLLRRCRLRLVEELQVDQLWDALLSSELFRPHMIEDIQ
RAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPT
LENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPC
GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSPHFMVEVKGDLTAKKMVLALLE
LAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLG
GKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISS
LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS
VKGIYKQMPGCFNFLRKKLFFKTS"
polyA_site 1963
/gene="Mch6"
BASE COUNT 430 a 515 c 544 g 474 t
ORIGIN
1 cggaagcgga ctgaggcggc ctggagtctt agttggctac tcgccatgga cgaagcggat
61 cggcggctcc tgcggcggtg ccggctgcgg ctggtggaag agctgcaggt ggaccagctc
121 tgggacgccc tgctgagcag cgagctgttc aggccccata tgatcgagga catccagcgg
181 gcaggctctg gatctcggcg ggatcaggcc aggcagctga tcatagatct ggagactcga
241 gggagtcagg ctcttccttt gttcatctcc tgcttagagg acacaggcca ggacatgctg
301 gcttcgtttc tgcgaactaa caggcaagca gcaaagttgt cgaagccaac cctagaaaac
361 cttaccccag tggtgctcag accagagatt cgcaaaccag aggttctcag accggaaaca
421 cccagaccag tggacattgg ttctggagga tttggtgatg tcggtgctct tgagagtttg
481 aggggaaatg cagatttggc ttacatcctg agcatggagc cctgtggcca ctgcctcatt
541 atcaacaatg tgaacttctg ccgtgagtcc gggctccgca cccgcactgg ctccaacatc
601 gactgtgaga agttgcggcg tcgcttctcc tcgccgcatt tcatggtgga ggtgaagggc
661 gacctgactg ccaagaaaat ggtgctggct ttgctggagc tggcgcagca ggaccacggt
721 gctctggact gctgcgtggt ggtcattctc tctcacggct gtcaggccag ccacctgcag
781 ttcccagggg ctgtctacgg cacagatgga tgccctgtgt cggtcgagaa gattgtgaac
841 atcttcaatg ggaccagctg ccccagcctg ggaggaaagc ccaagctctt tttcatccag
901 gcctgtggtg gggagcagaa agaccatggg tttgaggtgg cctccacttc ccctgaagac
961 gagtcccctg gcagtaaccc cgagccagat gccaccccgt tccaggaagg tttgaggacc
1021 ttcgaccagc tggacgccat atctagtttg cccacaccca gtgacatctt tgtgtcctac
1081 tctactttcc caggttttgt ttcctggagg gaccccaaga gtggctcctg gtacgttgag
1141 accctggacg acatctttga gcagtgggct cactctgaag acctgcagtc cctcctgctt
1201 agggtcgcta atgctgtttc ggtgaaaggg atttataaac agatgcctgg ttgctttaat
1261 ttcctccgga aaaaactttt ctttaaaaca tcataaggcc agggcccctc accctgcctt
1321 atcttgcacc ccaaagcttt cctgccccag gcctgaaaga ggctgaggcc tggactttcc
1381 tgcaactcaa ggactttgca gccggcacag ggtctgctct ttctctgcca gtgacagaca
1441 ggctcttagc agcttccaga ttgacgacaa gtgctgaaca gtggaggaag agggacagat
1501 gaatgccgtg gattgcacgt ggcctcttga gcagtggctg gtccagggct agtgacttgt
1561 gtcccatgat ccctgtgttg tctctagagc agggattaac ctctgcacta ctgacatgtg
1621 gggccaggtc accctttgct gtgaggctgt cctgtacatt gtgggatgtt cagcactgtc
1681 ccttgcctca atgccagtaa cgcgtcttcc tgagtggtgc caaacaaaaa ggttctcagg
1741 tgttgccaaa tatgtcctgg ggtataaaac tttcctcgcc tgacaaccac tggtctgtag
1801 ggatttttgg ctacacacaa accagtatcg ctcatagatc agcaaaccgg ggcctactag
1861 agtctgaaca gctgtaatct atgaattcta agtgaaattt taaaaattgt taatttttcc
1921 tatattgcat taattttaaa aaataaatct gaggcaaata tgg
//