LOCUS HSU57650 5273 bp mRNA linear HUM 03-MAY-1997
DEFINITION Human SH2-containing inositol 5-phosphatase (hSHIP) mRNA, complete
cds.
ACCESSION U57650
VERSION U57650.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5273)
AUTHORS Ware,M.D., Rosten,P., Damen,J.E., Liu,L., Humphries,R.K. and
Krystal,G.
TITLE Cloning and characterization of human SHIP, the 145-kD inositol
5-phosphatase that associates with SHC after cytokine stimulation
JOURNAL Blood 88 (8), 2833-2840 (1996)
PUBMED 8874179
REFERENCE 2 (bases 1 to 5273)
AUTHORS Krystal,G.
TITLE Direct Submission
JOURNAL Submitted (06-MAY-1996) Gerald Krystal, Terry Fox Laboratory,
British Columbia Cancer Agency, 601 W. 10th Ave., Vancouver, B.C.
V5Z 1L3, Canada
FEATURES Location/Qualifiers
source 1..5273
/db_xref="H-InvDB:HIT000220495"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q36-37"
/cell_line="megakaryocytic cell line MO7e"
/clone_lib="lambda gt11"
gene 1..5273
/gene="hSHIP"
CDS 513..4079
/gene="hSHIP"
/note="type II 5-inositol phosphatase"
/codon_start=1
/product="SH2-containing inositol 5-phosphatase"
/protein_id="AAB53573.1"
/translation="MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCV
LYRNCVYTYRILPNEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVP
LEEEDTGDDPEEDTESVVSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLS
ETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKE
LYGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIED
KVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSE
DKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKN
KHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGT
QEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDN
VKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGD
KKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERR
EQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLV
HVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLK
TKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLD
QHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQ
GKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNY
MGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPK
KFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKP
APRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCS
SSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS
PAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ"
misc_feature 525..816
/gene="hSHIP"
/note="encodes SH2 domain"
misc_feature 2256..2291
/gene="hSHIP"
/note="encodes 5-ptase Motif 1"
misc_feature 2514..2546
/gene="hSHIP"
/note="encodes 5-ptase Motif 2"
repeat_region 4414..4438
/gene="hSHIP"
/note="TAA repeat; Alu-like repeat"
/rpt_family="Sx"
BASE COUNT 1258 a 1545 c 1428 g 1042 t
ORIGIN
1 ctagggcatg gcatcccacg tgggtgtcag cacggccgca gaagaaccac ttctctggcc
61 cacccatgcc tgctaggcca tgcttcttca gaagtggcca caactctcct gacgtctcca
121 gagccggtca ttccacccag ggggacttca gctgccactg gacacttcaa ttgtacgctg
181 cgaccagttg ccaggaagga gagggctggc aagaaagccg cggcagccgt ggcagggtgt
