LOCUS HSU56976 2265 bp mRNA linear HUM 21-OCT-1996
DEFINITION Human calmodulin dependent phosphodiesterase PDE1B1 mRNA, complete
cds.
ACCESSION U56976
VERSION U56976.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2265)
AUTHORS Jiang,X., Li,J., Paskind,M. and Epstein,P.M.
TITLE Inhibition of calmodulin-dependent phosphodiesterase induces
apoptosis in human leukemic cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (20), 11236-11241 (1996)
PUBMED 8855339
REFERENCE 2 (bases 1 to 2265)
AUTHORS Epstein,P.M.
TITLE Direct Submission
JOURNAL Submitted (29-APR-1996) Paul M. Epstein, Pharmacology, University
of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT
06030, USA
FEATURES Location/Qualifiers
source 1..2265
/db_xref="H-InvDB:HIT000220469"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="RPMI 8392 B lymphoblastoid"
/note="derived from a patient with acute lymphocytic
leukemia"
CDS 35..1645
/note="Method: conceptual translation supplied by author"
/codon_start=1
/product="calmodulin dependent phosphodiesterase PDE1B1"
/protein_id="AAC50769.1"
/translation="MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVK
QLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLA
STFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKN
LDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKY
KNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHI
QTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLAT
DMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEF
FRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADE
DSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQM
SIDELSPCEEEAPPSPAEDEHNQNGNLD"
BASE COUNT 506 a 629 c 628 g 499 t
ORIGIN
1 gctrgtccmy gccagccgca gaccgtggct gagcatggag ctgtcccccc gcagtcctcc
61 ggagatgctg gaggagtcgg attgcccgtc acccctggag ctgaagtcag cccccagcaa
121 gaagatgtgg attaagcttc ggtctctgct gcgctacatg gtgaagcagt tggagaatgg
181 ggagataaac attgaggagc tgaagaaaaa tctggagtac acagcttctc tgctggaagc
241 cgtctacata gatgagacac ggcaaatctt ggacacggag gacgagctgc aggagctgcg
301 gtcagatgcc gtgccttcgg aggtgcggga ctggctggcc tccaccttca cccagcaggc
361 ccgggccaaa ggccgccgag cagaggagaa gcccaagttc cgaagcattg tgcacgctgt
421 gcaggctggg atcttcgtgg aacggatgtt ccggagaaca tacacctctg tgggccccac
481 ttactctact gcggttctca actgtctcaa gaacctggat ctctggtgct ttgatgtctt
541 ttccttgaac caggcagcag atgaccatgc cctgaggacc attgtttttg agttgctgac
601 tcggcataac ctcatcagcc gcttcaagat tcccactgtg tttttgatga gtttcctgga
661 tgccttggag acaggctatg ggaagtacaa gaatccttac cacaaccaga tccacgcagc
721 cgatgttacc cagacagtcc attgcttctt gctccgcaca gggatggtgc actgcctgtc
781 ggagattgag ctcctggcca tcatctttgc tgcagctatc catgattatg agcacacggg
841 cactaccaac agcttccaca tccagaccaa gtcagaatgt gccatcgtgt acaatgatcg
901 ttcagtgctg gagaatcacc acatcagctc tgttttccga ttgatgcagg atgatgagat
961 gaacattttc atcaacctca ccaaggatga gtttgtagaa ctccgagccc tggtcattga
1021 gatggtgttg gccacagaca tgtcctgcca tttccagcaa gtgaagacca tgaagacagc
1081 cttgcaacag ctggagagga ttgacaagcc caaggccctg tctctactgc tccatgctgc
1141 tgacatcagc cacccaacca agcagtggtt ggtccacagc cgttggacca aggccctcat
1201 ggaggaattc ttccgtcagg gtgacaagga ggcagagttg ggcctgccct tttctccact
1261 ctgtgaccgc acttccactc tagtggcaca gtctcagata gggttcatcg acttcattgt
1321 ggagcccaca ttctctgtgc tgactgacgt ggcagagaag agtgttcagc ccctggcgga
1381 tgaggactcc aagtctaaaa accagcccag ctttcagtgg cgccagccct ctctggatgt
1441 ggaagtggga gaccccaacc ctgatgtggt cagctttcgt tccacctggg tcaagcgcat
1501 tcaggagaac aagcagaaat ggaaggaacg ggcagcaagt ggcatcacca accagatgtc
1561 cattgacgag ctgtccccct gtgaagaaga ggccccccca tcccctgccg aagatgaaca
1621 caaccagaat gggaatctgg attagccctg gggctggccc aggtcttcat tgagtccaaa
1681 gtgtttgatg tcatcagcac catccatcag gactggctcc cccatctgct ccaagggagc
1741 gtggtcgtgg aagaaacaac ccacctgaag gccaaatgcc agagatttgg ggttggggaa
1801 agggcccctc cccacctgac acccactggg gtgcacttta atgttccggc agcaagactg
1861 gggaacttca ggctcccagt ggtcactgtg cccatccctc agcctctgga ttctcttcat
1921 ggccaggtgg ctgccaggga gcggggagct tcctggaggc ttcccagggc cttggggaag
1981 ggtcagagat gccagccccc tgggacctcc cccatccttt ttgcctccaa gtttctaagc
2041 aatacatttt gggggttccc tcagcccccc accccagatc ttagctggca ggtctgggtg
2101 ccccttttcc tcccctggga agggctggaa taggatagaa agctgggggt tttcagagcc
2161 ctatgtgtgg ggaggggagt ggattccttc agggcatggt acctttctag gatctgggaa
2221 tggggtggag aggacatcct cttcacccca gaattgcggg aattc
//