LOCUS       HSU60520                1883 bp    mRNA    linear   HUM 20-AUG-1996
DEFINITION  Human apoptotic cysteine protease Mch5 isoform alpha (Mch5) mRNA,
            complete cds.
ACCESSION   U60520
VERSION     U60520.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
  TITLE     CPP32, a novel human apoptotic protein with homology to
            Caenorhabditis elegans cell death protein Ced-3 and mammalian
            interleukin-1 beta-converting enzyme
  JOURNAL   J. Biol. Chem. 269 (49), 30761-30764 (1994)
   PUBMED   7983002
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Fernandes-Alnemri,T.F., Takahashi,A., Armstrong,R., Krebs,J.,
            Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salvesen,G.,
            Earnshaw,W.C., Litwack,G. and Alnemri,E.S.
  TITLE     Mch3, a novel human apoptotic cysteine protease highly related to
            CPP32
  JOURNAL   Cancer Res. 55 (24), 6045-6052 (1995)
   PUBMED   8521391
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Fernandes-Alnemri,T.F., Armstrong,R.C., Krebs,J., Srinivasula,S.M.,
            Wang,L., Bullrich,F., Fritz,L.C., Trapani,J.A., Tomaselli,K.J.,
            Litwack,G. and Alnemri,E.S.
  TITLE     In vitro activation of CPP32 and Mch3 by Mch4, a novel human
            apoptotic cysteine protease containing two FADD-like domains
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (15), 7464-7469 (1996)
   PUBMED   8755496
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Alnemri,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-1996) Pharmacology, Thomas Jefferson University,
            Jefferson Cancer Institute, 233, S. Tenth Street, Philadelphia, PA
            19107, USA
FEATURES             Location/Qualifiers
     source          1..1883
                     /db_xref="H-InvDB:HIT000220638"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="Mch5-RT"
                     /cell_line="Jurkat"
                     /cell_type="T-lymphocyte"
     gene            1..1883
                     /gene="Mch5"
     CDS             257..1747
                     /gene="Mch5"
                     /note="the prodomain of this protease contains FADD-like
                     death effector domains; a new member of the
                     aspartate-specific cysteine protease family"
                     /codon_start=1
                     /product="apoptotic cysteine protease Mch5 isoform alpha"
                     /protein_id="AAC50645.1"
                     /translation="MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALML
                     FQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR
                     FHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEI
                     SKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEE
                     LCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRD
                     RNGTHLDAGALTTTFEELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSH
                     GDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
                     EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERC
                     PRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD"
BASE COUNT          527 a          420 c          465 g          471 t
ORIGIN      
        1 tgaaggctgg ttgttcagac tgagcttcct gcctgcctgt accccgccaa cagcttcaga
       61 agaaggtgac tggtggctgc ctgaggaata ccagtgggca agagaattag catttctgga
      121 gcatctgctg tctgagcagc ccctgggtgc gtccactttc tgggcacgtg aggttgggcc
      181 ttggccgcct gagcccttga gttggtcact tgaaccttgg gaatattgag attatattct
      241 cctgcctttt aaaaagatgg acttcagcag aaatctttat gatattgggg aacaactgga
      301 cagtgaagat ctggcctccc tcaagttcct gagcctggac tacattccgc aaaggaagca
      361 agaacccatc aaggatgcct tgatgttatt ccagagactc caggaaaaga gaatgttgga
      421 ggaaagcaat ctgtccttcc tgaaggagct gctcttccga attaatagac tggatttgct
      481 gattacctac ctaaacacta gaaaggagga gatggaaagg gaacttcaga caccaggcag
      541 ggctcaaatt tctgcctaca ggttccactt ctgccgcatg agctgggctg aagcaaacag
      601 ccagtgccag acacagtctg tacctttctg gcggagggtc gatcatctat taataagggt
      661 catgctctat cagatttcag aagaagtgag cagatcagaa ttgaggtctt ttaagtttct
      721 tttgcaagag gaaatctcca aatgcaaact ggatgatgac atgaacctgc tggatatttt
      781 catagagatg gagaagaggg tcatcctggg agaaggaaag ttggacatcc tgaaaagagt
      841 ctgtgcccaa atcaacaaga gcctgctgaa gataatcaac gactatgaag aattcagcaa
      901 aggggaggag ttgtgtgggg taatgacaat ctcggactct ccaagagaac aggatagtga
      961 atcacagact ttggacaaag tttaccaaat gaaaagcaaa cctcggggat actgtctgat
     1021 catcaacaat cacaattttg caaaagcacg ggagaaagtg cccaaacttc acagcattag
     1081 ggacaggaat ggaacacact tggatgcagg ggctttgacc acgacctttg aagagcttca
     1141 ttttgagatc aagccccacc atgactgcac agtagagcaa atctatgaga ttttgaaaat
     1201 ctaccaactc atggaccaca gtaacatgga ctgcttcatc tgctgtatcc tctcccatgg
     1261 agacaagggc atcatctatg gcactgatgg acaggaggcc cccatctatg agctgacatc
     1321 tcagttcact ggtttgaagt gcccttccct tgctggaaaa cccaaagtgt tttttattca
     1381 ggcttgtcag ggggataact accagaaagg tatacctgtt gagactgatt cagaggagca
     1441 accctattta gaaatggatt tatcatcacc tcaaacgaga tatatcccgg atgaggctga
     1501 ctttctgctg gggatggcca ctgtgaataa ctgtgtttcc taccgaaacc ctgcagaggg
     1561 aacctggtac atccagtcac tttgccagag cctgagagag cgatgtcctc gaggcgatga
     1621 tattctcacc atcctgactg aagtgaacta tgaagtaagc aacaaggatg acaagaaaaa
     1681 catggggaaa cagatgcctc agcctacttt cacactaaga aaaaaacttg tcttcccttc
     1741 tgattgatgg tgctattttg tttgttttgt tttgttttgt ttttttgaga cagaatctcg
     1801 ctctgtcgcc caggctggag tgcagtggcg tgatctcggc tcaccgcaag ctccgcctcc
     1861 cgggttcagg ccattctcct gct
//