241 atgggacggt ggacggccag ggcccccccc tctctctctt tctctctctc tctcttgctt
301 ggtttctgta atgaggaagt tctccgcagc tcagtttcct ttccctcact gagcgcctga
361 aacaggaagt cagtcagtta agctggtggc agcagccgag gccaccaaga ggcaacgggc
421 ggcaggttgc agtggagggg cctccgctcc cctcggtggt gtgtgggtcc tgggggtgcc
481 tgccggccca gccgaggagg cccacgccca ccatggtccc ctgctggaac catggcaaca
541 tcacccgctc caaggcggag gagctgcttt ccaggacagg caaggacggg agcttcctcg
601 tgcgtgccag cgagtccatc tcccgggcat acgcgctctg cgtgctgtat cggaattgcg
661 tttacactta cagaattctg cccaatgaag atgataaatt cactgttcag gcatccgaag
721 gcgtctccat gaggttcttc accaagctgg accagctcat cgagttttac aagaaggaaa
781 acatggggct ggtgacccat ctgcaatacc ctgtgccgct ggaggaagag gacacaggcg
841 acgaccctga ggaggacaca gaaagtgtcg tgtctccacc cgagctgccc ccaagaaaca
901 tcccgctgac tgccagctcc tgtgaggcca aggaggttcc tttttcaaac gagaatcccc
961 gagcgaccga gaccagccgg ccgagcctct ccgagacatt gttccagcga ctgcaaagca
1021 tggacaccag tgggcttcca gaagagcatc ttaaggccat ccaagattat ttaagcactc
1081 agctcgccca ggactctgaa tttgtgaaga cagggtccag cagtcttcct cacctgaaga
1141 aactgaccac actgctctgc aaggagctct atggagaagt catccggacc ctcccatccc
1201 tggagtctct gcagaggtta tttgaccagc agctctcccc gggcctccgt ccacgtcctc
1261 aggttcctgg tgaggccaat cccatcaaca tggtgtccaa gctcagccaa ctgacaagcc
1321 tgttgtcatc cattgaagac aaggtcaagg ccttgctgca cgagggtcct gagtctccgc
1381 accggccctc ccttatccct ccagtcacct ttgaggtgaa ggcagagtct ctggggattc
1441 ctcagaaaat gcagctcaaa gtcgacgttg agtctgggaa actgatcatt aagaagtcca
1501 aggatggttc tgaggacaag ttctacagcc acaagaaaat cctgcagctc attaagtcac
1561 agaaatttct gaataagttg gtgatcttgg tggaaacaga gaaggagaag atcctgcgga
1621 aggaatatgt ttttgctgac tccaaaaaga gagaaggctt ctgccagctc ctgcagcaga
1681 tgaagaacaa gcactcagag cagccggagc ccgacatgat caccatcttc atcggcacct
1741 ggaacatggg taacgccccc cctcccaaga agatcacgtc ctggtttctc tccaaggggc
1801 agggaaagac gcgggacgac tctgcggact acatccccca tgacatttac gtgatcggca
1861 cccaagagga ccccctgagt gagaaggagt ggctggagat cctcaaacac tccctgcaag
1921 aaatcaccag tgtgactttt aaaacagtcg ccatccacac gctctggaac atccgcatcg
1981 tggtgctggc caagcctgag cacgagaacc ggatcagcca catctgtact gacaacgtga
2041 agacaggcat tgcaaacaca ctggggaaca agggagccgt gggggtgtcg ttcatgttca
2101 atggaacctc cttagggttc gtcaacagcc acttgacttc aggaagtgaa aagaaactca
2161 ggcgaaacca aaactatatg aacattctcc ggttcctggc cctgggcgac aagaagctga
2221 gtccctttaa catcactcac cgcttcacgc acctcttctg gtttggggat cttaactacc
2281 gtgtggatct gcctacctgg gaggcagaaa ccatcatcca aaaaatcaag cagcagcagt
2341 acgcagacct cctgtcccac gaccagctgc tcacagagag gagggagcag aaggtcttcc
2401 tacacttcga ggaggaagaa atcacgtttg ccccaaccta ccgttttgag agactgactc
2461 gggacaaata cgcctacacc aagcagaaag cgacagggat gaagtacaac ttgccttcct
2521 ggtgtgaccg agtcctctgg aagtcttatc ccctggtgca cgtggtgtgt cagtcttatg
2581 gcagtaccag cgacatcatg acgagtgacc acagccctgt ctttgccaca tttgaggcag
2641 gagtcacttc ccagtttgtc tccaagaacg gtcccgggac tgttgacagc caaggacaga
2701 ttgagtttct caggtgctat gccacattga agaccaagtc ccagaccaaa ttctacctgg
