LOCUS HSU60520 1883 bp mRNA linear HUM 20-AUG-1996 DEFINITION Human apoptotic cysteine protease Mch5 isoform alpha (Mch5) mRNA, complete cds. ACCESSION U60520 VERSION U60520.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1883) AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. TITLE CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994) PUBMED 7983002 REFERENCE 2 (bases 1 to 1883) AUTHORS Fernandes-Alnemri,T.F., Takahashi,A., Armstrong,R., Krebs,J., Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salvesen,G., Earnshaw,W.C., Litwack,G. and Alnemri,E.S. TITLE Mch3, a novel human apoptotic cysteine protease highly related to CPP32 JOURNAL Cancer Res. 55 (24), 6045-6052 (1995) PUBMED 8521391 REFERENCE 3 (bases 1 to 1883) AUTHORS Fernandes-Alnemri,T.F., Armstrong,R.C., Krebs,J., Srinivasula,S.M., Wang,L., Bullrich,F., Fritz,L.C., Trapani,J.A., Tomaselli,K.J., Litwack,G. and Alnemri,E.S. TITLE In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (15), 7464-7469 (1996) PUBMED 8755496 REFERENCE 4 (bases 1 to 1883) AUTHORS Alnemri,E.S. TITLE Direct Submission JOURNAL Submitted (11-JUN-1996) Pharmacology, Thomas Jefferson University, Jefferson Cancer Institute, 233, S. Tenth Street, Philadelphia, PA 19107, USA FEATURES Location/Qualifiers source 1..1883 /db_xref="H-InvDB:HIT000220638" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="Mch5-RT" /cell_line="Jurkat" /cell_type="T-lymphocyte" gene 1..1883 /gene="Mch5" CDS 257..1747 /gene="Mch5" /note="the prodomain of this protease contains FADD-like death effector domains; a new member of the aspartate-specific cysteine protease family" /codon_start=1 /product="apoptotic cysteine protease Mch5 isoform alpha" /protein_id="AAC50645.1" /translation="MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALML FQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR FHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEI SKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEE LCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRD RNGTHLDAGALTTTFEELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSH GDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERC PRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD" BASE COUNT 527 a 420 c 465 g 471 t ORIGIN 1 tgaaggctgg ttgttcagac tgagcttcct gcctgcctgt accccgccaa cagcttcaga 61 agaaggtgac tggtggctgc ctgaggaata ccagtgggca agagaattag catttctgga 121 gcatctgctg tctgagcagc ccctgggtgc gtccactttc tgggcacgtg aggttgggcc 181 ttggccgcct gagcccttga gttggtcact tgaaccttgg gaatattgag attatattct 241 cctgcctttt aaaaagatgg acttcagcag aaatctttat gatattgggg aacaactgga 301 cagtgaagat ctggcctccc tcaagttcct gagcctggac tacattccgc aaaggaagca 361 agaacccatc aaggatgcct tgatgttatt ccagagactc caggaaaaga gaatgttgga 421 ggaaagcaat ctgtccttcc tgaaggagct gctcttccga attaatagac tggatttgct 481 gattacctac ctaaacacta gaaaggagga gatggaaagg gaacttcaga caccaggcag 541 ggctcaaatt tctgcctaca ggttccactt ctgccgcatg agctgggctg aagcaaacag 601 ccagtgccag acacagtctg tacctttctg gcggagggtc gatcatctat taataagggt 661 catgctctat cagatttcag aagaagtgag cagatcagaa ttgaggtctt ttaagtttct 721 tttgcaagag gaaatctcca aatgcaaact ggatgatgac atgaacctgc tggatatttt 781 catagagatg gagaagaggg tcatcctggg agaaggaaag ttggacatcc tgaaaagagt 841 ctgtgcccaa atcaacaaga gcctgctgaa gataatcaac gactatgaag aattcagcaa 901 aggggaggag ttgtgtgggg taatgacaat ctcggactct ccaagagaac aggatagtga 961 atcacagact ttggacaaag tttaccaaat gaaaagcaaa cctcggggat actgtctgat 1021 catcaacaat cacaattttg caaaagcacg ggagaaagtg cccaaacttc acagcattag 1081 ggacaggaat ggaacacact tggatgcagg ggctttgacc acgacctttg aagagcttca 1141 ttttgagatc aagccccacc atgactgcac agtagagcaa atctatgaga ttttgaaaat 1201 ctaccaactc atggaccaca gtaacatgga ctgcttcatc tgctgtatcc tctcccatgg 1261 agacaagggc atcatctatg gcactgatgg acaggaggcc cccatctatg agctgacatc 1321 tcagttcact ggtttgaagt gcccttccct tgctggaaaa cccaaagtgt tttttattca 1381 ggcttgtcag ggggataact accagaaagg tatacctgtt gagactgatt cagaggagca 1441 accctattta gaaatggatt tatcatcacc tcaaacgaga tatatcccgg atgaggctga 1501 ctttctgctg gggatggcca ctgtgaataa ctgtgtttcc taccgaaacc ctgcagaggg 1561 aacctggtac atccagtcac tttgccagag cctgagagag cgatgtcctc gaggcgatga 1621 tattctcacc atcctgactg aagtgaacta tgaagtaagc aacaaggatg acaagaaaaa 1681 catggggaaa cagatgcctc agcctacttt cacactaaga aaaaaacttg tcttcccttc 1741 tgattgatgg tgctattttg tttgttttgt tttgttttgt ttttttgaga cagaatctcg 1801 ctctgtcgcc caggctggag tgcagtggcg tgatctcggc tcaccgcaag ctccgcctcc 1861 cgggttcagg ccattctcct gct //