2761 agttccactc gagctgcttg gagagttttg tcaagagtca ggaaggagaa aatgaagaag
2821 gaagtgaggg ggagctggtg gtgaagtttg gtgagactct tccaaagctg aagcccatta
2881 tctctgaccc tgagtacctg ctagaccagc acatcctcat cagcatcaag tcctctgaca
2941 gcgacgaatc ctatggcgag ggctgcattg cccttcggtt agaggccaca gaaacgcagc
3001 tgcccatcta cacgcctctc acccaccatg gggagttgac aggccacttc cagggggaga
3061 tcaagctgca gacctctcag ggcaagacga gggagaagct ctatgacttt gtgaagacgg
3121 agcgtgatga atccagtggg ccaaagaccc tgaagagcct caccagccac gaccccatga
3181 agcagtggga agtcactagc agggcccctc cgtgcagtgg ctccagcatc actgaaatca
3241 tcaaccccaa ctacatggga gtggggccct ttgggccacc aatgcccctg cacgtgaagc
3301 agaccttgtc ccctgaccag cagcccacag cctggagcta cgaccagccg cccaaggact
3361 ccccgctggg gccctgcagg ggagaaagtc ctccgacacc tcccggccag ccgcccatat
3421 cacccaagaa gtttttaccc tcaacagcaa accggggtct ccctcccagg acacaggagt
3481 caaggcccag tgacctgggg aagaacgcag gggacacgct gcctcaggag gacctgccgc
3541 tgacgaagcc cgagatgttt gagaaccccc tgtatgggtc cctgagttcc ttccctaagc
3601 ctgctcccag gaaggaccag gaatccccca aaatgccgcg gaaggaaccc ccgccctgcc
3661 cggaacccgg catcttgtcg cccagcatcg tgctcaccaa agcccaggag gctgatcgcg
3721 gcgaggggcc cggcaagcag gtgcccgcgc cccggctgcg ctccttcacg tgctcatcct
3781 ctgccgaggg cagggcggcc ggcggggaca agagccaagg gaagcccaag accccggtca
3841 gctcccaggc cccggtgccg gccaagaggc ccatcaagcc ttccagatcg gaaatcaacc
3901 agcagacccc gcccaccccg acgccgcggc cgccgctgcc agtcaagagc ccggcggtgc
3961 tgcacctcca gcactccaag ggccgcgact accgcgacaa caccgagctc ccgcatcacg
4021 gcaagcaccg gccggaggag gggccaccag ggcctctagg caggactgcc atgcagtgaa
4081 gccctcagtg agctgccact gagtcgggag cccagaggaa cggcgtgaag ccactggacc
4141 ctctcccggg acctcctgct ggctcctcct gcccagcttc ctatgcaagg ctttgtgttt
4201 tcaggaaagg gcctagcttc tgtgtggccc acagagttca ctgcctgtga ggcttagcac
4261 caagtgctga ggctggaaga aaaacgcaca ccagacgggc aacaaacagt ctgggtcccc
4321 agctcgctct tggtacttgg gaccccagtg cctcgttgag ggcgccattc tgaagaaagg
4381 aactgcagcg ccgatttgag ggtggagata tagataataa taatattaat aataataatg
4441 gccacatgga tcgaacactc atgatgtgcc aagtgctgtg ctaagtgctt tacgaacatt
4501 cgtcatatca ggatgacctc gagagctgag gctctagcca cctaaaacac gtgcccaaac
4561 ccaccagttt aaaacggtgt gtgttcggag gggtgaaagc attaagaagc ccagtgccct
4621 cctggagtga gacaagggct cggccttaag gagctgaaga gtctgggtag cttgtttagg
4681 gtacaagaag cctgttctgt ccagcttcag tgacacaagc tgctttagct aaagtcccgc
4741 gggttccggc atggctaggc tgagagcagg gatctacctg gcttctcagt tctttggttg
4801 gaaggagcag gaaatcagct cctattctcc agtggagaga tctggcctca gcttgggcta
4861 gagatgccaa ggcctgtgcc aggttccctg tgccctcctc gaggtgggca gccatcacca
4921 gccacagtta agccaagccc cccaacatgt attccatcgt gctggtagaa gagtctttgc
4981 tgttgctccc gaaagccgtg ctctccagcc tggctgccag ggagggtggg cctcttggtt
5041 ccaggctctt gaaatagtgc agccttttct tcctatctct gtggctttca gctctgcttc
5101 cttggttatt aggagaatag atgggtgatg tctttcctta tgttgctttt tcaacatagc
5161 agaattaatg tagggagcta aatccagtgg tgtgtgtgaa tgcagaaggg aatgcacccc
5221 acattcccat gatggaagtc tgcgtaacca ataaattgtg cctttcttaa aaa
//